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| 1 | 尖锐心肌的梗塞: 在在新加坡的年轻成年人的临床的特征和结果显示文摘 AIM: To investigate the clinical features and in-hospital outcomes of young adults with acute myocardial infarction (AMI) in Singapore. METHODS: Between January 2005 to September 2010, 333 consecutive patients aged ≤ 45 years old were diagnosed to have AMI at our institution. As Singapore is a multi-ethnic society, we also analysed whether ethnic differences exist between the three dominant ethnic groups, Malay, Chinese and Indian with regards to the clinical features. Clinical data was collected retrospectively on demographic characteristics, presenting signs and symptoms, blood investigation, angiographic findings and in-hospital clinical outcomes. RESULTS: The mean age at presentation was 40.2 ± 4.0 years with male predominance (94%). The majority of patients were Chinese (51%) followed by Indians (31%) and Malays (18%). The most common risk factor was smoking (74%) followed by hypertension (28.5%) and hyperlipidemia (20.0%). 37% of patients were obese. The majority of patients had single vessel disease (46%) on coronary angiography. The mean total cholesterol, low-density lipoprotein and highdensity lipoprotein levels were 5.6±1.2 mmol/L, 3.8±1.1 mmol/L and 0.93±0.25 mmol/L respectively. The mean left ventricular function was 44%±10% with the incidence of heart failure 3% and cardiogenic shock 4.5%. Overall in-hospital mortality was low with 4 deaths (1.2%). For ethnic subgroup analysis, Indians have a 3-fold risk of developing premature AMI when compared to other ethnic groups. CONCLUSION: Young AMI patients in Singapore are characterized by male predominance, high incidence of smoking and obesity. Overall in-hospital clinical outcomes are favourable. Among the 3 ethnic groups, Indians have the highest risk of developing premature AMI. | Chun Pong Wong Seet Yoong Loh Kwok Kong Loh Paul Jau Lueng Ong David Foo Hee Hwa Ho | 2012 | World Journal of Cardiology2012，4，6： | 13 |
| 2 | 亚洲近视管理共识显示文摘指南的目标本指南是从国际近视研究所(IMI)白皮书中提取出来的有关近视管理方面的建议[1,2]。本指南所提供的内容都是根据现有最新数据(截至2022年3月)而来,其治疗可行性和执业范围因地区而异,应根据实际情况做调整。眼保健专家组通过对现有最优科学数据进行分析诠释,从而形成了本指南。在工作中,近视管理从业者应该将患者需求放在首位,全面考虑患者具体情况后再提出合适的处理意见。 | Monica Jong Serge Resnikoff Kah Ooi Tan 吕帆 Kah Meng Chung 胡楚南 Ian Morgan Oliver Kam Tong Woo 蓝卫忠 齐备 瞿佳 杨智宽 樊志诚 吴佩昌 Ian Flitcroft Murphy Hian Kee Chan Thok Chuan Tan Charlie Ho David Chai Wong Chong Liang Hwee Koh Olivia Qian Ru Cheng | 2022 | 中华眼视光学与视觉科学杂志2022，24，3： | 11 |
| 3 | 髂动脉内支架植入术后临床及血管造影随访显示文摘目的 评价经皮腔内成形术 (PTA)及支架植入术治疗髂动脉的动脉硬化性狭窄的早期及晚期临床疗效。方法 从 1994年 12月~ 2 0 0 0年 2月 ,为 31名患者的 4 2条髂动脉血管内植入 4 4个Wallstent支架 ,进行临床及血管造影随访。结果 4 4个支架植入操作均获成功。 1例患者回家后第 3天穿刺部位血肿 ,超声检查为假性动脉瘤 ,行外科手术修复 ,术后半年血管造影检查无再狭窄。临床随访 (36± 13)个月 ,术后间歇性跛行及休息痛等症状均消失。 31例患者中有 2 0例 (2 9条血管 )进行血管造影随访 ,随访时间 (10± 5 )个月。血管造影随访时有 1例患者的 1条髂动脉出现再狭窄 ,再狭窄率 2 %(1/ 4 2 ) ,成功地再次行PTA。结论 髂动脉PTA和支架术是一种安全有效的方法 ,成功率高 ,并发症少 ,再狭窄率低 ,可作为髂动脉狭窄的首选治疗方法。 | 卢成志 David Ho 李玉光 王焱 | 2002 | 介入放射学杂志2002，11，3： | 6 |
| 4 | The interplay of aging,genetics and environmental factors in the pathogenesis of Parkinson’s disease显示文摘Background:Parkinson’s disease(PD)is characterized by dopaminergic neuronal loss in the substantia nigra pars compacta and intracellular inclusions called Lewy bodies(LB).During the course of disease,misfoldedα-synuclein,the major constituent of LB,spreads to different regions of the brain in a prion-like fashion,giving rise to successive non-motor and motor symptoms.Etiology is likely multifactorial,and involves interplay among aging,genetic susceptibility and environmental factors.Main body:The prevalence of PD rises exponentially with age,and aging is associated with impairment of cellular pathways which increases susceptibility of dopaminergic neurons to cell death.However,the majority of those over the age of 80 do not have PD,thus other factors in addition to aging are needed to cause disease.Discovery of neurotoxins which can result in parkinsonism led to efforts in identifying environmental factors which may influence PD risk.Nevertheless,the causality of most environmental factors is not conclusively established,and alternative explanations such as reverse causality and recall bias cannot be excluded.The lack of geographic clusters and conjugal cases also go against environmental toxins as a major cause of PD.Rare mutations as well as common variants in genes such as SNCA,LRRK2 and GBA are associated with risk of PD,but Mendelian causes collectively only account for 5%of PD and common polymorphisms are associated with small increase in PD risk.Heritability of PD has been estimated to be around 30%.Thus,aging,genetics and environmental factors each alone is rarely sufficient to cause PD for most patients.Conclusion:PD is a multifactorial disorder involving interplay of aging,genetics and environmental factors.This has implications on the development of appropriate animal models of PD which take all these factors into account.Common converging pathways likely include mitochondrial dysfunction,impaired autophagy,oxidative stress and neuroinflammation,which are associated with the accumulation and spread of misfoldedα-synuclein and neurodegeneration.Understanding the mechanisms involved in the initiation and progression of PD may lead to potential therapeutic targets to prevent PD or modify its course. | Shirley Yin-Yu Pang Philip Wing-Lok Ho Hui-Fang Liu Chi-Ting Leung Lingfei Li Eunice Eun Seo Chang David Boyer Ramsden Shu-Leong Ho | 2019 | Translational Neurodegeneration2019，8，1： | 5 |
| 5 | Significance of CD90 + Cancer Stem Cells in Human Liver Cancer显示文摘 | Zhen Fan Yang David W. Ho Michael N. Ng Chi Keung Lau Wan Ching Yu Patricia Ngai Patrick W.K. Chu Chi Tat Lam Ronnie T.P. Poon Sheung Tat Fan | 2008 | Cancer Cell2008，，2： | 5 |
| 6 | Clinical outcomes of elderly South-East Asian patients in primary percutaneous coronary intervention for ST- elevation myocardial infarction显示文摘评估临床的特征和经历主要经皮的冠的干预(PPCI ) 的老东南亚洲病人的在里面医院结果 .MethodsFrom 2009 年 1 月到 2012 年 12 月, 1268 个病人(86.4% 男性, 58.4 楴 的吝啬的年龄? | Jieli Tong Wen Wei Xiang An Shing Ang Wen Jun Sim Kien Hong Quah David Foo Paul Jau Lueng Ong Hee Hwa Ho | 2016 | Journal of Geriatric Cardiology2016，13，10： | 4 |
| 7 | 冠心病与肾动脉狭窄相关性研究显示文摘目的:评价冠心病与动脉硬化性肾动脉狭窄的相关性,以及引起肾动脉狭窄的危险因素。方法:1997年6月~1999年12月,对临床诊断或怀疑冠心病需要行冠状动脉造影的患者,在冠状动脉造影同时常规进行肾动脉造影,同时调查动脉粥样硬化的常见易患因素及血肌酐水平与肾动脉狭窄的关系。结果:260例进行造影的患者中,30%(79/260)患者有肾动脉狭窄,其中肾动脉明显狭窄41例(16%),轻度狭窄38例(15%);共有188例(72%)患者有冠状动脉狭窄。在188例有冠状动脉狭窄患者中,37%(71/188)患者有肾动脉狭窄,其中肾动脉明显狭窄21%(39/188),而72例无冠状动脉狭窄患者中,仅8%(6/72)患者有肾动脉狭窄。肾动脉狭窄也多见于高龄、有肾功能不全及有高血压病史的患者中。结论:在冠状动脉造影中有冠状动脉狭窄的患者,特别是合并有肾功能不全或高血压者,常伴有肾动脉狭窄。因此,对冠状动脉狭窄的患者有必要同时行肾动脉造影。 | 卢成志 张元春 李玉光 David Ho 王焱 | 2000 | 实用医学杂志2000，16，11： | 4 |
| 8 | 锁骨下动脉狭窄经皮血管腔内成形术及支架植入术治疗显示文摘 | 元小冬 David Ho 王焱 | 2001 | 中国煤炭工业医学杂志2001，4，12： | 4 |
| 9 | The next detectors for gravitational wave astronomy显示文摘This paper focuses on the next detectors for gravitational wave astronomy which will be required after the current ground based detectors have completed their initial observations, and probably achieved the first direct detection of gravitational waves. The next detectors will need to have greater sensitivity, while also enabling the world array of detectors to have improved angular resolution to allow localisation of signal sources. Sect. 1 of this paper begins by reviewing proposals for the next ground based detectors,and presents an analysis of the sensitivity of an 8 km armlength detector, which is proposed as a safe and cost-effective means to attain a 4-fold improvement in sensitivity. The scientific benefits of creating a pair of such detectors in China and Australia is emphasised. Sect. 2 of this paper discusses the high performance suspension systems for test masses that will be an essential component for future detectors, while sect. 3 discusses solutions to the problem of Newtonian noise which arise from fluctuations in gravity gradient forces acting on test masses. Such gravitational perturbations cannot be shielded, and set limits to low frequency sensitivity unless measured and suppressed. Sects. 4 and 5 address critical operational technologies that will be ongoing issues in future detectors. Sect. 4 addresses the design of thermal compensation systems needed in all high optical power interferometers operating at room temperature. Parametric instability control is addressed in sect. 5. Only recently proven to occur in Advanced LIGO, parametric instability phenomenon brings both risks and opportunities for future detectors. The path to future enhancements of detectors will come from quantum measurement technologies. Sect. 6 focuses on the use of optomechanical devices for obtaining enhanced sensitivity, while sect. 7 reviews a range of quantum measurement options. | BLAIR David JU Li ZHAO ChunNong WEN LinQing MIAO HaiXing CAI RongGen GAO JiangRui LIN XueChun LIU Dong WU Ling-An ZHU ZongHong HAMMOND Giles PAIK Ho Jung FAFONE Viviana ROCCHI Alessio BLAIR Carl MA YiQiu QIN JiaYi PAGE Michael | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，12： | 3 |
| 10 | Common amino acid sequence domains among the LEA proteins of higher plants显示文摘 | Leon Dure Martha Crouch John Harada Tuan-Hua David Ho John Mundy Ralph Quatrano Terry Thomas Z. R. Sung | 1989 | Plant Molecular Biology1989，，5： | 3 |
| 11 | 颅外脑血管疾病的经皮腔内血管成形术和支架置入术显示文摘文章对经皮血管成形术和支架置入术治疗颅外颈动脉、椎动脉和锁骨下动脉的狭窄或闭塞性疾病的可行性、手术方法、适应证、并发症处理以及手术的近期和远期疗效进行了综述。 | 元小冬 David Ho 王焱 | 2001 | 国外医学(脑血管疾病分册)2001，9，1： | 3 |
| 12 | 小P值并不能保证可靠结果:以帕金森病的静息态脑功能成像元分析为例显示文摘Thousands of resting state functional magnetic resonance imaging(RS-f MRI)articles have been published on brain disorders.For precise localization of abnormal brain activity,a voxel-level comparison is needed.Because of the large number of voxels in the brain,multiple comparison correction(MCC)must be performed to reduce false positive rates,and a smaller P value(usually including either liberal or stringent MCC)is widely recommended[1]. | 贾熙泽 赵娜 董昊铭 孙家伟 Marek Barton Roxana Burciu Nicolas Carrière Antonio Cerasa 陈博宇 陈俊 Stephen Coombes Luc Defebvre Christine Delmaire Kathy Dujardin Fabrizio Esposito 范国光 Federica Di Nardo 冯怡萱 Brett W.Fling Saurabh Garg Moran Gilat Martin Gorges Shu-Leong Ho Fay B.Horak 胡晓 胡晓飞 黄飚 黄沛钰 贾泽娟 Christina Jones Jan Kassubek Lenka Krajcovicova Ajay Kurani 李静 李晴 刘爱萍 刘波 刘虎 刘卫国 Renaud Lopes 娄毓婷 罗巍 Tara Madhyastha 毛妮妮 Grainne McAlonan Martin J.McKeown Shirley Pang Andrea Quattrone Irena Rektorova Alessia Sarica 商慧芳 James M.Shine Priyank Shukla Tomas Slavicek 宋潇鹏 Gioacchino Tedeschi Alessandro Tessitore David Vaillancourt 王健 王珏 Z.Jane Wang 魏鲁庆 邬霞 徐晓俊 闫磊 杨靓 杨万群 姚乃琳 张得龙 张久权 张敏鸣 张艳玲 周彩红 严超赣 左西年 Mark Hallett 吴涛 臧玉峰 | 2021 | Science Bulletin2021，66，21： | 3 |
| 13 | Mitochondrial neuronal uncoupling proteins:a target for potential disease-modification in Parkinson’s disease Philip显示文摘This review gives a brief insight into the role of mitochondrial dysfunction and oxidative stress in the converging pathogenic processes involved in Parkinson’s disease(PD).Mitochondria provide cellular energy in the form of ATP via oxidative phosphorylation,but as an integral part of this process,superoxides and other reactive oxygen species are also produced.Excessive free radical production contributes to oxidative stress.Cells have evolved to handle such stress via various endogenous anti-oxidant proteins.One such family of proteins is the mitochondrial uncoupling proteins(UCPs),which are anion carriers located in the mitochondrial inner membrane.There are five known homologues(UCP1 to 5),of which UCP4 and 5 are predominantly expressed in neural cells.In a series of previous publications,we have shown how these neuronal UCPs respond to 1-methyl-4-phenylpyridinium(MPP+;toxic metabolite of MPTP)and dopamine-induced toxicity to alleviate neuronal cell death by preserving ATP levels and mitochondrial membrane potential,and reducing oxidative stress.We also showed how their expression can be influenced by nuclear factor kappa-B(NF-B)signaling pathway specifically in UCP4.Furthermore,we previously reported an interesting link between PD and metabolic processes through the protective effects of leptin(hormone produced by adipocytes)acting via UCP2 against MPP+-induced toxicity.There is increasing evidence that these endogenous neuronal UCPs can play a vital role to protect neurons against various pathogenic stresses including those associated with PD.Their expression,which can be induced,may well be a potential therapeutic target for various drugs to alleviate the harmful effects of pathogenic processes in PD and hence modify the progression of this disease. | WL Ho Jessica WM Ho Hui-Fang Liu Danny HF So Zero HM Tse Koon-Ho Chan David B Ramsden Shu-Leong Ho | 2012 | Translational Neurodegeneration2012，1，1： | 3 |
| 14 | 高职“建筑行业英语”教材编写必要性的研究显示文摘在'工学结合'的指导思想下,建筑行业的高职英语教学需要考虑提高学生的就业竞争力。教材好坏直接影响教学过程的质量和效果,是实现培养目标的重要保证。基于前人对高职英语教材的研究,目前高职院校采用的《新编实用英语》有一定的局限性;同时,对建筑类毕业生的调查发现,大多数学生认为在工作中或自我职业的发展中需要了解和使用建筑行业英语。目前对高职建筑行业英语教材编写的研究很缺乏,高职院校对建筑行业英语教材编写进行研究很有必要。 | 何飞云 David HO | 2010 | 金华职业技术学院学报2010，10，3： | 3 |
| 15 | Improved biomass productivity and water use efficiency under water deficit conditions in transgenic wheat constitutively expressing the barley HVA 1 gene显示文摘 | Elumalai Sivamani Ahmed Bahieldin Jon M Wraith Thamir Al-Niemi William E Dyer Tuan-Hua David Ho Rongda Qu | 2000 | Plant Science2000，，1： | 2 |
| 16 | HBsAg Seroclearance in Chronic Hepatitis B in Asian Patients: Replicative Level and Risk of Hepatocellular Carcinoma显示文摘 | Man–Fung Yuen Danny Ka–Ho Wong James Fung Philip Ip David But Ivan Hung Kevin Lau John Chi–Hang Yuen Ching–Lung Lai | 2008 | Gastroenterology2008，，4： | 2 |
| 17 | Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial显示文摘 | Brian I Rini Bernard Escudier Piotr Tomczak Andrey Kaprin Cezary Szczylik Thomas E Hutson M Dror Michaelson Vera A Gorbunova Martin E Gore Igor G Rusakov Sylvie Negrier Yen-Chuan Ou Daniel Castellano Ho Yeong Lim Hirotsugu Uemura Jamal Tarazi David Cella | 2011 | The Lancet . 2011 (9807)2011，，9807： | 2 |
| 18 | Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial显示文摘 | Brian I Rini Bernard Escudier Piotr Tomczak Andrey Kaprin Cezary Szczylik Thomas E Hutson M Dror Michaelson Vera A Gorbunova Martin E Gore Igor G Rusakov Sylvie Negrier Yen-Chuan Ou Daniel Castellano Ho Yeong Lim Hirotsugu Uemura Jamal Tarazi David Cella | 2011 | The Lancet2011，，9807： | 2 |
| 19 | Percutaneous Endoscopic Gastrostomy: Strategies for Prevention and Management of Complications显示文摘 | Ho‐ShengLin Hani Z.Ibrahim Jennifer W.Kheng Willard E.Fee David J.Terris | 2009 | The Laryngoscope2009，，10： | 2 |
| 20 | Collateral Flow Predicts Response to Endovascular Therapy for Acute Ischemic Stroke显示文摘 | Oh Young Bang Jeffrey L. Saver Suk Jae Kim Gyeong-Moon Kim Chin-Sang Chung Bruce Ovbiagele Kwang Ho Lee David S. Liebeskind | 2011 | Stroke2011，，3： | 2 |
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