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| 1 | Cognitive disorder and dementia in type 2 diabetes mellitus显示文摘Insulin,a key pleiotropic hormone,regulates metabolism through several signaling pathways in target tissues including skeletal muscle,liver,and brain.In the brain,insulin modulates learning and memory,and impaired insulin signaling is associated with metabolic dysregulation and neurodegenerative diseases.At the receptor level,in aging and Alzheimer’s disease(AD)models,the amount of insulin receptors and their functions are decreased.Clinical and animal model studies suggest that memory improvements are due to changes in insulin levels.Furthermore,diabetes mellitus(DM)and insulin resistance are associated with age-related cognitive decline,increased levels ofβ-amyloid peptide,phosphorylation of tau protein;oxidative stress,pro-inflammatory cytokine production and dyslipidemia. Recent evidence shows that deleting brain insulin receptors leads to mildobesity and insulin resistance without influencing brain size and apoptosis development.Conversely, deleting insulin-like growth factor 1 receptor (IGF-1R) affects brain size anddevelopment, and contributes to behavior changes. Insulin is synthesized locally in the brain andis released from the neurons. Here, we reviewed proposed pathophysiological hypotheses toexplain increased risk of dementia in the presence of DM. Regardless of the exact sequence ofevents leading to neurodegeneration, there is strong evidence that mitochondrial dysfunctionplays a key role in AD and DM. A triple transgenic mouse model of AD showed mitochondrialdysfunction, oxidative stress, and loss of synaptic integrity. These alterations are comparable tothose induced in wild-type mice treated with sucrose, which is consistent with the proposal thatmitochondrial alterations are associated with DM and contribute to AD development. Alterationsin insulin/IGF-1 signaling in DM could lead to mitochondrial dysfunction and low antioxidantcapacity of the cell. Thus, insulin/IGF-1 signaling is important for increased neural processing andsystemic metabolism, and could be a specific target for therapeutic strategies to decreasealterations associated with age-related cognitive decline. | Genaro G Ortiz Miguel Huerta Héctor A González-Usigli Erandis D Torres-Sánchez Daniela LC Delgado-Lara Fermín P Pacheco-Moisés Mario A Mireles-Ramírez Blanca MG Torres-Mendoza Roxana I Moreno-Cih Irma E Velázquez-Brizuela | 2022 | World Journal of Diabetes2022，13，4： | 2 |
| 2 | Organicsulfonic acid-functionalized mesoporous silicas for the esterification of fatty acid 显示文摘 | Mbaraka I K Daniela R R Lin V S | 2003 | Journal of Catalysis2003，219，： | 1 |
| 3 | Psychiatric comorbility in patientswith chronic daily headache and migraine:A selective overviewincluding personality traits and suicide risk显示文摘 | Pompili M Daniela D C Marco I | 2009 | Headache Pain2009，10，4： | 1 |
| 4 | Ki-67 expression in gastric cancer显示文摘 | Daniela Lazar Sorina Taban I Sporea | 2010 | Romanian Journal of Morphology and Embryology2010，51，4： | 1 |
| 5 | Synthesis of pyrimidine- containing 3-aminobutenolides显示文摘 | Ugo C Daniela I Anna P | 2004 | Tetrahedron2004，60，： | 1 |
| 6 | Leaf shape evolution through duplication, regulatory diversification, and loss of a homeobox gene显示文摘 | Daniela V Daniel K Madlen I R | 2014 | Science2014，343，： | 1 |
| 7 | Mechanical thrombectomy in acute occlusion of the carotid-T : a retrospective single centre study in 51 pa- tients显示文摘 | Daniela F Silke W Miriam I | 2016 | Clin Neumradiol2016，26，1： | 1 |
| 8 | Multiple aspects of homocysteine neurotoxicity:Glutamate excitotoxicity,Kinase hyperactivation and DNA damage 显示文摘 | Pei I Ho Daniela Ortiz | 2002 | Journal of Neuroscience Research2002，70，5： | 1 |
| 9 | Influence of retrograde flushing via the caval vein on the post- reperfusion syndrome in liver transplantation 显示文摘 | DANIELA K MICHAEL Z FLORIAN I | 2004 | Clin Transplant2004，18，6： | 1 |
| 10 | Two acylated monoterpene glucosides from Paeonia peregina显示文摘 | Ivanka N K Mario F S Daniela I T | 1998 | Phytochemistry1998，48，3： | 1 |
| 11 | Cystatin C and estimates ofrenal function : searching for a better measure of kidney function indiabetic patient显示文摘 | Laura P Stefano T Daniela I | 2007 | Clin Chem2007，53，3： | 1 |
| 12 | An analysis of the Brown-Biefeld effect显示文摘 | Reuven I Daniela S Moshe M | 2011 | Journal of Electrostatics2011，69，6： | 1 |
| 13 | Influence of retrograde flushing via the caval vein on the post-reperfusion syndrome in liver transplantation显示文摘 | DANIELA K MICHAEL Z FLORIAN I | 2004 | Clin Transplant2004，18，： | 1 |
| 14 | Serine/ threonine protein phosphatases type 2A and their roles in stress signaling 显示文摘 | Silvia M P Maria T T I Daniela A C | 2009 | Plant Signal Behav2009，4，11： | 1 |
| 15 | Low density polyethylene – Chitosan composites显示文摘 | Cornelia Vasile Raluca Nicoleta Darie Catalina Natalia Cheaburu-Yilmaz Gina-Mihaela Pricope Matej Bra?i? Daniela Pamfil Gabriela Elena Hitruc Donatella Duraccio | 2013 | Composites Part B2013，，： | 1 |
| 16 | Occupational risk in healthcare and research显示文摘 | Daniela V Annie JS Cristina I | 2003 | Am J Industmed2003，43，4： | 1 |
| 17 | StateModelling of the Land Mobile Propagation Channel with MultipleSatellites显示文摘 | DANIELA ALEXANDER I’ ALBERT H | 2012 | International Journal of Antennas and Propagation2012，22，4： | 1 |
| 18 | The influence of the electrostatic stress on cell proliferation in plants显示文摘 | Daniela I Dorina C Alina R | 2007 | Journal of Electrostatics2007，65，7： | 1 |
| 19 | 显示文摘 | Daniela R R Lin V S | 2003 | J Catal2003，219，： | 1 |
| 20 | Somatic D-loop mitochondrial DNA mutation are frequent in uterine serous carcinoma显示文摘 | Tanja P Daniela L Marilyn I | 2004 | Eur Cancer2004，40，16： | 1 |
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