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| 1 | Acute fatty liver of pregnancy associated with severe acute pancreatitis:A case report显示文摘Acute fatty liver of pregnancy is a rare disease that affects women in the third trimester of pregnancy. Although infrequent, the disease can cause maternal mortality. The diagnosis is not always clear until the pregnancy is terminated, and significant complications, such as acute pancreatitis, can occur. Pancreatic involvement typically only occurs in severe cases after the development of hepatic and renal impairment. To date, little knowledge is available regarding how the disease causes pancreatitis. Treatment involves supportive measures and pregnancy interruption. In this report, we describe a case of a previously healthy 26-year-old woman at a gestational age of 27 wk and 6 d who was admitted with severe abdominal pain and vomiting. This case illustrates the clinical and laboratory overlap between acute fatty liver of pregnancy and pancreatitis, highlighting the difficulties in differentiating each disease. Furthermore, the hypothesis for this overlapping is presented, and the therapeutic options are discussed. | Cássio Vieira de Oliveira Alecsro Moreira Julio P Baima Leticia de C Franzoni Talles B Lima Fabio da S Yamashiro Kunie Yabuki Rabelo Coelho Ligia Y Sassaki Carlos Antonio Caramori Ferno G Romeiro Giovanni F Silva | 2014 | World Journal of Hepatology2014，6，7： | 3 |
| 2 | Association of nonalcoholic fatty liver disease and liver cancer显示文摘AIM:To investigate the association between nonalcoholic fatty liver disease(NAFLD) and liver cancer,and NAFLD prevalence in different liver tumors.METHODS:This is a retrospective study of the clinical,laboratory and histological data of 120 patients diagnosed with primary or secondary hepatic neoplasms and treated at a tertiary center where they underwent hepatic resection and/or liver transplantation,with subsequent evaluation of the explant or liver biopsy.The following criteria were used to exclude patients from the study:a history of alcohol abuse,hepatitis B or C infection,no tumor detected in the liver tissue examined by histological analysis,and the presence of chronic autoimmune hepatitis,hemochromatosis,Wilson's disease,or hepatoblastoma.The occurrence of NAFLD and the association with its known risk factors were studied.The risk factors considered were diabetes mellitus,impaired glucose tolerance,impaired fasting glucose,body mass index,dyslipidemia,and arterial hypertension.Presence of reticulin fibers in the hepatic neoplasms was assessed by histological analysis using slide-mounted specimens stained with either hematoxylin and eosin or Masson's trichrome and silver impregnation.Analysis of tumor-free liver parenchyma was carried out to determine the association between NAFLD and its histological grade.RESULTS:No difference was found in the association of NAFLD with the general population(34.2% and 30.0% respectively,95%CI:25.8-43.4).Evaluation by cancer type showed that NAFLD was more prevalent in patients with liver metastasis of colorectal cancer than in patients with hepatocellular carcinoma and intrahepatic cholangiocarcinoma(OR = 3.99,95%CI:1.78-8.94,P < 0.001 vs OR = 0.60,95%CI:0.18-2.01,P = 0.406 and OR = 0.70,95%CI:0.18-2.80,P = 0.613,respectively).There was a higher prevalence of liver fibrosis in patients with hepatocellular carcinoma(OR = 3.50,95%CI:1.06-11.57,P = 0.032).Evaluation of the relationship between the presence of NAFLD,nonalcoholic steatohepatitis,and liver fibrosis,and their risk factors,showed no significant statistical association for any of the tumors studied.CONCLUSION:NAFLD is more common in patients with liver metastases caused by colorectal cancer. | Perla Oliveira Schulz Fabio Goncalves Ferreira Maria de Fátima Araújo Nascimento Andrea Vieira Mauricio Alves Ribeiro André Ibrahim David Luiz Arnaldo Szutan | 2015 | World Journal of Gastroenterology2015，21，3： | 2 |
| 3 | Phase II study of cetuximab in combination with FOLFIRI in patients with untreated advanced gastric or gastroesophageal junction adenocarcinoma ( FOLCETUX study) 显示文摘 | PINTO C DI FABIO F SIENA S | 2007 | Ann Oncol2007，18，3： | 1 |
| 4 | Phase Ⅱ study of cetuximab plus FOLFIRI as first-line treatment in patients with unresectable/metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma (FOLCETUX study):preliminary results显示文摘 | Pinto C Di Fabio F Siena S | 2006 | J Clin Oncol2006，24，18： | 1 |
| 5 | Percutaneous calcaneo- plasty in displaced intraarticular calcaneal fractures 显示文摘 | Biggi F Di Fabio S D'Antimo C | 2013 | J Ortho- paed Traumatol2013，14，4： | 1 |
| 6 | Phase Ⅱ study of cetuximab in combination with FOLFIRI in patients with untreated advanced gastric or gastroesophageal junction adenocarcinoma (FOLCETUX study)显示文摘 | Pinto C Fabio F D Siena S | 2007 | Annals of Oncology2007，18，3： | 1 |
| 7 | Tibial plateau fractures : Inter- nal fixation with locking plates and the MIPPO technique显示文摘 | Biggi F Di Fabio S D' Antimo C | 2010 | Injury2010，41，11： | 1 |
| 8 | Nerve growth factor expression correlates with perineural invasion and pain in human pancreatic cancer显示文摘 | Zhu ZW Friess H Fabio F | 1999 | J Clin Oncol1999，17，8： | 1 |
| 9 | Capecitabine plus oxaliplatin(xelox)versus protracted5-fluorouracil venous infusion plus oxaliplatin(pvifox)as first-line treatment in advanced colorectal cancer:A GOAM phase II randomised study(FOCA trial)显示文摘 | Martonia AA Pinto C Di Fabio F | 2006 | Eur J Cancer2006，42，18： | 1 |
| 10 | Phase Ⅱ study of cetuximab in combination with FOLFIRI in patients with untreated advanced gastric or gastroesophageal junction adenocarcinoma (FOLCETUX study)显示文摘 | Pinto C Di Fabio F Siena S | 2007 | Ann Oncol2007，18，3： | 1 |
| 11 | Nerve growth factor expression correlates with perineural invasion and pain in human pancreatic cancer 显示文摘 | Zhu ZW Friess H Fabio F | 1999 | J Clin Oncol1999，17，8： | 1 |
| 12 | Protein-Nanoparticle Interaction:Identification of the Ubiquitin-Gold Nanoparticle Interaction Site显示文摘 | Luigi C Fabio F Douglas G | | 0，，： | 1 |
| 13 | Somatic mosaicism ofthe androgen receptor CAG repeats in colorectal carcinomaepithelial cells from men显示文摘 | Di Fabio F Alvarado C Gologan A | 2009 | J Surg Res2009，154，1： | 1 |
| 14 | Tibial plateau fractures : internal fixation with locking plates and the MI- PO technique显示文摘 | Biggi F Di Fabio S D' Antimo C | 2010 | Injury2010，41，11： | 1 |
| 15 | Phase Ⅱ study of eetuximab in combination with FOLFIR1 in patients with untreated advanced gastric or gastroe sophageal junction adenocarcinoma 显示文摘 | Pinto C Di Fabio F Siena S | 2007 | Ann Oncol2007，18，3： | 1 |
| 16 | Molecular identification and osmotolerant profile of wine yeasts that ferment a high suger grape must 显示文摘 | Tofalo R Chaves - Lopez C Di Fabio F | 2009 | Int J Food Microbio12009，130，3： | 1 |
| 17 | Prospective phase Ⅱ study of single-agent gemcitabine in untreated elderly patients with stage Ⅲ B/Ⅳ non-small cell lung cancer显示文摘 | Martoni A Di Fabio F Guaraldi M | 2001 | AM J Clin Oncol2001，24，6： | 1 |
| 18 | Identification of patients at low risk for thyroidectomy-related hypocalce-mia by intraoperative quick PTH显示文摘 | Di Fabio F Casella C Bugari G | | 0，，8： | 1 |
| 19 | Phase Ⅱ study of cetuximab in combination with FOLFIRI in patients with untreated advanced gastric or gastroesophageal junction adenocarcinoma ( FOLCETUX study) 显示文摘 | Pinto C Di Fabio F Siena S | 2007 | Annals of oncology: official journal of the European So- ciety for Medical Oncology/ESMO2007，18，3： | 1 |
| 20 | Phase II study of cetuximab in combination with FOLFIRI in patients with untreated advanced gastric or gastroesophageal junction adenocarcinoma (FOLCETUX study)显示文摘 | Pinto C Di Fabio F Siena S | 2007 | Ann Oncol2007，18，3： | 1 |
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