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| 1 | Cognitive disorder and dementia in type 2 diabetes mellitus显示文摘Insulin,a key pleiotropic hormone,regulates metabolism through several signaling pathways in target tissues including skeletal muscle,liver,and brain.In the brain,insulin modulates learning and memory,and impaired insulin signaling is associated with metabolic dysregulation and neurodegenerative diseases.At the receptor level,in aging and Alzheimer’s disease(AD)models,the amount of insulin receptors and their functions are decreased.Clinical and animal model studies suggest that memory improvements are due to changes in insulin levels.Furthermore,diabetes mellitus(DM)and insulin resistance are associated with age-related cognitive decline,increased levels ofβ-amyloid peptide,phosphorylation of tau protein;oxidative stress,pro-inflammatory cytokine production and dyslipidemia. Recent evidence shows that deleting brain insulin receptors leads to mildobesity and insulin resistance without influencing brain size and apoptosis development.Conversely, deleting insulin-like growth factor 1 receptor (IGF-1R) affects brain size anddevelopment, and contributes to behavior changes. Insulin is synthesized locally in the brain andis released from the neurons. Here, we reviewed proposed pathophysiological hypotheses toexplain increased risk of dementia in the presence of DM. Regardless of the exact sequence ofevents leading to neurodegeneration, there is strong evidence that mitochondrial dysfunctionplays a key role in AD and DM. A triple transgenic mouse model of AD showed mitochondrialdysfunction, oxidative stress, and loss of synaptic integrity. These alterations are comparable tothose induced in wild-type mice treated with sucrose, which is consistent with the proposal thatmitochondrial alterations are associated with DM and contribute to AD development. Alterationsin insulin/IGF-1 signaling in DM could lead to mitochondrial dysfunction and low antioxidantcapacity of the cell. Thus, insulin/IGF-1 signaling is important for increased neural processing andsystemic metabolism, and could be a specific target for therapeutic strategies to decreasealterations associated with age-related cognitive decline. | Genaro G Ortiz Miguel Huerta Héctor A González-Usigli Erandis D Torres-Sánchez Daniela LC Delgado-Lara Fermín P Pacheco-Moisés Mario A Mireles-Ramírez Blanca MG Torres-Mendoza Roxana I Moreno-Cih Irma E Velázquez-Brizuela | 2022 | World Journal of Diabetes2022，13，4： | 2 |
| 2 | Science Letters:Quantification of Helicobacter pylori levels in soil samples from public playgrounds in Spain显示文摘Helicobacter pylori are ubiquitous Gram-negative bacteria with a high estimated level of infection in the world populations, but a majority of the infected persons are asymptomatic. This pathogen has been classified by the World Health Organization as a class I carcinogen and recognized as the causal agent of most peptic ulcers and chronic gastritis that might lead to stomach cancer. Although not all the transmission pathways of these bacteria into humans have been properly identified, enough data have suggested that the oral-oral or fecal-oral ones are the main infection routes. Helicobacter pylori have been detected in non-treated water and in drinking water, which suggested that water might be an important infection source. As childhood is the critical period of infection, the aim of the present work was to examine the presence of Helicobacter pylori in soil samples from public playing areas of Spanish parks. | Leonardo Martín PéREZ Francesc CODONY Daniela LóPEZ LEYTON Mariana FITTIPALDI Bárbara ADRADOS Jordi MORATó | 2010 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2010，11，1： | 2 |
| 3 | Risk for esophageal neoplasia in B arrett’s esophagus patients with mucosal changes indefinite for dysplasia显示文摘 | Bela Horvath Prabhdeep Singh Hao Xie Prashanthi N Thota Daniela S Allende Rish K Pai Deepa T Patil Thomas P Plesec John R Goldblum Xiuli Liu | 2015 | J Gastroenterol Hepatol2015，，： | 2 |
| 4 | High performance cellular level A- gent-based simulation with FLAME for the GPU显示文摘 | RICHMOND P DANIELA R | 2010 | Briefings in Bioinformatics2010，11，3： | 1 |
| 5 | The quality of life of patients suffering from schizophrenia-acomparison with healthy controls 显示文摘 | Monika S Jan P Daniela J | 2011 | Biomed Pap Med Fac Univ Palacky Olomouc Czech Re- pub2011，155，2： | 1 |
| 6 | The severity of pandemic H1N1 in fluenza in the United States,from April to July 2009:a Bayesian analysis显示文摘 | Anne M P Daniela D A The New York City Swine Flu Investigation | 2009 | PLoS Med2009，6，12： | 1 |
| 7 | Excitotoxic damage,disrupted energy metabolism,and oxidative stress in the rat brain:antioxidant and neuroprotective effects of L-carnitine显示文摘 | DANIELA S A VERONICA P D C MARA N H M | 2008 | Jonrnal of Neurochemistry2008，105，： | 1 |
| 8 | Participation of GABA- benzodiazepine receptor complex in the anxiolytic effect of PassiJTora alata curtis (Passifloraceae)显示文摘 | Gustavo P Franis N Daniela V | 2008 | Lat Am J Pharm2008，27，6： | 1 |
| 9 | Synthesis of pyrimidine- containing 3-aminobutenolides显示文摘 | Ugo C Daniela I Anna P | 2004 | Tetrahedron2004，60，： | 1 |
| 10 | PEComas: The past, the present and the future 显示文摘 | Guido M Maurizio P Daniela R | 2008 | Virchows Arch2008，452，： | 1 |
| 11 | Neurospheres enriched in cancer stem like cells are highly effective in eliciting a den- dritic cell mediated immune response against malignant gliomas 显示文摘 | Serena P Pietro L P Daniela C | 2006 | Cancer Res2006，66，10： | 1 |
| 12 | Varicocelectomy does not impact pregnancy outcomes following intracytoplasmic sperm injection procedures显示文摘 | Fabio F Daniela P Rita C | 2012 | J Androl2012，33，2： | 1 |
| 13 | Multi-residue Method for the Determination of Organochlorine Pesticides in Fish Feed Based on a Cleanup Approach Followed by Gas Chromatography-Triple Quadrupole Tandem Mass Spectrometry显示文摘 | VALERIA N DANIELA D CARMEN P | 2010 | Journal of Chromatography A2010，1217，30： | 1 |
| 14 | High D-dimer levels are associ- ated with poor prognosis in cancer patients 显示文摘 | Cihan Ay Daniela D Robert P | 2012 | Haematologica2012，97，8： | 1 |
| 15 | Improved electrochemical performance of a LiFePO4-based composite cathode 显示文摘 | PIER P P DANIELA Z MAURO P | 2001 | Electrochimica Acta2001，46，23： | 1 |
| 16 | An image adaptive,wavelet-based watermarking of digital images显示文摘 | SANTA A GUIDO A DANIELA P | 2007 | Journal of Computational and Applied Mathematics2007，210，12： | 1 |
| 17 | Improved electrochemical performance of a LiFePO4 - based composite cathode 显示文摘 | Pier P P Daniela Z Mauro P | 2001 | Electrochemica acta2001，46，23： | 1 |
| 18 | Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway显示文摘 | Peng J Daniela C Z P Stephanie C | 2004 | Nature neuroscience2004，7，2： | 1 |
| 19 | Identification, sequence and developmental expression of invertebrate flotillins from Drosophila melanogaster 1 The nucleotide sequences reported in this paper have been submitted to the GenBank/EMBL Data Bank with accession Nos AF044734 and AF044916. 1显示文摘 | Ferruccio Galbiati Daniela Volonté Jason S Goltz Zac Steele Jonaki Sen Jennifer Jurcsak David Stein Leslie Stevens Michael P Lisanti | 1998 | Gene1998，，2： | 1 |
| 20 | Direct mono-N-alkylation of amines in ionic liquids : chemoselectivity and reactivity 显示文摘 | Cinzia C Daniela P | 2003 | Green Chem2003，5，2： | 1 |
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