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| 1 | Nature:死亡的肿瘤细胞释放出胞内钾离子来阻断免疫系统显示文摘在一项新的研究中。来自美国国家癌症研究所和英国巴布拉汉研究所的研究人员发现当肿瘤组织死亡时从它当中泄露出来的一种无机离子起着阻止抗肿瘤免疫细胞发挥功能的作用。这一发现为开发调动免疫系统抵抗癌症的疗法提供一种新的方法。相关研究结果在线发表在Nature期刊上。 | Robert Eil, Suman K. Vodnala, David Clever, Christopher A. Klebanoff, Madhusudhanan Sukumar, Jenny H. Pan, Douglas C. Palmer, Alena Gros, Tori N. Yamamoto, Shashank J. Patel, Geoffrey C. Guittard, Zhiya Yu, David S. Schrump, W. Marston Linehan, Nicholas P. Restifo Christopher A. Klebanoff Valentina Carbonaro, Klaus Okkenhaug, Rahul Roychoudhuri | 2016 | 现代生物医学进展2016，16，31： | 12 |
| 2 | 基于高光谱遥感数据提取森林结构参数的研究(英文)显示文摘以位于三峡库区的龙门河森林自然保护区为研究区,综合利用线性光谱混合模型和几何光学模型,基于高光谱遥感数据提取森林结构参数是本文研究的重点。在研究区地面调查数据的基础上,通过高光谱数据和混合光谱分解法,获得反演几何光学模型所需的四分量参数,根据背景光照分量与森林植被冠层各参数间的关系,反演得到森林冠层郁闭度及平均冠幅的定量分布图,并利用37个野外实测样本进行结果验证。 | 曾源 Michael E. Schaepman 吴炳方 Jan G. P. W. Clevers Arnold K. Bregt | 2007 | 遥感学报2007，11，5： | 9 |
| 3 | Stem Cells, Self-Renewal, and Differentiation in the Intestinal Epithelium显示文摘 | Laurens G. van der Flier Hans Clevers | 2009 | Annual Review of Physiology2009，，： | 4 |
| 4 | Wnt/β-Catenin Signaling and Disease显示文摘 | Hans Clevers Roel Nusse | 2012 | Cell2012，，6： | 4 |
| 5 | Wnt/β-Catenin Signaling in Development and Disease显示文摘 | Hans Clevers | 2006 | Cell2006，，3： | 4 |
| 6 | Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-Cell-like Properties显示文摘 | Sarah Schwitalla Alexander A. Fingerle Patrizia Cammareri Tim Nebelsiek Serkan I. G?ktuna Paul K. Ziegler Ozge Canli Jarom Heijmans David J. Huels Guenievre Moreaux Rudolf A. Rupec Markus Gerhard Roland Schmid Nick Barker Hans Clevers Roland Lang Jens Neu | 2013 | Cell2013，，： | 3 |
| 7 | The Intestinal Crypt, A Prototype Stem Cell Compartment显示文摘 | Hans Clevers | 2013 | Cell2013，，2： | 3 |
| 8 | At the Crossroads of Inflammation and Cancer显示文摘 | Hans Clevers | 2004 | Cell2004，，6： | 2 |
| 9 | Monoclonal Antibodies Against Lgr5 Identify Human Colorectal Cancer Stem Cells显示文摘 | Kristel Kemper Pramudita R. Prasetyanti Wim De Lau Hans Rodermond Hans Clevers Jan Paul Medema | 2012 | STEM CELLS2012，，11： | 2 |
| 10 | Identifying the Stem Cell of the Intestinal Crypt: Strategies and Pitfalls显示文摘 | Nick Barker Alexander van Oudenaarden Hans Clevers | 2012 | Cell Stem Cell2012，，4： | 2 |
| 11 | Retinoic Acid–Induced Pancreatic Stellate Cell Quiescence Reduces Paracrine Wnt–β-Catenin Signaling to Slow Tumor Progression显示文摘 | Fieke E.M. Froeling Christine Feig Claude Chelala Richard Dobson Charles E. Mein David A. Tuveson Hans Clevers Ian R. Hart Hemant M. Kocher | 2011 | Gastroenterology2011，，4： | 2 |
| 12 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 13 | Caught up in a Wnt storm: Wnt signaling in cancer显示文摘 | Rachel H. Giles Johan H. van Es Hans Clevers | 2003 | BBA - Reviews on Cancer2003，，1： | 2 |
| 14 | Monoclonal Antibodies Against Lgr5 Identify Human Colorectal Cancer Stem Cells显示文摘 | Kristel Kemper Pramudita R. Prasetyanti Wim De Lau Hans Rodermond Hans Clevers Jan Paul Medema | 2012 | STEM CELLS2012，，11： | 2 |
| 15 | The application of a weighted infraredred vegetation index for estimating leaf area index by correcting for soil moisture 显示文摘 | Clevers J G P W | 1989 | Remote Sens Environ1989，29，： | 1 |
| 16 | Wnt/beta-catenin signaling in development and disease 显示文摘 | Clevers H | 2006 | Cell2006，127，3： | 1 |
| 17 | Catenins,Wnt signaling and cancer显示文摘 | Barker N Clevers H | 2000 | Bioessaya2000，22，11： | 1 |
| 18 | The cancer stem cell: premises, promises and challenges 显示文摘 | Clevers H | 2011 | Nat Med2011，17，3： | 1 |
| 19 | Wnt/13-catenin signaling and disease 显示文摘 | Clevers Hans Nusse Roel | 2012 | Cell2012，149，6： | 1 |
| 20 | Using spectral information from the NIR water absorption features for the retrieval of canopy water content 显示文摘 | Clevers J G P W Kooistra L Schaepman M E | 2008 | International Journal of Applied Earth Observation and Geoinformation2008，10，3： | 1 |
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