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| 1 | FDG-PET/CT response evaluation during EGFR-TKI treatment in patients with NSCLC显示文摘Over recent years,[18F]-fluorodeoxyglucose positron emission tomography acquired together with low dose computed tomography(FDG-PET/CT)has proven its role as a staging modality in patients with non-small cell lung cancer(NSCLC).The purpose of this review was to present the evidence to use FDG-PET/CT for response evaluation in patients with NSCLC,treated with epidermal growth factor receptor(EGFR)-tyrosine kinase inhibitors(TKI).All published articles from 1November 2003 to 1 November 2013 reporting on 18FFDG-PET response evaluation during EGFR-TKI treatment in patients with NSCLC were collected.In total 7studies,including data of 210 patients were eligible for analyses.Our report shows that FDG-PET/CT responseduring EGFR-TKI therapy has potential in targeted treatment for NSCLC.FDG-PET/CT response is associated with clinical and radiologic response and with survival.Furthermore FDG-PET/CT response monitoring can be performed as early as 1-2 wk after initiation of EGFR-TKI treatment.Patients with substantial decrease of metabolic activity during EGFR-TKI treatment will probably benefit from continued treatment.If metabolic response does not occur within the first weeks of EGFR-TKI treatment,patients may be spared(further)unnecessary toxicity of ineffective treatment.Refining FDG-PET response criteria may help the clinician to decide on continuation or discontinuation of targeted treatment. | Matthijs H van Gool Tjeerd S Aukema Koen J Hartemink Renato A Valdés Olmos Houke M Klomp Harm van Tinteren | 2014 | World Journal of Radiology2014，6，7： | 8 |
| 2 | Jasmonates differentially affect interconnected signal-transduction pathways of Pieris rapae-induced defenses in Arabidopsis thaliana显示文摘jasmonic 酸(JA ) 小径是昆虫 folivory 导致的主要 signal-transduction 小径。在 jasmonate 小径(18:0 或 16:0-oxylipin 线路) 影响的变异的植物被学习在在 Arabidopsis 位于导致的防卫下面的互连的 signal-transduction 小径上估计 JA 和它的 oxylipin 中介 12-oxophytodienoic 酸(OPDA ) 和 dinor-OPDA (dnOPDA ) 的效果。我们 oxylipin jasmonates dnOPDA, OPDA 和 JA 举办的数据表演在防卫发信号的不同角色在由咀嚼咬毛虫 Pieris rapae 喂以后导致了。Jasmonic 酸,并且不 OPDA 或 dnOPDA,主要发信号混合物为防卫相关的基因 LOX2 (Lipoxygenase 2 ) 的正式就职被要求, OPR3 (12-Oxophytodienoate reductase 3 ) , ACX1 (Acyl-CoA oxidase 1 ) 并且 PAL1 (本氨基丙酸 ammonia-lyase 1 ) 。监视 PAL1 抄本层次清楚地在 P 之上显示出 JA 的那累积。喂的 rapae 导致水杨酸酸小径的正式就职。而且, JA 是为 P 要求的主要发信号混合物。防卫相关的基因 HPL1 的导致 rapae 的表示(Hydroperoxide lyase 1 ) 。jasmonate dnOPDA 也影响 HPL 分支的正式就职,还它的效果对 JA 的效果对抗。我们这些 jasmonates 可以被用来调整 Arabidopsis 的数据表演导致草食动物的回答以从 oxylipin 小径的 HPL 分支。 | Tjeerd A.L. Snoeren Colette Broekgaarden Marcel Dicke | 2011 | Insect Science2011，18，3： | 4 |
| 3 | Initial assessment of chest X-ray in thoracic trauma patients: Awareness of specific injuries显示文摘AIM: To compare the reported injuries on initial assessment of the chest X-ray (CXR) in thoracic trauma patients to a second read performed by a dedicated trauma radiologist. METHODS: By retrospective analysis of a prospective database, 712 patients with an injury to the chest admitted to the University Medical Center Utrecht were studied. All patients with a CXR were included in the study. Every CXR was re-evaluated by a trauma radiologist, who was blinded for the initial results. The findings of the trauma radiologist regarding rib fractures, pneumothoraces, hemothoraces and lung contusions were compared with the initial reports from the trauma team, derived from the original patient files. RESULTS: A total of 516 patients with both thorax trauma and an initial CXR were included in the study. After re-evaluation of the initial CXR significantly more lung contusions (53.3% vs 34.1%, P < 0.001), hemothoraces (17.8% vs 11.0%, P < 0.001) and pneumothoraces (34.4% vs 26.4%, P < 0.001) were detected.During initial assessment significantly more rib fractures were reported (69.8% vs 62.3%, P < 0.001). CONCLUSION: During the initial assessment of a CXR from trauma patients in the emergency department, a significant number of treatment-dictating injuries are missed. More awareness for these specific injuries is needed. | Tjeerd S Aukema Ludo FM Beenen Falco Hietbrink Luke PH Leenen | 2012 | World Journal of Radiology2012，4，2： | 3 |
| 4 | Irreversible protein kinase inhibitors: balancing the benefits and risks 显示文摘 | Barf Tjeerd Kaptein A | 2012 | J Med Chem2012，55，14： | 1 |
| 5 | Study motivation under social temptation;effects of trait procrastination显示文摘 | Henri C Schouwenburg & Jan Tjeerd Groenewoud | 2001 | Personality and Individual Differences2001，30，： | 1 |
| 6 | Multifunctional Land Use --An Opportunity for Promoting Urban Agriculture in Europe显示文摘 | Tjeerd Deelstra Donald Boyd Maaike van den Biggelaar | 2001 | Urban Agriculture Magazine2001，，4： | 1 |
| 7 | Coordination of gaze and hand movements for tracking and tracing in 3D显示文摘 | Constantinus C.A.M. Gielen Tjeerd M.H. Dijkstra Irene J. Roozen Joke Welten | 2008 | Cortex2008，，3： | 1 |
| 8 | 风暴在长江三角洲侵蚀和沉积物向南输运中的控制作用显示文摘Densely populated coasts are vulnerable to storm damage. Episodic storm-induced redistribution of coastal sediment is known to have major geological and ecological implications [1,2], but little is known about storm-driven delta erosion and longshore sediment transport. The Yangtze (Changjiang) Delta and Zhejiang–Fujian coasts (Fig. S1 online) are among the world’s largest coastal depositional systems, and play an important role in supporting China’s socioeconomic development [3,4]. | 杨世伦 Tjeerd J.Bouma Kehui Xu 史本伟 杨海飞 张文祥 罗向欣 李鹏 黄远光 田敏 郭磊城 戴志军 | 2023 | Science Bulletin2023，68，6： | 1 |
| 9 | Geo-physical studies in the Angola diapir field显示文摘 | Richard P Von Herzen Hartley Hoskins Tjeerd HVan Andel | 1972 | Geological Societyof America Bulletin1972，83，： | 1 |
| 10 | Challenges for porcine reproductive and respiratory syndrome virus (PRRSV) vaccinology 显示文摘 | TJEERD G K LISETTE A C ROB J M | 2009 | Vaccine2009，27，28： | 1 |
| 11 | Estimating respiration of roots in soil: Interactions with soil CO2, soil temperature and soil water content显示文摘 | Tjeerd J. Bouma Kai L. Nielsen David M. Eissenstat Jonathan P. Lynch | 1997 | Plant and Soil1997，，2： | 1 |
| 12 | Benthic dynamics and carbon fluxes on the NW European continental margin显示文摘 | TJEERD C E STIGTERA H C BALZERB W | 2001 | Deep-Sea Research Ⅱ2001，48，： | 1 |
| 13 | Challenges for porcine reproductive and respiratory syndrome virus(PRRSV)vaccinology显示文摘 | Tjeerd G K Lisette A C Rob J M | 2009 | Vaccine Volume2009，28，27： | 1 |
| 14 | The promises of educational technology:a reassessment显示文摘 | Donald Ely Tjeerd Plomp | 1986 | Intemational Review of Education1986，32，3： | 1 |
| 15 | An indirect double-antibody sandwich enzyme-linked immunosorbent assay(ELISA)using baculovirus-expressed antigen for the detection of antibodies to glycoprotein E of Pseudorabies virus and comparison of the method with blocking ELISAs显示文摘 | Tjeerd G Kimman Olav De Leeuw Grazyna Kochan etal | 1996 | Clin Diagn Lab Immunol1996，3，2： | 1 |
| 16 | Opportunistic screening for atrial fibrillation with a single lead device in geriatric patients显示文摘Objective To determine the diagnostic yield of repeated screening for atrial fibrillation(AF)among geriatric patients.Methods A pragmatic prospective cohort study into applying opportunistic screening for AF with a handheld single lead ECG device(SLD)in a geriatric cohort.Consecutive patients of 65 years old and older visiting the geriatric outpatient clinic were eligible for inclusion.A 12 lead ECG was performed,followed by measurements with the SLD during every visit to the geriatric outpatient clinic.A frailty index was based on the accumulation of deficits model.Results 478 patients were eligible.Patients were excluded if they did not give informed consent(17 patients),had a pacemaker or implantable cardioverter defibrillator(20 patients),or had incomplete medical files(two patients).After exclusion,439 patients participated in this study.The mean age was 78 years(range 65 to 100 years),54%were female.AF was known in 89 patients(20%),first detected on the baseline ECG in four patients(1%)and first detected with the SLD in 20 patients(5%)during follow up visits.Sensitivity of the SLD was 90.0%,specificity 99.0%,negative predictive value 99.7%,and positive predictive value 73.5%.Most patients(82%)with AF were frail and 53%were severely frail.Conclusion Repeated screening in geriatric patients has a five times higher diagnostic yield than usual care.It was easily combined with usual care.Because of the positive predictive value of 73.5%,it remains necessary to confirm AF with a 12 lead ECG or 24-h Holter monitoring. | Lennaert AR Zwart Rene WMM Jansen Jacob H Ruiter Tjeerd Germans Suat Simsek Martin EW Hemels | 2020 | Journal of Geriatric Cardiology2020，17，3： | 1 |
| 17 | Benthic dynamics and canbon fluxes on the NW European continental margin显示文摘 | Tjeerd C E van Weeringa De Stigtera Henko C Balzerb W | 2001 | Dee - Sea Research (H)2001，48，： | 1 |
| 18 | 5-aminosalicylic acids and the risk of renal disease: A large British epidemiologic study显示文摘 | Tjeerd P. Van Staa Simon Travis Hubert G.M. Leufkens Richard F. Logan | 2004 | Gastroenterology2004，，7： | 1 |
| 19 | Design and First Results of an Innovative and Dedicated Breast PET显示文摘 | Antonio J. Gonzalez Martinez Tjeerd S. Aukema Julio B. Ballester Jose M. Benlloch Baviera Carlos C. Salvador Abel O. Palomares Antonio S. Asensi Wouter Vogel Carlor V. Barreiros Luis F. Vidal San Sebastian Renato A. Valdes Olmos | 2012 | Current Medical Imaging Reviews2012，，2： | 1 |
| 20 | Nitrate reductase activity in leaves and roots ofAlnus glutinosa (L) Gaertner显示文摘 | Tjeerd Blacquière Sep R. Troelstra | 1986 | Plant and Soil1986，，3： | 1 |
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