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| 1 | Sleep,immunity and inflammation in gastrointestinal disorders显示文摘Sleep disorders have become a global issue,and discovering their causes and consequences are the focus of many research endeavors.An estimated 70 million Americans suffer from some form of sleep disorder.Certain sleep disorders have been shown to cause neurocognitive impairment such as decreased cognitive ability,slower response times and performance detriments.Recent research suggests that individuals with sleep abnormalities are also at greater risk of serious adverse health,economic consequences,and most importantly increased all-cause mortality.Several research studies support the associations among sleep,immune function and inflammation.Here,we review the current research linking sleep,immune function,and gastrointestinal diseases and discuss the interdependent relationship between sleep and these gastrointestinal disorders.Different physiologic processes including immune system and inflammatory cytokines help regulate the sleep.The inflammatory cytokines such as tumor necrosis factor,interleukin-1(IL-1),and IL-6 have been shown to be a significant contributor of sleep disturbances.On the other hand,sleep disturbances such as sleep deprivation have been shown to up regulate these inflammatory cytokines.Alterations in these cytokine levels have been demonstrated in certain gastrointestinal diseases such as inflammatory bowel disease,gastro-esophageal reflux,liver disorders and colorectal cancer.In turn,abnormal sleep brought on by these diseases is shown to contribute to the severity of these same gastrointestinal diseases.Knowledge of these relationships will allow gastroenterologists a great opportunity to enhance the care of their patients. | Tauseef Ali James Choe Ahmed Awab Theodore L Wagener William C Orr | 2013 | World Journal of Gastroenterology2013，19，48： | 15 |
| 2 | Serum cytokine profile in patients with hepatitis B e antigen-negative chronic active hepatitis B and inactive hepatitis B virus carriers显示文摘An insufficient cellular immune response seems to be critical for the immunopathogenesis of chronic hepatitis B virus infection.We have previously demonstrated no differences of T-lymphocyte subsets in blood between inactive hepatitis B s antigen(HBsAg) carriers and patients with HBeAg-negative chronic active hepatitis B.This study investigated the peripheral blood cytokine profile in patients with HBeAg-negative chronic active hepatitis B infection(Group A,n = 21) and inactive HBsAg carriers(Group B,n = 13).Serum cytokines [interferon(IFN)-γ,tumor necrosis factor-α,interleukin(IL)-1b,IL-4,IL-12,IL-10,IL-2,IL-5,IL-8] were analyzed by using flow cytometry.Patients with chronic active disease presented with significantly decreased levels of IFN-γ and IL-10 compared to inac-tive carriers(P = 0.048 and P = 0.008,respectively).In HBeAg-negative chronic active hepatitis B patients,a significant negative correlation of IFN-γ levels with serum hepatitis B viral load was noted(P = 0.021).In conclusion,patients with HBeAg-negative chronic active hepatitis B and HBsAg inactive carriers display a different cytokine profile.Decreased Th1 response observed in patients with chronic active hepatitis B could be implicated in the persistence of virus replication and ongoing progression of liver disease. | Dimitra Dimitropoulou Marina Karakantza Georgios L Theodorou Lydia Leonidou Stelios F Assimakopoulos Athanasia Mouzaki Charalambos A Gogos | 2013 | World Journal of Gastrointestinal Pathophysiology2013，4，1： | 13 |
| 3 | A semi-automated in vitro gas production technique for ruminant feedstuff evaluation显示文摘 | Rogerio M Mauricio Fergus L Mould Mewa S Dhanoa Emyr Owen Kulwant S Channa Michael K Theodorou | 1999 | Animal Feed Science and Technology1999，，4： | 2 |
| 4 | Prevention of gut leakiness by a probiotic treatment leads to attenuated HPA response to an acute psychological stress in rats显示文摘 | Afifa Ait-Belgnaoui Henri Durand Christel Cartier Gilles Chaumaz Hélène Eutamene Laurent Ferrier Eric Houdeau Jean Fioramonti Lionel Bueno Vassilia Theodorou | 2012 | Psychoneuroendocrinology2012，，11： | 2 |
| 5 | Blood glucose and heart failure in nondiabetic patients显示文摘 | Christopher N Theodore L | 2005 | Diabetes Care2005，28，3： | 1 |
| 6 | The role of sandwich holography in ICF 显示文摘 | Theodore R Pattinson Donald L | 1989 | J Vac Sci Technol1989，7，3： | 1 |
| 7 | Detection of pancre- atic carcinoma: diagnostic value of K-ras mutations in circu- lating DNA from serum 显示文摘 | Theodor L Melzer E Sologov M | 1999 | Dig Dis Sci1999，44，10： | 1 |
| 8 | Blood glucose and heart failure in nondi- abetic patients显示文摘 | Christopher N Theodore L | 2005 | Diabetes Care2005，28，3： | 1 |
| 9 | Phytic acid as a food antioxidant 显示文摘 | KATHERINE L EMPSON THEODORE P L | 1991 | Journal of Food Science1991，，2： | 1 |
| 10 | International SMA consortium meeting report 显示文摘 | Theodore L Kay E | 1992 | Neuromusc Disord1992，2，56： | 1 |
| 11 | Finite Element Analysis of Steel Beam to Column Connections Subjected to Blast Loads 显示文摘 | TAPAN S DANIEL L THEODOR K | 2005 | International Journal of Impact Engineering2005，31，2005： | 1 |
| 12 | Acetylation-deacetylation of the transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) regulates its transcriptional activity and nucleocytoplasmic localization 显示文摘 | Kawai Y Gardano L Theodore M | 2011 | J Biol Chem2011，286，9： | 1 |
| 13 | Acetylation-Deacetylation of the Transcription Factor Nrf2(Nuclear Factor Erythroid 2-related Factor 2)regulates its transcriptional activity and nucleocytoplasmic localization显示文摘 | Kawai Y Gardufto L Theodore M | 2011 | J Biol Chem2011，286，9： | 1 |
| 14 | Acetylation-deacetylation of the transcripttion factor Nrf2 (nuclear factor erythroid 2-related factor 2) regulates its transcriptional activity and nucleocytoplasmic localization显示文摘 | Kawai Y Garduno L Theodore M | 2011 | J Biol Chem2011，286，9： | 1 |
| 15 | Resistant hypertension, obesity, sleep apnea and alodosterone: theory and therapy显示文摘 | Theodore L Goodfriend David A | 2004 | Hypertension2004，43，3： | 1 |
| 16 | Effectiveness of live - attenuated Japanese encephalitis vaccine ( SA14 - 14 - 2 ): a case - control study显示文摘 | Hennessy S Zhengle L Theodore FT | 1996 | The Lancet1996，347，8： | 1 |
| 17 | Combined genotypes of CCR5, CCR2, SDF1, and HLA genes can predict the long-term nonprogressor status in HIV-1 infected individuals显示文摘 | Magdalena M Theodorou L Debre P | 1999 | Blood1999，93，3： | 1 |
| 18 | Genetic algorithms for autonomous robot navigation显示文摘 | Theodore W M Kaveh A Roger L W | 2007 | IEEE Instrumentation and Mea- surement Magazine2007，12，1： | 1 |
| 19 | EGFR as a prognostic marker for gastric cancer显示文摘 | Theodore L Nikolaos X Dimosthenis Z | 2008 | World J Surg2008，32，6： | 1 |
| 20 | HIF-1 reduces ischaemi- a-reperfusion injury in the heart by targeting the mitochondrial per- meability transition pore 显示文摘 | Ong S G Lee W H Theodorou L | 2014 | Cardiovasc Res2014，104，1： | 1 |
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