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| 1 | 3种抗精神病药治疗首发精神分裂患者疗效的6个月随访显示文摘目的:通过随访,比较非典型抗精神病药的疗效和安全性,并就其对于服药依从性和社会功能的影响进行对比。方法:采用阳性和阴性症状评定量表(PANSS)、UKU不良反应量表、个人与社会表现量表(PSP)、服药态度量表(DAI)在基线和治疗6个月末对103例患者进行评估。结果:①6个月末,奥氮平组PANSS一般病理学量表总分较之阿立哌唑组显著降低(P<0.05),3种药物组PANSS阳性症状总分、PANSS阴性症状总分和PANSS总分均无显著性差异。②6个月末3种药物组DAI、PSP评分均无显著性差异。③利培酮组肌张力障碍及震颤发生率较高,分别为26.5%和20.6%。奥氮平组思睡/镇静、口干、便秘及体质量增加发生率均显著高于其他组(P<0.01)。结论:3种非典型抗精神病药物对于首发精神分裂症患者的阳性症状和阴性症状的改善作用相当,在改善服药依从性及社会功能方面作用差别不明显。 | 黄楠 陆峥 盛建华 刘娜 张洁 何磊英 杨程青 陈发展 Goorah Deenoo Bharathi Anisha Heeramun-Aubeeluck 熊祥玉 应颖 薛振康 郭珍 骆艳丽 | 2013 | 临床精神医学杂志2013，23，1： | 36 |
| 2 | 精神分裂症首次发病患者治疗早期神经认知功能改变的对照研究显示文摘目的探讨精神分裂症首次发病患者治疗早期神经认知功能受损的程度和范围。方法采用成套神经心理测验T具,包括连线测验A、颜色连线测验、《韦克斯勒记忆量表(第3版)》空间广度测验、《韦克斯勒量表(第3版)》(WAIS—m)符号搜索和数字符号、霍普金斯词汇学习测验-修订版(HVLT—R)、简易视觉空间记忆测验-修订版(BVMT—R)、沟槽钉板测验和定步调听觉连续加法测验(PASAT)测试77例16—28岁的精神分裂症首次发病患者(病例组)和80名健康者(对照组)的学习和记忆、精细动作、信息处理速度以及执行功能,采用SPSS16.0统计软件包对所有数据进行统计学分析。结果共有21项评价指标的效应值〉0.80(P〈0.001),整体受损效应值在0.47~3.41个标准差;病例组沟槽钉板测验完成时间[利手(84.774-31.55)S,非利手(97.954-42.30)S]均显著长于对照组[(59.00±7.57)S,ES=3.41,F=43.28;(66.84±10.74)S,ES=2.90,F=35.75;P均〈0.001],连线测验A[(50.884-27.45)S]、颜色连线1完成时间[(54.59-4-25.62)S]和颜色连线2完成时间[(117.384-52.66)s]显著长于对照组[(27.25-4-8.49)S,ES=2.78,F=42.66;(29.64±9.49)S,ES=2.63,F=58.82;(66.34±15.06)S,ES=3.39,F=60.51;P〈0.001],PASAT尝试数[(36.43±9.88)个]和正确数[(31.11±11.09)个]显著低于对照组[(46.85-4-3.42)个,ES=-3.04,F=72.52:(44.15±5.08)个,ES=-2.57,F=81.10;P均〈0.001],WAIS.III数字符号得分[(59.81±15.11)分]显著低于对照组[(91.13±10.87)分,ES=-2.88,F=179.33,P〈0.001],病例组BVMT—R测试各项得分显著低于对照组(P〈0.050)。结论精神分裂症首次发病患者神经认知功能全面受损。 | 刘娜 陆峥 盛建华 张洁 黄楠 何磊英 杨程青 陈发展 Goorah Deenoo Bharathi Anisha Heeramun-Aubeeluck 熊祥玉 应颖 薛振康 郭珍 骆艳丽 江学锋 于欣 | 2013 | 中华精神科杂志2013，46，2： | 18 |
| 3 | 大学生中精神病风险综合征的早期识别与临床特征显示文摘目的:探索大学生人群中精神病风险综合征(PRS)的发生率和临床特征。方法:第1阶段使用16条目前驱期问卷(PQ-16)对579名在校本科生进行筛查,PQ-16阳性以及随机选取的阴性对照进入第2阶段的精神病风险综合征结构式访谈(SIPS),建立PRS诊断。最后使用简明国际神经精神访谈(M.I.N.I)对符合诊断的PRS个体进行访谈,评估共病情况。结果:PRS的检出率约为3.5%。精神病风险症状特征表现为轻微阳性症状多于其他症状,其中最常见的是'异常思维内容'(65%)和'知觉异常/幻觉'(50%)。检出的PRS者目前或既往共病至少1种精神障碍的比例为63.2%,其中抑郁障碍(31.6%)和特定恐惧症(31.6%)最多见。结论:大学生人群中存在一定比例的精神病风险综合征个体,与焦虑障碍和抑郁障碍的共病现象较为普遍。 | 陈发展 王璐 袁加贝 史靖宇 HEERAMUN-AUBEELUCK Anisha 赵旭东 | 2013 | 中国心理卫生杂志2013，27，10： | 10 |
| 4 | 精神分裂症首次发病患者治疗依从性的影响因素分析及1年随访显示文摘目的:探讨首发精神分裂症患者服药依从性的变化情况及影响因素。方法:采用阳性和阴性症状量表(PANSS)、UKU不良反应量表和服药态度量表(DAI)在治疗前和治疗6个月、治疗12个月对103例精神分裂症患者进行评估,并用线性回归的方法筛选对依从性产生影响的相关因素。结果:治疗12个月时,线性回归分析显示文化程度、精神症状改善情况、不良反应及婚姻与依从性有关(P<0.05或P<0.01)。治疗6个月时,DAI总分较基线时升高(P<0.01),治疗12个月,DAI总分较治疗6个月时下降(P<0.01)。结论:受教育程度高、家庭支持好、治疗后症状改善明显、药物不良反应较小的首发精神分裂症患者总体依从性较好;患者的服药依从性随时间推移而逐渐降低。 | 张洁 陆峥 盛建华 刘娜 黄楠 何磊英 杨程青 熊祥玉 应颖 薛振康 郭珍 骆艳丽 陈发展 Goorah Deenoo Bharathi Anisha Heeramun-Aubeeluck | 2014 | 临床精神医学杂志2014，24，5： | 8 |
| 5 | In vivo imaging of structural,metabolic and functional brain changes in glaucoma显示文摘Glaucoma, the world's leading cause of irreversible blindness, is a condition for which elevated intraocular pressure is currently the only modifiable risk factor. However, the disorder can continue to progress even at reduced intraocular pressure. This indicates additional key factors that contribute to the etiopathogenesis. There has been a growing amount of literature suggesting glaucoma as a neurodegenerative disease of the visual system. However, it remains debatable whether the observed pathophysiological conditions are causes or consequences. This review summarizes recent in vivo imaging studies that helped advance the understanding of early glaucoma involvements and disease progression in the brains of humans and experimental animal models. In particular, we focused on the non-invasive detection of early structural and functional brain changes before substantial clinical visual field loss in glaucoma patients; the eye-brain interactions across disease severity; the metabolic changes occurring in the brain's visual system in glaucoma; and, the widespread brain involvements beyond the visual pathway as well as the potential behavioral relevance. If the mechanisms of glaucomatous brain changes are reliably identified, novel neurotherapeutics that target parameters beyond intraocular pressure lowering can be the promise of the near future, which would lead to reduced prevalence of this irreversible but preventable disease. | Anisha Kasi Muneeb A.Faiq Kevin C.Chan | 2019 | Neural Regeneration Research2019，14，3： | 3 |
| 6 | Bacterial extracellular vesicle applications in cancer immunotherapy显示文摘Cancer therapy is undergoing a paradigm shift toward immunotherapy focusing on various approaches to activate the host immune system.As research to identify appropriate immune cells and activate anti-tumor immunity continues to expand,scientists are looking at microbial sources given their inherent ability to elicit an immune response.Bacterial extracellular vesicles(BEVs)are actively studied to control systemic humoral and cellular immune responses instead of using whole microorganisms or other types of extracellular vesicles(EVs).BEVs also provide the opportunity as versatile drug delivery carriers.Unlike mammalian EVs,BEVs have already made it to the clinic with the meningococcal vaccine(Bexsero®).However,there are still many unanswered questions in the use of BEVs,especially for chronic systemically administered immunotherapies.In this review,we address the opportunities and challenges in the use of BEVs for cancer immunotherapy and provide an outlook towards development of BEV products that can ultimately translate to the clinic. | Kanika Suri Anisha D’Souza Di Huang Aashray Bhavsar Mansoor Amiji | 2023 | Bioactive Materials2023，，4： | 2 |
| 7 | Delayed atomoxetine or fluoxetine treatment coupled with limited voluntary running promotes motor recovery in mice after ischemic stroke显示文摘Currently, there is an unmet need for treatments promoting post-stroke functional recovery.The aim of this study was to evaluate and compare the dose-dependent effect of delayed atomoxetine or fluoxetine therapy(starting on post-stroke day 5), coupled with limited physical exercise(2 hours daily voluntary wheel running;post-stroke days 9 to 42), on motor recovery of adult male mice after photothrombotic stroke.These drugs are selective norepinephrine or serotonin reuptake inhibitors indicated for disorders unrelated to stroke.The predetermined primary end-point for this study was motor function measured in two tasks of spontaneous motor behaviors in grid-walking and cylinder tests.Additionally, we quantified the running distance and speed throughout the study, the number of parvalbumin-positive neurons in the medial agranular cortex and infarct volumes.Both sensorimotor tests revealed that neither limited physical exercise nor a drug treatment alone significantly facilitated motor recovery in mice after stroke.However, combination of physical exercise with either of the drugs promoted restoration of motor function by day 42 post-stroke, with atomoxetine being a more potent drug.This was accompanied by a significant decrease in parvalbumin-positive inhibitory interneurons in the ipsilateral medial agranular cortex of mice with recovering motor function, while infarct volumes were comparable among experimental groups.If further validated in larger studies, our observations suggest that add-on atomoxetine or fluoxetine therapy coupled with limited, structured physical rehabilitation could offer therapeutic modality for stroke survivors who have difficulty to engage in early, high-intensity physiotherapy.Furthermore, in light of the recently completed Assessment o F Fluoxet INe In s Troke recover Y(AFFINITY) and Efficacy o F Fluoxetine-a randomis Ed Controlled Trial in Stroke(EFFECTS) trials, our observations call for newly designed studies where fluoxetine or atomoxetine pharmacotherapy is evaluated in combination with structured physical rehabilitation rather than alone.This study was approved by the Texas Tech University Health Sciences Center Institutional Animal Care and Use Committee(protocol # 16019). | Faisal F.Alamri Abdullah Al Shoyaib Nausheen Syeara Anisha Paul Srinidhi Jayaraman Serob T.Karamyan Thiruma V.Arumugam Vardan T.Karamyan | 2021 | Neural Regeneration Research2021，16，7： | 2 |
| 8 | Nuclear Factor (Erythroid-Derived 2)-Like-2 Factor (Nrf2), a Key Regulator of the Antioxidant Response to Protect Against Atherosclerosis and Nonalcoholic Steatohepatitis显示文摘 | Anisha A. Gupte Christopher J. Lyon Willa A. Hsueh | 2013 | Current Diabetes Reports2013，，3： | 2 |
| 9 | 首次发病的青少年精神分裂症患者执行功能的研究显示文摘目的:探讨首次发病的青少年精神分裂症患者执行功能及其与精神症状的关系。方法:采用威斯康星卡片分类测验(WCST)及韦克斯勒记忆量表第3版(WMS-Ⅲ)空间广度测验测试75例首次发病的青少年精神分裂症患者(病例组)和80名健康对照者(对照组)的执行功能;病例组同时应用阳性和阴性症状量表(PANSS)评定病情。结果:病例组WCST的错误总数、持续反应数和持续错误数显著高于对照组,正确总数显著低于对照组(P均<0.01);WMS-Ⅲ总分和空间广度逆行分显著低于对照组(P均<0.05)。病例组PANSS阴性症状分与WMS-Ⅲ空间广度逆行分及总分负相关(r=-0.276,r=-0.230;P均<0.05);阳性症状分与WCST完成分类数负相关(r=-0.258,P<0.05);一般病理学总分与WMS-Ⅲ空间广度逆行分负相关(r=-0.244,P<0.05)。结论:首次发病的青少年精神分裂症患者执行功能显著受损,并与病情有关。 | 刘娜 陆峥 盛建华 张洁 黄楠 何磊英 杨程青 陈发展 Goorah Deenoo Bharathi Anisha Heeramun-Aubeeluck 熊祥玉 应颖 薛振康 郭珍 骆艳丽 江学锋 于欣 | 2013 | 临床精神医学杂志2013，23，4： | 2 |
| 10 | Effects on startle responses in neonatally MSG-treated rats显示文摘 | YANG F C JOLIEN CONNOR ANISHA PATEL | 2000 | Physiology & Behavior2000，69，3： | 1 |
| 11 | Micro and maeroalgal biomass: a renewable source for bioethanol 显示文摘 | John RP Anisha GS Narnpoothiri KM | 2011 | Bioresource Technology2011，102，： | 1 |
| 12 | Reduction of non-digestible oligosaccharides in horse gram and green gram flours using crude c-galactosidase from Streptomyces griseoloalbus显示文摘 | Anisha G S Prema P | 2008 | Food Chemistry2008，106，： | 1 |
| 13 | Chitosan- hyaluronie aeid/VEGF loaded fibrin nanopartieles composite sponges for enhancing angiogenesis in wounds显示文摘 | Mohandas A Anisha BS Chennazhi KP | 2015 | Colloids Surf B Biointerfaees2015，127，： | 1 |
| 14 | Cell immobilization technique for the enhanced production of α-galactosidaze by Streptomyees griseoloalbus显示文摘 | Anisha G S Prema P | 2008 | Bioresource Technology2008，99，9： | 1 |
| 15 | Hydrolysis of pectin: An enzymatic approach and its application in banana fiber processing显示文摘 | Jacob N Niladevi K N Anisha G S | 2008 | Microbiological Research2008，163，2： | 1 |
| 16 | Metallophthalocyanine coated porous silicon gas sensor selective to NO 2显示文摘 | Gokarna Anisha | 2003 | Sensors and Actuators B2003，92，： | 1 |
| 17 | Metal sensitivity to Elektra prostheses-two cases from a metal on metal implant for hand joint replacement 显示文摘 | Emma S Anisha JM Barry NS | 2009 | Contact Dermatitis2009，60，： | 1 |
| 18 | Micro and macroalgal biomass:A renewable source for bioethanol显示文摘 | ROJAN P J ANISHA G S NAMPOOTHIRI K M | 2011 | Bioresource Technology2011，102，3： | 1 |
| 19 | Internal hemorrhoid harboring adenocarcinoma:A case report显示文摘BACKGROUND The incidence of carcinoma found within an internal hemorrhoid specimen is exceptionally rare.Further,the presence of primary anal canal adenocarcinoma within internal hemorrhoids is even more infrequent.We describe a case in which anal canal adenocarcinoma was found within an internal hemorrhoidectomy specimen and perform a review of the current literature.CASE SUMMARY The patient was a 79-year-old male who presented with rectal bleeding and was found to have large thrombosed internal hemorrhoids during screening colonoscopy.The patient subsequently underwent a three-column hemorrhoidectomy.Pathologic analysis revealed one of three specimens containing a 1.5 cm moderate-to-poorly differentiated adenocarcinoma of anal origin with superficial submucosal invasion.At three-month follow up,he was taken to the operating theatre for biopsy and re-excision of his non-healing wound,which showed no recurrence.His wound has since healed and he was cancer free at ten-month follow up.CONCLUSION When faced with primary anal canal adenocarcinoma an interdisciplinary approach to treatment should be considered.Routine pathological analysis of hemorrhoidectomy specimens may be beneficial due to the severity of anal canal carcinomas if left undiagnosed and untreated in a timely manner. | Michael L Caparelli Jason C Batey Anisha Tailor Timothy Braverman Cory Barrat | 2021 | World Journal of Gastrointestinal Oncology2021，13，1： | 1 |
| 20 | Coordinated multitissue transcriptional and plasma metabonomic profiles following acute caloric restriction in mice显示文摘 | COLIN S NICOLA D K ANISHA C | 2006 | Physiological Genomics2006，27，6： | 1 |
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