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1254篇 您的检索式:作者名="Thomes"
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1Involvement of autophagy in alcoholic liver injury and hepatitis C pathogenesis显示文摘This review describes the principal pathways of macroautophagy (i.e. autophagy), microautophagy and chaperone-mediated autophagy as they are currently known to occur in mammalian cells. Because of its crucial role as an accessory digestive organ, the liver has a particularly robust autophagic activity that is sensitive to changes in plasma and dietary components. Ethanol consumption causes major changes in hepatic protein and lipid metabolism and both are regulated by autophagy, which is significantly affected by hepatic ethanol metabolism. Ethanol exposure enhances autophagosome formation in liver cells, but suppresses lysosome function. Excessive ethanol consumption synergizes with hepatitis C virus (HCV) to exacerbate liver injury, as alcohol-consuming HCV patients frequently have a longer course of infection and more severe manifestations of chronic hepatitis than abstinent HCV patients. Alcohol-elicited exacerbation of HCV infection pathogenesis is related to modulation by ethanol metabolism of HCV replication. Additionally, as part of this mechanism, autophagic proteins have been shown to regulate viral (HCV) replication and their intracel-lular accumulation. Because ethanol induces autophagosome expression, enhanced levels of autophagic proteins may enhance HCV infectivity in liver cells of alcoholics and heavy drinkers.Natalia A Osna Paul G Thomes Terrence M Donohue 2011World Journal of Gastroenterology2011,17,20:5
2Alcohol Consumption Decreases Rat Hepatic Creatine Biosynthesis Via Altered Guanidinoacetate Methyltransferase Activity显示文摘Kusum K. Kharbanda Sandra L. Todero Jordan C. Moats Ryan M. Harris Natalia A. Osna Paul G. Thomes Dean J. Tuma 2014Alcohol Clin Exp Res2014,,3:2
3Cardiac troponins in serum in chronic renal failure显示文摘Hafiner J Thome Kromer B Schanbe J 1994Clinical Chemistry1994,40,9:1
4Inhibition of death receptor signals by cellular FLIP显示文摘Irmler M Thome M Hahne M 1997Nature1997,388,6638:1
5Film condensation of R- 134a on tube array with plain and enhanced surfaces ( Ⅱ ) : empirical prediction of inundation effects 显示文摘GSTOEHL D THOME J R 2006Journal of Heat Transfer2006,128,:1
6Paroxetine augmentation with risperidone in therapy-resistant depression显示文摘Knopf U Hubrich-Ungureanu P Thome J 2001Psychiatr Prax2001,28,8:1
7Conden- sation in horizontal tubes: part 2 New heat transfer model based on flow regimes 显示文摘HAJAL J E THOME J R CAVALLINI A 2003International Jour- nal of Heat and Mass Transfer2003,46,18:1
8Regulation of cocaine reward by CREB显示文摘Carlezon WAJ Thome J Olson VG 1998Science1998,282,:1
9Data-based Methods for Quality Improvement by Process Step Integration显示文摘Haald Peters Norbet Link und Thomes Hecken Thaler 2000Stahl und Eisen2000,,8:1
10The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex显示文摘Micheau o Thome M Schneider P 2002J Biol Chem2002,277,45:1
11Feelings of patients on the waiting list for a kidney transplant显示文摘Flores R V Thome E G 2004Rev Bras En- ferm2004,57,6:1
12Falling films on arrays of horizontal tubes with R-134a, Part I: Boiling heat transfer results for four types of tubes显示文摘Roques J F Thome J R 2007Heat Transfer Engineering2007,28,5:1
13The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex显示文摘Micheau O Thome M Schneider P 2002J Biol Chemistry2002,277,45:1
14Modulation of sodium transport in fetal alveolar epithelial cells by oxygen and eorticosterone显示文摘Thome U H Davis I C Nguyen S V 2003Am J Physiol Lung Cell Mol Physiol2003,284,2:1
15Group inverse and group involutory matrices显示文摘 Thome N 1998Linear and Multilinear Algebra1998,,45:1
16MieroRNA expression profiling of human breast cancer identifies new markers of tumor subtype显示文摘Blenkiron C Goldstein ID Thome NP 2007Genome Biol2007,8,10:1
17Regional cerebral blood flow monitoring in the diagnosis of delayed ischemia following aneurysmal subarachnoid hemorrhage显示文摘Vajkoczy P Horn P Thome C 2003J Neurosurg2003,98,6:1
18Inhibition of death receptor signals bycelluar FLIP显示文摘Irmler M Thome M Hahne M 1997Nature1997,388,6638:1
19Inhibition of fas death signals by FLIPs显示文摘Tschopp J Irmler M Thome M 1998Curr Opin Immunol1998,10,:1
20Eccentric over load training for patients with chronic Achilles tendon pain a randomized controlled study with reliability testing of the evaluation methods显示文摘Silbemagel K G Thomee R Thomee P 2001Scand J Med Sci Sports2001,11,4:1
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