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| 1 | High circulating D-dimers are associated with ascites and hepatocellular carcinoma in liver cirrhosis显示文摘AIM: To measure plasma D-dimer levels in cirrhotic patients with and without ascites, assessing the effect of ascites resolution in D-dimer concentration. METHODS: Seventy consecutive cirrhotic patients (M = 44, F = 26, mean age 65 years, SD ± 13), observed from October 2005 to March 2006 were enrolled. Circulating D-dimer levels were measured using a latex-enhanced, immunoturbidimetric test. In patients with ascites (n = 42) the test was repeated after ascites resolution. RESULTS: Ascites was present in 42 patients (group A) and absent in 28 (group B). Group A patients had more advanced liver disease. Hepatocellular carcinoma (HCC) was diagnosed in 14 patients and was more frequent in group B. Above normal range D-dimers were found in 45/70 patients. High D-dimers were more frequent in group A than in group B (P = 0.001). High D-dimers were associated with presence of HCC (P = 0.048) only in group B. After ascites resolution, obtained in all patients, mean D-dimer values decreased in those 34 patients with high basal levels (P = 0.007), returning to normal in 17. CONCLUSION: In patients with liver cirrhosis, ascites and HCC are the main factors associated with increased fibrinolytic activity. | Aldo Spadaro Vincenza Tortorella Carmela Morace Agostino Fortiguerra Paola Composto Caterina Bonfiglio Angela Alibrandi Carmelo Luigiano Giuseppe De Caro Antonino Ajello Oscar Ferraù Maria Antonietta Freni | 2008 | World Journal of Gastroenterology2008，14，10： | 19 |
| 2 | Elastic membrane that undergoes mechanical deformation enhances osteoblast cellular attachment and proliferation显示文摘 | Toworfe GK Composto RJ Lee MH | 2010 | Int J Biomater2010，1，2： | 1 |
| 3 | Covalent nanoparticle assembly onto random copolymer films 显示文摘 | McConnell M D Yang S Composto R J | 2008 | Macromolecules2008，42，2： | 1 |
| 4 | Nuclea tion and growth of calcium phosphate on amine-, carboxyland hydroxyl-silane self-assembled monolayers显示文摘 | Toworfe G K Composto R J Shapiro I M | 2006 | Biomate rials2006，27，4： | 1 |
| 5 | Nucleation and growth of calcium phosphate on amine-, carboxyl- and hydroxyl-silane self-assembled monolayers显示文摘 | G.K. Toworfe R.J. Composto I.M. Shapiro P. Ducheyne | 2005 | Biomaterials2005，，4： | 1 |
| 6 | Nucleation and growth of calcium phosphate on amine-, carboxyl- and hydroxyl-silane selfassembled monolayers 显示文摘 | Toworfe G K Composto R J Shapiro I M | 2006 | Biomaterials2006，27，4： | 1 |
| 7 | RGD pep- tides immobilized on a mechanically deformable surface promote osteoblast differentiation显示文摘 | Cavalcanti-Adam EA Shapiro IM Composto RJ | 2002 | J Bone Miner Res2002，17，12： | 1 |
| 8 | Effect of biomaterial surface properties on fibronectin– α 5 β 1 integrin interaction and cellular attachment显示文摘 | Mark H. Lee Paul Ducheyne Laura Lynch David Boettiger Russell J. Composto | 2005 | Biomaterials2005，，9： | 1 |
| 9 | Nucleation and growth of calcium phosphate on amine-, carboxyl-and hydroxyl -silane self-assembled monolayers显示文摘 | Toworfe GK Composto RJ Shapiro IM | 2006 | Biomaterials2006，27，4： | 1 |
| 10 | Nucleation and growth of calcium phosphate on amine-, carboxyl- and hydroxyl-silane self-assembled monolayers显示文摘 | Toworfe G K Composto R J Shapiro I M | 2006 | Biornaterials2006，27，4： | 1 |
| 11 | Cellular Up- take and lntracellular Cargo Release From Dextran Based Nanogel Drug Carriers 显示文摘 | Carme Coil Fetter M Sobolewski P Composto R J | 2013 | J Nanotechnol Eng Med2013，4，11： | 1 |
| 12 | RGD peptides immobilized on a mechanically deformable surface promote osteoblast differentiation 显示文摘 | Cavalcanti-AdamEA Shapiro IM Composto RJ | 2002 | J Bone MineraRes2002，17，12： | 1 |
| 13 | Structural changes in hair follicles and sebaceous glands of hairless mice following exposure to sulfur mustard显示文摘 | Joseph LB Heck DE Cervelli JA Composto GM Babin MC Casillas RP | 2014 | Exp Mol Pathol2014，96，3： | 1 |
| 14 | Surface segregation and formation of silver nanoparticles created in situ in poly(methyl methacrylate) films显示文摘 | Deshmukh R D Composto R J | 2007 | Chem Mater2007，19，4： | 1 |
| 15 | 显示文摘 | Deshmukh Ranjan D Composto Russell J | 2007 | Chemistry of Materials2007，19，： | 1 |
| 16 | Two-dimensional confinement of nanorods in block copolymer domains显示文摘 | Deshmukh R D Liu Y Composto R J | 2007 | Nano Letters2007，7，12： | 1 |
| 17 | Biomaterials显示文摘 | Toworfea G Composto R Shapiro I | 2006 | 27:6312006，27，： | 1 |
| 18 | CD28 ligation increases macrophage suppression of T-cell proliferation显示文摘什么时候与怒气或淋巴节点房间相比,居民腹洞房间在 vitro 对 T 房间激活糟糕作出回应。在这房间来源的巨噬细胞的更伟大的比例的表示被显示了活跃地压制 T 房间反应。腹巨噬细胞展出不成熟的显型(MHC 班 II lo , B7 作为介绍抗原的房间减少他们的功效的 lo ) 。而且,这些房间乐意地表示可诱导的氮的氧化物 synthase (iNOS ) ,由限制氨基酸精氨酸的分解代谢支持 T 房间忍耐的酶。这里,我们调查外长的 T 房间 costimulation 的能力恢复腹 T 房间反应。我们证明 CD28 结扎没能恢复腹 T 房间反应并且实际上压制了被禁止 iNOS 恢复了的回答。是由 cytokine ELISpot 和抵销的 monoclonal 显示了抗体(mAb ) 处理,这 ‘ cosuppression’反应由于增加干扰素(IFN ) 的数字的 CD28 结扎是 -γ-secreting 房间。我们的结果说明那篇细胞的作文和 cytokine 周围影响 T 房间 costimulation 生物学。 | Daniel Silberman Amanda Bucknum Thomas Bartlett Gabriella Composto Megan Kozlowskil Amanda Walker Amy Werda Jackelyn Cua Arlene H Sharpe John E Somerville James E Riggs | 2012 | Cellular & Molecular Immunology2012，9，4： | 0 |
| 19 | Effects of oncological treatments on semen quality in patients with testicular neoplasia or lymphoproliferative disorders显示文摘在年轻人的 Pretherapy 精子 cryopreservation 当前为癌症病人在好临床的实践指南被包括。这份报纸的目的在有阴囊的瘤形成或 lymphoproliferative 混乱的病人是在精液上构画出不同 oncological 治疗的效果优秀的,基于一所大公共医院的 Cryopreservation 中心的 8 年的经验。有阴囊的瘤形成的 261 个病人和经历了化疗或放射疗法和 pretherapy 精液 cryopreservation 的有 lymphoproliferative 混乱的 219 个病人被评估。精子和神经质的参数(刺激滤泡的荷尔蒙(FSH ) , luteinizing 荷尔蒙(LH ) ,睾丸激素, inhibin B 层次) 被估计在以前并且在癌症治疗的结束以后的 6, 12, 18, 24 和 36 个月。与 lymphoproliferative 混乱比在病人与恶意的阴囊的瘤形成在病人在很大程度上在精子收集,基线 FSH 水平和精子集中的时候被损害。精子发生上的有毒的效果在在癌症治疗的结束以后的 6 和 12 个月仍然是明显的,当精液的参数的改进在 18 个月以后被观察时。在结论,精子集中的全面增加被记录在在病人的多数的癌症治疗的结束以后的大约 18 个月,就算预言各单个的盒子 ‘ 的进化不是可能的; priori' 。为这个原因, pretherapy 精液 cryopreservation 应该在所有年轻癌症病人被考虑。 | Cataldo Di Bisceglie Angela Bertagna Emanuela R Composto Fabio Lanfranco Matteo Baldi Giovanna Motta Anna M Barberis Emanuela Napolitano Elena Castellano Chiara Manieri | 2013 | Asian Journal of Andrology2013，15，3： | 0 |
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