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70篇 您的检索式：作者名="Gavin O"

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	题名	作者	年代	出处	被引量
1	Cyclooxygenase-2 plays a central role in the genesis of pancreatitis and associated lung injury显示文摘BACKGROUND: The exact mechanism by which cyclooxy- genase-2 (COX-2) promotes inflammation in pancreatitis in obscure. This study was undertaken to investigate the role of COX-2 inhibition in an animal model of pancreati- tis , a disease process characterized by a systemic inflamma- tory response and ensuing neutrophil-mediated lung injury. METHODS: Pancreatitis was induced in 24 Sprague-Daw- ley rats by intraperitoneal injection of 20% L-arginine (500 mg/100 g body weight). The animals were randomized into 3 groups (8 rats in each group); controls and rats with pancreatitis intravenously resuscitated with either normal saline (0.9% NaCl 3 ml/kg) at 24 and 48 hours or COX-2 inhibitor (parecoxib 1 mg/kg). Pancreatic and lung inju- ries were assessed histologically. Lung injury was assessed utilizing wet;dry ratio and myeloperoxidase activity to in- dicate pulmonary neutrophil infiltration. A Western blot was used to determine COX-2 protein expression in pancrea- tic tissue. RESULTS: The animals treated with COX-2 inhibitors dis- played significantly less pancreatic and lung injuries than their normal saline counterparts. Histological pancreatic and lung injury scores were significantly reduced (P <0.05) in the COX-2 treated group. Lung wet: dry ratios were sig- nificantly improved and pulmonary neutrophil infiltration was attenuated in the COX-2 group (P<0.05). Western blot analysis confirmed attenuated COX-2 protein expression. CONCLUSION: This study shows, for the first time in a rat model, that adjuvant COX-2 inhibition significandy attenu- ates the severity of both pancreatitis and its associated sys- temic inflammatory response and end-organ injury.	Gavin O'Brien Conor J Shields Desmond C Winter John P Dillon	2005	Hepatobiliary & Pancreatic Diseases International2005，4，1：	12
2	Blockade of PD1 and TIM3 Restores Innate and Adaptive Immunity in Patients with Acute Alcoholic Hepatitis显示文摘	Lee J.L. Markwick Antonio Riva Jennifer M. Ryan Helen Cooksley Elena Palma Tom H. Tranah Godhev K. Manakkat Vijay Nikhil Vergis Mark Thursz Alex Evans Gavin Wright Sarah Tarff John O’Grady Roger Williams Debbie L. Shawcross Shilpa Chokshi	2014	Gastroenterology2014，，：	2
3	Polyhedron 显示文摘	Michael Devereux Denis O' Shea Mark O' Connor Helen Grehan Gavin Connor	2007	26:4073-40842007，26，：	1
4	Effect of friction fatigue on pile capacity in dense sand显示文摘	Gavin Kenneth G O'Kelly Brendan C	2007	Journal of Geotechnical and Geo-environmental Engineering2007，133，1：	1
5	Cytokine and chemokine profiles in fibromyalgia,rheumatoid arthritis and systemic lupus erythematosus: a potentially useful tool in differential diagnosis显示文摘	Wallace DJ Gavin IM Karpenko O	2015	Rheumatol Int2015，35，6：	1
6	High power,low frequency uhrasound:meniscal tissue interaction and ablation characteristics 显示文摘	Morris E Gavin GP O' Keane C	2011	Ultrasound Med Biol2011，37，4：	1
7	Effect of friction fatigue on pile capacity in dense sand 显示文摘	GAVIN K G O KELLY B C	2007	Journal of Geotech- nical and Geoenvironmental Engineering2007，133，1：	1
8	Visualizing biological data-now and in the future 显示文摘	O'Donoghue S I Gavin A C Gehlenborg N	2010	Nature Methods2010，7，：	1
9	The role of ion mobility spectrometry-mass spectrometry in the analysis of protein reference standards显示文摘	Caroline P Gavin O Alison E A	2013	Analytical Chemistry2013，85，15：	1
10	Development of microbial community structure and activity in a high-rate anaerobic biorcactor at 18 ℃ 显示文摘	CONNAUGHTON Scan COLLINS Gavin O' FLAHERTY Vincent	2006	Water Research2006，40，13：	1
11	The chemistry of suspended particulate material in a highly contarninated embayment of port Jackson(Australia) under quiescent,high-wind and heavy-rainfall conditions显示文摘	Gavin B Laura O H		0，，03：	1
12	New insights into cellular prion protein (PrPc) functions:The 'ying and yang' of a relevant protein显示文摘	Nicolas O Gavin R del Rio JA	2009	Brain Res Rev2009，61，2：	1
13	A self-expanding metal stent for complicated variceal hemorrhage: experience at a single center显示文摘	Gavin Wright Heather Lewis Brian Hogan Andrew Burroughs David Patch James O’Beirne	2010	Gastrointestinal Endoscopy2010，，1：	1
14	Loss of ACE2 augments angiotensin II-induced myocardial hypertrophy and remodeling with increased Profilin-1 expression 显示文摘	Zhong JC Jin HY Gavin O	2011	Heart2011，97，3：	1
15	Effect of friction fatigue on pile capacity in dense sand显示文摘	GAVIN K G O'KELLY B C	2007	Journal of Geotechnical and Geoenvironmental Engineering2007，133，1：	1
16	Antimycobacterial activity of lichen metabolites in vitro显示文摘	Krist n lng o lfsd o ttir Gavin A C Chung Vilhj 6 lmur G Sk u lason	1998	European Journal of Pharmaceutical Sciences1998，6，2：	1
17	Efficacy and safety of colonic stenting for malignant disease in the elderly显示文摘	Fergal Donnellan Garret Cullen Daniel Cagney Phil O’Halloran Gavin C. Harewood Frank E. Murray Stephen E. Patchett	2010	International Journal of Colorectal Disease2010，，6：	1
18	Effect of friction fatigue on pile capacity in Densen sand显示文摘	KENNETH G Gavin Brendan C O'Kelly	2007	Jour of Geotech Geoenvir Engng ASCE2007，133，1：	1
19	Psychrophilic and mesophilic anaerobic digestion of brewery effluent: A comparative study显示文摘	Sean Connaughton Gavin Collins Vincent O’Flaherty	2006	Water Research2006，，13：	1
20	Effect of friction fatigue on pile capacity in dense sand显示文摘	GAVIN K G O'KELLY B C	2007	Journal of Geoteehnieal and Geoenvironmental Engineering2007，133，1：	1

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