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| 1 | 婴幼儿卒中的处理:来自美国心脏协会卒中委员会和青少年心血管病委员会专门写作组的科学声明显示文摘目的:本声明旨在回顾有关儿童卒中的文献,为最佳的诊断和治疗提供推荐意见,供负责诊断和治疗婴儿、儿童和青少年脑血管病的医生使用。方法:写作组成员由美国心脏协会卒中委员会科学声明监督委员会任命,由多个不同领域的专家组成。应用美国心脏协会卒中委员会的证据分级标准对每条推荐意见进行分级。在经过小组成员审查后,草稿由4位同行评议专家和卒中委员会指导委员会成员审阅,并由美国心脏协会科学咨询和协调委员会批准。我们预计该声明需在4年内进行更新。结果:为镰状细胞病、烟雾病、颈一脑动脉夹层分离和心源性栓塞引起的缺血性卒中的预防提供循证推荐,同时为出血性卒中的评价和处理提供推荐意见。提出儿童使用肝素和华法林的剂量方案。另外,还为围产期卒中和儿童脑静脉窦血栓形成的评价和处理提供推荐。 | E.Steve Roach(著) Meredith R. Golomb(著) Robert Adams(著) Jose Biller(著) Stephen Daniels(著) Gabrielle deVeber(著) Donna Ferriero(著) Blaise V. Jones(著) Fenella J. Kirkham(著) R. Michael Scott(著) Edward R. Smith(著) 刘丽芳(译) 王胜男(译) 王伟(译) 林镇洲(译) 朱佳佳(译) 潘速跃(译) | 2008 | 国际脑血管病杂志2008，16，11： | 60 |
| 2 | Update on the management of pancreatic cancer:Surgery is not enough显示文摘Pancreatic ductal adenocarcinoma(PDAC) represents the fourth cause of death in cancer and has a 5-year survival of < 5%.Only about 15% of the patients present with a resectable PDAC with potential to undergo 'curative' surgery.After surgery,local and systemic recurrence,is though very common.The median survival of resected patients with adjuvant chemotherapy after surgery is only 20-23 mo.This underscores the significant need to improve PDAC management strategies.Increased survival rate is dependent on new breakthroughs in our understanding of not at least tumor biology.The aim of this review is to update and comment on recent knowledge concerning PDAC biology and new diagnostics and treatment modalities.One fundamental approach to improve survival rates is by earlier and improved diagnosis of the disease.In recent years,novel blood-based biomarkers have emerged based on genetic,epigenetic and protein changes in PDAC with very promising results.For biomarkers to enter clinical practice they need to have been developed using adequate control groups and provide high sensitivity and specificity and by this identify patients at risk already in a pre-symptomatic stage.Another way to improve outcomes,is by employing neoadjuvant treatments thereby increasing the number of resectable cases.Novel systemic treatment regimes like FOLFIRINOX and nab-paclitaxel have demonstrated improvements in prolonging survival in advanced cases,but long-term survival is still scarce.The future improved understanding of PDAC biology will inevitably render new treatment options directed against both the cancer cells and the surrounding microenvironment. | Daniel Ansari Adam Gustafsson Roland Andersson | 2015 | World Journal of Gastroenterology2015，21，11： | 18 |
| 3 | Non-transgenic Plant Genome Editing Using Purified Sequence-Specific Nucleases显示文摘Dear Editor, Sequence-specific nucleases,including zinc-finger nucleases,meganucleases,TAL effector nucleases (TALENs),and CRISPR/ Cas systems,have been used to introduce targeted mutations in a wide range of plant species (Voytas,2013;Baltes and Voytas,2015).However,delivery of these nucleases using traditional transformation methods (e.g.,particle bombardment,Agrobacterium or protoplast transformation) may result in undesired genetic alterations due to random insertion of nucleaseencoding DNA intothe host genome. | Song Luo Jin Li Thomas J. Stoddard Nicholas J. Baltes Zachary L. Demorest Benjamin M. Clasen Andrew Coffman Adam Retterath Luc Mathis Daniel F. Voytas Feng Zhang | 2015 | Molecular Plant2015，8，9： | 7 |
| 4 | Radiofrequency ablation vs surgical resection in elderly patients with hepatocellular carcinoma in Milan criteria显示文摘BACKGROUND Surgical resection and radiofrequency ablation(RFA)represent two possible strategy in treatment of hepatocellular carcinoma(HCC)in Milan criteria.AIM To evaluate short-and long-term outcome in elderly patients(>70 years)with HCC in Milan criteria,which underwent liver resection(LR)or RFA.METHODS The study included 594 patients with HCC in Milan criteria(429 in LR group and 165 in RFA group)managed in 10 European centers.Statistical analysis was performed using the Kaplan-Meier method before and after propensity score matching(PSM)and Cox regression.RESULTS After PSM,we compared 136 patients in the LR group with 136 patients in the RFA group.Overall survival at 1,3,and 5 years was 91%,80%,and 76%in the LR group and 97%,67%,and 41%in the RFA group respectively(P=0.001).Diseasefree survival at 1,3,and 5 years was 84%,60%and 44%for the LR group,and 63%,36%,and 25%for the RFA group(P=0.001).Postoperative Clavien-Dindo IIIIV complications were lower in the RFA group(1%vs 11%,P=0.001)in association with a shorter length of stay(2 d vs 7 d,P=0.001).In multivariate analysis,Model for End-stage Liver Disease(MELD)score(>10)[odds ratio(OR)=1.89],increased value of international normalized ratio(>1.3)(OR=1.60),treatment with radiofrequency(OR=1.46),and multiple nodules(OR=1.19)were independent predictors of a poor overall survival while a high MELD score(>10)(OR=1.51)and radiofrequency(OR=1.37)were independent factors associated with a higher recurrence rate.CONCLUSION Despite a longer length of stay and a higher rate of severe postoperative complications,surgery provided better results in long-term oncological outcomes as compared to ablation in elderly patients(>70 years)with HCC in Milan criteria. | Maria Conticchio Riccardo Inchingolo Antonella Delvecchio Letizia Laera Francesca Ratti Maximiliano Gelli Ferdinando Anelli Alexis Laurent Giulio Vitali Paolo Magistri Giacomo Assirati Emanuele Felli Taiga Wakabayashi Patrick Pessaux Tullio Piardi Fabrizio di Benedetto Nicola de'Angelis Javier Briceño AntonioRampoldi RenèAdam Daniel Cherqui Luca Antonio Aldrighetti Riccardo Memeo | 2021 | World Journal of Gastroenterology2021，27，18： | 4 |
| 5 | Heart Disease and Stroke Statistics—2009 Update: A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee显示文摘 | Donald Lloyd-Jones Robert Adams Mercedes Carnethon Giovanni De Simone T Bruce Ferguson Katherine Flegal Earl Ford Karen Furie Alan Go Kurt Greenlund Nancy Haase Susan Hailpern Michael Ho Virginia Howard Brett Kissela Steven Kittner Daniel Lackland Lynda L | 2009 | Circulation2009，，3： | 4 |
| 6 | Targeting DNA Double-Strand Breaks with TAL Effector Nucleases显示文摘 | Christian Michelle Cermak Tomas Doyle Erin L Schmidt Clarice Zhang Feng Hummel Aaron Bogdanove Adam J Voytas Daniel F | 2010 | Genetics2010，，2： | 3 |
| 7 | Women in the boardroom and their impact on governance and performance显示文摘 | Renée B. Adams Daniel Ferreira | 2009 | Journal of Financial Economics2009，，2： | 3 |
| 8 | Probabilistic analysis of ultimate seismic bearing capacity of strip foundations显示文摘This paper presents a reliability analysis of the pseudo-static seismic bearing capacity of a strip foundation using the limit equilibrium theory. The first-order reliability method(FORM) is employed to calculate the reliability index. The response surface methodology(RSM) is used to assess the Hasofer e Lind reliability index and then it is optimized using a genetic algorithm(GA). The random variables used are the soil shear strength parameters and the seismic coefficients(k_h and k_v). Two assumptions(normal and non-normal distribution) are used for the random variables. The assumption of uncorrelated variables was found to be conservative in comparison to that of negatively correlated soil shear strength parameters. The assumption of non-normal distribution for the random variables can induce a negative effect on the reliability index of the practical range of the seismic bearing capacity. | Adam Hamrouni Badreddine Sbartai Daniel Dias | 2018 | Journal of Rock Mechanics and Geotechnical Engineering2018，10，4： | 3 |
| 9 | Evolution of liver transplantation in Europe: Report of the European Liver Transplant Registry显示文摘 | René Adam Paul McMaster John G. O’Grady Denis Castaing Jurgen L. Klempnauer Neville Jamieson Peter Neuhaus Jan Lerut Mauro Salizzoni Stephen Pollard Ferdinand Muhlbacher Xavier Rogiers Juan Carlos Garcia Valdecasas Joaquin Berenguer Daniel Jaeck Enrique M | 2003 | Liver Transplantation2003，，12： | 2 |
| 10 | Tumor Progression While on Chemotherapy: A Contraindication to Liver Resection for Multiple Colorectal Metastases?显示文摘 | René Adam Gerard Pascal Denis Castaing Daniel Azoulay Valerie Delvart Bernard Paule Francis Levi Henri Bismuth | 2004 | Annals of Surgery2004，，6： | 2 |
| 11 | GENCODE: The reference human genome annotation for The ENCODE Project显示文摘 | Jennifer Harrow Adam Frankish Jose M. Gonzalez Electra Tapanari Mark Diekhans Felix Kokocinski Bronwen L. Aken Daniel Barrell Amonida Zadissa Stephen Searle If Barnes Alexandra Bignell Veronika Boychenko Toby Hunt Mike Kay Gaurab Mukherjee Jeena Rajan Glo | 2012 | Genome Research2012，，9： | 2 |
| 12 | The Role of Synthetic Biology in Atmospheric Greenhouse Gas Reduction: Prospects and Challenges显示文摘The long atmospheric residence time of CO2 creates an urgent need to add atmospheric carbon drawdown to CO2 regulatory strategies.Synthetic and systems biology(SSB),which enables manipulation of cellular phenotypes,offers a powerful approach to amplifying and adding new possibilities to current land management practices aimed at reducing atmospheric carbon.The participants(in attendance:Christina Agapakis,George Annas,Adam Arkin,George Church,Robert Cook-Deegan,Charles DeLisi,Dan Drell,Sheldon Glashow,Steve Hamburg,Henry Jacoby,Henry Kelly,Mark Kon,Todd Kuiken,Mary Lidstrom,Mike MacCracken,June Medford,Jerry Melillo,Ron Milo,Pilar Ossorio,Ari Patrinos,Keith Paustian,Kristala Jones Prather,Kent Redford,David Resnik,John Reilly,Richard J.Roberts,Daniel Segre,Susan Solomon,Elizabeth Strychalski,Chris Voigt,Dominic Woolf,Stan Wullschleger,and Xiaohan Yang)identified a range of possibilities by which SSB might help reduce greenhouse gas concentrations and which might also contribute to environmental sustainability and adaptation.These include,among other possibilities,engineering plants to convert CO2 produced by respiration into a stable carbonate,designing plants with an increased root-to-shoot ratio,and creating plants with the ability to self-fertilize.A number of serious ecological and societal challenges must,however,be confronted and resolved before any such application can be fully assessed,realized,and deployed. | Charles DeLisi Aristides Patrinos Michael MacCracken Dan Drell George Annas Adam Arkin George Church Robert Cook-Deegan Henry Jacoby Mary Lidstrom Jerry Melillo Ron Milo Keith Paustian John Reilly Richard J.Roberts Daniel Segrè Susan Solomon Dominic Woolf Stan D.Wullschleger Xiaohan Yang | 2020 | BioDesign Research2020，，1： | 2 |
| 13 | Evolution of liver transplantation in Europe: Report of the European Liver Transplant Registry显示文摘 | René Adam Paul McMaster John G. O’Grady Denis Castaing Jurgen L. Klempnauer Neville Jamieson Peter Neuhaus Jan Lerut Mauro Salizzoni Stephen Pollard Ferdinand Muhlbacher Xavier Rogiers Juan Carlos Garcia Valdecasas Joaquin Berenguer Daniel Jaeck Enrique M | 2003 | Liver Transplantation2003，，12： | 2 |
| 14 | Therapeutic Strategies in Symptomatic Portal Biliopathy显示文摘 | Eric Vibert Daniel Azoulay Thomas Aloia Gérard Pascal Luc-Antoine Veilhan René Adam Didier Samuel Denis Castaing | 2007 | Annals of Surgery2007，，1： | 2 |
| 15 | Donor-specific cell-free DNA as a biomarker in liver transplantation:A review显示文摘Due to advances in modern medicine,liver transplantation has revolutionised the prognosis of many previously incurable liver diseases.This progress has largely been due to advances in immunosuppressant therapy.However,despite the judicious use of immunosuppression,many liver transplant recipients still experience complications such as rejection,which necessitates diagnosis via invasive liver biopsy.There is a clear need for novel,minimally-invasive tests to optimise immunosuppression and improve patient outcomes.An emerging biomarker in this‘‘precision medicine’‘liver transplantation field is that of donorspecific cell free DNA.In this review,we detail the background and methods of detecting this biomarker,examine its utility in liver transplantation and discuss future research directions that may be most impactful. | Tess McClure Su Kah Goh Daniel Cox Vijayaragavan Muralidharan Alexander Dobrovic Adam G Testro | 2020 | World Journal of Transplantation2020，10，11： | 2 |
| 16 | ERCP-Directed Radiofrequency Ablation and Photodynamic Therapy Are Associated with Comparable Survival in the Treatment of Unresectable Cholangiocarcinoma显示文摘 | Daniel S. Strand Natalie D. Cosgrove James T. Patrie Dawn G. Cox Todd W. Bauer Reid B. Adams James A. Mann Bryan G. Sauer Vanessa M. Shami Andrew Y. Wang | 2014 | Gastrointestinal Endoscopy2014，，： | 2 |
| 17 | Whither the virtuous cycle? Past and future trends in black–white inequality in educational attainment显示文摘 | Daniel A. Long Sean Kelly Adam Gamoran | 2011 | Social Science Research2011，，1： | 2 |
| 18 | Hepatic Resection for Noncolorectal Nonendocrine Liver Metastases: Analysis of 1452 Patients and Development of a Prognostic Model显示文摘 | René Adam Laurence Chiche Thomas Aloia Dominique Elias Rémy Salmon Michel Rivoire Daniel Jaeck Jean Saric Yves Patrice Le Treut Jacques Belghiti Georges Mantion Gilles Mentha | 2006 | Annals of Surgery2006，，4： | 2 |
| 19 | Rescue Surgery for Unresectable Colorectal Liver Metastases Downstaged by Chemotherapy: A Model to Predict Long-term Survival显示文摘 | René Adam Valérie Delvart Gérard Pascal Adrian Valeanu Denis Castaing Daniel Azoulay Sylvie Giacchetti Bernard Paule Francis Kunstlinger Odile Ghémard Francis Levi Henri Bismuth | 2004 | Annals of Surgery2004，，4： | 2 |
| 20 | The Place of Liver Transplantation in the Treatment of Hepatic Epitheloid Hemangioendothelioma: Report of the European Liver Transplant Registry显示文摘 | Jan P. Lerut Giuseppe Orlando Rene Adam Marcello Schiavo Jurgen Klempnauer Darius Mirza Emmanuel Boleslawski Andrew Burroughs Carlos Fernandez Sellés Daniel Jaeck Robert Pfitzmann Mauro Salizzoni Gunner S?derdahl Rudi Steininger Andre Wettergren Vincenzo | 2007 | Annals of Surgery2007，，6： | 2 |
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