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| 1 | Wnt signaling in disease and in development显示文摘The highly conserved Wnt secreted proteins are critical mediators of cell-to-cell signaling during development of animals. Recent biochemical and genetic analyses have led to significant insight into understanding how Wnt signals work. The catalogue of Wnt signaling components has exploded. We now realize that multiple extracellular, cytoplasmic, and nuclear components modulate Wnt signaling. Moreover, receptor-ligand specificity and multiple feedback loops determine Wnt signaling outputs. It is also clear that Wnt signals are required for adult tissue maintenance. Perturbations in Wnt signaling cause human degenerative diseases as well as cancer. | Roel NUSSE | 2005 | Cell Research2005，15，1： | 83 |
| 2 | Wnt signaling and stem cell control显示文摘发信号的 Wnt 在对干细胞的各种各样的类型的控制被含有并且可以充当一个壁龛因素处于一个自我更新的状态维持干细胞。当当前理解, Wnt 蛋白质在房间表面上绑在 Frizzled 和 LRP 家庭的受体。通过几个细胞质的继电器部件,信号是到 ss-catenin 的 transduced,它然后进入原子核并且与 TCF 形成建筑群激活 Wnt 目标基因的抄写。Wnts 能也通过酷氨酸 kinase 受体,特别地 ROR 和 RYK 受体发信号,导致 Wnt 发信号的其他的模式。在纸巾的生长期间,这些 ligands 和受体动态地被表示,经常, Wnt 控制的抄写联盟者表明自己,保证在增长和区别之间的正确平衡。孤立的 Wnt 蛋白质在许多干细胞上是活跃的,包括神经、乳房、胚胎的干细胞。一般来说, Wnt 蛋白质行动维持干细胞的无差别的状态,当另外的生长因素指示房间增殖时。这些另外的因素包括 FGF 和 EGF,通过酷氨酸 kinase 小径发信号。 | Roel Nusse | 2008 | Cell Research2008，18，5： | 29 |
| 3 | THE WNT SIGNALING PATHWAY IN DEVELOPMENT AND DISEASE显示文摘 | Catriona Y. Logan Roel Nusse | 2004 | Annual Review of Cell and Developmental Biology2004，，： | 6 |
| 4 | Wnt/β-Catenin Signaling and Disease显示文摘 | Hans Clevers Roel Nusse | 2012 | Cell2012，，6： | 4 |
| 5 | 昆明山海棠诱导Jurkat等3个细胞株微核形成的研究显示文摘目的 为研究昆明山海棠 (THH)的毒理作用。方法 使用流式细胞仪检测发现THH均可诱导Jurkat、CHE和NIH3T3细胞株微核形成和细胞凋亡。结果 3个细胞株表现出完全相似的变化规律 ,但Jurkat淋巴瘤细胞更为敏感 ,仅 2 5 μl/皿即在各时相点出现微核形成高峰 ,5 0 μl/皿即出现细胞凋亡高峰。 | 孙华明 曹佳 Michael Nusse | 2001 | 第三军医大学学报2001，23，3： | 4 |
| 6 | A 10-year review of a minimally invasive technique for the correction of pectus excavatum显示文摘 | Donald Nuss Robert E Kelly Daniel P Croitoru Michael E Katz | 1998 | Journal of Pediatric Surgery1998，，4： | 4 |
| 7 | β-catenin: a key mediator of Wnt signaling显示文摘 | Karl Willert Roel Nusse | 1998 | Current Opinion in Genetics & Development1998，，1： | 2 |
| 8 | Experimental tracheal replacement using a revascularized jejunal autograft with an implantable Dacron mesh tube显示文摘 | Costantino MPD Nuss DW Sonyderman CH | 1992 | Ann Rhinol Laryngol1992，101，10： | 2 |
| 9 | Twenty-One Years of Experience With Minimally Invasive Repair of Pectus Excavatum by the Nuss Procedure in 1215 Patients显示文摘 | Robert E. Kelly Michael J. Goretsky Robert Obermeyer Marcia Ann Kuhn Richard Redlinger Tina S. Haney Alan Moskowitz Donald Nuss | 2010 | Annals of Surgery2010，，6： | 2 |
| 10 | A 10 - year review of minimalky invasive technique for the correction of pectus excavatum 显示文摘 | Nuss D Kelly RE | 1998 | J Pedlatr Surg1998，33，： | 1 |
| 11 | Using chimeric hypoviruses to fine-turn the interaction betweena pathogenic fungus and its plants host显示文摘 | CHEN B LYNN M NUSS D L | 2000 | J Virology2000，74，： | 1 |
| 12 | Micronuclei containing whole chromosomes harbouring the selectable gene do not lead to mutagenesis显示文摘 | Eckert I Caspary WJ Nusse M | 1997 | Exp Toxicol Pathol1997，49，12： | 1 |
| 13 | A new nomenclature for int-1and related genes:the Wnt gene family显示文摘 | Nusse R Brown A Papkoff J | 1991 | Cell1991，64，2： | 1 |
| 14 | Wnt/13-catenin signaling and disease 显示文摘 | Clevers Hans Nusse Roel | 2012 | Cell2012，149，6： | 1 |
| 15 | The Wnt signaling pathway in development and diease显示文摘 | Logan CY Nusse R | 2004 | Annu Rev Cell Dev Bilo2004，20，： | 1 |
| 16 | Imaging with terahertz waves 显示文摘 | Hu B B Nuss M C | 1995 | Optics letters1995，20，16： | 1 |
| 17 | Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface 显示文摘 | Nusse R | 2003 | Development2003，130，22： | 1 |
| 18 | A 10-year review of a minimally invasive technique for the correction of pectus excavatum显示文摘 | Nuss D Kelly RE Jr Croitoru DP | 1998 | J Pediatr Surg1998，33，4： | 1 |
| 19 | Convergence Of Wnt, 13 - catenin and cadher- in pathways 显示文摘 | Nelson WJ Nusse R | 2004 | Science2004，303，5663： | 1 |
| 20 | Hypovirulence of chestnut blight fungus conferred by an infectious viral cDNA显示文摘 | CHOI G H NUSS D L | 1992 | Science1992，257，： | 1 |
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