|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Impact of CYP2D*6 in the adjuvant treatment of breast cancer patients with tamoxifen显示文摘Biotransformation of tamoxifen to the potent antiestrogen endoxifen is performed by cytochrome P450(CYP) enzymes, in particular the CYP2D6 isoform. CYP2D6*4 is one of the most frequent alleles associated with loss of enzymatic activity. The incidence of CYP2D6*4 among Caucasians is estimated up to 27%, while it is present in up to 90% of all poor metabolizers within the Caucasian population. The hypothesis under question is whether the presence of one or two non-functioning(null) alleles predicts an inferior outcome in postmenopausal women with breast cancer receiving adjuvant treatment with tamoxifen. The numerous existing studies investigating the association of CYP2D6 with treatment failure in breast cancer are inconsistent and give rather conflicting results. Currently, routine CYP2D6 testing among women with breast cancer is not recommended and the significance of CYP2D6 phenotype in decision making regarding the administration of tamoxifen is unclear. The present study summarizes current literature regarding clinical studies on CYP2D6*4, par-ticularly in terms of response to tamoxifen therapy and breast cancer outcome. | Christos Markopoulos Stylianos Kykalos Dimitrios Mantas | 2014 | World Journal of Clinical Oncology2014，5，3： | 4 |
| 2 | VL30 retrotransposition signals activation of a caspaseindependent and p53-dependent death pathway associated with mitochondrial and lysosomal damage显示文摘长终端重复(LTR ) 的影响房间命运上的 retrotransposition 是未知的。这里,我们在转变 SV40 的老鼠 SVTT1 房间在房间死亡上调查了 VL30 retrotransposition 的效果。VL30 retrotransposon 的 Transfection 减少了由 17 褶层的 SVTT1 的 clonogenicity,作为与父母 NIH3T3 房间相比。频率和房间死亡率在 retrotransposition 积极的 SVTT1 被发现的 retrotransposition 的相关层次克隆房间,展出 DNA 破碎,原子冷凝作用, multinucleation 和细胞质的 vacuolization。受动器 caspases 的激活的分析揭示了 caspase 独立的房间死亡机制。然而,房间死亡与感应的 p53 和 Bcl-2 和 Hsp70 蛋白质表示的美洲狮伪和 Bax 和 downregulation 的伴随物 upregulation 被联系。而且,我们发现了大 T 抗原(副)/p53 和 p53 translocation 的 colocalization 的部分损失到线粒体,导致外部膜 permeabilization (MOMP ) 由 lysosomal 膜 permeabilization (LMP ) 伴随了的 mitochondrial。有趣地,有抗氧化剂 N-acetylcysteine 的处理废除了细胞死亡,建议导出 mitochondrial 的反应的氧种类的参与,并且导致了 retrotransposition 频率的增加。重要地,当 VL30 动员被导致,房间死亡的正式就职是 retrotransposon 特定的 VL30;相反, non-LTR L1 的动员(LINE-1,长散布的原子 element-1 ) , B2 和 LTR MusD retrotransposons 减少了。第一次,我们的结果提供 VL30 retrotransposition 调停的充分证据经由 mitochondrial 和 lysosomal 损坏的房间死亡,揭开是的 retrotransposition 的角色在触发房间死亡激活 mitochondrial-lysosomal 串音的一个原子信号。 | Dimitrios Noutsopoulos Georgios Markopoulos Georgios Vartholomatos Evangelos Kolettas Nicolaos Kolaitis Theodore Tzavaras | 2010 | Cell Research2010，20，5： | 3 |
| 3 | Evaluation of Corvis ST tonometer with the updated software in glaucoma practice显示文摘AIM: To evaluate the agreement of biomechanically corrected intraocular pressure(b-IOP) and central corneal thickness(CCT) measurements obtained with the updated Corvis ST tonometer versus Goldmann applanation tonometry(GAT) and optical-based corneal pachymetry(OB-CCT) in controls, patients with ocular hypertension(OHT) and primary open angle glaucoma(POAG).Additionally, we examined the differences in corneal deformation parameters provided by the updated Corvis ST among the three groups.METHODS: For each participant, GAT IOP, OB-CCT and measurements with a Corvis ST with updated software were obtained.Bland-Altman analysis was used to assess the agreement between the two measurement methods.RESULTS: A consecutive series of 80 eyes from 80 participants(30 with POAG, 25 with OHT and 25 normal controls) were included in this prospective study.The mean GAT IOP of all eyes was 17.2±3.6 mm Hg, and the mean b-IOP was 15.9±3.7 mm Hg(Spearman’s rho=0.767, P<0.001).The 95% limits of agreement(Lo As) ranged from-3.1 mm Hg to 5.5 mm Hg for GAT IOP and b-IOP.b-IOP was not correlated with OB-CCT(Spearman’s rho=-0.13 P=0.917).Meanwhile there was a weak positive corelation between OB-CCT and GAT IOP–b-IOP difference(Spearman’s rho=0.378, P=0.001).The mean OB-CCT was 549.5±36.4 μm, and the Corvis-CCT was 556.1±41.5 μm(Spearman’s rho=0.900, P<0.001).No statistically significant difference in the new indices provided by the updated Corvis ST was detected among the three groups.Compared with control eyes, POAG eyes had a significantly reduced applanation time 2 after adjusting for OB-CCT and GAT IOP(P=0.048).CONCLUSION: Corvis b-IOP and CCT correlate well with GAT IOP and OB-CCT.b-IOP is not affected by CCT, which might be an advantage, especially in thick or thin corneas.Corvis ST yields shorter applanation time 2 measurements in patients with POAG, which might reflect altered corneal viscoelasticity. | Ioannis Halkiadakis Vasilios Tzimis Alexandros Gryparis Ioannis Markopoulos Vasiliki Konstadinidou Elias Zintzaras Michalis Tzakos | 2022 | International Journal of Ophthalmology(English edition)2022，15，3： | 2 |
| 4 | 可穿戴传感系统在上肢康复中应用的研究与实践显示文摘本文对可穿戴传感系统在上肢康复领域中的研究进行综述调研,根据论题相关的关键词搜到61篇文章,基于对文章摘要的初选和全文的筛选最终纳入18篇。这些文章可以分为三类:进行运动和姿势监测;提供终端用户反馈;整合交互游戏。基于现有文献的技术成熟度,临床证据的有效性和系统可用性等方面对其进行探讨,设计出一套智能康复服装系统,可用于多种病症康复。该系统包括一件整合了可穿戴电子元器件和智能织物的服装和基于安卓设备的反馈平台,可以实时通过衣服上的震动模块或来自手机的屏幕反馈、语音提示给予用户反馈。 | 王琦 陈炜 Panos Markopoulos | 2016 | 中国康复理论与实践2016，22，12： | 2 |
| 5 | Bilateralbreast cancer 显示文摘 | Gogas J Markopoulos C Skandalakis P | 1993 | Am Surg1993，59，11： | 1 |
| 6 | Failure mechanisms analysis of 2D carbon/carbon using acoustic emission monitoring显示文摘 | Y Z Pappas Y P Markopoulos | 1998 | NDT& E International1998，31，： | 1 |
| 7 | Impact of breast cancer surgery on the self-esteem and sexual life of female patients 显示文摘 | Markopoulos C Tsaroucha AK Kouskos E | 2009 | J Int Med Res2009，37，1： | 1 |
| 8 | Current aspects on oral squamous cell carcinoma显示文摘 | Markopoulos AK | 2012 | Open Dent J2012，6，1： | 1 |
| 9 | Anemia of chronic disease and defective erythropoietin production in patients with celiac disease显示文摘 | Bergamaschi G Markopoulos K Albertini M | 2008 | Hematologica2008，93，12： | 1 |
| 10 | Carcinosarcoma of the breast:report of two cases 显示文摘 | Gogas J Kouskos E Markopoulos C | 2003 | Eur J Gynaeeol Oncol2003，24，1： | 1 |
| 11 | Prolonged disease free survival with aggressive adjuvant chemotherapy in a case of large cell neuroendocrine carcinoma of the uterine cervix 显示文摘 | Markopoulos MC Lagadas AA Alexandrou P | 2009 | J BUON2009，14，2： | 1 |
| 12 | Arthroscopic bankart suture-anchor repair: radiologieal and clinical outcome at minimum 10 years of follow-up显示文摘 | CASTAGNA A MARKOPOULOS N CONTI M | 2010 | Am J Sports Med2010，38，10： | 1 |
| 13 | Carcinosarcoma of the breast: report of two cases显示文摘 | GOGAS J KOUSKOS E MARKOPOULOS C | 2003 | EurJ Gynaecol Oncol2003，24，1： | 1 |
| 14 | Optical coherence tomography and multifocal electroretinogram study in human immunodeficiency virus-positive children without in-fectious retinitis显示文摘 | Moschos MM Margetis I Markopoulos I Moschos MN | 2011 | Clin Exp Optom2011，94，3： | 1 |
| 15 | Arthroscopic Bankart suture-anchor repair: radiological and clinical outcome at minimum 10 years of follow-up显示文摘 | Castagna A Markopoulos N Conti M | 2010 | Am J Sports Med2010，38，10： | 1 |
| 16 | De-tection of T cells secreting type 1 and type 2 cytokines in the peripher-al blood of patients with oral lichen planus显示文摘 | Kalogerakou F Albanidou-Farmaki E Markopoulos AK | 2008 | Hippokratia2008，12，4： | 1 |
| 17 | Association between age at diagnosis and disease-specific mortality among postmenopausal women with hormone receptor-positive breast cancer显示文摘 | van de Water W Markopoulos C | 2012 | JAMA2012，307，： | 1 |
| 18 | Leptin and insulin growth factor I in relation to breast cancer (Greece) 显示文摘 | Petridou E Papadiamantis Y Markopoulos C | 2000 | Cancer Causes Control2000，11，5： | 1 |
| 19 | Surgical management of nipple discharge显示文摘 | Markopoulos C Mantas D Kouskos E | 2006 | Eur J Gynaecol Oncol2006，27，3： | 1 |
| 20 | Overview of the use of Oncotype DXi as an addi- tional treatment decision tool in early breast cancer显示文摘 | Markopoulos C | 2013 | Expert Rev Andcancer Ther2013，13，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员