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| 1 | Adipokines levels are associated with the severity of liver disease in patients with alcoholic cirrhosis显示文摘AIM:To investigate the adipokine levels of leptin,adiponectin,resistin,visfatin,retinol-binding protein 4(RBP4),apelin in alcoholic liver cirrhosis(ALC).METHODS:Forty non-diabetic ALC patients[median age:59 years,males:35(87.5%),Child-Pugh(CP)score:median 7(5-12),CP A/B/C:18/10/12,Model for End-stage Liver Disease(MELD):median 10(6-25),follow-up:median 32.5 mo(10-43)]were prospectively included.The serum adipokine levels were estimated in duplicate by ELISA.Somatometric characteristics were assessed with tetrapolar bioelectrical impedance analysis.Pearson’s rank correlation coefficient was used to assess possible associations with adipokine levels.Univariate and multivariate Cox regression analysis was used to determine independent predictors for overallsurvival.RESULTS:Body mass index:median 25.9(range:20.1-39.3),fat:23.4%(7.6-42.1),fat mass:17.8(5.49-45.4),free fat mass:56.1(39.6-74.4),total body water(TBW):40.6(29.8-58.8).Leptin and visfatin levels were positively associated with fat mass(P<0.001/P=0.027,respectively)and RBP4 with TBW(P=0.025).Median adiponectin levels were significantly higher in CPC compared to CPA(CPA:7.99±14.07,CPB:7.66±3.48,CPC:25.73±26.8,P=0.04),whereas median RBP4 and apelin levels decreased across the spectrum of disease severity(P=0.006/P=0.034,respectively).Following adjustment for fat mass,visfatin and adiponectin levels were significantly increased from CPA to CPC(both P<0.001),whereas an inverse correlation was observed for both RBP4 and apelin(both P<0.001).In the multivariate Cox regression analysis,only MELD had an independent association with overall survival(HR=1.53,95%CI:1.05-2.32;P=0.029).CONCLUSION:Adipokines are associated with deteriorating liver function in a complex manner in patients with alcoholic liver cirrhosis. | Maria Kalafateli Christos Triantos Emmanuel Tsochatzis Marina Michalaki Efstratios Koutroumpakis Konstantinos Thomopoulos Venetsanea Kyriazopoulou Eleni Jelastopulu Andrew Burroughs Chryssoula Lambropoulou-Karatza Vasiliki Nikolopoulou | 2015 | World Journal of Gastroenterology2015，21，10： | 8 |
| 2 | Protective effect of amifostine during fractionated radiotherapy in patients with pelvic carcinomas: Results of a randomized trial显示文摘 | Helen Athanassiou Dosia Antonadou Nikos Coliarakis Athina Kouveli Maria Synodinou Michalakis Paraskevaidis George Sarris Gregory R Georgakopoulos Katerina Panousaki Pantelis Karageorgis Nicolas Throuvalas | 2003 | International Journal of Radiation Oncology, Biology, Physics2003，，4： | 2 |
| 3 | Genetic diversity and pathogenic variation of Colletotrichum lindemuthianum in the three centers of diversity of its host, Phaseolus vulgaris 显示文摘 | SICARD D MICHALAKIS Y DRON M | 1997 | Phytopathology1997，87，8： | 1 |
| 4 | Optical behavior of current ceramic systems显示文摘 | Raptis NV Michalakis KX Hirayama H | | 0，，01： | 1 |
| 5 | Thyroid function in humans with morbid obesity显示文摘 | Michalaki MA Vagenakis AG etal | 2006 | Thyroid2006，16，1： | 1 |
| 6 | HCN2 channels in localinhibitory interneurons constrain LTP in the hippocampal direct per-forant path显示文摘 | Matt L Michalakis S Hofmann F | 2011 | Cell Mol Life Sci2011，68，： | 1 |
| 7 | Fracture resistance of metal ceramic restorations with two different margin designs after exposure to masticatory simul-ation显示文摘 | Michalakis K X Stratos A Hirayama H | 2009 | J Prosthet Dent2009，102，3： | 1 |
| 8 | Cytoldne produc- tion and hospital mortality in patients with sepsis-induced stress hyperglycemia显示文摘 | Leonidou L Mouzaki A Michalaki M | 2007 | Infection2007，55，4： | 1 |
| 9 | Postoperative adhesion prevention using a statin-containing cellulose film in an experimental model显示文摘 | Lalountas M Ballas K D Michalakis A | | 0，，： | 1 |
| 10 | Thyroid cancer in patients with hyperthyroidism显示文摘 | Pazaitou-Panayiotou K Michalakis K Paschke R | 2012 | Hormo Metabo Res2012，44，4： | 1 |
| 11 | Greek lignites as additives for controlling filtration prop- erties of water-bentonite suspensions at high tempera- tures显示文摘 | Kelessidis V C Tsamantaki C Michalakis A | 2007 | The Science and Technology of Fuel and Energy2007，86，11： | 1 |
| 12 | Value of the pubic tubercle as a CT reference point in groin hernias显示文摘 | Delabrousse E Michalakis D Sarliève P | 2005 | J Radiol2005，86，61： | 1 |
| 13 | Stress-induced hy- perglycemia in patients with severe sepsis a compromising factor for survival显示文摘 | Leonidou L Michalaki M Leonardou A | 2008 | Am J Med Sci2008，336，6： | 1 |
| 14 | The impact of bariatric surgery procedures on type 2 diabetes,hyperlipidemia and hypertension显示文摘 | Polymeris A Karoutsou E Michalakis K | 2013 | Hellenic J Cardio2013，54，3： | 1 |
| 15 | Gemcitabine combined with 5-fluoreuracil for the treatment of advanced carcinoma of the pancreas显示文摘 | Gennatas C Michalaki V Mouratidou D | 2006 | In Vivo2006，20，2： | 1 |
| 16 | Stress- induced hyperglycemia in patients with severe sepsis: a compromising factor for survival显示文摘 | Leonidou L Michalaki M Leonardou A | 2008 | Am J Med Sci2008，336，6： | 1 |
| 17 | Optical behavior of current ceramic systems 显示文摘 | Raptis NV Michalakis KX Hirayama H | 2006 | Int J Periodontics Restorative Dent2006，26，1： | 1 |
| 18 | Ⅱ:modeling显示文摘 | Michalakis Constantinou Anoop Mokha Andrei Re-inhorn Teflon bearings in base isolation | 1990 | Journal of Structural Engineering1990，116，2： | 1 |
| 19 | Serum adiponectin in chronic hepatitis C and B显示文摘 | SIAGRIS D VAF1ADIS G MICHALAKI M | 2007 | J Viral Hepat2007，14，： | 1 |
| 20 | Low-dose capecitabine plus docetaxel as first-line therapy for metastatic breast cancer:phase Ⅱ results显示文摘 | Michalaki V Gennatas S Gennatas K | 2009 | Anticancer Drugs2009，20，3： | 1 |
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