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| 1 | Cytoprotective role of heme oxygenase-1 and heme degradation derived end products in liver injury显示文摘The activation of heme oxygenase-1(HO-1) appears to be an endogenous defensive mechanism used by cells to reduce inflammation and tissue damage in a number of injury models. HO-1, a stress-responsive enzyme that catabolizes heme into carbon monoxide(CO), biliverdin and iron, has previously been shown to protect grafts from ischemia/reperfusion and rejection.In addition, the products of the HO-catalyzed reaction, particularly CO and biliverdin/bilirubin, have been shown to exert protective effects in the liver against a number of stimuli, as in chronic hepatitis C and in transplanted liver grafts. Furthermore, the induction of HO-1 expression can protect the liver against damage caused by a number of chemical compounds. More specifically, the CO derived from HO-1-mediated heme catabolism has been shown to be involved in the regulation of inflammation; furthermore, administration of low concentrations of exogenous CO has a protective effect against inflammation. Both murine and human HO-1 deficiencies have systemic manifestations associated with iron metabolism, such as hepatic overload(with signs of a chronic hepatitis) and iron deficiency anemia(with paradoxical increased levels of ferritin).Hypoxia induces HO-1 expression in multiple rodent,bovine and monkey cell lines, but interestingly, hypoxia represses expression of the human HO-1 gene in a variety of human cell types(endothelial cells, epithelial cells, T cells). These data suggest that HO-1 and CO are promising novel therapeutic molecules for patients with inflammatory diseases. In this review, we present what is currently known regarding the role of HO-1 in liver injuries and in particular, we focus on the implications of targeted induction of HO-1 as a potential therapeutic strategy to protect the liver against chemically induced injury. | Clarice Silvia Taemi Origassa Niels Olsen Saraiva Cmara | 2013 | World Journal of Hepatology2013，5，10： | 17 |
| 2 | Common dental diseases in children and malocclusion显示文摘Malocclusion is a worldwide dental problem that influences the affected individuals to varying degrees. Many factors contribute to the anomaly in dentition, including hereditary and environmental aspects. Dental caries, pulpal and periapical lesions, dental trauma, abnormality of development, and oral habits are most common dental diseases in children that strongly relate to malocclusion. Management of oral health in the early childhood stage is carried out in clinic work of pediatric dentistry to minimize the unwanted effect of these diseases on dentition. This article highlights these diseases and their impacts on malocclusion in sequence. Prevention, treatment, and management of these conditions are also illustrated in order to achieve successful oral health for children and adolescents, even for their adult stage. | Jing Zou Mingmei Meng Clarice S Law Yale Rao Xuedong Zhou | 2018 | International Journal of Oral Science2018，10，2： | 16 |
| 3 | Polymorphisms in base excision repair genes: Breast cancer risk and individual radiosensitivity显示文摘Breast cancer(BC) is the most common cancer among women worldwide. The aetiology and carcinogenesis of BC are not clearly defined, although genetic, hormonal, lifestyle and environmental risk factors have been established. The most common treatment for BC includes breast-conserving surgery followed by a standard radiotherapy(RT) regimen. However, radiation hypersensitivity and the occurrence of RT-induced toxicity in normal tissue may affect patients' treatment. The role of DNA repair in cancer has been extensively investigated, and an impaired DNA damage response may increase the risk of BC and individual radiosensitivity. Single nucleotide polymorphisms(SNPs) in DNA repair genes may alter protein function and modulate DNA repair efficiency, influencing the development of various cancers, including BC. SNPs in DNA repair genes have also been studied as potential predictive factors for the risk of RT-induced side effects. Here, we review the literature on the association between SNPs in base excision repair(BER) genes and BC risk. We focusedon X-ray repair cross complementing group 1(XRCC1), which plays a key role in BER, and on 8-oxoguanine DNA glycosylase 1, apurinic/apyrimidinic endonuclease 1 and poly(ADP-ribose) polymerase-1, which encode three important BER enzymes that interact with XRCC1. Although no association between SNPs and radiation toxicity has been validated thus far, we also report published studies on XRCC1 SNPs and variants in other BER genes and RT-induced side effects in BC patients, emphasising that large well-designed studies are needed to determine the genetic components of individual radiosensitivity. | Clarice Patrono Silvia Sterpone Antonella Testa Renata Cozzi | 2014 | World Journal of Clinical Oncology2014，5，5： | 8 |
| 4 | Targeting DNA Double-Strand Breaks with TAL Effector Nucleases显示文摘 | Christian Michelle Cermak Tomas Doyle Erin L Schmidt Clarice Zhang Feng Hummel Aaron Bogdanove Adam J Voytas Daniel F | 2010 | Genetics2010，，2： | 3 |
| 5 | Development of a panel of unigene-derived polymorphic EST–SSR markers in lentil using public database information显示文摘Lentil(Lens culinaris Medik.), a diploid(2n = 14) with a genome size greater than 4000 Mbp, is an important cool season food legume grown worldwide. The availability of genomic resources is limited in this crop species. The objective of this study was to develop polymorphic markers in lentil using publicly available curated expressed sequence tag information(ESTs). In this study, 9513 ESTs were downloaded from the National Center for Biotechnology Information(NCBI) database to develop unigene-based simple sequence repeat(SSR) markers. The ESTs were assembled into 4053 unigenes and then analyzed to identify 374 SSRs using the MISA microsatellite identification tool. Among the 374 SSRs, 26 compound SSRs were observed.Primer pairs for these SSRs were designed using Primer3 version 1.14. To classify the functional annotation of ESTs and EST–SSRs, BLASTx searches(using E-value 1 × 10-5) against the public UniP rot(http://gffzzc0d2db89b939488bhk6vfx9666w0f66bv.ffgz.tsg.suse.edu.cn/) and NCBI(http://gffzz5b533c64939a43b3hk6vfx9666w0f66bv.ffgz.tsg.suse.edu.cn/) databases were performed. Further functional annotation was performed using PLAZA(version3.0) comparative genomics and GO annotation was summarized using the Plant GO slim category. Among the synthesized 312 primers, 219 successfully amplified Lens DNA. A diverse panel of 24 Lens genotypes was used to identify polymorphic markers. A polymorphic set of 57 markers successfully discriminated the test genotypes. This set of polymorphic markers with functional annotation data could be used as molecular tools in lentil breeding. | Debjyoti Sen Gupta Peng Cheng Gaurav Sablok Dil Thavarajah Pushparajah Thavarajah Clarice J.Coyne Shiv Kumar Michael Baum Rebecca J.McGee | 2016 | The Crop Journal2016，4，5： | 2 |
| 6 | Hepatitis C virus: Promising discoveries and new treatments显示文摘Despite advances in therapy, hepatitis C virus(HCV) infection remains an important global health issue. It is estimated that a significant part of the world population is chronically infected with the virus, and many of those affected may develop cirrhosis or liver cancer. The virus shows considerable variability, a characteristic that directly interferes with disease treatment. The response to treatment varies according to HCV genotype and subtype. The continuous generation of variants(quasispecies) allows the virus to escape control by antivirals. Historically, the combination of ribavirin and interferon therapy has represented the only treatment option for the disease. Currently, several new treatment options are emerging and are available to a large part of the affected population. In addition, the search for new substances with antiviral activity against HCV continues, promising future improvements in treatment. Researchers should consider the mutation capacity of the virus and the other variables that affect treatment success. | Juliana Cristina Santiago Bastos Marina Aiello Padilla Leonardo Cardia Caserta Noelle Miotto Aline Gonzalez Vigani Clarice Weis Arns | 2016 | World Journal of Gastroenterology2016，22，28： | 2 |
| 7 | Essential oils and their compounds as Aedes aegypti L. (Diptera: Culicidae) larvicides: review显示文摘 | Clarice Noleto Dias Denise Fernandes Coutinho Moraes | 2014 | Parasitology Research2014，，2： | 2 |
| 8 | Effects of flow cytometry analysis on morphology and viability of fragile phytoplankton显示文摘 | ELIN M H TERRY L C CLARICE M Y | 1987 | Applied and Environmental Microbiology1987，53，11： | 1 |
| 9 | Estimating Intraclass Correlation for Binary Data 显示文摘 | Martin S R Clarice G B and David F | 1999 | Bio- metrics1999，55，1： | 1 |
| 10 | Mycophenolate mofetil prevents the development of glomerular injury in experiment diabetes显示文摘 | Ricardo U Clarice KF Ana LM | 2003 | Kidney Int2003，63，： | 1 |
| 11 | Resistance to soybean aphid in early maturing soybean germplasm显示文摘 | Clarice Mensah Christina DiFonzo | 2005 | Crop Science2005，45，6： | 1 |
| 12 | Mycophenolate mofetil prevents the development of glomerular injury in experiment diabetes 显示文摘 | Ricardo U Clarice K F Ana L M | 2003 | Kidney Int2003，63，4： | 1 |
| 13 | Chemical Composition and Larvicidal Activity of Essential Oils Extracted from Brazilian Legal Amazon Plants against Aedes aegypti L. (Diptera: Culicidae)显示文摘 | Clarice Noleto Dias Luciana Patrícia Lima Alves Klinger Antonio da Franca Rodrigues Maria Cristiane Aranha Brito Carliane dos Santos Rosa Flavia Maria Mendon?a do Amaral Odair dos Santos Monteiro Eloisa Helena de Aguiar Andrade José Guilherme Soares Maia | 2015 | Evidence-Based Complementary and Alternative Medicine2015，，： | 1 |
| 14 | River water genotoxicityevaluation using micronucleus assay in fish erythrocytes显示文摘 | Clarice T de L R del P M Terra N R | 2007 | Ecotoxicology and Environmental Safety2007，66，3： | 1 |
| 15 | Gene selection for sample classification based on gene expression data:study of sensitivity to choice of parameters of the GA/KNN method显示文摘 | Li Leping Weinberg Clarice R Darden Thomas A | 2001 | Bioinformatics2001，17，12： | 1 |
| 16 | Antismooth muscle and antiactin antibodies are indirect markers of histological and biochemical activity of autoimmune hepatitis显示文摘 | Claudia A. Couto Paulo L. Bittencourt Gilda Porta Clarice P. Abrantes‐Lemos Flair J. Carrilho Bianca D. Guardia Eduardo L.R. Can?ado | 2014 | Hepatology2014，，： | 1 |
| 17 | Vanadium complexes with thiosemicarbazones:Synthesis,characterization,crystal structure and anti-mycobacterium tuberculosis activity显示文摘 | Pedro I da S Maia Fernando R Pavan Clarice Q F Leite | 2009 | Polyhedron2009，28，： | 1 |
| 18 | Liver resection (and associated extrahepatic resections) for metastatic well-differentiated endocrine tumors: A 15-year single center prospective study显示文摘 | Dominique Elias Philippe Lasser Michel Ducreux Pierre Duvillard Jean-Francois Ouellet Clarice Dromain Martin Schlumberger Marc Pocard Valérie Boige Catherine Miquel Eric Baudin | 2003 | Surgery2003，，4： | 1 |
| 19 | Seasonal influence on the of idiopathic inflammatory myopathies in serologically difined groups显示文摘 | Kakali S Clarice RW Chester VO | 2005 | Arthr & Rheum2005，52，： | 1 |
| 20 | Chromonychia Secondary to Chemotherapy 显示文摘 | Marien Lopes Clarice Jordro Rachel Grynszpan | 2013 | Case Rep Dermatol2013，5，2： | 1 |
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