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| 1 | Regulated upon activation,normal T cell expressed and secreted(RANTES)levels in the peripheral blood of patients with Alzheimer’s disease显示文摘Alzheimer’s disease(AD)is the most common type of dementia,but it is very difficult to diagnose with certainty,so many AD studies have attempted to find early and relevant diagnostic markers.Regulated upon activation,normal T cell expressed and secreted(RANTES,also known as C-C chemokine ligand)is a chemokine involved in the migration of T cells and other lymphoid cells.Changes in RANTES levels and its expression in blood or in cerebrospinal fluid have been reported in some neurodegenerative diseases,such as Parkinson’s disease and multiple sclerosis,but also in metabolic diseases in which inflammation plays a role.The aim of this observational study was to assess RANTES levels in peripheral blood as clinical indicators of AD.Plasma levels of RANTES were investigated in 85 AD patients in a relatively early phase of AD(median 8.5 months after diagnosis;39 men and 46 women;average age 75.7 years),and in 78 control subjects(24 men and 54 women;average age 66 years).We found much higher plasma levels of RANTES in AD patients compared to controls.A negative correlation of RANTES levels with age,disease duration,Fazekas scale score,and the medial temporal lobe atrophy(MTA)score(Scheltens’s scale)was found in AD patients,i.e.,the higher levels corresponded to earlier stages of the disease.Plasma RANTES levels were not correlated with cognitive scores.In AD patients,RANTES levels were positively correlated with the levels of pro-inflammatory cytokines interleukin-6 and tumor necrosis factor-α,which is consistent with the wellknown fact that AD is associated with inflammatory processes.RANTES levels were also positively correlated with insulin levels in AD patients,with insulin resistance(HOMA-R)and pancreatic beta cell function(HOMA-F).This study evaluated several clinical and metabolic factors that may affect plasma levels of RANTES,but these factors could not explain the increases in RANTES levels observed in AD patients.Plasma levels of RANTES appear to be an interesting peripheral marker for early stages of AD.The study was approved by the Ethics Committee of Institute of Endocrinology,Prague,Czech Republic on July 22,2011. | Gabriela Vacínová Daniela Vejražkova Robert Rusina Iva Holmerová Hana Vaňková Eva Jarolímová Josef Včelák Běla Bendlová Markéta Vaňková | 2021 | Neural Regeneration Research2021，16，4： | 3 |
| 2 | Interleukin-1 beta induces the expression and production of stem cell factor by epithelial cells: crucial involvement of the PI-3K/mTOR pathway and HIF-1 transcription complex显示文摘在发炎和白血球过多症之间的潜在的交叉连接有一段时间被讨论了,但是支持这教义的试验性的证据是少见的。特别地,由煽动性的调停人理解为 proto-oncogenic 生长因素表情的潜在的 upregulation 负责的机制是重要的。这里,我们调查了高度煽动性的 cytokine interleukin-1 贝它的能力(IL-1β) 到导致干细胞因素(SCF ) 的生产,它是在造血的 myeloid 细胞的恶意的转变之上控制尖锐 myeloid 白血球过多症的前进的一个主要造血的生长因素。我们发现了那人的 IL-1β在 MCF-7 人的上皮的乳癌房间和那导致了 SCF 的表示 / 分泌物这个过程取决于组织缺氧可诱导的因素 1 (HIF-1 ) 抄写建筑群。我们也表明了 phosphatidylinositol-3 kinase (PI-3K ) 的一个关键角色 rapamycin (mTOR ) 的 /mammalian 目标在 IL-1β 的小径;导致的 HIF-1α在 MCF-7 房间的累积。重要地, mTOR 也被发现在 IL-1β 起一个作用;导致的 SCF 生产。而且,为 IL-1β 的积极关联的一个趋势;并且在健康人的施主的血浆的 SCF 层次被观察。总的来说,我们的结果表明那 IL-1β,它通常衔接天生、适应的免疫,通过 PI-3K/mTOR 小径和 HIF-1 抄写建筑群导致主要 haematopoietic/proleukaemic 生长因素 SCF 的生产。这些调查结果强烈支持在发炎和尖锐 myeloid 白血球过多症之间的串音。 | Rafal W Wyszynski Bernhard F Gibbs Luca Varani Daniela Iannotta Vadim V Sumbayev | 2016 | Cellular & Molecular Immunology2016，13，1： | 2 |
| 3 | Chronic hepatitis C virus infection:Serum biomarkers inpredicting liver damage显示文摘Currently, a major clinical challenge in the management of the increasing number of hepatitis C virus(HCV) infected patients is determining the best means for evaluating liver impairment. Prognosis and treatment of chronic hepatitis C(CHC) are partly dependent on the assessment of histological activity, namely cell necrosis and inflammation, and the degree of liver fibrosis. These parameters can be provided by liver biopsy; however, in addition to the risks related to an invasive procedure, liver biopsy has been associated with sampling error mostly due to suboptimal biopsy size. To avoid these pitfalls, several markers have been proposed as non-invasive alternatives for the diagnosis of liver damage. Distinct approaches among the currently available non-invasive methods are(1) the physical ones based on imaging techniques; and(2) the biological ones based on serum biomarkers. In this review, we discuss these approaches with special focus on currently available non-invasive serum markers. We will discuss:(1) class?Ⅰ?serum biomarkers individually and as combined panels, particularly those that mirror the metabolism of liver extracellular matrix turnover and/or fibrogenic cell changes;(2) class Ⅱ biomarkers that are indirect serum markers and are based on the evaluation of common functional alterations in the liver; and(3) biomarkers of liver cell death, since hepatocyte apoptosis plays a significant role in the pathogenesis of HCV infection. We highlight in this review the evidence behind the use of these markers and assess the diagnostic accuracy as well as advantages, limitations, and application in clinical practice of each test for predicting liver damage in CHC. | Pamela Valva Daniela A Ríos Elena De Matteo Maria V Preciado | 2016 | World Journal of Gastroenterology2016，22，4： | 2 |
| 4 | Organicsulfonic acid-functionalized mesoporous silicas for the esterification of fatty acid 显示文摘 | Mbaraka I K Daniela R R Lin V S | 2003 | Journal of Catalysis2003，219，： | 1 |
| 5 | The half-life of internet references cited in communication journals 显示文摘 | DANIELA V DIMITROVA BUGEJA M | 2007 | New Media & Society2007，9，： | 1 |
| 6 | Participation of GABA- benzodiazepine receptor complex in the anxiolytic effect of PassiJTora alata curtis (Passifloraceae)显示文摘 | Gustavo P Franis N Daniela V | 2008 | Lat Am J Pharm2008，27，6： | 1 |
| 7 | Improved synthesis of graphene oxide 显示文摘 | Daniela C Marcano Dmitry V Kosynkin Jacob M Berlin | 2010 | ACS Nano2010，4，8： | 1 |
| 8 | Modification of glass transition temperature through carbohydrates addition and anthocyanin and soluble phenol stability of frozen blueberry juices显示文摘 | Anna R Renato C N Daniela V | 2003 | Food Eng2003，56，23： | 1 |
| 9 | Occupational risk in healthcare andresearch显示文摘 | Daniela V Annie JS CristinaI | 2003 | Am J Indust Med2003，43，4： | 1 |
| 10 | Leaf shape evolution through duplication, regulatory diversification, and loss of a homeobox gene显示文摘 | Daniela V Daniel K Madlen I R | 2014 | Science2014，343，： | 1 |
| 11 | Improved synthesis of graphene oxide显示文摘 | Daniela C Marcano Dmitry V Kosynkin | 2010 | ACS nano2010，4，8： | 1 |
| 12 | Modification of glass transition temperature though carbohydrates addition and anthocyanin and soluble phenol stability of frozen blueberry juices显示文摘 | Anna R Renato C N Daniela V | 2003 | Food Eng2003，56，23： | 1 |
| 13 | Improved synthesis of graphene oxide 显示文摘 | Daniela C Marcano Dmitry V Kosynkin Jacob M Berlin | 2010 | ACS Nano2010，4，： | 1 |
| 14 | Modification of glasstransition temperature through carbohydrates addition andanthocyanin and soluble phenol stability of frozen blueberryjuices显示文摘 | Anna R Renato C N Daniela V | 2003 | Food of Engineering2003，56，23： | 1 |
| 15 | Modification of glass transition temperature though carbohydrates addition and anthocyanin and soluble phenol stability of frozen blueberry juices 显示文摘 | ANNA P RENATO C N DANIELA V | 2003 | Food Eng2003，56，23： | 1 |
| 16 | Amyloid-β peptide inhibits activation of the nitric oxided/cGMP/cAMPresponsive element-binding protein pathway during hippocampal synaptic plasticity显示文摘 | Daniela P Ottavie V Fabrizio T | 2005 | J Neurosci2005，25，29： | 1 |
| 17 | Improving light fastness of nat-ural dyes on cotton yarn 显示文摘 | DANIELA C GERARD V | 2006 | Dyes and Pigments2006，70，3： | 1 |
| 18 | Mineral composition and bitter pit severity in ‘Catarina' apples 显示文摘 | Cassandro V T A Daniela V C Paulo R E | 2006 | Rev Bras Frutic2006，28，1： | 1 |
| 19 | Improved synthesis of graphene oxide 显示文摘 | Daniela C Marcano Dmitry V Kosynkin Jacob M Berlin | 2010 | ACS nano2010，4，8： | 1 |
| 20 | Nonsymbiotic hemoglobin-2 leads to an elevated energy state and to a combined in crease in polyunsaturated fatty acids and total oil content when overexpressed in developing seeds of transgenie Arabidopsis plants 显示文摘 | Helene V Daniela H Peter G | 2011 | Plant Physiology2011，155，： | 1 |
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