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| 1 | Systems biology approaches for studying the pathogenesis of non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD) is a progressive disease of increasing public health concern.In western populations the disease has an estimated prevalence of 20%-40%,rising to 70%-90% in obese and type Ⅱ diabetic individuals.Simplistically,NAFLD is the macroscopic accumulation of lipid in the liver,and is viewed as the hepatic manifestation of the metabolic syndrome.However,the molecular mechanisms mediating both the initial development of steatosis and its progression through non-alcoholic steatohepatitis to debilitating and potentially fatal fibrosis and cirrhosis are only partially understood.Despite increased research in this field,the development of non-invasive clinical diagnostic tools and the discovery of novel therapeutic targets has been frustratingly slow.We note that,to date,NAFLD research has been dominated by in vivo experiments in animal models and human clinical studies.Systems biology tools and novel computational simulation techniques allow the study of large-scale metabolic networks and the impact of their dysregulation on health.Here we review current systems biology tools and discuss the benefits to their application to the study of NAFLD.We propose that a systems approach utilising novel in silico modelling and simulation techniques is key to a more comprehensive,better targeted NAFLD research strategy.Such an approach will accelerate the progress of research and vital translation into clinic. | Ciarán P Fisher Andrzej M Kierzek Nick J Plant J Bernadette Moore | 2014 | World Journal of Gastroenterology2014，20，41： | 2 |
| 2 | Association between antibody response to toxin A and protection against recurrent Clostridium difficile diarrhoea显示文摘 | Lorraine Kyne Michel Warny Amir Qamar Ciarán P Kelly | 2001 | 2001 (9251)2001，，9251： | 1 |
| 3 | Requirement of bic/mi- croRNA - 155 for normal immune function显示文摘 | Rodriguez A Vigurito E Ciare S | 2007 | Science2007，316，： | 1 |
| 4 | Saccharomyces boulardii produces a soluble anti-inflammatory factor that inhibits NF-κB-mediated IL-8 gene expression显示文摘 | Stavros Sougioultzis Simos Simeonidis K. Ramakrishnan Bhaskar Xinhua Chen Pauline M. Anton Sarah Keates Charalabos Pothoulakis Ciarán P. Kelly | 2006 | Biochemical and Biophysical Research Communications2006，，1： | 1 |
| 5 | Horseradish and soybean peroxidases: comparable tools for alternative niches?显示文摘 | Barry J. Ryan Neil Carolan Ciarán ó’Fágáin | 2006 | Trends in Biotechnology2006，，8： | 1 |
| 6 | Influence of Chloride Ion Adsorption on Hydrogen Evolution Reaction on Iron 显示文摘 | Vra ciar L Drazi6 D M | 1992 | J Electroanal Chem1992，339，12： | 1 |
| 7 | Enzyme stabilization-recent experimental progress显示文摘 | Ciar An OF | 2003 | Enzyme and microbial Technology2003，33，： | 1 |
| 8 | Prospective Derivation and Validation of a Clinical Prediction Rule for Recurrent Clostridium difficile Infection显示文摘 | Mary Y. Hu Kianoosh Katchar Lorraine Kyne Seema Maroo Sanjeev Tummala Valley Dreisbach Hua Xu Daniel A. Leffler Ciarán P. Kelly | 2009 | Gastroenterology2009，，4： | 1 |
| 9 | Biodegradation of central intermediate compoundsproduced from biodegradation of aromatic compounds显示文摘 | ?zer Ciar | 2004 | Bioprocess Biosyst Eng2004，26，： | 1 |
| 10 | Doubly fed induction generator using back-toack PWM converters and its application to vailable speed wind-energy generation显示文摘 | PENA R CIARE J C ASHER G M | 1996 | IEE Proc Electr Power Appl1996，143，3： | 1 |
| 11 | Simple fisheye calibration method with accuracy evaluation显示文摘 | Ciar'an Hughes Martin Glavin Edward Jones | 2011 | Electronic Letters on Computer Vision and Image Analysis2011，10，1： | 1 |
| 12 | Bioactive Milk peptides:A prospectus显示文摘 | CIARE D A SWAISGOOD H E | 2000 | Journal of Dairy Science2000，83，6： | 1 |
| 13 | Doubly-fed induction generator using back-to-back PWM converters and its application to variable-speed wind-energy generation显示文摘 | PENA R CIARE J C ASHER G M | 1996 | IEEE proc 2electr1996，143，3： | 1 |
| 14 | Antitumor effects of ZD6474, a small molecule vascular endothelial growth factor recep for tyrosine kinase inhibitor, with additional activity against epidermal growth factor receptor tyrosine kinase 显示文摘 | CIAR IF CAPUTO R DAMIANO V | 2003 | Clin Cancer Res2003，9，4： | 1 |
| 15 | Clostridium difficile toxoid vaccine in recurrent C. difficile -associated diarrhea显示文摘 | Stavros Sougioultzis Lorraine Kyne Denise Drudy Sarah Keates Seema Maroo Charalabos Pothoulakis Paul J. Giannasca Cynthia K. Lee Michel Warny Thomas P. Monath Ciarán P. Kelly | 2005 | Gastroenterology2005，，3： | 1 |
| 16 | Phenol removal by modified peroxidases显示文摘 | ENDA J A MALCOLM M D CIAR S M | 1996 | Enzyme and Microbial Technology1996，67，： | 1 |
| 17 | Prospective Derivation and Validation of a Clinical Prediction Rule for Recurrent Clostridium difficile Infection显示文摘 | Mary Y. Hu Kianoosh Katchar Lorraine Kyne Seema Maroo Sanjeev Tummala Valley Dreisbach Hua Xu Daniel A. Leffler Ciarán P. Kelly | 2009 | Gastroenterology2009，，4： | 1 |
| 18 | Application of Isothermal Helicase-Dependent Amplification with a Disposable Detection Device in a Simple Sensitive Stool Test for Toxigenic Clostridium difficile显示文摘 | Wing Huen A. Chow Cindy McCloskey Yanhong Tong Lin Hu Qimin You Ciarán P. Kelly Huimin Kong Yi-Wei Tang Wen Tang | 2008 | The Journal of Molecular Diagnostics2008，，5： | 1 |
| 19 | Enzyme stabilization-recent experimental progress显示文摘 | Ciarán(O)' Fágáin | 2003 | Enzyme and Microbial Technology2003，33，： | 1 |
| 20 | Seasonal variations in nutritive and botanical composition properties of multispecies grazing swards over an entire dairy grazing season显示文摘Background Recently,there has been increasing interest in the use of multispecies(MS)swards in dairy grazing systems.Methods A plot grazing study was established to investigate the potential contribution of different sward species(perennial ryegrass,legumes and herbs)sown in grazing pastures.Ten sward mixtures were sown,ranging in complexity from a perennial ryegrass(PRG)monoculture to binary mixtures including either forage legumes or herbs to a five-species mixture;four different nitrogen(N)application rates of 0,100,150 and 200 kg N ha−1 were applied to each sward.Results Species abundance for all sward species components was associated with the interaction of time point and sward mixture;species abundance for all sward components,except PRG,was associated with the interaction of N application and sward mixture.The interactions of time point and sward mixture,and time point and N application rate,were associated with all analysed sward chemical components,except for sward digestibility.Conclusions Increased N application rates reduced the level of clover in all sward mixtures.Increased levels of white clover led to increased sward crude protein levels;the inclusion of ribwort plantain led to some seasonal variation in the nutritive value of swards. | Ciarán Hearn Michael Egan Mary Bridget Lynch Christina Fleming Michael O'Donovan | 2022 | Grassland Research2022，1，4： | 0 |
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