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| 1 | Mechanisms of dysregulation of low-density lipoprotein receptor expression in HepG2 cells induced by inflammatory cytokines显示文摘背景低密度的脂蛋白( LDL )受体通常经由依赖于细胞内部的胆固醇 levels.We 的一个反馈系统被调整证明了 cytokines 破坏调停胆固醇的 LDL 受体反馈规定引起在外部 cells.Liver 的未修改的 LDL 的细胞内部的累积是 centraI 机关因为这研究的类脂化合物 homeostasis.The 目的是调查规定胆固醇经由在人的 h 的 LDL | CHEN Ya-xi RUAN Xiong-zhong HUANG Ai-long LI Qiu John F. Moorhead Zac Varghese | 2007 | Chinese Medical Journal2007，，24： | 5 |
| 2 | Clinical utility of cerebrovascular reactivity mapping in patients with low grade gliomas显示文摘AIM:To evaluate neurovascular uncoupling(NVU)associated with low grade gliomas(LGG)using blood oxygen level dependent(BOLD)cerebrovascular reactivity mapping.METHODS:Seven patients with low grade gliomas referred by neurosurgeons for presurgical mapping were included in this pilot study.Cerebrovascular reactivity(CVR)mapping was performed by acquiring BOLD images while patients performed a block-design breath-hold(BH)hypercapnia task.CVR mapping was expressed as BOLD percentage signal change(PSC)from baseline associated with performance of the BH hypercapnia task.Standard T2*Dynamic Susceptibility Contrast perfusion imaging was performed and relative cerebral blood volume(rCBV)and relative cerebral blood flow(rCBF)maps were generated.Structural T1 weighted MR images were also acquired.A correlation analysis between intratumoral normalized(via ratio with contralateral homologous regions)BOLD BH PSC[referred to as(nCVR)]and intratumoral normalized resting state rCBV(rCBF)values(i.e.,nCBV and nCBF,respectively)was performed.RESULTS:No significant correlation was seen between the normalized BOLD BH PSC(i.e.,nCBV)and nCBV or nCBF.However,the average nCVR(median=0.50,z=-2.28,P=0.01)was significantly less than 1.0,indicating abnormally reduced vascular responses in the tumor regions relative to normal contralesional homologous regions,whereas the average nCBV(median=0.94,z=-0.92,P=0.375)and nCBF(median=0.93,z=-1.16,P=0.25)were not significantly higher or lower than 1.0,indicating iso-perfusion in the tumor regions relative to normal contralesional homologous regions.These findings suggest that in LGG,hyperperfusion that is seen in high grade gliomas is not present,but,nevertheless,abnormally decreased regional CVR is present within and adjacent to LGG.Since the patients all demonstrated at least some residual function attributable to the cortical regions of impaired CVR,but were incapable of producing a BOLD response in these regions regardless of the tasks performed,such regionally decreased CVR is indicative of NVU.The low nCVR ratios indicate high prevalence of NVU in this LGG cohort,which is an important consideration in the interpretation of clinical presurgical mapping with functional magnetic resonance(MR)imaging.CONCLUSION:Our preliminary study shows that BH CVR mapping is clinically feasible and demonstrates an unexpectedly high prevalence of NVU in patients with LGG. | Jay J Pillai Domenico Zacá | 2011 | World Journal of Clinical Oncology2011，2，12： | 4 |
| 3 | The molecular pathogenic role of inflammatory stress in dysregulation of lipid homeostasis and hepatic steatosis显示文摘Non-alcoholic Fatty Liver Disease(NAFLD)is becoming the leading cause of chronic liver injury in developed countries and China.Chronic systemic inflammation plays a decisive role and is fundamental in the progression of NAFLD from simple steatosis(SS)toward higher risk nonalcoholic steatohepatitis(NASH)states.However,the exact mechanisms by which inflammation leading to NASH are incompletely understood.In this review,we focus the role of the cross talk between inflammation and lipid homeostasis on the progression of NAFLD. | Yaxi Chen Zac Varghese Xiong Z.Ruan | 2014 | Genes & Diseases2014，1，1： | 2 |
| 4 | Endoplasmic reticulum stress is involved in acetylated low-density lipoprotein induced apoptosis in THP-1 differentiated macrophages显示文摘背景心血管的疾病在有在先进动脉粥样硬化的死亡支持的长期的肾 disease.Macrophage 的病人是死亡和病态的一个主要原因从腹巨噬细胞表演 apoptosis 的坏死和匾 destabilization.In vitro 数据通过 endoplasmic 蜂窝胃被触发(嗯)免费胆固醇累积引起的应力玩我们使用了的重要 role.Here THP-1 房间旁边区分了为是的五天的 phorbol 12十四酸盐13醋酸盐( PMA )的 100 ng/ml 一在里面 vitro 模型。 | TAO Jian-ling RUAN Xiong-zhong LI Hang LI Xue-mei John E Moorhead Zac Varghese LI Xue-wang | 2009 | Chinese Medical Journal2009，，15： | 2 |
| 5 | Identification, sequence and developmental expression of invertebrate flotillins from Drosophila melanogaster 1 The nucleotide sequences reported in this paper have been submitted to the GenBank/EMBL Data Bank with accession Nos AF044734 and AF044916. 1显示文摘 | Ferruccio Galbiati Daniela Volonté Jason S Goltz Zac Steele Jonaki Sen Jennifer Jurcsak David Stein Leslie Stevens Michael P Lisanti | 1998 | Gene1998，，2： | 1 |
| 6 | Content of polychlorinated dibenzo-p-dioxins, dibenzofurans and dioxin-like polychlorinated biphenyls in fish from Latvian lakes显示文摘 | D. Zacs V. Bartkevics A. Viksna | 2012 | Chemosphere2012，，： | 1 |
| 7 | Moisture Distribution in Activated Sludges : A Review显示文摘 | Vaxelaire J C 6 zac P | 2004 | Water Research2004，38，9： | 1 |
| 8 | New perspectives on diastereoselective deter-mination of hexabromocyclododecane traces in fish by ultra high performanceliquid chromatography-high resolution Orbitrap mass spectrometry显示文摘 | ZACS D RJABOVA J BARTKEVICS V | 2014 | J Chro-matogr A2014，1330，： | 1 |
| 9 | Moisture distribution in activated sludges: a review显示文摘 | J. Vaxelaire P. Cézac | 2004 | Water Research2004，，9： | 1 |
| 10 | The effect of surgical procedures on serum albumin concentration显示文摘 | Alberti LR Petroianu A Zac RI | 2008 | Chirurgia(Bucur)2008，103，： | 1 |
| 11 | Detection of Early Left Ventricular and Atrial Dysfunction in Overweight Patients with Preserved Ejection Fraction: A Speckle Tracking Analysis显示文摘 | Maria Caputo Rossella Urselli Valerio Zacà Eugenia Capati Margherita Padeletti Silvia De Nicola Romina Navarri Giovanni Antonelli Claudia Nucci Elisa Giacomin Sergio Mondillo | 2013 | Echocardiography2013，，5： | 1 |
| 12 | Examination of the wind accretion scenario for barium stars显示文摘 | BOFFIN H M J ZACS L | 1994 | A&A1994，291，： | 1 |
| 13 | Fecal loading in the cecum as a new radiological sign of acute appendicitis显示文摘AIM: Although the radiological features of acute appendicitis have been well documented, the value of plain radiography has not been fully appreciated. The aim of this study was to determine the frequency of the association of acute appendicitis with images of fecal loading in the cecum.METHODS: Plain abdominal radiographs of 400 patients operated upon for acute appendicitis (n = 100), acute cholecystitis (n = 100), right acute pelvic inflammatory disease (n = 100) and right nephrolithiasis (n = 100)were assessed. The presence of fecal loading was recorded and the sensitivity and specificity of this sign for acute appendicitis were calculated.RESULTS: The presence of fecal loading in the cecum occurred in 97 patients with acute appendicitis, 13 patients with acute cholecystitis, 12 patients with acute inflammatory pelvic disease and 19 patients with nephrolithiasis. The sensitivity of this sign for appendicitis was 97% and its specificity to this disease was 85.3%. Its positive predictive value for appendicitis was 68.7%; however, its negative predictive value for appendicitis was 98.8%.CONCLUSION: The present study suggests that the presence of radiological images of fecal loading in the cecum may be a useful sign of acute appendicitis, and the absence of this sign probably excludes this disease.This is the first description of fecal loading as a radiological sign for acute appendicitis. | Andy Petroianu Luiz Ronaldo Alberti Renata Indelicato Zac | 2005 | World Journal of Gastroenterology2005，11，27： | 1 |
| 14 | 奔向鲸鲨和马荣火山 菲律宾吕宋岛东南部拜访记显示文摘在菲律宾面值一百元的比索上,印着这个热带岛国的两个标志:马荣火山和鲸鲨。巧的是,这两个旅游胜地都位于菲徨宾吕宋岛东南部的比科尔地区。其中,作为首府的黎牙实比是一座“水与火交融”的城市,拥有世界上最完美火山锥的马荣火山便坐落于此;不远处是海边小镇栋索尔,曾被美国《时代》杂志评为“全亚洲最好的亲密接触动物之地”。“上山看马菜火山,下海与鲸鲨共舞”,让我们跟随作者塔塔的脚步,一起探索这片艳阳之地的无穷魅力。 | 塔塔 Dexbaldon Zac Wolf | 2017 | 环球人文地理2017，0，10： | 1 |
| 15 | Hantavirus Nucleocaopsid Protein Oligomerization显示文摘 | Ayna Alfadhli Zac Love Brian Arvidson | 2001 | Journal of Virology2001，176，： | 1 |
| 16 | Moisture distribution in activated sludges:a re-view显示文摘 | Vaxelaire J Cézac P | 2004 | Water Research2004，38，9： | 1 |
| 17 | DNA methylation and miRNA expression profiling in childhood B-cell acute lymphoblastic leukemia显示文摘 | Zac Chatterton Leah Morenos Richard Saffery Jeffrey M Craig David Ashley Nicholas C Wong | 2010 | Epigenomics2010，，5： | 1 |
| 18 | Coronary arterypulmonary artery fistula: case report显示文摘 | Quatrini I Zac V MondiUo S | 2007 | Cardiovasc Ultrasound2007，5，： | 1 |
| 19 | Broadband,high-resolution spatial heterodyne spectrometer显示文摘 | JAMES E L ZAC E L JOHN M H | 2008 | Applied Optics2008，47，34： | 1 |
| 20 | Content of polyehlori- noted dibenzo-p-dioxins, dibenzofurans and dioxin-like poly- chlorinated biphenyls in fish from Latvian lakes显示文摘 | ZACS D BARTKEVICS V VIKSNA A | 2013 | Chemo- sphere2013，91，2： | 1 |
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