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| 1 | Cyclooxygenase-2 plays a central role in the genesis of pancreatitis and associated lung injury显示文摘BACKGROUND: The exact mechanism by which cyclooxy- genase-2 (COX-2) promotes inflammation in pancreatitis in obscure. This study was undertaken to investigate the role of COX-2 inhibition in an animal model of pancreati- tis , a disease process characterized by a systemic inflamma- tory response and ensuing neutrophil-mediated lung injury. METHODS: Pancreatitis was induced in 24 Sprague-Daw- ley rats by intraperitoneal injection of 20% L-arginine (500 mg/100 g body weight). The animals were randomized into 3 groups (8 rats in each group); controls and rats with pancreatitis intravenously resuscitated with either normal saline (0.9% NaCl 3 ml/kg) at 24 and 48 hours or COX-2 inhibitor (parecoxib 1 mg/kg). Pancreatic and lung inju- ries were assessed histologically. Lung injury was assessed utilizing wet;dry ratio and myeloperoxidase activity to in- dicate pulmonary neutrophil infiltration. A Western blot was used to determine COX-2 protein expression in pancrea- tic tissue. RESULTS: The animals treated with COX-2 inhibitors dis- played significantly less pancreatic and lung injuries than their normal saline counterparts. Histological pancreatic and lung injury scores were significantly reduced (P <0.05) in the COX-2 treated group. Lung wet: dry ratios were sig- nificantly improved and pulmonary neutrophil infiltration was attenuated in the COX-2 group (P<0.05). Western blot analysis confirmed attenuated COX-2 protein expression. CONCLUSION: This study shows, for the first time in a rat model, that adjuvant COX-2 inhibition significandy attenu- ates the severity of both pancreatitis and its associated sys- temic inflammatory response and end-organ injury. | Gavin O'Brien Conor J Shields Desmond C Winter John P Dillon | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，1： | 12 |
| 2 | C-reactive protein and radiographic findings of lower respiratory tract infection in infants显示文摘AIM To evaluate the association between C-reactive protein(CRP) and radiological evidence of lower respiratory tract infection(LRTI) in infants.METHODS All patients aged less than 4 years who presented with suspected lower respiratory tract infection,who received a peri-presentation chest radiograph and CRP blood measurement over an 18-mo period were included in the study.Age,gender,source of referral,CRP,white cell count,neutrophil count along with the patients' symptoms and radiologist's report were recorded.RESULTS Three hundred and eleven patients met the inclusioncriteria.Abnormal chest radiographs were more common in patients with elevated CRP levels(P < 0.01).Radiologic signs of LRTI were identified in 73.7% of chest radiographs when a patient had a CRP level between 50-99 mg/L.CRP levels were a better predictor of positive chest radiograph findings for those aged greater than I year compared to those 1 year or less.CONCLUSION CRP may be used in patients with suspected LRTI diagnosis to select those who are likely to have positive findings on chest radiograph,thus reducing unnecessary chest radiographs. | Maria Twomey Hannah Fleming Fiachra Moloney Kevin P Murphy Lee Crush Siobhan B O’Neill Oisin Flanagan Karl James Conor Bogue Owen J O’Connor Michael M Maher | 2017 | World Journal of Radiology2017，9，4： | 2 |
| 3 | Unlocking quality in endoscopic mucosal resection显示文摘A review of the development of the key performance metrics of endoscopic mucosal resection(EMR),learning from the experience of the establishment of widespread colonoscopy quality measurements.Potential future performance markers for both colonoscopy and EMR are also evaluated to ensure continued high quality performance is maintained with a focus service framework and predictors of patient outcome. | Eoin Keating Jan Leyden Donal B O'Connor Conor Lahiff | 2023 | World Journal of Gastrointestinal Endoscopy2023，15，5： | 2 |
| 4 | Improving the resilience of metro vehicle and passengers for an elt~tiw~ emergency response to terrorist attacks显示文摘 | Jean-I~ut' Bruyella Conor O'Neil EI-Miloudi EI-Koursi | 2014 | Safety Science2014，62，2： | 1 |
| 5 | Fatigue does not correlate with the degree of hepatitis or the presence of autoimmune disorders in chronic hepatitis C infection显示文摘 | Jason Goh Barbara Coughlan John Quinn J. Conor O?Keane John Crowe | 1999 | European Journal of Gastroenterology & Hepatology1999，，8： | 1 |
| 6 | Control of apoptosis during angiogenesis by survivin expression in endothelial cells 显示文摘 | O'conor DS Schechner JS Adida C | 2000 | Am Pathol2000，156，2： | 1 |
| 7 | Diagnosing traumatic rupture of the thoracic aorta in the emergency department显示文摘 | O' Conor CE | 2004 | Emerg Med2004，21，4： | 1 |
| 8 | Control of apoptosis during angiogenesis by survivin expression in endothelial cells显示文摘 | Schechner JS Adida C | 2000 | Am Pathol2000，156，2： | 1 |
| 9 | Long-term prospective study ofHelicobacter pylori in nonulcer dyspepsia显示文摘 | Conor McCarthy MRCPI Stephen Patchett MRCPI Rose Mary Collins MB Shona Beattie SRN Conor Keane MD Professor Colm O’Morain MD | 1995 | Digestive Diseases and Sciences1995，，1： | 1 |
| 10 | Detection of Cloud-Base Height Using Jenoptik CHM15K and Vaisala CL31 Ceilometers显示文摘 | Martucci Giovanni Milroy Conor O’Dowd Colin D | 2010 | Journal of Atmospheric and Oceanic Technology2010，，2： | 1 |
| 11 | Segmental resection for carcino-ma of the bladder review of 102patients显示文摘 | RESNICK MI OCONOR VJ | 1973 | J Urol1973，109，： | 1 |
| 12 | Inhibition of LPS- induced airway neutrophilic inflammation in healthy volunteers with an oral CXCR2 antagonist显示文摘 | Leaker BR Barnes P] O' Conor B | 2013 | Respir Res2013，14，： | 1 |
| 13 | Treatment of prostate cancer by radioiodine therapy after tissues-specific expression of sodium/iodide symporter显示文摘 | SPITZWEG C O'CONOR M K BERGEN E R | 2000 | Cancer Res2000，60，： | 1 |
| 14 | The Effects of Smoking Status on Walking Ability and Health-Related Quality of Life in Patients With Peripheral Arterial Disease显示文摘 | Cynthia Fritschi Eileen G. Collins Susan O’Connell Conor McBurney Jolene Butler Lonnie Edwards | 2013 | The Journal of Cardiovascular Nursing2013，，4： | 1 |
| 15 | Subgroups of Positive Discs on Discography显示文摘 | Conor O'Neill Marina Kurgansky | 2002 | Spine2002，29，19： | 1 |
| 16 | The Utility of provocation discography in the evaluation and treatment of chronic low back pain: a state of the art debate显示文摘 | Conor O'Neill Todd Alamin | 2005 | Spineline2005，34，： | 1 |
| 17 | Comparison of biomaterial delivery vehicles for improving acute retention of stem cells in the infarcted heart显示文摘 | Ellen T. Roche Conn L. Hastings Sarah A. Lewin Dmitry E. Shvartsman Yevgeny Brudno Nikolay V. Vasilyev Fergal J. O’Brien Conor J. Walsh Garry P. Duffy David J. Mooney | 2014 | Biomaterials2014，，25： | 1 |
| 18 | Does Decentralisation Make Government More Efficient and Effective?显示文摘 | Conor O’dwyer Daniel Ziblatt | 2006 | Commonwealth & Comparative Politics2006，，3： | 1 |
| 19 | Control of apoptosisduring angiogenesis by survivin expression in endothelial cells显示文摘 | O’conor DS Schechner JS Adida C | 2000 | Am Pathol2000，156，2： | 1 |
| 20 | Developing a Standardised Model for Internal Control Evaluation显示文摘 | O'Leary Conor | | 0，，： | 1 |
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