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| 1 | The adult human testis transcriptional cell atlas显示文摘Human adult spermatogenesis balances spermatogonial stem cell (SSC) self-renewal and differentiation,alongside complex germ cell-niche interactions,to ensure long-term fertility and faithful genome propagation. Here,we performed single-cell RNA sequencing of -6500 testicular cells from young adults. We found five niche/somatic cell types (Leydig,myoid,Sertoli,endothelial,macrophage),and observed germline-niche interactions and key human-mouse differences. Spermatogenesis,including meiosis,was reconstructed computationally,revealing sequential coding,non-coding,and repeat-element transcriptional signatures. Interestingly,we identified five discrete transcriptional/developmental spermatogonial states,including a novel early SSC state,termed State 0. Epigenetic features and nascent transcription analyses suggested developmental plasticity within spermatogonial States. To understand the or丨gin of State 0,we profiled testicular cells from infants,and identified distinct similarities between adult State 0 and infant SSCs. Overall,our datasets describe key transcriptional and epigenetic signatures of the normal adult human testis,and provide new insights into germ cell developmental transitions and plasticity. | Jingtao Guo Edward J. Grow Hana Mlcochova Geoffrey J. Maher Cecilia Lindskog Xichen Nie Yixuan Guo Yodai Takei Jina Yun Long Cai Robin Kim Douglas T. Carrell Anne Goriely James M. Hotaling Bradley R. Cairns | 2018 | Cell Research2018，28，12： | 12 |
| 2 | Role of MGMT as biomarker in colorectal cancer显示文摘O6-methylguanine DNA methyltransferase(MGMT) gene promoter methylation plays an important role in colorectal carcinogenesis, occurring in about 30%-40% of metastatic colorectal cancer. Its prognostic role has not been defined yet, but loss of expression of MGMT, which is secondary to gene promoter methylation, results in an interesting high response to alkylating agents such as dacarbazine and temozolomide. In a phase 2 study on heavily pre-treated patients with MGMT methylated metastatic colorectal cancer, temozolomide achieved about 30% of disease control rate. Activating mutations of RAS or BRAF genes as well as mismatch repair deficiency may represent mechanisms of resistance to alkylating agents, but a dose-dense schedule of temozolomide may potentially restore sensitivity in RAS-mutant patients. Further development of temozolomide in MGMT methylated colorectal cancer includes investigation of synergic combinations with other agents such as fluoropyrimidines and research for additional biomarkers, in order to better define the role of temozolomide in the treatment of individual patients. | Alessandro Inno Giuseppe Fanetti Maria Di Bartolomeo Stefania Gori Claudia Maggi Massimo Cirillo Roberto Iacovelli Federico Nichetti Antonia Martinetti Filippo de Braud Ilaria Bossi Filippo Pietrantonio | 2014 | World Journal of Clinical Cases2014，2，12： | 10 |
| 3 | NGR-tagged nano-gold: A new CD13-selective carrier for cytokine delivery to tumors显示文摘胶体的黄金(Au ) ,容忍得好的 nanomaterial,当前在 nanomedicine 为几个应用程序被利用。我们显示出与包含 Asn-Gly-Arg (NGR ) 的新奇肿瘤家肽标注的那金 nanoparticles, CD13 的 ligand 由肿瘤 neovasculature 表示了,能为 cytokine 交货作为搬运人被利用到肿瘤。生物化学、功能的研究证明为金 functionalization 使用的 NGR 分子的支架 / 连接器为 CD13 识别是批评的。用忍受纤维肉瘤的老鼠,标注 NGR 的 nanodrugs 能交付极其低,还肿瘤坏死因素(TNF ) 的 pharmacologically 活跃的剂量, anticancer cytokine,到没有毒性的证据的肿瘤。机械学的研究证实指向的 CD13 是药交货的主要机制并且排除了对 NGR deamidation 作为结果的指向的 integrin 的一个主要角色,产生 isoAsp-Gly-Arg (isoDGR ) 的降级反应 integrin ligand。原则上,标注 NGR 的金 nanoparticles 罐头为癌症治疗为 single-cytokine 或 multi-cytokine 交货被用作一个新奇平台到肿瘤 endothelial 房间。 | Flavio Curnis Martina Fiocch Angelina Sacchi Alessandro Gori Anna Gasparri Angelo Corti | 2016 | Nano Research2016，9，5： | 5 |
| 4 | Use of a new retrograde filling material(Biodentine) for endodontic surgery: two case reports显示文摘Mineral trioxide aggregate(MTA) is considered at the present time as the gold standard for root-end filling in endodontic surgery.However, this biocompatible material presents several drawbacks such as a long setting time and handling difficulties. The aim of this article is to present a new commercialized calcium silicate-based material named Biodentine with physical improved properties compared to MTA in a clinical application. Two endodontic microsurgeries were performed by using specific armamentarium(microsurgical instrumentation, ultrasonic tips) under high-power magnification with an operatory microscope. Biodentine was used as a root-end filling in order to seal the root canal system. The two cases were considered completely healed at 1 year and were followed for one more year. The 2-year follow-up consolidated the previous observation with absence of clinical symptoms and radiographic evidence of regeneration of the periapical tissues. | Grégory Caron Jean Azérad Marie-Odile Faure Pierre Machtou Yves Boucher | 2014 | International Journal of Oral Science2014，6，4： | 5 |
| 5 | Enteric neuropathology of congenital intestinal obstruction:A case report显示文摘试验性的证据显示肠的长期的机械亚吸藏可以损坏伤寒神经系统(ENS ) ,尽管在人的数据正在缺乏。我们这里描述伤寒的第一诉讼与内脏的先天的阻塞有关的退化神经病。3 年的 A 和老女孩开始抱怨了呕吐的 9 瞬间,腹的扩张,有空气液体的便秘在飞机铺平腹的辐射学。她的随后的病历被 3 操作描绘:首先显示出的扩大 duodeno-jejunal 当闭塞的损害不在时循环;第二(2 年以后) 被执行获得扩大的肠的环的完整厚度的活体检视并且在组织病理学说揭示了 hyperganglionosis;第三(在 hyperganglionosis 以后的 9 年被识别) 揭示了 Ladd 被移开的乐队,联系内脏旋转不良被改正。完整厚度的活体检视显示出的重复 intraoperative 与 Cajal 的减少的空隙的房间一起的退化神经病在 Ladd 的乐队下面在阻塞和正常的神经与肌的层上面在扩大的环联网的伤寒。病人容忍了的在最近的外科以后的一年口头的喂并且很好,建议那先天(部分) 在人的小肠的机械阻塞能唤起类似于在肠的机械吸藏的动物模型发现的那些的 ENS 的进步适应变化。如此的 ENS 变化模仿在肠的伪阻塞观察的神经元畸形。 | Giovanni Di Nardo Vincenzo Stanghellini Salvatore Cucchiara Giovanni Barbara Gianandrea Pasquinelli Donatella Santini Cristina Felicani Gianluca Grazi Antonio D Pinna Rosanna Cogliandro Cesare Cremon Alessandra Gori Roberto Corinaldesi Kenton M Sanders Roberto De Giorgio | 2006 | World Journal of Gastroenterology2006，12，32： | 4 |
| 6 | Association Between Diabetes and Stroke Subtype on Survival and Functional Outcome 3 Months After Stroke: Data From the European BIOMED Stroke Project显示文摘 | Salah-Eddine Megherbi Chantal Milan Dominique Minier Grégory Couvreur Guy-Victor Osseby Kate Tilling Antonio Di Carlo Domenico Inzitari Charles D.A. Wolfe Thibault Moreau Maurice Giroud | 2003 | Stroke: Journal of the American Heart Association2003，，3： | 3 |
| 7 | 氯乙酰化制备强碱离子交换纤维的工艺研究显示文摘以PP-St-DVB接枝纤维为起始原料,氯乙酰氯为酰基化试剂、三氯化铝为催化剂,采用傅-克酰基化反应的方法,避免了强碱纤维制备过程中使用致癌性的氯甲醚,优化了溶胀时间、反应温度、反应时间、氯乙酰氯用量、催化剂用量对酰基化后纤维增重率的影响,接枝率大于等于135%的PP-St-DVB纤维最终季铵化反应后可以得到3.0 mmol/g以上的新型强碱离子交换纤维. | 张本尚 田青亮 刘树博 GRéGORY Delécaut 杨明成 | 2018 | 河南科学2018，36，1： | 3 |
| 8 | Differential expression of the fractalkine chemokine receptor (CX3CR 1) in human rnonocytes during differentiation显示文摘传播单核白血球(瞬间) 可以连续地使人重新住入巨噬细胞(MAC ) 或树枝状的房间(DC ) 维持动态平衡的人口。MAC 和 DC 是玩不同、互补的免疫学的功能的专业化房间。因此,他们现在的不同迁移的性质。明确地,而 MAC 大部分留在纸巾, DC 能够从外部纸巾移居到淋巴的机关。这个工作的目的是分析 fractalkine 受体的表达式(CX 3 CR1 ) 在 monocytic 区别进程期间。两 CX 3 CR1 mRNA 和蛋白质。在瞬间区别过程期间, CX 3 CR1 是在 DC 和 MAC 的 downregulated。然而, MAC 显示出显著地更高的 CX 3 CR1 表示层次比 DC。我们也观察了对抗 CX 3 由干扰素(IFN ) 的 CR1 规定 -γ并且 interleukin (IL )-4 在通过古典、其他的 MAC 小径的 MAC 激活期间分别地。IFN-γ禁止了 CX 3 CR1,而是 IL-4 导致了它。另外,我们表明了在 CX 3 由可溶的 fractalkine 的 CR1 表示和 apoptosis 预防(sCX 3 CL1 ) 在瞬间, DC 和 MAC。这是表明顺序、微分的 CX 3 CR1 调整在瞬间区别期间。最重要地,我们表明了在 CX 3 CR1 表示和房间幸存面对 sCX 3 CL1。 | Cecilia Analia Panek Maria Victoria Ramos Maria Pilar Mejias Maria Iimena Abrey-Recalde Romina Iimena Fernandez-Brando Maria Soledad Gori Gabriela Veronica Salamone2 Marina Sandra Palermo | 2015 | Cellular & Molecular Immunology2015，12，6： | 3 |
| 9 | 欧洲传统医学中的耳针疗法显示文摘耳针是通过刺激耳部特定位置发挥诊断和治疗作用的方法,最早的耳针疗法可以追溯至石器时代,古代的中国、埃及、罗马、希腊均有应用历史。耳针是利用反射学原理发挥作用的一种微针灸法,其可能的作用原理是耳部的多功能细胞群储存着全身的基因信息,并对应着身体的特定部位,因此刺激耳部的特定部位可以缓解身体远端的一些不适症状。现代医学已经证实耳针对焦虑症、失眠的疗效,对成瘾症(烟瘾、药瘾)的疗效正在验证之中。简要介绍欧洲传统医学中耳针疗法的起源和理论基础,为耳针的现代化推广奠定基础。 | Luigi Gori Fabio Firenzuol | 2018 | 亚太传统医药2018，14，3： | 3 |
| 10 | RIPL – Reference Input Parameter Library for Calculation of Nuclear Reactions and Nuclear Data Evaluations显示文摘 | R. Capote M. Herman P. Oblo?insky P.G. Young S. Goriely T. Belgya A.V. Ignatyuk A.J. Koning S. Hilaire V.A. Plujko M. Avrigeanu O. Bersillon M.B. Chadwick T. Fukahori Zhigang Ge Yinlu Han S. Kailas J. Kopecky V.M. Maslov G. Reffo M. Sin E.Sh. Soukhovitski | 2009 | Nuclear Data Sheets2009，，12： | 2 |
| 11 | Autophagy Induction by the Pathogen Receptor CD46显示文摘 | Pierre-Emmanuel Joubert Grégory Meiffren Isabel Pombo Grégoire Guillemette Pontini Clémence Richetta Monique Flacher Olga Azocar Pierre-Olivier Vidalain Marc Vidal Vincent Lotteau Patrice Codogno Chantal Rabourdin-Combe Mathias Faure | 2009 | Cell Host & Microbe2009，，4： | 2 |
| 12 | Impact of Platelet Reactivity After Clopidogrel Administration on Drug-Eluting Stent Thrombosis显示文摘 | Piergiovanni Buonamici Rossella Marcucci Angela Migliorini Gian Franco Gensini Alberto Santini Rita Paniccia Guia Moschi Anna Maria Gori Rosanna Abbate David Antoniucci | 2007 | Journal of the American College of Cardiology2007，，： | 2 |
| 13 | Morphological Control for High Performance, Solution‐Processed Planar Heterojunction Perovskite Solar Cells显示文摘 | Giles E. Eperon Victor M. Burlakov Pablo Docampo Alain Goriely Henry J. Snaith | 2014 | Adv. Funct. Mater2014，，1： | 2 |
| 14 | Severe COVID-19 patients exhibit an ILC2 NKG2D^(+) population in their impaired ILC compartment显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is responsible for the current COVID-19 disease pandemic.In some patients,the symptoms are mild,and a fraction of SARS-CoV-2-infected individuals develop severe illness with a high fatality rate due to lung damage and acute respiratory distress syndrome.1 Innate lymphoid cells(ILCs)are a recently identified type of effector immune cells that rapidly sense environmental stimuli and participate in early immune responses by promptly secreting large amounts of cytokines.2 The ILC2 subpopulation was shown to mediate Type 2 responses and to recruit eosinophils during viral lung infections upon the release of alarmins(e.g.,IL-33)by damaged epithelial cells.3,4,5 ILC2s were also shown to participate in the termination of inflammatory responses and tissue repair by amphiregulin secretion.In addition,ILC2s are critical in the early phases of allergic lung inflammation,including that induced by the protease allergen papain.6 Based on the essential function of the papain-like protease PLpro in regulating SARS-CoV-27(Fig.1a)and the severe lung damage caused by this virus,we sought to investigate the potential involvement of ILC2s in immune responses to COVID-19. | Alejandra Gomez-Cadena Laurie Spehner Marie Kroemer Myriam Ben Khelil Kevin Bouiller Grégory Verdeil Sara Trabanelli Christophe Borg Romain Loyon Camilla Jandus | 2021 | Cellular & Molecular Immunology2021，18，2： | 2 |
| 15 | Immune activation, apoptosis, and Treg activity are associated with persistently reduced CD4+ T-cell counts during antiretroviral therapy显示文摘 | Stefania Piconi Daria Trabattoni Andrea Gori Serena Parisotto Carlo Magni Paola Meraviglia Alessandra Bandera Amedeo Capetti Giuliano Rizzardini Mario Clerici | 2010 | AIDS2010，，13： | 2 |
| 16 | Cretaceous tectonic evolution of the Neo-Tethys in Central Iran:Evidence from petrology and age of the Nain-Ashin ophiolitic basalts显示文摘The Nain and Ashin ophiolites consist of Mesozoic melange units that were emplaced in the Late Cretaceous onto the continental basement of the Central-East Iran microcontinent(CEIM).They largely consist of serpentinized peridotites slices;nonetheless,minor tectonic slices of sheeted dykes and pillow lavas-locally stratigraphically associated with radiolarian cherts-can be found in these ophiolitic melanges.Based on their whole rock geochemistry and mineral chemistry,these rocks can be divided into two geochemical groups.The sheeted dykes and most of the pillow lavas show island arc tholeiitic(IAT)affinity,whereas a few pillow lavas from the Nain ophiolites show calc-alkaline(CA)affinity.Petrogenetic modeling based on trace elements composition indicates that both IAT and CA rocks derived from partial melting of depleted mantle sources that underwent enrichment in subduction-derived components prior to melting.Petrogenetic modeling shows that these components were represented by pure aqueous fluids,or sediment melts,or a combination of both,suggesting that the studied rocks were formed in an arc-forearc tectonic setting.Our new biostratigraphic data indicate this arc-forearc setting was active in the Early Cretaceous.Previous tectonic interpretations suggested that the Nain ophiolites formed,in a Late Cretaceous backarc basin located in the south of the CEIM(the so-called Nain-Baft basin).However,recent studies showed that the CEIM underwent a counter-clockwise rotation in the Cenozoic,which displaced the Nain and Ashin ophiolites in their present day position from an original northeastward location.This evidence combined with our new data and a comparison of the chemical features of volcanic rocks from different ophiolites around the CEIM allow us to suggest that the Nain-Ashin volcanic rocks and dykes were formed in a volcanic arc that developed on the northern margin of the CEIM during the Early Cretaceous in association with the subduction,below the CEIM,of a Neo-Tethys oceanic branch that was existing between the CEIM and the southern margin of Eurasia.As a major conclusion of this paper,a new geodynamic model for the Cretaceous evolution of the CEIM and surrounding Neo-Tethyan oceanic basins is proposed. | Tahmineh Pirnia Emilio Saccani Ghodrat Torabi Marco Chiari Spela Gorican Edoardo Barbero | 2020 | Geoscience Frontiers2020，11，1： | 2 |
| 17 | Difference of planktonic ciliate communities of the tropical West Pacific, the Bering Sea and the Arctic Ocean显示文摘Ciliates are important components in planktonic food webs,but our understanding of their community structures in different oceanic water masses is limited.We report pelagic ciliate community characteristics in three seas:the tropical West Pacific,the Bering Sea and the Arctic Ocean.Planktonic ciliate abundance had'bimodal-peak','surface-peak'and'DCM(deep chlorophyll a maximum layer)-peak'vertical distribution patterns in the tropical West Pacific,the Bering Sea and the Arctic Ocean,respectively.The abundance proportion of tintinnid to total ciliate in the Bering Sea(42.6%)was higher than both the tropical West Pacific(7.8%)and the Arctic Ocean(2.0%).The abundance proportion of small aloricate ciliates(10–20μm size-fraction)in the tropical West Pacific was highest in these three seas.The Arctic Ocean had higher abundance proportion of tintinnids in larger LOD(lorica oral diameter)size-class.Proportion of redundant species increased from the Arctic Ocean to the tropical West Pacific.Our result provided useful data to further understand ecology roles of planktonic ciliates in different marine habitats. | Chaofeng Wang Haibo Li Zhiqiang Xu Shan Zheng Qiang Hao Yi Dong Li Zhao Wuchang Zhang Yuan Zhao Gérald Grégori Tian Xiao | 2020 | Acta Oceanologica Sinica2020，39，4： | 2 |
| 18 | MicroRNAs in Nonalcoholic Fatty Liver Disease: Novel Biomarkers and Prognostic Tools during the Transition from Steatosis to Hepatocarcinoma显示文摘 | Manuele Gori Mario Arciello Clara Balsano Luca Miele | 2014 | BioMed Research International2014，，： | 2 |
| 19 | Matched or nonmatched interventions based on the transtheoretical model to promote physical activity.A meta-analysis of randomized controlled trials显示文摘Purpose: The aim of this study was to examine whether the efficacy of transtheoretical model(TTM)-based interventions on physical activity(PA)varied according to the following criteria:(1) interventions targeted the actual stages of change(SOCs) or did not;(2) participants were selected according to their SOC or were not; and(3) its theoretical constructs(decisional balance, temptation, self-efficacy, processes of change).Methods: Thirty-three randomized controlled trials assessing TTM-based interventions promoting PA in adults were systematically identified.Results: The between-group heterogeneity statistic(Qb) did not reveal any differential efficacy either in interventions targeting the actual SOC compared with those that did not(Qb = 1.48, p = 0.22) or in interventions selecting participants according to their SOC compared with those that did not(Qb = 0.01, p = 0.91). TTM-based interventions enhanced PA behavior whether they targeted the actual SOC(Cohen's d = 0.36; 95%confidence interval(CI): 0.22–0.49) or not(d = 0.23; 95%CI: 0.09–0.38) and whether they selected their participants according to their SOC(d = 0.33; 95%CI: 0.13–0.53) or not(d = 0.32; 95%CI: 0.19–0.44). The moderators of the efficacy of TTM-based interventions were the number of theoretical constructs used to tailor the intervention(Qb = 8.82, p = 0.003), the use of self-efficacy(Qb = 6.09, p = 0.01), and the processes of change(Qb = 3.51, p = 0.06).Conclusion: TTM-based interventions significantly improved PA behavior, and their efficacy was not moderated by SOC but by the TTM theoretical constructs. | Ahmed Jerome Romain Catherine Bortolon Mathieu Gourlan Marion Carayol Emmanuelle Decker Olivier Lareyre Grégory Ninot Julie Boiché Paquito Bernard | 2018 | Journal of Sport and Health Science2018，7，1： | 2 |
| 20 | Oxidative stress and endothelial dysfunction: Therapeutic implications显示文摘 | Tommaso Gori Thomas Münzel | 2011 | Annals of Medicine2011，，4： | 2 |
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