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| 1 | Prolonged feeding with guanidinoacetate, a methyl group consumer, exacerbates ethanol-induced liver injury显示文摘AIM To investigate the hypothesis that exposure to guanidinoacetate(GAA, a potent methyl-group consumer) either alone or combined with ethanol intake for a prolonged period of time would cause more advanced liver pathology thus identifying methylation defects as the initiator and stimulator for progressive liver damage.METHODS Adult male Wistar rats were fed the control or ethanolLieber De Carli diet in the absence or presence of GAA supplementation. At the end of 6 wk of the feeding regimen, various biochemical and histological analyses were conducted. RESULTS Contrary to our expectations, we observed that GAA treatment alone resulted in a histologically normal liver without evidence of hepatosteatosis despite persistence of some abnormal biochemical parameters. This protection could result from the generation of creatine from the ingested GAA. Ethanol treatment for 6 wk exhibited changes in liver methionine metabolism and persistence of histological and biochemical defects as reported before. Further, when the rats were fed the GAA-supplemented ethanol diet, similar histological and biochemical changes as observed after 2 wk of combined treatment, including inflammation, macroand micro-vesicular steatosis and a marked decrease in the methylation index were noted. In addition, rats on the combined treatment exhibited increased liver toxicity and even early fibrotic changes in a subset of animals in this group. The worsening liver pathology could be related to the profound reduction in the hepatic methylation index, an increased accumulation of GAA and the inability of creatine generated to exert its hepato-protective effects in the setting of ethanol.CONCLUSION To conclude, prolonged exposure to a methyl consumer superimposed on chronic ethanol consumption causes persistent and pronounced liver damage. | Natalia A Osna Dan Feng Murali Ganesan Priya F Maillacheruvu David J Orlicky Samuel W French Dean J Tuma Kusum K Kharbanda | 2016 | World Journal of Gastroenterology2016，22，38： | 2 |
| 2 | Increased Carbonylation of the Lipid Phosphatase PTEN contributes to Akt2 Activation in a Murine Model of Early Alcohol-induced Steatosis显示文摘 | C.T. Shearn R.L. Smathers D.S. Backos P. Reigan D.J. Orlicky Dennis R. Petersen | 2013 | Free Radical Biology and Medicine2013，，： | 2 |
| 3 | Deposition of inhaled aerosol particles in a generation of the tracheobronchial tree显示文摘 | Orlicki D | 1990 | Journal of Aerosol Science1990，21，： | 1 |
| 4 | Expression of survivin in normal,hyperplastic and neoplastic colonic mucosa显示文摘 | Gianani R Jarboe E Orlicky D | | 0，，： | 1 |
| 5 | Immunohistochemical localization of survivin in benign cervical mucosa,cervical dysplasia,and invasive squamous cell carcinoma显示文摘 | Frost M Jarboe EA Orlicky D | | 0，，： | 1 |
| 6 | Post-thyroidectomy hemorrhage显示文摘 | Ci chon S Anielski R Orlicki P | | 0，，07： | 1 |
| 7 | Immunohistochemical localization of survivin in benign cervical mucosa,cervical dysplesia,and invasive squamous cell carcinoma显示文摘 | Jarboe EA Orlicky D | 2002 | Am Clin Pathol2002，117，5： | 1 |
| 8 | Immunohistochemical localization of survivin in benign cervical mucosa, cervical dysplasia, and in- vasive squamous cell carcinoma 显示文摘 | Frost M Jarboe EA Orlicky D | 2002 | Am J Clin Pathol2002，117，5： | 1 |
| 9 | Post-thyroidectomy hem- orrhage显示文摘 | Cichon S Anie|ski R Orlicki P | 2002 | Przegl Lek2002，59，7： | 1 |
| 10 | Surface- modified nanofibrous biomaterial bridge for the enhancement and con- trol of neurite outgrowth显示文摘 | Zander NE Orlicki JA Rawlett AM | 2010 | Biointerphases2010，5，： | 1 |
| 11 | Expression of survivin in normal, hyperplastic, and neoplastic colonic mucosa显示文摘 | Gianani R Jarboe E Orlicky D | 2001 | Human Path2001，32，： | 1 |
| 12 | Effect of hy-perbranched surface - migrating additives on the electro-spinning behavior of poly (methyl methacrylate) 显示文摘 | Hunley M T Harber A Orlicki J A | 2008 | Lang-muir2008，24，3： | 1 |
| 13 | Immunohistochemical lo calization of survivin in benign cervical mucosa, cervical dysplasi a,and invasive squamous cell carcinoma显示文摘 | Frost M Jarboe EA Orlicky D etal | 2002 | Am J Clin Pathol2002，117，5： | 1 |
| 14 | Use of limited proteolysis to identify protein domains suitable for structural analysis显示文摘 | Koth C M Orlicky S M Larson S M | 2003 | Methods Enzymology2003，368，： | 1 |
| 15 | Expression of survivin in normal, hyperplastic, and neoplastic colonic mucosa 显示文摘 | Gianani R Jarboe E Orlicky D | 2001 | Hum Pathol2001，32，1： | 1 |
| 16 | The use of bimodal blends of vinyl ester monomers to improve resin processing and toughen polymer properties显示文摘 | John J La Scala Joshua A Orlicki Cherise Winston | 2005 | Polymer2005，46，： | 1 |
| 17 | Immunohistochemical localization of survivin in benign cervical mucosa, cervical dysplasia , and invasive squamous cell carcinoma显示文摘 | Frost M Jarboe E Orlicky D | 2002 | Am J Clin Pathol2002，117，： | 1 |
| 18 | The use of bimodal blends of vinyl ester monomers to improve resin processing and toughen polymer properties显示文摘 | John J La Scala Joshua A Orlicki Cherise Winston | 2005 | Poly- mer2005，46，9： | 1 |
| 19 | Immunohistochemical localization of survivin in benign cervical mucosa, cervical dysplasiao and invasive squamous cell carcinoma显示文摘 | Frost M Jarboe EA Orlicky D et al | 2002 | Am J Clin Pathol2002，117，5： | 1 |
| 20 | Expression of Survivin in normal,hyperplastic and neoplastic colonic mucosa显示文摘 | Gianani R Jarboe E Orlicky D | 2001 | Hum Pathol2001，32，1： | 1 |
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