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15篇 您的检索式：作者名="Michael Howell"

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		题名	作者	年代	出处	被引量
	1	Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies显示文摘在地岬基因的 Oncogenic 变化在人的癌症是很普通的,导致有描绘得好的选择优点,而且不太听说得好的危险的房间。我们执行了一幅大规模 loss-of-function 屏幕识别被转变 KRAS 的结肠癌房间,然而并非由缺乏这 oncogene 的衍生物要求的基因。最高得分的基因然后在 KRAS 变异、野类型的癌症房间的一块更大的面板被测试。表示 oncogenic KRAS 的癌症房间被发现高度依赖于抄写因素 GATA2 和 DNA 复制开始管理者 CDC6。与已知的目标用许多药扩大这分析,我们发现有变异的 KRAS 的癌症房间与 topoisomerase 抑制显示出选择嗜好到 proteasome 功能,以及合成致命性。联合指向引起的这些功能改善了相对野类型的房间 KRAS 变异的房间杀死。这些观察建议新奇目标和在地岬变异的癌症为最佳的效果联合存在治疗的新方法,它传统地被看作对治疗高度倔强。	Michael Steckel Miriam Molina-Arcas Britta Weigelt Michaela Marani Patricia H Warne Hanna Kuznetsov Gavin Kelly Becky Saunders Michael Howell Julian Downward David C Hancock	2012	Cell Research2012，22，8：	5
	2	Peginterferon and Ribavirin Treatment in African American and Caucasian American Patients With Hepatitis C Genotype 1显示文摘	Hari S. Conjeevaram Michael W. Fried Lennox J. Jeffers Norah A. Terrault Thelma E. Wiley–Lucas Nezam Afdhal Robert S. Brown Steven H. Belle Jay H. Hoofnagle David E. Kleiner Charles D. Howell	2006	Gastroenterology2006，，2：	2
	3	Does cultural socialization predict multiple bases and foci of commitment?显示文摘	Michael Clugston Jon P Howell Peter W Dorfman	2000	Journal of Management2000，，1：	1
	4	Review of methodology for the determination of macrocyclic lactone residues in biological matrices显示文摘	Martin Danaher Laurence C. Howells Steven R.H. Crooks Vesna Cerkvenik-Flajs Michael O’Keeffe	2006	Journal of Chromatography B2006，，2：	1
	5	Cytokine modulation of atopic dermatitis filaggrin skin expression显示文摘	Michael D. Howell Byung Eui Kim Peisong Gao Audrey V. Grant Mark Boguniewicz Anna DeBenedetto Lynda Schneider Lisa A. Beck Kathleen C. Barnes Donald Y.M. Leung	2009	The Journal of Allergy and Clinical Immunology2009，，3：	1
	6	Outcome of critically ill patients with acute kidney injury using the Acute Kidney Injury Network criteria显示文摘	Tal Mandelbaum Daniel J. Scott Joon Lee Roger G. Mark Atul Malhotra Sushrut S. Waikar Michael D. Howell Daniel Talmor	2011	Critical Care Medicine2011，，12：	1
	7	Using routine inpatient data to identify patient at risk of hospital readmissian 显示文摘	STUART HOWELL MICHAEL COORY STEPHEN DUCKETT	2009	BMC Health Services Research2009，9，：	1
	8	Correction of congenital diaphragmatic hernia in utero VIII: Response of the hypoplastic lung to tracheal occlusion显示文摘	Michael R Harrison N.Scott Adzick Alan W Flake Karen J VanderWall John F Bealer Lori J Howell Jody A Farrell Roy A Filly Mark A Rosen Augusto Sola James D Goldberg	1996	Journal of Pediatric Surgery1996，，10：	1
	9	A robust system for RNA interference in the chicken using a modified microRNA operon显示文摘	Raman M. Das Nick J. Van Hateren Gareth R. Howell Elizabeth R. Farrell Fiona K. Bangs Victoria C. Porteous Elizabeth M. Manning Michael J. McGrew Kyoji Ohyama Melanie A. Sacco Pam A. Halley Helen M. Sang Kate G. Storey Marysia Placzek Cheryll Tickle Venug	2006	Developmental Biology2006，，2：	1
	10	A self-contained system for observing and quantifying the behavior of Atlantic cod, Gadus morhua, in an offshore aquaculture cage显示文摘	Chris Rillahan Michael Chambers Howell W H	2009	Aquaculture2009，293，12：	1
	11	Functional screening identifies MCT4 as a key regulator of breast cancer cell metabolism and survival显示文摘	Franziska Baenke Sébastien Dubuis Charlene Brault Britta Weigelt Beatrice Dankworth Beatrice Griffiths Ming Jiang Alan Mackay Becky Saunders Bradley Spencer‐Dene Susana Ros Gordon Stamp Jorge S Reis‐Filho Michael Howell Nicola Zamboni Almut Schulze	2015	J. Pathol2015，，2：	1
	12	Single nucleotide polymorphism upstream of interleukin 28B associated with phase 1 and phase 2 of early viral kinetics in patients infected with HCV genotype 1显示文摘	Charles D. Howell Alexis Gorden Kathleen A. Ryan Alexander J. Thompson Chadi Ibrahim Michael Fried Nezam H. Afdhal John G. McHutchison Kevin V. Shianna David B. Goldstein Alan R. Shuldiner Braxton D. Mitchell	2012	Journal of Hepatology2012，，3：	1
	13	Radiation treatment inhibits monocyte entry into the optic nerve head and prevents neuronal damage in a mouse model of glaucoma显示文摘	Howell Gareth R Soto Ileana Zhu Xianjun Ryan Margaret Macalinao Danilo G Sousa Gregory L Caddle Lura B MacNicoII Katharine H Barbay Jessica M Porciatti Vittorio Anderson Michael G Smith Richard S Clark Abbot F Libby Richard T John Simon W M	2012	EN2012，，4：	1
	14	IL-31 is associated with cutaneous lymphocyte antigen–positive skin homing T cells in patients with atopic dermatitis显示文摘	Janine Bilsborough Donald Y.M. Leung Mark Maurer Michael Howell Mark Boguniewcz Lena Yao Harold Storey Cosette LeCiel Brandon Harder Jane A. Gross	2006	The Journal of Allergy and Clinical Immunology2006，，2：	1
	15	A and C Genome Distinction and Chromosome Identification in Brassica napus by Sequential Fluorescence in Situ Hybridization and Genomic in Situ Hybridization显示文摘	Howell Elaine C Kearsey Michael J Jones Gareth H King Graham J Armstrong Susan J	2008	Genetics2008，，4：	1

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