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24篇 您的检索式:作者名="David Hancock"
    题名 作者 年代 出处 被引量
1Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies显示文摘在地岬基因的 Oncogenic 变化在人的癌症是很普通的,导致有描绘得好的选择优点,而且不太听说得好的危险的房间。我们执行了一幅大规模 loss-of-function 屏幕识别被转变 KRAS 的结肠癌房间,然而并非由缺乏这 oncogene 的衍生物要求的基因。最高得分的基因然后在 KRAS 变异、野类型的癌症房间的一块更大的面板被测试。表示 oncogenic KRAS 的癌症房间被发现高度依赖于抄写因素 GATA2 和 DNA 复制开始管理者 CDC6。与已知的目标用许多药扩大这分析,我们发现有变异的 KRAS 的癌症房间与 topoisomerase 抑制显示出选择嗜好到 proteasome 功能,以及合成致命性。联合指向引起的这些功能改善了相对野类型的房间 KRAS 变异的房间杀死。这些观察建议新奇目标和在地岬变异的癌症为最佳的效果联合存在治疗的新方法,它传统地被看作对治疗高度倔强。Michael Steckel Miriam Molina-Arcas Britta Weigelt Michaela Marani Patricia H Warne Hanna Kuznetsov Gavin Kelly Becky Saunders Michael Howell Julian Downward David C Hancock 2012Cell Research2012,22,8:5
2Total Anomalous Pulmonary Venous Connection: An Analysis of Current Management Strategies in a Single Institution显示文摘Camille L. Hancock Friesen David Zurakowski Ravi R. Thiagarajan Joseph M. Forbess Pedro J. del Nido John E. Mayer Richard A. Jonas 2005The Annals of Thoracic Surgery2005,,2:2
3Adaptations to new environments in humans: the role of subtle allele frequency shifts显示文摘Angela M. Hancock Gorka Alkorta-Aranburu David B. Witonsky Anna Di Rienzo 2010Philosophical Transactions of the Royal Society B2010,,1552:1
4NASA radar altimeter for the TOPEX/POSEIDON project显示文摘Alfred R Zieger David W Hancock George S Hayne Craig L Purdy 1991Proceedings of the IEEE1991,79,6:1
5The GATA2 Transcriptional Network Is Requisite for RAS Oncogene-Driven Non-Small Cell Lung Cancer显示文摘Madhu S. Kumar David C. Hancock Miriam Molina-Arcas Michael Steckel Phillip East Markus Diefenbacher Elena Armenteros-Monterroso Fran?ois Lassailly Nik Matthews Emma Nye Gordon Stamp Axel Behrens Julian Downward 2012Cell2012,,3:1
6Total anomalous pulmonary venous connection: an anomalous of current management strategies in a single institution 显示文摘Camille L Hancock Friesen David Zurakowski 2005Ann Thorac Surg2005,79,2:1
7Dual- photoelastic-modulator-based polarimetrie imaging con- cept for aerosol remote sensing 显示文摘Diner David J Davis Ab Hancock Bruce 2007Applied Optics2007,46,35:1
8Dual-pho- toelastic-modulator-based polarimetric imaging concept for aerosol remote sensing 显示文摘David J Diner Ab Davis Bruce Hancock 2007Applied Optics2007,46,35:1
9The evolving research on intellectual capital显示文摘Hong Pew Tan David Plowman Phil Hancock 2008Journal of Intellectual Capital2008,,4:1
10The evolving research on intellectual capital 显示文摘HONG PEW TAN DAVID PLOWMAN PHIL HANCOCK 2008Journal of intellectual capital2008,9,4:1
11Total anomalous pulmonary venous connection an anomalous of current management strategies in a single institution显示文摘Camille L Hancock Friesen David Zurakow ski 2005Ann Thorac Surg2005,79,2:1
12The evolving research on intellectual capital 显示文摘Hong Pew Tan David Plowman Phil Hancock 2008Journal of Intellectual Capital2008,,:1
13The evolving research on intellectual capital显示文摘HONG PEW TAN DAVID PLOWMAN PHlL HANCOCK 0,,04:1
14Dual-photoelastic-modulator-based polarimetric imaging concept for aerosol remote sensing 显示文摘David J Diner Davis A b Bruce Hancock 2007Applied Optics(S0003-6935)2007,46,35:1
15Dual-photoelastic-modulator-based polarimetric imaging concept for aerosol remote sensing 显示文摘David J Diner Ab Davis Bruce Hancock 2007Applied Optics(S0003-6935)2007,46,35:1
16Association of polymorphisms of angiogenesis genes with breast cancer显示文摘Bryan P. Schneider Milan Radovich George W. Sledge Jason D. Robarge Lang Li Anna M. Storniolo Suzanne Lemler Anne T. Nguyen Bradley A. Hancock Michael Stout Todd Skaar David A. Flockhart 2008Breast Cancer Research and Treatment2008,,1:1
17Total Anomalous Pulmonary Venous Connection: An Analysis of Current Management Strategies in a Single Institution显示文摘Camille L. Hancock Friesen David Zurakowski Ravi R. Thiagarajan Joseph M. Forbess Pedro J. del Nido John E. Mayer Richard A. Jonas 2005The Annals of Thoracic Surgery2005,,2:1
18Effects of spatangoid heart urchins on O2 supply into coastal sediment显示文摘Kay Vopell A V David Thistle Nicole Hancock 0,,:1
19Traumatic coronary artery fistula management显示文摘Camille Hancock Friesen Jonathon G Howlett David B Ross 2000The Annals of Thoracic Surgery2000,,6:1
20Characterization of Infiltration Rates from Landfills: Supporting Groundwater Modeling Efforts显示文摘Horace Moo-Young Barnes Johnson Ann Johnson David Carson Christine Lew Salley Liu Katherine Hancock 2004Environmental Monitoring and Assessment (-)2004,,1:1
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