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| 1 | Enhanced recovery programme in colorectal surgery:Does one size fit all?显示文摘Enhanced recovery after surgery(ERAS) employs a multimodal perioperative care pathway with the aim of attenuating the stress response to surgery and accelerating recovery.It has been difficult to determine the relative importance of some of the individual components of these pathways such as epidural analgesia and laparoscopic colorectal surgery.Some argue that only a rigid adherence to the published ERAS protocol can achieve the proposed benefits of fast-track surgery.In this article,we explore some of the areas where the evidence base may be changing and ask whether a more flexible and individualised approach should be considered. | Alison Lyon Christopher J Payne Graham J MacKay | 2012 | World Journal of Gastroenterology2012，18，40： | 18 |
| 2 | Clinical applications of exosome membrane proteins显示文摘Extracellular vesicles(EVs)are small membranous particles that can mediate cell-to-cell communication and which are divided into at least three categories according to their subcellular origin and size:exosomes,microvesicles,and apoptotic bodies.Exosomes are the smallest(30–150 nm)of these EVs,and play an important role in EV-mediated cell-to-cell interactions,by transferring proteins,nucleic acids and,lipids from their parental cells to adjacent or distant cells to alter their phenotypes.Most exosome studies in the past two decades have focused on their nucleic acid composition and their transfer ofmRNAs and microRNAs to neighboring cells.However,exosomes also carry specific membrane proteins that can identify the physiological and pathological states of their parental cells or indicate their preferential target cells or tissues.Exosome membrane protein expression can also be directly employed or modified to allow exosomes to serve as drug delivery systems and therapeutic platforms,including in targeted therapy approaches.This review will briefly summarize information on exosome membrane proteins components and their role in exosome–cell interactions,including proteins associated with specific cell-interactions and diseases,and the potential for using exosome membrane proteins in therapeutic targeting approaches. | Qian Hu Hang Su Juan Li Christopher Lyon Wenfu Tang Meihua Wan Tony Ye Hu | 2020 | Precision Clinical Medicine2020，3，1： | 6 |
| 3 | Extracellular vesicles:Emerging tools as therapeutic agent carriers显示文摘Extracellular vesicles(EVs)are secreted by both eukaryotes and prokaryotes,and are present in all biological fluids of vertebrates,where they transfer DNA,RNA,proteins,lipids,and metabolites from donor to recipient cells in cell-to-cell communication.Some EV components can also indicate the type and biological status of their parent cells and serve as diagnostic targets for liquid biopsy.EVs can also natively carry or be modified to contain therapeutic agents(e.g.,nucleic acids,proteins,polysaccharides,and small molecules)by physical,chemical,or bioengineering strategies.Due to their excellent biocompatibility and stability,EVs are ideal nanocarriers for bioactive ingredients to induce signal transduction,immunoregulation,or other therapeutic effects,which can be targeted to specific cell types.Herein,we review EV classification,intercellular communication,isolation,and characterization strategies as they apply to EV therapeutics.This review focuses on recent advances in EV applications as therapeutic carriers from in vitro research towards in vivo animal models and early clinical applications,using representative examples in the fields of cancer chemotherapeutic drug,cancer vaccine,infectious disease vaccines,regenerative medicine and gene therapy.Finally,we discuss current challenges for EV therapeutics and their future development. | Shan Liu Xue Wu Sutapa Chandra Christopher Lyon Bo Ning Li jiang Jia Fan Tony Y.Hu | 2022 | Acta Pharmaceutica Sinica B2022，12，10： | 2 |
| 4 | Nuclear Factor (Erythroid-Derived 2)-Like-2 Factor (Nrf2), a Key Regulator of the Antioxidant Response to Protect Against Atherosclerosis and Nonalcoholic Steatohepatitis显示文摘 | Anisha A. Gupte Christopher J. Lyon Willa A. Hsueh | 2013 | Current Diabetes Reports2013，，3： | 2 |
| 5 | Melt-electrospinning part i:processing parameters and geometric properties 显示文摘 | Jason Lyons Christopher Li Frank Ko | 2004 | Polymer2004，45，22： | 1 |
| 6 | The draft genome of the transgenic tropical fruit tree papaya ( Carica pap aya Linnaeus ) 显示文摘 | MING R HOU S B FENG Y YU Q DIONNE-LAPORTE A SAW J H SENIN P WANG W LY B V LEWIS K L T SALZBERG S L FENG L GONES M R SKELTON R L MURRAYJ E CHEN C QIAN W SHEN J DU P EUSTICE M TONG E TANG H LYONS E PAULL R E MICHAEL T P WALL K RICE D W ALBERT H WANG M L ZHU Y J SCHATZ M NAGARAJAN N ACOB R A GUAN P BLAS A WAI C M ACKERMAN C M REN Y LIU C WANG J M WANG J P NA J SHAKIROV E V HAAS B THIMMAPURAM J NELSON D WANG X BOWERS J E GSCHWEND A R DELCHER A L SINGH R SUZUKI J Y TRIPATHI S NEUPANE K WEI H IRIKURA B PAIDI M JIANG N ZHANG W PRESTING G WINDSOR A NAVAJAS-PEREZ R TORRES M J FELTUS A PORTER B LI Y BURROUGHS A M LUO M C LIU L CHRISTOPHER D A MOUNT S M MOORE P H SUGIMURA T JIANG J SCHULER M A FRIEDMAN V MITCHELL-OLDS T SHIPPEN D E PAMPHILIS C W PALMER J D FREELING M PATERSON A H GONSALVES D WANG L ALAM M | 2008 | Nature2008，452，： | 1 |
| 7 | Adiposity, inflammation atherogenesis 显示文摘 | Lyon Christopher J Law | 2003 | Endocinology2003，144，6： | 1 |
| 8 | Environmentally benign multiphase catalysis with dense phase carbon dioxide显示文摘 | BALA SUBRAMANIAM CHRISTOPHER J LYON VENU ARUNAJATESAN | 2002 | Applied Catalysis B:Environmental2002，37，： | 1 |
| 9 | The draft genome of the transgenic tropical fruit tree papaya (Carica papaya Linnaeus ) 显示文摘 | MING R HOU S B FENG Y YU Q Y DIONNE-LAPORTE A SAW J H SENIN P WANG W LY B V LEWIS K L T SALZBERG S L FENG L JONES M R SKELTON R L MURRAY J E CHEN C X QIAN W B SHEN J G DU P EUSTICE M TONG E TANG H B LYONS E PAULL R E MICHAEL T P WALL K RICE D W AL- BERT H WANG M L ZHU Y J SCHATZ M NAGARAJAN N A- COB R A GUAN P Z BLAS A WAI C M ACKERMAN C M REN Y LIU C WANG J M WANG J P NA J K SHAKIROV E V HAAS B THIMMAPURAM J NELSON D WANG X Y BOWERS J E GSCHWEND A R DELCHER A L SINGH R SUZUKI J Y TRI- PATHI S NEUPANE K WEI H R IRIKURA B PAIDI M JIANG N ZHANG W L PRESTING G WINDSOR A NAVAJAS-P?REZ R TORRES M J FELTUS F A PORTER B LI Y J BURROUGHS A M LUO M C LIU L CHRISTOPHER D A MOUNT S M MOORE P H SUGIMURA T JIANG J M SCHULER M A FRIEDMAN V MITCHELL-OLDS T SHIPPEN D E DEPAMPHILIS C W PALMER J D FREELING M PATERSON A H GONSALVES D WANG L ALAM M | 2008 | Nature2008，452，7190： | 1 |
| 10 | Adiposity inflammation atherogenesis显示文摘 | LYON CHRISTOPHER J LAW R E HSUEH W A | 2003 | Endocninology2003，144，6： | 1 |
| 11 | Age-Accelerated Atherosclerosis Correlates With Failure to Upregulate Antioxidant Genes显示文摘 | Alan R. Collins Christopher J. Lyon Xuefeng Xia Joey Z. Liu Rajendra K. Tangirala Fen Yin Rima Boyadjian Alfiya Bikineyeva Domenico Praticò David G. Harrison Willa A. Hsueh | 2009 | Circulation Research2009，，6： | 1 |
| 12 | Insulin resistance and the endothelium显示文摘 | Willa A Hsueh Christopher J Lyon Manuel J Qui?ones | 2004 | The American Journal of Medicine2004，，2： | 1 |
| 13 | The draft genome of the transgenic tropical fruit tree papaya (Caricapapaya Linnaeus) 显示文摘 | MING R HOU S FENG Y YU Q DIONNE-LAPORTE A SAW J H SENIN P WANG W LY B V LEWIS K L SALZBERG S L FENG L JONES M R SKELTON R L MURRAY J E CHEN C QIAN W SHEN J DU P EUSTICE M TONG E TANG H LYONS E PAULL R E MICHAEL T P WALL K RICE D W ALBERT H WANG M L ZHU Y J SCHATZ M NAGARAJAN N ACOB R A GUAN P BLAS A WA1 C M ACKERMAN C M REN Y LIU C WANG J WANG J NA J K SHAKIROV E V HAAS B THIMMAPURAM I NELSON D WANG X BOWERS J E GSCHWEND A R DELCHER A L SINGH R SUZUKI J TRIPATHI S NEUPANE K WEI H IRIKURA B PAIDI M JIANG N ZHANG W PRESTING G WINDSOR A NAVAJAS- P?REZ R TORRES M J FELTUS FA PORTER B LI Y BURROUGHS A M LUO MC LIU L CHRISTOPHER D A MOUNT S M MOORE P H SUGIMURA T JIANG J SCHULER M A FRIEDMAN V MITCHELL-OLDS T SHIPPEN D E DEPAMPHILIS C W PALMER J D FREELING M PATERSON A H GONSALVES D WANG L ALAM M | 2008 | Nature2008，452，： | 1 |
| 14 | A Highly Elastic and Adhesive Gelatin Tissue Sealant for Gastrointestinal Surgery and Colon Anastomosis显示文摘 | Tony Vuocolo Roger Haddad Glenn Edwards Russell Lyons Nancy Liyou Jerome Werkmeister John Ramshaw Christopher Elvin | 2012 | Journal of Gastrointestinal Surgery2012，，4： | 1 |
| 15 | Arunajatesan,Venu, Environmentally Benign Multiphase Catalysis with Dense Phase Carbon Dioxide显示文摘 | Subramaniam Bala Lyon Christopher J | 2002 | Appl Catal B Environ2002，，37： | 1 |
| 16 | Norovirus GII.4 variant 2006b caused epidemics of acute gastroenteritis in Australia during 2007 and 2008显示文摘 | John-Sebastian Eden Rowena A. Bull Elise Tu Christopher J. McIver Michael J. Lyon John A. Marshall David W. Smith Jennie Musto William D. Rawlinson Peter A. White | 2010 | Journal of Clinical Virology2010，，： | 1 |
| 17 | Adiposity, infammation atherogenesis显示文摘 | Lyon Christopher J Law | 2003 | Endocrinology2003，144，6： | 1 |
| 18 | Melt-electrospinning part I:Processing parameters and geometric properties显示文摘 | Lyons J Li Christopher Ko Frank | 2004 | Polymer2004，45，22： | 1 |
| 19 | Melt-electrospinning part Ⅰ:processing parameters and geometric properties显示文摘 | LYONS J CHRISTOPHER L I FRANK K O | 2004 | Polymer2004，45，： | 1 |
| 20 | Melt-electrospinningpart I:Processing parameters and geometric properties显示文摘 | Lyons Jason Li Christopher Ko Frank | 2004 | Pol-ymer2004，45，22： | 1 |
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