|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | HDAC inhibitors improve CRISPR-mediated HDR editing efficiency in iPSCs显示文摘Genome-edited human induced pluripotent stem cells(iPSCs)hold great promise for therapeutic applications.However,low editing efficiency has hampered the applications of CRISPR-Cas9 technology in creating knockout and homology-directed repair(HDR)-edited iPSC lines,particularly for silent genes.This is partially due to chromatin compaction,inevitably limiting Cas9 access to the target DNA.Among the six HDAC inhibitors we examined,vorinostat,or suberoylanilide hydroxamic acid(SAHA),led to the highest HDR efficiency at both open and closed loci,with acceptable toxicity.HDAC inhibitors equally increased non-homologous end joining(NHEJ)editing efficiencies(~50%)at both open and closed loci,due to the considerable HDAC inhibitor-mediated increase in Cas9 and sgRNA expression.However,we observed more substantial HDR efficiency improvement at closed loci relative to open chromatin(2.8 vs.1.7-fold change).These studies provide a new strategy for HDRediting of silent genes in iPSCs. | Jian-Ping Zhang Zhi-Xue Yang Feng Zhang Ya-Wen Fu Xin-Yue Dai Wei Wen Beldon Zhang Hannah Choi Wanqiu Chen Meredith Brown David Baylink Lei Zhang Hongyu Qiu Charles Wang Tao Cheng Xiao-Bing Zhang | 2021 | Science China(Life Sciences)2021，64，9： | 3 |
| 2 | Inhibition of Rho-kinase by fasudil attenuated angiotensin II-induced cardiac hypertrophy in apolipoprotein E deficient mice显示文摘 | Yi-Xin Wang Valdeci da Cunha Baby Martin-McNulty Jon Vincelette Weiwei Li David F. Choy Meredith Halks-Miller Mithra Mahmoudi Miriam Schroeder Anthony Johns David R. Light William P. Dole | 2005 | European Journal of Pharmacology2005，，2： | 2 |
| 3 | Optical and Nonlinear Optical Characterization of Molecularly Doped Thermotropic Liquid Crystalline Polymers 显示文摘 | Meredith G R Van Dusen J Williams David J | 1982 | Macromolecules1982，15，： | 1 |
| 4 | Do relationship benefits and maintenance drive commitment and loyalty?显示文摘 | Tracey S. Dagger Meredith E. David Sandy Ng | 2011 | Journal of Services Marketing2011，，4： | 1 |
| 5 | Systematic Review of the Epidemiology of Urinary Incontinence and Detrusor Overactivity among Patients with Neurogenic Overactive Bladder显示文摘 | Ruffion Alain Castro-diaz David Patel Hetal Khalaf Kristin Onyenwenyi Ahunna Globe Denise Lereun Corinne Teneishvili Mamuka Edwards Meredith | 2013 | Neuroepidemiology . 2013 (3-4)2013，，3： | 1 |
| 6 | Sensitization of Pancreatic Cancers to Gemcitabine Chemoradiation by WEE1 Kinase Inhibition Depends on Homologous Recombination Repair显示文摘 | Tasneem Kausar Jason S. Schreiber David Karnak Leslie A. Parsels Joshua D. Parsels Mary A. Davis Lili Zhao Jonathan Maybaum Theodore S. Lawrence Meredith A. Morgan | 2015 | Neoplasia2015，，10： | 1 |
| 7 | Suppliers' contributions to product development : An exploratory study 显示文摘 | Janet L Hartley Jack R Meredith David Mc Cutcheon | 1997 | IEEE TRANSACTIONS ON ENGINEERING MANAGEMENT1997，44，3： | 1 |
| 8 | What moves and works: Broadening the consideration of energy poverty显示文摘 | Benjamin K. Sovacool Christopher Cooper Morgan Bazilian Katie Johnson David Zoppo Shannon Clarke Jay Eidsness Meredith Crafton Thiyagarajan Velumail Hilal A. Raza | 2011 | Energy Policy2011，，： | 1 |
| 9 | Successful Transplantation of Single Kidneys From Pediatric Donors Weighing Less Than or Equal to 10 kg Into Standard Weight Adult Recipients显示文摘 | Vinod P. Balachandran Meredith J. Aull Maria Goris Jose Figueiro David B. Leeser Sandip Kapur | 2010 | Transplantation2010，，5： | 1 |
| 10 | Asymmetric effects of economic activity on inflation显示文摘 | Douglas Llaxton Guy Meredith and David Rose | 1995 | IMF staff papers1995，，： | 1 |
| 11 | Identification of Long stress-induced non-coding transcripts that have altered expression in cancer显示文摘 | Jessica M. Silva Damon S. Perez Jay R. Pritchett Meredith L. Halling Hui Tang David I. Smith | 2010 | Genomics2010，，： | 1 |
| 12 | Evaluation of antidotes for poisoning by organophosphorus pesticides显示文摘 | Dag Jacobsen Tim J Meredith Peter Eyer Andrew J Heath David A Ligtenstein Tim C Marrs Ladislaus Szinicz J Allister Vale and John A Haines | 2000 | Emergency Medicine2000，，12： | 1 |
| 13 | Combining urinary detection of TMPRSS2:ERG and PCA3 with serum PSA to predict diagnosis of prostate cancer显示文摘 | Simpa S. Salami Folke Schmidt Bharathi Laxman Meredith M. Regan David S. Rickman Douglas Scherr Gerardina Bueti Javed Siddiqui Scott A. Tomlins John T. Wei Arul M. Chinnaiyan Mark A. Rubin Martin G. Sanda | 2013 | Urologic Oncology: Seminars and Original Investigations2013，，5： | 1 |
| 14 | The Biological Role of Inflammation in Atherosclerosis显示文摘 | Brian W. Wong Anna Meredith David Lin Bruce M. McManus | 2012 | Canadian Journal of Cardiology2012，，6： | 1 |
| 15 | Comprehensive resequence analysis of a 136 kb region of human chromosome 8q24 associated with prostate and colon cancers显示文摘 | Meredith Yeager Nianqing Xiao Richard B. Hayes Pascal Bouffard Brian Desany Laura Burdett Nick Orr Casey Matthews Liqun Qi Andrew Crenshaw Zdenek Markovic Karin M. Fredrikson Kevin B. Jacobs Laufey Amundadottir Thomas P. Jarvie David J. Hunter Robert Hoov | 2009 | Human Genetics2009，，2： | 1 |
| 16 | A Perivascular Niche for Brain Tumor Stem Cells显示文摘 | Christopher Calabrese Helen Poppleton Mehmet Kocak Twala L. Hogg Christine Fuller Blair Hamner Eun Young Oh M. Waleed Gaber David Finklestein Meredith Allen Adrian Frank Ildar T. Bayazitov Stanislav S. Zakharenko Amar Gajjar Andrew Davidoff Richard J. Gil | 2007 | Cancer Cell2007，，1： | 1 |
| 17 | Optical and nonlinear optical characterization of molecu- larly doped thermotropic liquid crystalline polymers 显示文摘 | Gerald R Meredith John G Van Dhsen David J Williams | 1982 | Macromolecules1982，15，： | 1 |
| 18 | Application of business process execution language to scientific work- flows显示文摘 | Asif Akram Rob Allan David Meredith | 2007 | Journal Special Issue Edited2007，2，： | 1 |
| 19 | Severe Hyponatremia and Seizure Following a Polyethylene Glycol-based Bowel Preparation for Colonoscopy显示文摘 | Jerry Nagler David Poppers Meredith Turetz | 2006 | Journal of Clinical Gastroenterology2006，，6： | 1 |
| 20 | NONOPERATIVE MANAGEMENT OF BLUNT HEPATIC TRAUMA: THE EXCEPTION OR THE RULE?显示文摘 | J. Wayne Meredith Jeffrey S. Young Jack Bowling David Roboussin | 1994 | The Journal of Trauma: Injury, Infection, and Critical Care1994，，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员