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| 1 | Antimicrobial susceptibility testing for Helicobacter pylori in times of increasing antibiotic resistance显示文摘The gram-negative bacterium Helicobacter pylori(H.pylori)causes chronic gastritis,gastric and duodenal ulcers,gastric cancer and mucosa-associated lymphoid tissue lymphoma.Treatment is recommended in all symptomatic patients.The current treatment options for H.pylori infection are outlined in this review in light of the recent challenges in eradication success,largely due to the rapid emergence of antibiotic resistant strains of H.pylori.Antibiotic resistance is a constantly evolving process and numerous studies have shown that the prevalence of H.pylori antibiotic resistance varies significantly from country to country,and even between regions within the same country.In addition,recent data has shown that previous antibiotic use is associated with harbouring antibiotic resistant H.pylori.Local surveillance of antibiotic resistance is warranted to guide clinicians in their choice of therapy.Antimicrobial resistance is assessed by H.pylori culture and antimicrobial susceptibility testing.Recently developed molecular tests offer an attractive alternative to culture and allow for the rapid molecular genetic identification of H.pylori and resistance-associated mutations directly from biopsy samples or bacterial culture material.Accumulating evidence indicates that surveillance of antimicrobial resistance by susceptibility testing is feasible and necessary to inform clinicians in their choice of therapy for management of H.pylori infection. | Sinéad M Smith Colm O’Morain Deirdre McNamara | 2014 | World Journal of Gastroenterology2014，20，29： | 40 |
| 2 | Evaluating the performance of nanostructured materials as lithium-ion battery electrodes显示文摘锂离子房间的性能重重地依赖于主机电极的能力从本地结构提供并且释放 Li+ 离子。当电极材料的选择可以定义象房间潜力和能力那样的参数时,置闰的过程可以被率身体上限制固态 Li+ 散开。在锂离子电极的增加的散开率可以在散开路径通过减小被完成,由一可伸缩各自的电极尺寸完成了。另外,一些电极可以经历与收费并且排出联系的大体积变化,的紧张,可以更好通过 nanostructuring 被提供。主机的失败可以导致本地结构的 pulverisation 和能力的快速的损失提供如此的卷变化。在这篇评论文章,我们寻求在 nanostructured 锂离子电池体系结构(阳极和阴极) 的开发加亮很多重要获得,作为潜在的下一代的电气化学的精力存储设备的驱动程序。 | Mark J. Armstrong Colm O'Dwyer William J. Macklin Justin. D. Holmes | 2014 | Nano Research2014，7，1： | 23 |
| 3 | Efficacy,predictability and safety of small incision lenticule extraction(SMILE)显示文摘Background:The purpose of this case series is to report the one-year outcomes of small incision lenticule extraction(SMILE)using the VisuMax®femtosecond laser.Methods:Two hundred and six patients were recruited for this retrospective,single center study at TRSC International LASIK Center in Bangkok,Thailand.Patients underwent SMILE,whereby an intrastromal lenticule was cut using a femtosecond laser and then manually extracted without the need for flap creation.Outcome measures included refraction,visual acuity and contrast sensitivity evaluation.Patients were treated and followed for one year.Results:SMILE for the correction of low to high myopia was performed on 347 eyes of 206 patients.The mean preoperative spherical equivalent was−4.96±1.88 diopters(D).On the first day following surgery,for eyes with a plano target refraction(99.14%of all eyes),uncorrected distance visual acuity(UDVA)was 20/20 or better in 90%of eyes.At the one week postoperative exam,the mean spherical equivalent was 0.01±0.36 D and UDVA was 20/20 or better in 84%of eyes.After one year follow-up,no eyes showed loss of 2 or more lines of visual acuity and 31%of eyes gained one or more lines.The photopic contrast sensitivity of SMILE treated eyes at 12 and 18 cycles per degree(cpd)improved from 1.59 and 0.94 preoperatively to 1.6 and 0.98,respectively,after one year.Conclusions:In this series,SMILE using the VisuMax®femtosecond laser demonstrated that after one year it is an effective,predictable and safe minimally invasive corneal refractive procedure. | Ekktet Chansue Morakot Tanehsakdi Sukanda Swasdibutra Colm McAlinden | 2015 | Eye and Vision2015，2，1： | 16 |
| 4 | Role of Helicobacter pylori in functional dyspepsia显示文摘消化不良的原因论在病人的多数是未知的。Helicobacter pylori (H pylori ) 是在病人的一个子集的原因。估计 H pylori 的存在的非侵略的测试在不到 50 与消化不良介绍给一个家庭专业人员岁的病人的管理被推荐。脲呼吸测试或凳子抗原测试是最可靠的非侵略的测试。H pylori 的根除将与开发消化性溃疡的消化不良把风险归结为病人,如果规定,复杂并发症评估的还原剂非类固醇反煽动性的药和以后的还原剂胃的癌症的风险。推荐治疗为非与 H pylori 感染联系的溃疡消化不良应该是有 PPI 和二抗菌素的一个 10-d 疗程。治疗功效四个星期应该在与脲呼吸测试或凳子抗原测试完成治疗以后被估计。 | Colm O'Morain | 2006 | World Journal of Gastroenterology2006，12，17： | 9 |
| 5 | The evolution of corneal and refractive surgery with the femtosecond laser显示文摘The use of femtosecond lasers has created an evolution in modern corneal and refractive surgery.With accuracy,safety,and repeatability,eye surgeons can utilize the femtosecond laser in almost all anterior refractive procedures;laser in situ keratomileusis(LASIK),small incision lenticule extraction(SMILE),penetrating keratoplasty(PKP),insertion of intracorneal ring segments,anterior and posterior lamellar keratoplasty(Deep anterior lamellar keratoplasty(DALK)and Descemet's stripping endothelial keratoplasty(DSEK)),insertion of corneal inlays and cataract surgery.As the technology matures,it will push surgical limits and open new avenues for ophthalmic intervention in areas not yet explored.As we witness the transition from femto-LASIK to femto-cataract surgery it becomes obvious that this innovation is here to stay.This article presents some of the most relevant advances of femtosecond lasers to modern corneal and refractive surgery. | Antonis Aristeidou Elise V.Taniguchi Michael Tsatsos Rodrigo Muller Colm McAlinden Roberto Pineda Eleftherios I.Paschalis | 2015 | Eye and Vision2015，2，1： | 9 |
| 6 | Femtosecond laser cataract surgery显示文摘Femtosecond laser(FSL)cataract surgery is in its infancy but is rapidly gaining popularity due to the improved consistency and predictability for corneal incisions and anterior capsulorhexis.It enables subsequently less phacoemulsification energy and time to be employed,which has gains in terms of reduced corneal oedema.In addition,the FSL allows better circularity of the anterior capsulotomy,capsule overlap,intraocular lens(IOL)placement and centration of the IOL.These advantages have resulted in improved visual and refractive outcomes in the short term.Complication rates are low which reduce with surgeon experience.This review article focuses on the Alcon LenSx system. | Zoltan Z.Nagy Colm McAlinden | 2015 | Eye and Vision2015，2，1： | 8 |
| 7 | Colorectal cancer screening显示文摘Colorectal cancer is a major public health burden worldwide. There is clear-cut evidence that screening will reduce colorectal cancer mortality and the only contentious issue is which screening tool to use. Mos evidence points towards screening with fecal occul blood testing. The immunochemical fecal occult blood tests have a higher sensitivity than the guaiac-based tests. In addition, their automation and haemoglobin quantification allows a threshold for colonoscopy to be selected that can be accommodated within individua health care systems. | Ramona M McLoughlin Colm A O'Morain | 2006 | World Journal of Gastroenterology2006，12，42： | 8 |
| 8 | Centration axis in refractive surgery显示文摘The human eye is an asymmetric optical system and the real cornea is not a rotationally symmetrical volume.Each optical element in the eye has its own optical and neural axes.Defining the optimum center for laser ablation is difficult with many available approaches.We explain the various centration approaches(based on these reference axes)in refractive surgery and review their clinical outcomes.The line-of-sight(LOS)(the line joining the entrance pupil center with the fixation point)is often the recommended reference axis for representing wavefront aberrations of the whole eye(derived from the definition of chief ray in geometrical optics);however pupil centration can be unstable and change with the pupil size.The corneal vertex(CV)represents a stable preferable morphologic reference which is the best approximate for alignment to the visual axis.However,the corneal light reflex can be considered as non-constant,but dependent on the direction of gaze of the eye with respect to the light source.A compromise between the pupil and CV centered ablations is seen in the form of an asymmetric offset where the manifest refraction is referenced to the CV while the higher order aberrations are referenced to the pupil center.There is a need for a flexible choice of centration in excimer laser systems to design customized and non-customized treatments optimally. | Samuel Arba Mosquera Shwetabh Verma Colm McAlinden | 2015 | Eye and Vision2015，2，1： | 7 |
| 9 | Molecular detection of Helicobacter pylori antibiotic resistance in stool vs biopsy samples显示文摘AIM To compare(1) demographics in urea breath test(UBT) vs endoscopy patients; and(2) the molecular detection of antibiotic resistance in stool vs biopsy samples.METHODS Six hundred and sixteen adult patients undergoing endoscopy or a UBT were prospectively recruited to the study. The Geno Type Helico DR assay was used to detect Helicobacter pylori(H. pylori) and antibiotic resistance using biopsy and/or stool samples from CLOpositive endoscopy patients and stool samples from UBT-positive patients. RESULTS Infection rates were significantly higher in patients referred for a UBT than endoscopy(overall rates: 33% vs 19%; treatment-na?ve patients: 33% vs 14.7%, respectively). H. pylori-infected UBT patients were younger than H. pylori-infected endoscopy patients(41.4 vs 48.4 years, respectively, P < 0.005), with a higher percentage of H. pylori-infected males in the endoscopy-compared to the UBT-cohort(52.6% vs 33.3%, P = 0.03). The Geno Type Helico DR assay was more accurate at detecting H. pylori infection using biopsy samples than stool samples [98.2%(n = 54/55) vs 80.3%(n =53/66), P < 0.005]. Subset analysis using stool and biopsy samples from CLO-positive endoscopy patients revealed a higher detection rate ofresistance-associated mutations using stool samples compared to biopsies. The concordance rates between stool and biopsy samples for the detection of H. pylori DNA, clarithromycin and fluoroquinolone resistance were just 85%, 53% and 35%, respectively. CONCLUSION Differences between endoscopy and UBT patients provide a rationale for non-invasive detection of H. pylori antibiotic resistance. However, the Geno Type Helico DR assay is an unsuitable approach. | Denise E Brennan Joseph Omorogbe Mary Hussey Donal Tighe Grainne Holleran Colm O'Morain Sinéad M Smith Deirdre McNamara | 2016 | World Journal of Gastroenterology2016，22，41： | 6 |
| 10 | Identifying more reliable parameters for the detection of change during the follow-up of mild to moderate keratoconus patients显示文摘Background:Reaching a consensus on which parameters are most reliable at detecting progressive keratoconus patients with serial topography imaging is not evident.The aim of the study was to isolate the parameters best positioned to detect keratoconus progression using the Pentacam HR^(®)measures based on the respective limits of repeatability and range of measurement.Method:Using the Pentacam HR^(®),a tolerance index was calculated on anterior segment parameters in healthy and keratoconic eyes.The tolerance index provides a scale from least to most affected parameters in terms of measurement noise relative to that observed in healthy eyes.Then,based on the“number of increments”from no disease to advanced disease,a relative utility(RU)score was also calculated.RU values close to 1 indicate parameters best positioned to detect a change in keratoconic eyes.Results:The tolerance index values indicated that 36%of ocular parameters for keratoconic eyes had repeatability limits which were wider than normative limits(worse),but 28%of the ocular parameters were narrower than normative limits(better).Considering only those parameters with a RU greater than 0.95,a small number of parameters were within this range,such as corneal curvature and asphericity indices.Conclusions:This study demonstrates that measurement error in keratoconic eyes is significantly greater than healthy eyes.Indices implemented here provide guidance on the levels of expected precision in keratoconic eyes relative to healthy eyes to aid clinicians in distinguishing real change from noise.Importantly maximal keratometry(Kmax),central corneal thickness(CCT)and thinnest corneal thickness(TCT)were highlighted as problematic indices for the follow-up of keratoconus in terms of repeatability. | Ivo Guber Colm McAlinden François Majo Ciara Bergin | 2017 | Eye and Vision2017，4，1： | 6 |
| 11 | Metal-assisted chemical etching of silicon and the behavior of nanoscale silicon materials as Li-ion battery anodes显示文摘这评论在硅的帮助金属的化学蚀刻构画出开发和最近的进步,总结许多基本、创新的过程并且蚀刻形成大量 nanoscale 硅结构的方法。,为 Li 离子电池的阳极也是的硅的使用考察了因素象电影厚度那样,做, alloying,和他们对可逆 lithiation 进程的反应关于电池房间性能被总结并且讨论。在在 Li 离子电池改进基于硅的阳极的表演的最近的进展也被讨论。当 Li 离子电池阳极被构画出,许多 nanostructured 硅结构的使用由许多不同方法形成了,特别地集中于集体装载,核心壳结构,传导性的添加剂,和另外的参数的影响。电气化学的反应和硅阳极的房间性能上的孔,掺杂物类型,和做的水平的影响基于最近的调查结果被详细说明。硅和相关材料的未来上的观点,和他们为经由几电气化学的机制的精力存储的组合、结构的修正,也被提供。 | William McSweeney | 2015 | Nano Research2015，8，5： | 5 |
| 12 | Can bacterial virulence factors predict antibiotic resistant Helicobacter pylori infection?显示文摘AIM To evaluate the association between virulence factor status and antibiotic resistance in Helicobacter pylori(H. pylori)-infected patients in Ireland. METHODS DNA was extracted from antral and corpus biopsies obtained from 165 H. pylori-infected patients. Genotyping for clarithromycin and fluoroquinolone-mediating mutations was performed using the Genotype Helico DR assay. cag A and vac A genotypes were investigated using PCR. RESULTS Primary, secondary and overall resistance rates for clarithromycin were 50.5%(n = 53/105), 78.3%(n = 47/60) and 60.6%(n = 100/165), respectively. Primary, secondary and overall resistance rates for fluoroquinolones were 15.2%(n = 16/105) and 28.3%(n = 17/60) and 20%(n = 33/165), respectively. Resistance to both antibiotics was 12.4%(n = 13/105) in treatment-na?ve patients, 25%(n = 15/60) in those previously treated and 17%(n = 28/165) overall. A cag A-positive genotype was detected in 22.4%(n = 37/165) of patient samples. The dominant vac A genotype was S1/M2 at 44.8%(n = 74/165), followed by S2/M2 at 26.7%(n = 44/165), S1/M1 at 23.6%(n = 39/165) and S2/M1 at 4.8%(n = 8/165). Primary clarithromycin resistance was significantly lower in cag A-positive strains than in cag A-negative strains [32%(n = 8/25) vs 56.3%(n = 45/80); P = 0.03]. Similarly, in patients infected with more virulent H. pylori strains bearing the vac A s1 genotype, primary clarithromycin resistance was significantly lower than in those infected with less virulent strains bearing the vac A s2 genotype, [41%(n = 32/78) vs 77.8%(n = 21/27); P = 0.0001]. No statistically significant association was found between primary fluoroquinolone resistance and virulence factor status.CONCLUSION Genotypic H. pylori clarithromycin resistance is high and cag A-negative strains are dominant in our population. Less virulent(cag A-negative and vac A S2-containing) strains of H. pylori are associated with primary clarithromycin resistance. | Denise E Brennan Colin Dowd Colm O'Morain Deirdre McNamara Sinéad M Smith | 2018 | World Journal of Gastroenterology2018，24，9： | 4 |
| 13 | Safety and efficacy of VisuMax®circle patterns for flap creation and enhancement following small incision lenticule extraction显示文摘Background:The purpose of this case series is to evaluate the safety and efficacy of VisuMax®Circle patterns in eyes that have undergone small incision lenticule extraction,thus creating a flap to perform an enhancement procedure or residual lenticule extraction.Methods:This prospective,single center,case study series evaluated the use of a VisuMax®Circle pattern to create a corneal flap following small incision lenticule extraction.Patients were treated and followed at TRSC International LASIK Center(Bangkok,Thailand)for 3 months to assess the efficacy and safety of the procedure.Efficacy was determined by the surgeon’s ability to lift the created corneal flap.Results:The study enrolled 28 eyes.Twenty-seven underwent the VisuMax®Circle pattern procedure for refractive enhancement,and one for residual lenticule extraction.In 100%of cases(28 eyes)the lifting of the flap was possible,as planned.In all cases of refractive enhancement(27 eyes)by laser in situ keratomileusis(LASIK),the exposure of the stromal bed was sufficient for the necessary excimer laser ablation.No eyes lost two or more Snellen lines of corrected distance visual acuity(CDVA)and no procedure or flap-related complications or serious adverse events occurred.Conclusions:This initial case series demonstrates that VisuMax®Circle pattern is efficacious and a suitable method to create a corneal flap for enhancement,following small incision lenticule extraction. | Ekktet Chansue Morakot Tanehsakdi Sukanda Swasdibutra Colm McAlinden | 2015 | Eye and Vision2015，2，1： | 4 |
| 14 | 多路同步采样ADC实现高性能多通道电网监测显示文摘本文介绍了同步采样ADC在电网监测中的应用,并对构建电力线测量系统时所要考虑的问题进行了讨论。 | Colm Slattery | 2007 | 电子产品世界2007，14，8： | 3 |
| 15 | Vitamin D deficiency in Crohn’s disease: Prevalence, risk factors and supplement use in an outpatient setting显示文摘 | Treasa Nic Suibhne Gerry Cox Martin Healy Colm O’Morain Maria O’Sullivan | 2011 | Journal of Crohn’s and Colitis2011，，2： | 3 |
| 16 | 高性能低成本电子秤的参考设计显示文摘引言
电子秤向提高精度和降低成本方向发展的趋势引起了对低成本、高性能模拟信号处理器件需求的增加.大多数电子秤是以1:3,000或1:10,000的分辨率输出最终的称重值,使用12bit~14bit的模数转换器很容易慢足要求.然而,高精密检测的电子秤表明要达到这种分辨率,ADC的精度需要接近于20 bit.本文将讨论一些电子秤系统的技术指标以及设计和构建一个电子秤系统所需考虑的问题.设计中主要考虑峰峰值(PP)噪声分辨率、ADC的动态范围、增益漂移和滤波.我们使用作为评估板的电子秤参考设计,将来自实际称重传感器(又称作负荷传感器)的测量结果与来自稳定参考电压源的输入进行对比. | Colm Slattery Mariah Nie | 2006 | 世界电子元器件2006，，5： | 2 |
| 17 | Mismatch repair enzyme expression in primary and castrate resistant prostate cancer显示文摘Objective:Although the utility of immunohistochemistry(IHC)for assessing mismatch repair(MMR)protein expression has been demonstrated in solid tumors including primary prostate cancer(PCa),its utility has not been assessed in castration-resistant PCa(CRPC).Methods:Tissue microarrays were constructed from 127 radical prostatectomies and 155 CRPC metastases from 50 patients.MMR(MLH1,MSH2,MSH6,and PMS2)expression was assessed by IHC and gene expression arrays.Associations between MMR protein expression in PCa and CRPC and biochemical recurrence(BCR)or time from diagnosis to death respectively were determined.Results:There was no correlation between levels of MMR protein and BCR.Absence of MSH2 and MSH6 was the most pronounced at 15%and 22%in PCa and 17.8%and 16%in CRPC patients,respectively.MSH2 and MSH6 protein were absent in 9.4%and 8%of PCa and CRPC respectively.Absence of individual MMR proteins did not correlate with BCR or time from diagnosis to death.However absent MSH2/MSH6 in CRPC was associated with shorter time to death(pZ0.0006).Loss of MSH2 was verified at the gene expression level.This finding correlated with microsatellite instability previously reported in this CRPC cohort. | Belinda Nghiem Xiaotun Zhang Hung-Ming Lam Lawrence DTrue Ilsa Coleman Celestia SHigano Peter SNelson Colin CPritchard Colm Morrissey | 2016 | Asian Journal of Urology2016，3，4： | 2 |
| 18 | Recent technological advances for the determination of food authenticity显示文摘 | Linda M. Reid Colm P. O’Donnell Gerard Downey | 2006 | Trends in Food Science & Technology2006，，7： | 2 |
| 19 | Treatment of H elicobacter pylori Infection 2013显示文摘 | Anthony O’Connor Javier Molina‐Infante Javier P. Gisbert Colm O’Morain | 2013 | Helicobacter2013，，： | 2 |
| 20 | Confirmation of food origin claims by fourier transform infrared spectroscopy and chemometrics: extra virgin olive oil from Liguria 显示文摘 | Hennessy S Gerard D and Colm P O | 2009 | Journal of Agricultural and Food Chemistry2009，57，： | 1 |
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