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| 1 | Structure and deformation around the Gyirong basin, north Himalaya, and onset of the south Tibetan detachment system显示文摘Gyirong basin and its adjacent area are located at a special position in the Himalayan orogen, where the south Tibetan detachment system (STDS) and N-S trending rift converged. The north Himalayan orogen here can be divided into five petrologic-tectonic units successively from south to north: 1) the Greater Himalayan crystalline complex (GHC); 2) the STDS shear zone; 3) the Tethyan Himalayan sedimentary sequence (THS); 4) the late Cenozoic sedimentary basins, such as Gyirong and Oma basins; and 5) the Malashan gneiss dome. Structural studies show that this area experienced four stages of deformation: 1) the earlier south-directed thrusting, preserved both in the GHC and THS; 2) top-down-to-north slip along the STDS, normal faults related to this slip formed the early controlling structures of the Cenozoic basins,and the tilted pattern of the blocks between the basins indicated a north-directed slip; 3) east-west extension, the resultant N-S trending normal fault formed the eastern boundary of the basins; and 4) late gravitational collapse. Zircon SHRIMP U-Pb dating on the syn-deformational (leuco-) granite along the STDS indicates that the major activity of the STDS occurred at ca. 26 Ma, but its onset may have begun as early as ca. 36 Ma. | YANG XiongYing ZHANG JinJiang QI GuoWei WANG DeChao GUO Lei LI PengYuan LIU Jiang | 2009 | Science China Earth Sciences2009，52，8： | 33 |
| 2 | A novel cancer vaccine with the ability to simultaneously produce anti-PD-1 antibody and GM-CSF in cancer cells and enhance Th1-biased antitumor immunity显示文摘Tumor escape from immune-mediated destruction has been associated with immunosuppressive mechanisms that inhibit T-cell activation.A promising strategy for cancer immunotherapy is to disrupt key pathways regulating immune tolerance,such as program death-1(PD-1/PD-L1)pathway in the tumor environment.However,the determinants of response to anti-PD-1 monoclonal antibodies(mAbs)treatment remain incompletely understood.In murine models,PD-1 blockade alone fails to induce effective immune responses to poorly immunogenic tumors,but is successful when combined with additional interventions,such as cancer vaccines.Novel cancer vaccines combined with antibody may offer promising control of cancer development and progression.In this investigation,we generated a novel tumor cell vaccine simultaneously expressing anti-PD-1 mAbs and granulocyte-macrophage colony stimulating factor(GM-CSF)in CT26 colon cancer and B16-F10 melanoma.The antitumor effect of the vaccine was verified by therapeutic and adoptive animal experiments in vivo.The antitumor mechanism was analyzed using Flow cytometry,Elispot and in vivo intervention approaches.The results showed that tumor cell vaccine secreting PD-1 neutralizing antibodies and GM-CSF induced remarkable antitumor immune effects and prolonged the survival of tumor-bearing animals compared with animals treated with either PD-1 mAbs or GM-CSF alone.Antitumor effects and prolonged survival correlated with strong antigen-specific T-cell responses by analyzing CD11c^(+)CD86^(+)DC,CD11b^(+)F4/80^(+)MΦcells,increased ratio of Teff/Treg in the tumor microenvironment,and higher secretion levels of Th1 proinflammatory cytokines in serum.Furthermore,the results of ELISPOT and in vivo blocking strategies further confirmed that the antitumor immune response is acquired by CD4 and CD8 T immune responses,primarily dependent on CD4 Th1 immune response,not NK innate immune response.The combination of PD-1 blockade with GM-CSF secretion potency creates a novel tumor cell vaccine immunotherapy,affording significantly improved antitumor responses by releasing the state of immunosuppressive microenvironment and augmenting the tumor-reactive T-cell responses. | Hongwei Tian Gang Shi Qin Wang Yiming Li Qianmei Yang Chunlei Li Guoyou Yang Min Wu Qian Xie Shuang Zhang Yang Yang Rong Xiang Dechao Yu Yuquan Wei Hongxin Deng | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 3 | MINERALOGICAL FEATURES OF ULTRAMAFIC HYPOXENOLITHS IN ALKALI-RICH PORPHYRY显示文摘Ultramafic hypoxenoliths found in the alkali-rich porphyry in the Liuhe Village, Heqing, Yunnan,China, are of great significance in understanding the origin and evolution of the porphyry. This paper discusses the mineralogical features of the hypoxenoliths. It shows that the xenoliths are characterized by the upper mantle rocks modified to certain extent by the enriched mantle fluid metasomatism in the mantle environment, with the enriched mantle property of Iow-degree partial melting. This constitutes the important mineralogical evidence for the petrogenesis and mineralization of alkali-rich porphyry. | LIU Xianfan , YANG Zhengxi, LIU Jiaduo, ZHANG Chengjiang, WU Dechao and LI Youguo(Institute of Earth Science, Chengdu University of Technology, Erxianqiao Dongsan Road 1#,Chengdu, SC610059, China) | 2003 | Geotectonica et Metallogenia2003，27，1： | 2 |
| 4 | Identification of prognostic biomarkers in hepatitis B virus-related hepatocellular carcinoma and stratification by integrative multi-omics analysis显示文摘 | Ruoyu Miao Haitao Luo Huandi Zhou Guangbing Li Dechao Bu Xiaobo Yang Xue Zhao Haohai Zhang Song Liu Ying Zhong Zhen Zou Yan Zhao Kuntao Yu Lian He Xinting Sang Shouxian Zhong Jiefu Huang Yan Wu Rebecca A. Miksad Simon C. Robson Chengyu Jiang Yi Zhao Haita | 2014 | Journal of Hepatology2014，，： | 2 |
| 5 | Enhanced performance of ZnO piezoelectric nanogenerators by using Au‐coated nanowire arrays as top electrode显示文摘 | Dechao Yang Wenbin Song Hui Chen Yapeng Li Zhen Zhang Jin Xu Shukun Zhao Xiaoling Sun Yu Qiu | 2015 | Phys. Status Solidi A2015，，： | 1 |
| 6 | A generalizable strategy based on the rule of“like dissolves like”to construct porous liquids with low viscosity for CO_(2)capture显示文摘Porous liquids(PLs),an emerging porous material with permanent cavities,have attracted extensive attention in recent years.However,the current construction methods are complicated and resulting PLs possess high viscosity values,which cannot meet the requirements of practical industrial applications.Herein,we demonstrate a generalizable and simple strategy to prepare type III PLs with low viscosity based on the rule of“like dissolves like”.Specifically,the monoglycidyl ether terminated polydimethylsiloxane(denoted by E-PDMS)is attached to the surface of Universitetet i Oslo(UiO)-66-NH_(2)via covalent linkage,constructing the pore generator(UiO-66-NH_(2)-E-PDMS,denoted by P-UiO-66).Then,P-UiO-66 is dispersed into different types and amounts of sterically hindered solvents(PDMS400 or PDMS6000),obtaining a series of type III PLs(denoted by P-UiO-66-PLs)with permanent cavities and low viscosities.The gas sorption-desorption test shows that P-UiO-66-PLs have an enormous potential for CO_(2)/N_(2) selective separation.Besides,the porosity of P-UiO-66-PLs and the CO_(2)sorption mechanism are demonstrated by molecular simulation.Furthermore,the generality of the synthesis strategy is confirmed by the successful construction of PLs using two other amino-metal-organic frameworks(MOFs)(MIL-53(Al)-NH_(2)and MIL-88B(Fe)-NH_(2)).Importantly,it’s worth noting that the strategy based on the rule of“like dissolves like”sheds light on the preparation of other types of PLs for task-specific applications. | Yangyang Xin Hailong Ning Dechao Wang(✉) Xiaoqian Li Wendi Fan Xiaoqian Ju Hongni Wang Yichi Zhang Zhiyuan Yang Dongdong Yao Yaping Zheng | 2023 | Nano Research2023，16，7： | 1 |
| 7 | CloudLCA: finding the lowest common ancestor in metagenome analysis using cloud computing显示文摘Estimating taxonomic content constitutes a key problem in metagenomic sequencing data analysis.However,extracting such content from high-throughput data of next-generation sequencing is very time-consuming with the currently available software.Here,we present CloudLCA,a parallel LCA algorithm that significantly improves the efficiency of determining taxonomic composition in metagenomic data analysis.Results show that CloudLCA(1)has a running time nearly linear with the increase of dataset magnitude,(2)displays linear speedup as the number of processors grows,especially for large datasets,and(3)reaches a speed of nearly 215 million reads each minute on a cluster with ten thin nodes.In comparison with MEGAN,a well-known metagenome analyzer,the speed of CloudLCA is up to 5 more times faster,and its peak memory usage is approximately 18.5%that of MEGAN,running on a fat node.CloudLCA can be run on one multiprocessor node or a cluster.It is expected to be part of MEGAN to accelerate analyzing reads,with the same output generated as MEGAN,which can be import into MEGAN in a direct way to finish the following analysis.Moreover,CloudLCA is a universal solution for finding the lowest common ancestor,and it can be applied in other fields requiring an LCA algorithm. | Guoguang Zhao Dechao Bu Changning Liu Jing Li Jian Yang Zhiyong Liu Yi Zhao Runsheng Chen | 2012 | Protein & Cell2012，3，2： | 1 |
| 8 | Multi-stage anisotropic etching of two-dimensional heterostructures显示文摘Regarding the reverse process of materials growth,etching has been widely concerned to indirectly probe the growth kinetics,offering an avenue in governing the growth of two-dimensional(2D)materials.In this work,interface-driven anisotropic etching mode is demonstrated for the first time to be generally applied to 2D heterostructures.It is shown that the typical in-plane graphene and hexagonal boron nitride(h-BN)heterostructures follow a multi-stage etching behavior initiated first along the interfacial region between the two materials and then along edges of neighboring h-BN flakes and finally along central edges of hBN.By accurately tuning etching conditions in the chemical vapor deposition process,series of etched 2D heterostructure patterns are controllably produced.Furthermore,scaled formation of graphene and h-BN heterostructures arrays has been realized with full assist of as-proposed etching mechanism,offering a direct top-down method to make 2D orientated heterostructures with order and complexity.Detection of interface-driven multi-staged anisotropic etching mode will shed light on understanding growth mechanism and further expanding wide applications of 2D heterostructures. | Lin Li Jichen Dong Dechao Geng Menghan Li Wei Fu Feng Ding Wenping Hu Hui Ying Yang | 2022 | Nano Research2022，15，6： | 0 |
| 9 | Selective Growth of GaN on Slope Cone-shaped Patterned Sapphire Substrate显示文摘 | YANG Dechao LIANG Hongwei QIU Yu LI Pengchong LIU Yang SHEN Rensheng XIA Xiaochuan YU Zhennan CHANG Yuchun ZHANG Yuantao DU Guotong | 2014 | Chemical Research in Chinese Universities2014，30，4： | 0 |
| 10 | Erratum to:Multi-stage anisotropic etching of two-dimensional heterostructures显示文摘Erratum to Nano Research 2022,15(6):4909−4915 http://gffzzd3cc09b8251d45dfsuvkbwbuf66566bk9.ffgz.tsg.suse.edu.cn/10.1007/s12274-022-4193-x The affiliation of the author“Feng Ding”was unfortunately mistakenly marked.This error did not affect any of the content and conclusions from the published paper.In addition,one funding was unfortunately forgotten.This error did not affect any of the content and conclusions from the published paper. | Lin Li Jichen Dong Dechao Geng Menghan Li Wei Fu Feng Ding Wenping Hu Hui Ying Yang | 2022 | Nano Research2022，15，7： | 0 |
| 11 | van der Waals type II carbon nitride homojunctions for visible light photocatalytic hydrogen evolution显示文摘Photocatalytic hydrogen evolution reaction(PC-HER)provides a solution to energy crisis and environmental pollution.Herein,different graphitic carbon nitride(g-C_(3)N_(4))-based van der Waals(vdW)type II homojunctions have been fabricated and g-C_(3)N_(4)/Kdoped g-C_(3)N_(4)nanosheets have an outstanding PC-HER rate of 1,243μmol·h^(−1)·g^(−1)under visible light,higher than that of bulk g-C_(3)N_(4),doped g-C_(3)N_(4)nanosheets,and mixed nanosheets.The enhanced PC-HER performance can be ascribed to the cooperative effects of the shortened bandgap,enlarged specific surface area,matched type II energy band structure,“face to face”vdW charge interaction,and peculiarly partite positions of the conduction and valence bands in different layers.Besides,the type II junctions were found superior to binary type II junction.This study highlights the synergistic effect of different strategies in improving the PC-HER capacities of g-C_(3)N_(4),especially the application of particular vdW junctions,and provides new insights to the structures and mechanism. | Xiaojie Li Panpan Zhang Huayang Zhang Wenjie Tian Yangyang Yang Kunsheng Hu Dechao Chen Qin Li Xiaoguang Duan Hongqi Sun Shaobin Wang | 2023 | Nano Research2023，16，4： | 0 |
| 12 | Simulation of Ultrasonic Propagation in Transformers within Thermal Fields and Intelligent Methodology for Hot-spot Temperature Recognition显示文摘Hot-spot temperature of transformer windings is a crucial indicator of internal defects.However,current methods for measuring the hot-spot temperature of transformers do not apply to those already in operation and suffer from data lag.This study introduces a novel inversion method that combines ultrasonic sensing technology,multiphysics simulation,and the K-nearest neighbors algorithm.Leveraging the penetrative ability and temperature sensitivity of ultrasonic sensing,a detailed physical field simulation model was established.This study extensively investigates the characteristics of ultrasonic wave signals inside transformers.The investigation includes different temperature fields,ranging from 40℃ to 110℃ at 10℃ intervals,and various ultrasonic wave emitter conditions.By extracting the key features of the acoustic signals,such as the peak time,propagation time,and peak amplitude,an accurate inversion of the winding hot-spot temperature is successfully achieved.The results demonstrate that this method achieves a high accuracy rate(98.57%)in inverting the internal winding hot-spot temperatures of transformers,offering an efficient and reliable new approach for measuring winding hot-spot temperatures. | Dongxin He Dechao Yang Xinhua Guo Jiefeng Liu Haoxin Guo Qingquan Li Gilbert Teyssedre | 2024 | Chinese Journal of Electrical Engineering2024，10，1： | 0 |
| 13 | Recent Advances in Growth,Properties and Applications of 2D Inorganic Molecular Crystals显示文摘Comprehensive Summary Since the concept of 2D inorganic molecular crystals(2DIMCs)was introduced,intensive attentions have been gradually devoted to this field.Herein,the very recent advances in growth,properties,and applications of 2D inorganic molecular crystals are comprehensively reviewed.Firstly,the newly emerged 2DIMCs are classified into three categories.Then the two typical production methods are present,thus leading to discrepancy in size,distribution,morphology and structures of 2DIMCs.Moreover,the unique physicochemical properties of 2DIMCs are demonstrated on the basis of the as-obtained 2DIMCs,the various applications are exhibited,demonstrating significant potential in related fields.Finally,the perspective and prospects are outlooked to offer insights in further development of 2DIMCs. | Menghan Li Yang Guo Lin Li Dechao Geng Wenping Hu | 2023 | Chinese Journal of Chemistry2023，41，15： | 0 |
| 14 | Spacecraft formation reconfiguration with multi-obstacle avoidance under navigation and control uncertainties using adaptive artificial potential function method显示文摘In this paper,an adaptive artificial potential function(AAPF)method is developed for spacecraft formation reconfiguration with multi-obstacle avoidance under navigation and control uncertainties.Furthermore,an improved Linear Quadratic Regular(ILQR)is proposed to track the reference trajectory and a Lyapunov-based method is employed to demonstrate the stability of the overall closed-loop system.Compared with the traditional APF method and the equal-collision-probability surface(ECPS)method,the AAPF method not only retains the advantages of APF method and ECPS method,such as low computational complexity,simple analytical control law and easy analytical validation progress,but also proposes a new APF to solve multi-obstacle avoidance problem considering the influence of the uncertainties.Moreover,the ILQR controller obtains high control accuracy to enhance the safe performance of the spacecraft formation reconfiguration.Finally,the effectiveness of the proposed AAPF method and the ILQR controller are verified by numerical simulations. | Yi Wang Xiaoqian Chen Dechao Ran Yong Zhao Yang Chen Yuzhu Bai | 2020 | Astrodynamics2020，4，1： | 0 |
| 15 | Variable optical splitter based on wavelength-sensitive components and related intelligent passive optical network显示文摘 | Dechao ZHANG Han LI Lei WANG Liang GENG Shiguang WANG Sheng LIU Yang GAO | 2017 | Frontiers of Optoelectronics2017，10，1： | 0 |
| 16 | Single-cell Long Non-coding RNA Landscape of T Cells in Human Cancer Immunity显示文摘The development of new biomarkers or therapeutic targets for cancer immunotherapies requires deep understanding of Tcells.To date,the complete landscape and systematic characterization of long noncoding RNAs(lncRNAs)in T cells in cancer immunity are lacking.Here,by systematically analyzing full-length single-cell RNA sequencing(scRNA-seq)data of more than 20,000 libraries of T cells across three cancer types,we provided the first comprehensive catalog and the functional repertoires of lncRNAs in human T cells.Specifically,we developed a custom pipeline for de novo transcriptome assembly and obtained a novel lncRNA catalog containing 9433 genes.This increased the number of current human lncRNA catalog by 16%and nearly doubled the number of lncRNAs expressed in T cells.We found that a portion of expressed genes in single T cells were lncRNAs which had been overlooked by the majority of previous studies.Based on metacell maps constructed by the MetaCell algorithm that partitions scRNA-seq datasets into disjointed and homogenous groups of cells(metacells),154 signature lncRNA genes were identified.They were associated with effector,exhausted,and regulatory T cell states.Moreover,84 of them were functionally annotated based on the co-expression networks,indicating that lncRNAs might broadly participate in the regulation of T cell functions.Our findings provide a new point of view and resource for investigating the mechanisms of T cell regulation in cancer immunity as well as for novel cancer-immune biomarker development and cancer immunotherapies. | Haitao Luo Dechao Bu Lijuan Shao Yang Li Liang Sun Ce Wang Jing Wang Wei Yang Xiaofei Yang Jun Dong Yi Zhao Furong Li | 2021 | Genomics, Proteomics & Bioinformatics2021，19，3： | 0 |
| 17 | Unveiling clinical significance and tumor immune landscape of CXCL12 in bladder cancer: Insights from multiple omics analysis显示文摘Objective: The interplay between chemokine C-X-C motif ligand 12(CXCL12) and its specific receptors is known to trigger various signaling pathways, contributing to tumor proliferation and metastasis. Consequently,targeting this signaling axis has emerged as a potential strategy in cancer therapy. However, the precise role of CXCL12 in clinical therapy, especially in immunotherapy for bladder cancer(BCa), remains poorly elucidated.Methods: We gathered multiple omics data from public databases to unveil the clinical relevance and tumor immune landscape associated with CXCL12 in BCa patients. Univariate and multivariate Cox regression analyses were employed to assess the independent prognostic significance of CXCL12 expression and formulate a nomogram. The expression of CXCL12 in BCa cell lines and clinical tissue samples was validated using enzymelinked immunosorbent assays(ELISA) and immunohistochemistry(IHC).Results: While transcriptional expression of CXCL12 exhibited a decrease in nearly all tumor tissues, CXCL12 methylation expression was notably increased in BCa tissues. Single-cell RNA analysis highlighted tissue stem cells and endothelial cells as the primary sources expressing CXCL12. Abnormal CXCL12 expression, based on transcriptional and methylation levels, correlated with various clinical characteristics in BCa patients. Functional analysis indicated enrichment of CXCL12 and its co-expression genes in immune regulation and cell adhesion. The immune landscape analysis unveiled a significant association between CXCL12 expression and M2 macrophages(CD163~+ cells) in BCa tissues. Notably, CXCL12 expression emerged as a potential predictor of immunotherapy response and chemotherapy drug sensitivity in BCa patients.Conclusions: Taken together, these findings suggest aberrant production of CXCL12 in BCa tissues,potentially influencing the treatment responses of affected individuals. | Zhouting Tuo Dechao Feng Zhiwei Jiang Liangkuan Bi Chao Yang Qi Wang | 2023 | Chinese Journal of Cancer Research2023，35，6： | 0 |
| 18 | Author Correction: A novel cancer vaccine with the ability to simultaneously produce anti-PD-1 antibody and GM-CSF in cancer cells and enhance Th1-biased antitumor immunity显示文摘Correction to:Signal Transduction and Targeted Therapy(2016)1:16025 http://gffzzd3cc09b8251d45dfsuvkbwbuf66566bk9.ffgz.tsg.suse.edu.cn/10.1038/sigtrans.2016.25,published online 18 November 2016 Since the publication of this research Article,we retrospected the paper and noticed two inadvertent mistakes that need to be corrected immediately.We have checked the original data and repeated the experiments;the correct data are provided in this Corrigendum as follows.The key findings of the article are not affected by these corrections. | Hongwei Tian Gang Shi Qin Wang Yiming Li Qianmei Yang Chunlei Li Guoyou Yang Min Wu Qian Xie Shuang Zhang Yang Yang Rong Xiang Dechao Yu Yuquan Wei Hongxin Deng | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 0 |
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