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| 1 | On ultrahigh temperature crustal metamorphism:Phase equilibria,trace element thermometry,bulk composition,heat sources,timescales and tectonic settings显示文摘Ultrahigh temperature(UHT) metamorphism is the most thermally extreme form of regional crustal metamorphism,with temperatures exceeding 900℃.UHT crustal metamorphism is recognised in more than 50 localities globally in the metaniorphic rock record and is accepted as 'normal' in the spectrum of regional crustal processes.UHT metamorphism is typically identified on the basis of diagnostic mineral assemblages such as sapphirine+ quartz,orthopyroxene + sillimanite ± quartz and osumilite in Mg-AIrich rock compositions,now usually coupled with pseudosection-based thermobarometry using internally-consistent thermodynamic data sets and/or Al-in-Orthopyroxene and ternary feldspar thermobarometry.Significant progress in the understanding of regional UHT metamorphism in recent years includes:(1) development of a ferric iron activity-composition thermodynamic model for sapphirine,allowing phase diagram calculations for oxidised rock compositions:(2) quantification of UHT conditions via trace element thermometry,with Zr-in-rutile more commonly recording higher temperatures than Ti-in-zircon.Rutile is likely to be stable at peak UHT conditions whereas zircon may only grow as UHT rocks are cooling.In addition,the extent to which Zr diffuses out of rutile is controlled by chemical communication with zircon;(3) more fully recognising and utilising temperature-dependent thermal properties of the crust,and the possible range of heat sources causing metamorphism in geodynamic modelling studies:(4) recognising that crust partially melted either in a previous event or earlier in a long-duration event has greater capacity than fertile,unmelted crust to achieve UHT conditions due to the heat energy consumed by partial melting reactions:(5) more strongly linking U-Pb geochronological data from zircon and monazite to P-T points or path segments through using Y + REE partitioning between accessory and major phases,as well as phase diagrams incorporating Zr and REE;and(6)improved insight into the settings and factors responsible for UHT metamorphism via geodynamic forward models.These models suggest that regional UHT metamorphism is,principally,geodynamically related to subduction,coupled with elevated crustal radiogenic heat generation rates. | David E.Kelsey Martin Hand | 2015 | Geoscience Frontiers2015，6，3： | 28 |
| 2 | 回到未来,战略性设计管理:彼时与现在显示文摘1965年,英国领先的设计顾问Michael Farr提出了这样一个问题“如今,我们为何需要设计管理?”,这可以说提供了设计管理的第一个正式的、作为关键性商业规则的定义。从那时起,设计管理便一直处于不断发展和完善的坚定旅程中,行走于设计理论和实践这两个相互关联的领域之间。作为一个有意识的活动领域,设计管理仍处于起步阶段。因此,再次提出Farr在50多年前提出的紧迫问题,既适时及时又至关重要的。 | David Hands | 2018 | 工业设计2018，，2： | 3 |
| 3 | The reference genetic linkage map for the multinational Brassica rapa genome sequencing project显示文摘 | Su Ryun Choi Graham R. Teakle Prikshit Plaha Jeong Hee Kim Charlotte J. Allender Elena Beynon Zhong Yun Piao Pilar Soengas Tae Ho Han Graham J. King Guy C. Barker Paul Hand Derek J. Lydiate Jacqueline Batley David Edwards Dal Hoe Koo Jae Wook Bang Beom-Se | 2007 | Theoretical and Applied Genetics2007，，6： | 2 |
| 4 | 论设计推动数字创新的密集性作用显示文摘为了帮助在数字环境压力下的企业和设计师更好地了解设计对于推动数字创新的角色和作用。本文结合理论与案例,基于内容、实践和结果三个方面探索了数字创新的独特特性,进行了系统性的分析和讨论。提出设计可以在多方面促进数字创新的密集性作用,对于设计的应用需要更加重视其整体的有效性。并对致力于通过数字创新为产品或商业模式增值的企业和设计师以及未来的设计教育提出建议。 | 高子童 David Hands | 2021 | 设计2021，34，2： | 2 |
| 5 | Defining the nature of human pluripotent stem cell progeny显示文摘当人的 pluripotent 干细胞(hPSCs ) 能区分产生各种各样的房间类型的一件礼服,是清楚的时,在 vitro,开发怎么仔细反射那,是未知的哪个发生在 vivo。决定人的胚胎的干细胞(hESCs ) 和导致人的 pluripotent 干细胞(hiPSCs ) 是否做相等的子孙,并且是否也使房间成为那类似于导出织物的房间,我们执行了净化的 PSC 衍生物和他们的导出织物的对应物介绍的全面 transcriptome。表示介绍证明 hESCs 和 hiPSCs 在 hiPSC 子孙用外长的 reprogramming 因素为重新表示的神经、肝、间充质的系,和缺席做将近相同的子孙。不管多么与一个导出织物的对应物相比, hESCs 和 hiPSCs 的子孙维持了通常与早哺乳动物的开发联系的基因的一个子集的表示,不管产生的房间的类型。当 pluripotent 基因(OCT4, SOX2, REX1,和 NANOG ) 看起来在从 hPSCs 的区别之上立即是 silenced 时,对早胚胎(LIN28A, LIN28B, DPPA4,和其它) 通常独特的基因不是充分在 hPSC 衍生物的 silenced。从在早人的胎儿的织物(开发的 3-16 星期) 的表达式模式的这些数据和证据建议 hPSCs 的区分的子孙很早人的开发是反射的(< 6 个星期) 。这些调查结果为 hPSCs 能在早人的开发的 vitro 模型作为有用服务的想法提供支持,而且为疾病建模和 hPSC 衍生物的临床的申请提出重要问题。 | Michaela Patterson David N Chan IrisHa Dana Case Yongyan Cui Ben Van Hande Hanna KA Mikkola William E Lowry | 2012 | Cell Research2012，22，1： | 2 |
| 6 | Identification of a volatile component in soybeans that contributes to raw bean flavor显示文摘 | LEONARD R MATTICK DAVID B HAND | 1969 | Journal of Agricukural Food Chemistry1969，17，1： | 1 |
| 7 | 2007 Focused Update of the ACC/AHA 2004 Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction显示文摘 | Elliott M. Antman Mary Hand Paul W. Armstrong Eric R. Bates Lee A. Green Lakshmi K. Halasyamani Judith S. Hochman Harlan M. Krumholz Gervasio A. Lamas Charles J. Mullany David L. Pearle Michael A. Sloan Sidney C. Smith | 2008 | Journal of the American College of Cardiology2008，，2： | 1 |
| 8 | Top 10 algorithms in data mining显示文摘 | Xindong Wu Vipin Kumar J. Ross Quinlan Joydeep Ghosh Qiang Yang Hiroshi Motoda Geoffrey J. McLachlan Angus Ng Bing Liu Philip S. Yu Zhi-Hua Zhou Michael Steinbach David J. Hand Dan Steinberg | 2008 | Knowledge and Information Systems2008，，1： | 1 |
| 9 | Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial显示文摘 | Stephen M Davis Geoffrey A Donnan Mark W Parsons Christopher Levi Kenneth S Butcher Andre Peeters P Alan Barber Christopher Bladin Deidre A De Silva Graham Byrnes Jonathan B Chalk John N Fink Thomas E Kimber David Schultz Peter J Hand Judith Frayne Graeme | 2008 | Lancet Neurology2008，，4： | 1 |
| 10 | 2007 Focused Update of the ACC/AHA 2004 Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction显示文摘 | Elliott M. Antman Mary Hand Paul W. Armstrong Eric R. Bates Lee A. Green Lakshmi K. Halasyamani Judith S. Hochman Harlan M. Krumholz Gervasio A. Lamas Charles J. Mullany David L. Pearle Michael A. Sloan Sidney C. Smith | 2008 | Journal of the American College of Cardiology2008，，2： | 1 |
| 11 | ACC/AHA Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction—Executive Summary显示文摘 | Elliott M. Antman Daniel T. Anbe Paul Wayne Armstrong Eric R. Bates Lee A. Green Mary Hand Judith S. Hochman Harlan M. Krumholz Frederick G. Kushner Gervasio A. Lamas Charles J. Mullany Joseph P. Ornato David L. Pearle Michael A. Sloan Sidney C. Smith Ell | 2004 | Journal of the American College of Cardiology2004，，3： | 1 |
| 12 | Determination of Henry's law constants for organosilieones in acutal and simulated wastewater显示文摘 | David M D Fendinger N J Hand V C | 2000 | Environmental Science and Technology2000，34，21： | 1 |
| 13 | Modern statistics:the myth and the magic显示文摘 | Hand David J | 2009 | Journal of the Royal Statistical Theory A2009，，172： | 1 |
| 14 | Principles of Data Mining显示文摘 | David Hand Heikki Mannila | 2001 | Massachusetts Institute of Technology2001，，： | 1 |
| 15 | Statistics and Data Mining: Intersecting Disciplines 显示文摘 | David J Hand | 1999 | ACM SIGKDD1999，，1： | 1 |
| 16 | A simple generalization of the area under the ROC curve for multiple class classification problems 显示文摘 | David J Hand Robert J Till | 2001 | Machine learning (S0885-6125)2001，45，2： | 1 |
| 17 | Top 10 algorithms in data mining显示文摘 | Xindong Wu Vipin Kumar J. Ross Quinlan Joydeep Ghosh Qiang Yang Hiroshi Motoda Geoffrey J. McLachlan Angus Ng Bing Liu Philip S. Yu Zhi-Hua Zhou Michael Steinbach David J. Hand Dan Steinberg | 2009 | Knowledge and Information Systems2009，，1： | 1 |
| 18 | Modern statistics:the myth and the magic显示文摘 | Hand David J | 2009 | Journal of the Royal Statistical Theory2009，，： | 1 |
| 19 | A Basic Multimedia Quality Model 显示文摘 | David S Hands | 2004 | IEEE Transactions on Multimedia2004，6，6： | 1 |
| 20 | Principles of Data Mining显示文摘 | David Hand Heikki Mannila Padhraic Smyth | 2001 | The MIT Press@2001，，： | 1 |
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