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| 1 | 由两倍汽球 enteroscopy 的小肠 polypectomy : 与优先的囊内视镜检查法的关联显示文摘 AIM:To investigate the feasibility of small bowel polypectomy using double balloon enteroscopy and to evaluate the correlation with capsule endoscopy(CE).METHODS:This is a retrospective review of a single tertiary hospital.Twenty-five patients treated by enteroscopy for small bowel polyps diagnosed by CE or other imaging techniques were included.The correlation between CE and enteroscopy(correlation coefficient of Kendall for the number of polyps,intra-class coefficient for the size and coefficient of correlation kappa for the location) was evaluated.RESULTS:There were 31 polypectomies and 12 endoscopic mucosal resections with limited morbidity and no mortality.Histological analysis revealed 27 hamartomas,6 adenomas and 3 lipomas.Strong agreement between CE and optical enteroscopy was observed for both location(Kappa value:0.90) and polyp size(Kappa value:0.76),but only moderate agreement was found for the number of polyps(Kendall value:0.47).CONCLUSION:Double balloon enteroscopy is safe for performing polypectomy.Previous CE is useful in selecting the endoscopic approach and to predicting the difficulty of the procedure. | Gabriel Rahmi Elia Samaha Camille Lorenceau-Savale Bruno Landi Joёl Edery Thibault Manière Jean-Marc Canard Georgia Malamut Gilles Chatellier Christophe Cellier | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，5： | 3 |
| 2 | Intensified chemotherapy with ACVBP plus rituximab versus standard CHOP plus rituximab for the treatment of diffuse large B-cell lymphoma (LNH03-2B): an open-label randomised phase 3 trial显示文摘 | Christian Récher Bertrand Coiffier Corinne Haioun Thierry Jo Molina Christophe Fermé Olivier Casasnovas Catherine Thiéblemont André Bosly Guy Laurent Franck Morschhauser Hervé Ghesquières Fabrice Jardin Serge Bologna Christophe Fruchart Bernadette Corront | 2011 | 2011 (9806)2011，，9806： | 2 |
| 3 | NT157 has antineoplastic effects and inhibits IRS1/2 and STAT3/5 in JAK2^(V617F)-positive myeloproliferative neoplasm cells显示文摘Recent data indicate that IGF1R/IRS signaling is a potential therapeutic target in BCR-ABL1-negative myeloproliferative neoplasms(MPN);in this pathway,IRS2 is involved in the malignant transformation induced by JAK2^(V617F),and upregulation of IGF1R signaling induces the MPN phenotype.NT157,a synthetic compound designed as an IGF1R-IRS1/2 inhibitor,has been shown to induce antineoplastic effects in solid tumors.Herein,we aimed to characterize the molecular and cellular effects of NT157 in JAK2^(V617F)positive MPN cell lines(HEL and SET2)and primary patient hematopoietic cells.In JAK2^(V617F)cell lines,NT157 decreased cell viability,clonogenicity,and cell proliferation,resulting in increases in apoptosis and cell cycle arrest in the G2/M phase(p<0.05).NT157 treatment inhibited IRS1/2,JAK2/STAT,and NFκB signaling,and it activated the AP-1 complex,downregulated four oncogenes(CCND1,MYB,WT1,and NFKB1),and upregulated three apoptotic-related genes(CDKN1A,FOS,and JUN)(p<0.05).NT157 induced genotoxic stress in a JAK2/STAT-independent manner.NT157 inhibited erythropoietin-independent colony formation in cells from polycythemia vera patients(p<0.05).These findings further elucidate the mechanism of NT157 action in a MPN context and suggest that targeting IRS1/2 proteins may represent a promising therapeutic strategy for MPN. | Bruna Alves Fenerich Jaqueline Cristina Fernandes Ana Paula Nunes Rodrigues Alves Juan Luiz Coelho-Silva Renata Scopim-Ribeiro Priscila Santos Scheucher Christopher A.Eide Cristina E.Tognon Brian J.Druker Eduardo Magalhães Rego João Agostinho Machado-Neto Fabiola Traina | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 2 |
| 4 | Combining non-thermal plasma with heterogeneous catalysis in waste gas treatment: A review显示文摘 | Jim Van Durme Jo Dewulf Christophe Leys Herman Van Langenhove | 2007 | Applied Catalysis B Environmental2007，，3： | 2 |
| 5 | 紫硫镍矿交代镍黄铁矿的水热反应机理及动力学显示文摘本工作首次在实验室条件下对浅生区紫硫镍矿(Ni,Fe)3S4交代镍黄铁矿(Ni,Fe)9S8水热反应的机理及动力学进行了研究。起始反应矿物采用高纯自然镍黄铁矿,合成纯镍黄铁矿或合成镍黄铁矿-磁黄铁矿集合体。反应pH值采用0.2M醋酸-醋酸纳缓冲溶液控制在3~5的范围内。反应进程由X-射线衍射物相定量分析及扫描电镜观察进行跟踪。结果表明,当反应温度恒定在80℃时,交代20(4)%的镍黄铁矿需792h。相同条件下加入少量H2S可将反应速率提高一倍。当反应在125℃饱和蒸汽压水热环境下进行时,完全交代纯镍黄铁矿需约168h。此过程由于磁黄铁矿的存在而被催化,交代集合体中的镍黄铁矿仅需68h,进一步反应磁黄铁矿被交代成白铁矿。磁黄铁矿的催化作用可能源于溶解产生的微裂纹加速了流体的传质过程。当反应温度升高至145℃时,速率反而下降,不遵循Arrhenius经验规律。动力学分析得80℃速率常数介于5.8×10-8~3.0×10-7/s之间,125℃及145℃速率常数分别介于2.8×10-6~2.08×10-5/s及1×10-6~5.1×10-6/s之间,远高于同温度下固相扩散反应的速率常数,表明该反应在地质时标上为一快速反应。此外,用背散射电子显微技术对矿物表面形貌进行了分析,发现交代产物紫硫镍矿具有颗粒细小及存在微裂纹等特征,与自然界浅生矿床中的紫硫镍矿非常相似;电镜实验还表明该交代作用是一个典型的耦合溶解-再沉淀反应。其耦合机制的驱动力可能与反应界面处微空隙对流体饱和度的控制有关。 | 夏方 陈国荣 Allan PRING Joёl BRUGGER Yung NGOTHAI Brain O'NEILL Chris COLBY Christophe TENAILLEAU 王海鹏 杨云霞 | 2007 | 地质学报2007，81，10： | 2 |
| 6 | Turbo equalization:adaptive equalization and channel decoding jointly optimized显示文摘 | Laot Christophe Glavieux Alain Labat Joěl | 2001 | IEEE JSAC2001，9，19： | 1 |
| 7 | Capsule Endoscopy or Push Enteroscopy for First-Line Exploration of Obscure Gastrointestinal Bleeding?显示文摘 | Antoine de Leusse Kouroche Vahedi Jo?l Edery Djamel Tiah Elisabeth Fery–Lemonnier Christophe Cellier Yoram Bouhnik Raymond Jian | 2007 | Gastroenterology2007，，3： | 1 |
| 8 | Results of a clinical phase I dose-escalation study of cytarabinein combination with fixed-dose vinorelbine, paclitaxel, etoposideand cisplatin for the treatment of relapsed/refractory lymphoma显示文摘 | Sagar Lonial Martha Arellano Donald Hutcherson Amelia Langston Christopher Flowers L. T. Heffner Elliott Winton Mary Jo Lechowicz Edmund K. Waller | 2006 | Leukemia & Lymphoma2006，，10： | 1 |
| 9 | Combining non-thermal plasma with heterogeneous catalysis in waste gas treatment: A review显示文摘 | Jim Van Durme Jo Dewulf Christophe Leys Herman Van Langenhove | 2007 | Applied Catalysis B Environmental2007，，3： | 1 |
| 10 | Combining non- thermal plasma with heterogeneous catalysis in waste gas treatment: A review显示文摘 | JIM V D JO D CHRISTOPHE L | 2008 | Applied Catalysis B: Envi- ronmental2008，78，： | 1 |
| 11 | Oxygenated polycyclic aromatic hydrocarbons in atmospheric particulate matter: Molecular characterization and occurrence显示文摘 | Christophe Walgraeve Kristof Demeestere Jo Dewulf Ralf Zimmermann Herman Van Langenhove | 2009 | Atmospheric Environment2009，，15： | 1 |
| 12 | Human resources for health: overcoming the crisis显示文摘 | Lincoln Chen Timothy Evans Sudhir Anand Jo Ivey Boufford Hilary Brown Mushtaque Chowdhury Marcos Cueto Lola Dare Gilles Dussault Gijs Elzinga Elizabeth Fee Demissie Habte Piya Hanvoravongchai Marian Jacobs Christoph Kurowski Sarah Michael Ariel Pablos-Men | 2004 | The Lancet . 2004 (9449)2004，，： | 1 |
| 13 | Association between the UGT1 Al * 28 allele, bilirubin levels, and coronary heart disease in the framingham heart study 显示文摘 | Lin JP Christopher JO Johannes PS | 2006 | Circulation2006，114，14： | 1 |
| 14 | Environmental contaminants and biomarker responses in fish from the Columbia River and its tributaries: Spatial and temporal trends 显示文摘 | Jo Ellen Hinck Christopher J Schmitt Vicki S Blazer | 2006 | Sci Total Environ2006，366，23： | 1 |
| 15 | Degradation of an azo dye orange Ⅱ using a gas phase dielectric barrier discharge reactor submerged in water显示文摘 | Yong S M Jo J O Christopher W | | 0，，： | 1 |
| 16 | Association between the UGT1A1*28 allele,bilirubin levels,and coronary heart disease in the Framingham heart study显示文摘 | Lin JP Christopher JO Johannes PS | 2006 | Circulation2006，114，14： | 1 |
| 17 | Intensified chemotherapy with ACVBP plus rituximab versus standard CHOP plus rituximab for the treatment of diffuse large B-cell lymphoma (LNH03-2B): an open-label randomised phase 3 trial显示文摘 | Christian Récher Bertrand Coiffier Corinne Haioun Thierry Jo Molina Christophe Fermé Olivier Casasnovas Catherine Thiéblemont André Bosly Guy Laurent Franck Morschhauser Hervé Ghesquières Fabrice Jardin Serge Bologna Christophe Fruchart Bernadette Corront | 2011 | The Lancet . 2011 (9806)2011，，： | 1 |
| 18 | Influence of Sputtering Conditions on Corrosion of Sputtered W-Ti-N Thin Film Hard Coatings:sah Spray Tests and Image Analysis 显示文摘 | Jo a o C O Albano Cavaleiro Christopher M A B | 2000 | Corrosion Science2000，，42： | 1 |
| 19 | Incidence and outcomes of the peripheral T-cell lymphoma subtypes in the United States显示文摘 | Abeer N. Abouyabis Pareen J. Shenoy Mary Jo Lechowicz Christopher R. Flowers | 2008 | Leukemia & Lymphoma2008，，11： | 1 |
| 20 | Accuracy of Physical Activity Monitors in Pregnant Women显示文摘 | CHRISTOPHER P. CONNOLLY DAWN P. COE JO M. KENDRICK DAVID R. BASSETT DIXIE L. THOMPSON | 2011 | Medicine & Science in Sports & Exercise2011，，6： | 1 |
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