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| 1 | Acute liver injury induced by weight-loss herbal supplements显示文摘We report three cases of patients with acute liver injury induced by weight-loss herbal supplements. One patient took Hydroxycut while the other two took Herbalife supplements. Liver biopsies for all patients dem onstrated f indings consistent with drug-induced acute liver injury. To our knowledge, we are the fi rst instit ute to report acute liver injury from both of these two typ es of weight-loss herbal supplements together as a case series. The series emphasizes the importance of taking a cautious approach when consuming herbal supp lements for the purpose of weight loss. | Gary C Chen Vivek S Ramanathan David Law Pauline Funchain George C Chen Samuel French Boris Shlopov Viktor Eysselein David Chung Sonya Reicher Binh V Pham | 2010 | World Journal of Hepatology2010，2，11： | 5 |
| 2 | Staining for p53 and Ki-67 increases the sensitivity of EUS-FNA to detect pancreatic malignancy显示文摘AIM:To investigate whether tumor marker staining can improve the sensitivity of endoscopic ultrasound-guided fine needle aspiration(EUS-FNA)to diagnose pancreatic malignancy. METHODS:Patients who underwent EUS-FNA were retrospectively identified.Each EUS-FNA specimen was evaluated by routine cytology and stained for tumor markers p53,Ki-67,carcinoembryonic antigen(CEA) and CA19-9.Sensitivity,specificity,positive and negative predictive values(PPV and NPV),and positive and negative likelihood ratios(PLR and NLR)were calculated in order to evaluate the performance of each test to detect malignancy. RESULTS:Sixty-one specimens had complete sets of stains,yielding 49 and 12 specimens from pancreatic adenocarcinomas and benign pancreatic lesions due to pancreatitis,respectively.Cytology alone had sensitivity and specificity of 41%and 100%to detect malignancy, respectively.In 46%of the specimens,routine cytology alone was deemed indeterminate.The addition of either p53 or Ki-67 increased the sensitivity to 51%and 53%,respectively,with perfect specificity,PPV and PLR (100%,100%and infinite).Both stains in combination increased the sensitivity to 57%.While additional staining with CEA and CA19-9 further increased the sensitivity to 86%,the specificity,PPV and PLR were significantly reduced(at minimum 42%,84%and 1,respectively).Markers in all combinations performed poorly as a negative test(NPV 26%to 47%,and NLR 0.27 and 0.70).CONCLUSION:Immunohistochemical staining for p53 and Ki-67 can improve the sensitivity of EUS-FNA to diagnose pancreatic adenocarcinoma. | Alexander W Jahng Sonya Reicher David Chung Donna Varela Rahul Chhablani Anil Dev Binh Pham Jose Nieto Rose J Venegas Samuel W French Bruce E Stabile Viktor E Eysselein | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，11： | 3 |
| 3 | Prolonged feeding with guanidinoacetate, a methyl group consumer, exacerbates ethanol-induced liver injury显示文摘AIM To investigate the hypothesis that exposure to guanidinoacetate(GAA, a potent methyl-group consumer) either alone or combined with ethanol intake for a prolonged period of time would cause more advanced liver pathology thus identifying methylation defects as the initiator and stimulator for progressive liver damage.METHODS Adult male Wistar rats were fed the control or ethanolLieber De Carli diet in the absence or presence of GAA supplementation. At the end of 6 wk of the feeding regimen, various biochemical and histological analyses were conducted. RESULTS Contrary to our expectations, we observed that GAA treatment alone resulted in a histologically normal liver without evidence of hepatosteatosis despite persistence of some abnormal biochemical parameters. This protection could result from the generation of creatine from the ingested GAA. Ethanol treatment for 6 wk exhibited changes in liver methionine metabolism and persistence of histological and biochemical defects as reported before. Further, when the rats were fed the GAA-supplemented ethanol diet, similar histological and biochemical changes as observed after 2 wk of combined treatment, including inflammation, macroand micro-vesicular steatosis and a marked decrease in the methylation index were noted. In addition, rats on the combined treatment exhibited increased liver toxicity and even early fibrotic changes in a subset of animals in this group. The worsening liver pathology could be related to the profound reduction in the hepatic methylation index, an increased accumulation of GAA and the inability of creatine generated to exert its hepato-protective effects in the setting of ethanol.CONCLUSION To conclude, prolonged exposure to a methyl consumer superimposed on chronic ethanol consumption causes persistent and pronounced liver damage. | Natalia A Osna Dan Feng Murali Ganesan Priya F Maillacheruvu David J Orlicky Samuel W French Dean J Tuma Kusum K Kharbanda | 2016 | World Journal of Gastroenterology2016，22，38： | 2 |
| 4 | HOXB7 promotes invasion and predicts survival in pancreatic adenocarcinoma显示文摘 | Anne Nguyen Kovochich Michael Arensman Anna R. Lay Nagesh P. Rao Timothy Donahue Xinmin Li Samuel W. French David W. Dawson | 2012 | Cancer2012，，3： | 2 |
| 5 | Quantifiea-tion of mineral matter in commercial cokes and their parent coals显示文摘 | David French Mihaela Grigore | 2007 | International Journal of Coal Geology2007，，1： | 1 |
| 6 | Determination of glass content and estimation of glass composition in fly ash using quantitative X-ray diffractometry显示文摘 | Colin R. Ward David French | 2006 | Fuel2006，，16： | 1 |
| 7 | Influence of thrombolytic therapy, with or without intra-aortic balloon counterpulsation, on 12-month survival in the SHOCK trial显示文摘 | John K French Henry A Feldman Susan F Assmann Timothy Sanborn Sebastian T Palmeri David Miller Jean Boland Christopher E Buller Richard Steingart Lynn A Sleeper Judith S Hochman | 2003 | American Heart Journal2003，，： | 1 |
| 8 | The use of genetically modified mice in cancer risk assessment: Challenges and limitations*显示文摘 | David A. Eastmond Suryanarayana V. Vulimiri John E. French Babasaheb Sonawane | 2013 | Critical Reviews in Toxicology2013，，8： | 1 |
| 9 | Behavior of coal mineral matter in sintering and slagging of ash during the gasification process 显示文摘 | Ratale H Matjie David French Colin R Ward | 2011 | Fuel Processing Technology2011，92，8： | 1 |
| 10 | Behavior of coal mineral matter in sintering and slagging of ash during the gasification process 显示文摘 | Ratale H Matjie David French Colin R Ward | 2011 | Fuel Processing Technology2011，92，8： | 1 |
| 11 | Ethanol-stimulated differentiated functions of human or mouse hepatic stellate cells are mediated by connective tissue growth factor显示文摘 | Li Chen Alyssa L. Charrier Andrew Leask Samuel W. French David R. Brigstock | 2010 | Journal of Hepatology2010，，2： | 1 |
| 12 | Gdf6a is required for the initiation of dorsal–ventral retinal patterning and lens development显示文摘 | Curtis R. French Timothy Erickson Danielle V. French David B. Pilgrim Andrew J. Waskiewicz | 2009 | Developmental Biology2009，，1： | 1 |
| 13 | Rationale for establishing regional ST-elevation myocardial infarction receiving center (SRC) networks显示文摘 | Ivan C. Rokos David M. Larson Timothy D. Henry William J. Koenig Marc Eckstein William J. French Christopher B. Granger Matthew T. Roe | 2006 | American Heart Journal2006，，4： | 1 |
| 14 | The importance of affective beliefs and attitudes in the theory of planned behavior:Predicting intention to increase physical activity显示文摘 | FRENCH DAVID P SUTTON STEPHEN HENNINGS SUSIE J MITCHELL JO WAREHAM NICHOLAS J GRIFFIN SIMON HARDEMAN WENDY KINMONTH ANN LOUISE | 2005 | Journal of Applied Social Psychology2005，35，9： | 1 |
| 15 | Increased methylation demand exacerbates ethanol-induced liver injury显示文摘 | Kusum K. Kharbanda Sandra L. Todero Paul G. Thomes David J. Orlicky Natalia A. Osna Samuel W. French Dean J. Tuma | 2014 | Experimental and Molecular Pathology2014，，1： | 1 |
| 16 | The importance of affective beliefs and attitudes in the theory nf planned behavior:predicting intention to increase physical activity显示文摘 | French David P Suttun S Hennings SJ | 2005 | Juurnal nf Applied Social Psychology2005，35，9： | 1 |
| 17 | Self-efficacy and psychological well-being of wheelchair tennis participants and wheelchair nontennis participants显示文摘 | C Michael Greenwood David A Dzewaltowski Ron French | 1990 | Adapted Physical Activity Quarterly1990，7，： | 1 |
| 18 | Assessment of coronary plaque morphology by contrast-enhanced computed tomographic angiography: comparison with intravascular ultrasound显示文摘 | Margaret Leila Rasouli David M. Shavelle William J. French Charles R. McKay Matthew J. Budoff | 2006 | Coronary Artery Disease2006，，4： | 1 |
| 19 | A comprehensive framework for knowledge - base verification and validation显示文摘 | Scott W French David Hamilton | 2007 | International Journal of Intelli- gent Systems2007，9，9： | 1 |
| 20 | Influ ence of Mineral Matter on Coke Reactivity With Carbon Diox- ide 显示文摘 | Mihaela Grigore Richard Sakurovs David French | 2006 | ISIJ Int2006，46，4： | 1 |
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