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| 1 | Visceral hypersensitivity and electromechanical dysfunction as therapeutic targets in pediatric functional dyspepsia显示文摘Functional gastrointestinal disorders(FGID) are common clinical syndromes diagnosed in the absence of biochemical,structural,or metabolic abnormalities. They account for significant morbidity and health care expenditures and are identifiable across variable age,geography,and culture. Etiology of abdominal pain associated FGIDs,including functional dyspepsia(FD),remains incompletely understood,but growing evidence implicates the importance of visceral hypersensitivity and electromechanical dysfunction. This manuscript explores data supporting the role of visceral hypersensitivity and electromechanical dysfunction in FD,with focus on pediatric data when available,and provides a summary of potential therapeutic targets. | John M Rosen Jose T Cocjin Jennifer V Schurman Jennifer M Colombo Craig A Friesen | 2014 | World Journal of Gastrointestinal Pharmacology and Therapeutics2014，5，3： | 16 |
| 2 | Therapeutic effect of melatonin on pediatric functional dyspepsia: A pilot study显示文摘AIM: To study the effectiveness of melatonin vs placebo in children with functional dyspepsia(FD).METHODS: The study was conducted as a double blind, randomized, placebo controlled crossover trial. Subjects were aged 8-17 years and diagnosed with FD based on Rome Ⅲ criteria. All subjects had failed to respond to 4 wk of acid suppression. Subjects receive a continuous two weeks of placebo and a continuous two weeks of melatonin in an order blinded to the participant and the study team. A Global Clinical Score was obtained to assess changes in abdominal pain. Pain was self-reported to be worse(grade 1), no change(grade 2), moderate improvement(grade 3), good(grade 4; minimal pain and not interfering with daily activities), or excellent(grade 5; no pain), respectively. A positive clinical response was defined as a grade 3 or greater response. Subjects wore an actigraph to assess sleep during a one week baseline period and during each treatment period. Subjects' sleep latency and total sleep time were recorded throughout the duration of the study. RESULTS: Fourteen subjects were enrolled and 12 completed the study. One withdrew prior to starting both melatonin and placebo and the other before starting melatonin. A positive clinical response(grade 3-5) was achieved in 42% of subjects on melatonin vs 50% of subjects on placebo(NS). Effect size was calculated and revealed a Cohen's D of 0.343 which demonstrates a medium effect favoring placebo. A grade 4 or grade 5 response was seen in 4 patients on melatonin and 5 patients on placebo. Baseline sleep parameters were in the healthy range with the longest sleep latency being just over 20 min(mean 7.46 ± 8.53 min) and the shortest sleep duration just over 7 h(mean 10.09 ± 2.72 h). The mean latency did not differ between periods of treatment with melatonin as compared to placebo(4.48 ± 6.45 min vs 3.58 ± 4.24 min; NS). The mean sleep duration did not differ between periods of treatment with melatonin as compared to placebo(9.90 ± 3.53 h vs 9.41 ± 2.70 h; NS).CONCLUSION: Melatonin does not appear to have efficacy in relieving pain in unselected pediatric FD. Future studies should consider FD subtypes, pathophysiologic mechanisms, and baseline sleep disturbances. | Katherine Zybach Craig A Friesen Jennifer V Schurman | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，1： | 6 |
| 3 | Eosinophils and mast cells as therapeutic targets in pediatric functional dyspepsia显示文摘There is an increasing appreciation for the importance of inflammation as a pathophysiologic entity that contributes to functional gastrointestinal disorders including functional dyspepsia(FD).Importantly,inflammation may serve as a mediator between psychologic and physiologic functions.This manuscript reviews the literature implicating two inflammatory cell types,mast cells and eosinophils,in the generation of dyspeptic symptoms and explores their potential as targets for the treatment of FD.There are a number of inciting events which may initiate an inflammatory response,and the subsequent recruitment and activation of mast cells and eosinophils.These include internal triggers such as stress and anxiety,as well as external triggers such as microbes and allergens.Previous studies suggest that there may be efficacy in utilizing medications directed at mast cells and eosinophils.Evidence exists to suggest that combining 'anti-inflammatory' medications with other treatments targeting stress can improve the rate of symptom resolution in pediatric FD. | Craig A Friesen Jennifer V Schurman Jennifer M Colombo Susan M Abdel-Rahman | 2013 | World Journal of Gastrointestinal Pharmacology and Therapeutics2013，4，4： | 4 |
| 4 | Comparison of the use of wireless capsule endoscopy with magnetic resonance enterography in children with inflammatory bowel disease显示文摘BACKGROUND Magnetic resonance enterography (MRE) and wireless capsule endoscopy (WCE) are equally accepted modalities for noninvasive screening of small bowel involvement (SBI) in children with Crohn’s disease (CD) and indeterminate colitis (IC) albeit there is a paucity of data comparing the two and thereby guiding the clinician in selecting the ideal diagnostic approach. Therefore, the goal of this study is to provide additional evidence for capsule endoscopy role in the evaluation of established Crohn’s disease exacerbation compared to MRE in relation to Pediatric Crohn's Disease Activity Index (PCDAI), and histological indices. AIM To prospectively compare the findings of MRE and WCE and their agreement with PCDAI or histology in children with CD or IC. METHODS Consecutive patients diagnosed with CD and IC were screened for inclusion. After informed consent, patient’s demographic and clinical data was abstracted. The current pediatric disease activity index (PCDAI) and endoscopic findings were included. Patients underwent MRE and WCE including preprocedural patency capsule within a maximum of 7 d of each other. Pathological presence of active small bowel disease in ileal and duodenal biopsies were collected if the endoscopy was performed within 2 mo of the WCE study. Patients who failed to pass the PC were excluded from the study. WCE was read by two different experienced gastroenterologists (Attard TM and Colombo JM) blinded to each other's findings and to the findings on MRE (Mardis NJ). Agreement between WCE reviewers, WCE and MRE findings and concordance between positive PCDAI and SBI based on MRE compared with WCE was computed. RESULTS Forty-five patients were included in the study, 18 withdrew and 27 (20 males and 20 CD), mean age (standard deviation) 13.46 (2.4) years, completed the study protocol. There were no instances of capsule retention. Concordance between gastroenterologist reviewers was excellent for the diagnosis of small intestinal CD with good correlation between the two Lewis scores (r=0.875, P<0.001). Concordance between WCE and MRE was poor (69%). In CD patients, when both MRE and WCE were compared using PCDAI>10 as the standard reference reflecting active small intestinal CD, the sensitivity of MRE and WCE were 100% and 83% respectively and the specificity of MRE and WCE were 57.14% and 78.6%, respectively. If the histology in ileum or/and duodenum was used as the reference for active small bowel involvement, WCE had a higher specificity as compared to MRE (83.3% vs 50%). In patients with Crohn’s disease, those with a positive PCDAI (>10) were more likely to have a positive WCE as compared to those with a negative PCDAI (83% vs 21%;P=0.018). CONCLUSION We suggest that MRE and WCE have a complementary role in the assessment of SBI in CD. WCE detected SBI with a much higher specificity while MRE had a higher sensitivity. | Nadia Mazen Hijaz Thomas Mario Attard Jennifer Marie Colombo Neil Joseph Mardis Craig Alan Friesen | 2019 | World Journal of Gastroenterology2019，25，28： | 3 |
| 5 | Present state and future challenges in pediatric abdominal pain therapeutics research: Looking beyond the forest显示文摘At the present time, it is nearly impossible to treat pediatric functional gastrointestinal disorders associated with pain in an evidence based fashion. This is due to the overall lack of controlled studies and, even more importantly, the complexity of the contributors to disease phenotype which are not controlled or accounted for in most therapeutic trials. In this manuscript, we review the challenges of defining entry criteria, controlling for the large number of biopsychosocial factors which may effect outcomes, and understanding pharmacokinetic and pharmacodynamic factors when designing therapeutic trials for abdominal pain in children. We also review the current state of pediatric abdominal pain therapeutics and discuss trial design considerations as we move forward. | Craig A Friesen Jennifer V Schurman Susan M Abdel-Rahman | 2015 | World Journal of Gastrointestinal Pharmacology and Therapeutics2015，6，4： | 3 |
| 6 | Total Anomalous Pulmonary Venous Connection: An Analysis of Current Management Strategies in a Single Institution显示文摘 | Camille L. Hancock Friesen David Zurakowski Ravi R. Thiagarajan Joseph M. Forbess Pedro J. del Nido John E. Mayer Richard A. Jonas | 2005 | The Annals of Thoracic Surgery2005，，2： | 2 |
| 7 | Symptoms and Subtypes in Pediatric Functional Dyspepsia: Relation to Mucosal Inflammation and Psychological Functioning显示文摘 | Jennifer V Schurman Meenal Singh Vivekanand Singh Nancy Neilan Craig A Friesen | 2010 | Journal of Pediatric Gastroenterology and Nutrition2010，，3： | 2 |
| 8 | Accuracy and reproducibility of 12 h esophageal pH monitoring显示文摘 | Friesen C A Hodge C Roberts C C | 1991 | J Pediatr Gastroenterol Nutr1991，12，2： | 2 |
| 9 | Strategy-making and Environment: the Third Link显示文摘 | Miller D Friesen H | 1983 | Strategic Management Journal1983，，4： | 1 |
| 10 | Identification of novel hradyzoite-specific Toxoplasma gondii genes with domains for protein-protein interactions by suppression subtractive hybridization 显示文摘 | FRIESEN J FLEIGE T GROSS U | 2008 | Mol Biochem Parasitol2008，157，2： | 1 |
| 11 | Total anomalous pulmonary venous connection:An analysis of current management strategies in a single institution显示文摘 | Hancock Friesen CL Zurakowski D Thiagarajan RR | 2005 | Ann Thorac Surg2005，79，2： | 1 |
| 12 | Transprostatic selective cystectomy with an ileal bladder 显示文摘 | Schilling A Friesen A | 1990 | Eur Urol1990，18，4： | 1 |
| 13 | Total a- nomalous pulmonary venous connection: an analysis of current man- agement strategies in a single institution 显示文摘 | Hancock Friesen CL Zurakowski D Thiagarajan RR | 2005 | Ann Thorac Surg2005，79，2： | 1 |
| 14 | Activation of apoptosis pathways in peripheral blood lymphocytes by in vivo chemotherapy显示文摘 | Simone Fulda Claudia Friesen | 2001 | Blood2001，98，： | 1 |
| 15 | Divergent Transcription of Early 35-and 94-Kilodalton Protein Genes Encoded by the Hind Ⅲ K Genome Fragment of the Baculovirus Autographa Californica Nuclear Polyhedrosis Virus显示文摘 | Friesen P D Miller L K | 1987 | J Virol1987，61，： | 1 |
| 16 | Induction of CD95 ligand and apoptosis by doxorubiein is modulated by the redox state in chemosensilive and drug resistant tumor cells显示文摘 | Friesen C Fulda S Debatin KM | 1999 | Cell Death Differ1999，6，5： | 1 |
| 17 | The repertoire of nonverbal behavior: categories, origins, usage, and coding 显示文摘 | Ekman Paul Friesen Wallace V | 1969 | Semiotica1969，，1： | 1 |
| 18 | The effect of enzyme supplementation on the apparent metabolizable energy and nutrient digestibility of wheat, barley, oat and rye for the young broiler chick 显示文摘 | Friesen O D Guenter W Marquardt R R | 1992 | Poultry Science1992，73，： | 1 |
| 19 | A wheat intervarietal genetic linkage map based on microsatellite and target region amplified polymorphism markers and its utility for detecting quantitative trait loci 显示文摘 | LIU Z H ANDERSON J A HU J FRIESEN T L RASMUSSEN J B FARIS J D | 2005 | Theoretical and Applied Genetics2005，111，4： | 1 |
| 20 | TP53 R249S mutation, genetic variations in HBX and risk of hepatocellular carcinoma in The Gambia显示文摘 | Doriane A. Gouas Stéphanie Villar Sandra Ortiz-Cuaran Pénélope Legros Gilles Ferro Gregory D. Kirk Olufunmilayo A. Lesi Maimuna Mendy Ebrima Bah Marlin D. Friesen John Groopman Isabelle Chemin Pierre Hainaut | 2012 | Carcinogenesis2012，，6： | 1 |
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