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| 1 | Growth differentiation factor-15 combined with N-terminal prohormone of brain natriuretic peptide increase 1-year prognosis prediction value for patients with acute heart failure: a prospective cohort study显示文摘Background:Clinical assessment and treatment guidance for heart failure depends on a variety of biomarkers.The objective of this study was to investigate the prognostic predictive value of growth differentiation factor-15(GDF-15)and N-terminal prohormone of brain natriuretic peptide(NT-proBNP)in assessing hospitalized patients with acute heart failure(AHF).Methods:In total,260 patients who were admitted for AHF in the First Affiliated Hospital of Nanjing Medical University were enrolled from April 2012 to May 2016.Medical history and blood samples were collected within 24 h after the admission.The primary endpoint was the all-cause mortality within 1 year.The patients were divided into survival group and death group based on the endpoint.With established mortality risk factors and serum GDF-15 level,receiver-operator characteristic(ROC)analyses were performed.Cox regression analyses were used to further analyze the combination values of NT-proBNP and GDF-15.Results:Baseline GDF-15 and NT-proBNP were significantly higher amongst deceased than those in survivors(P<0.001).In ROC analyses,area under curve(AUC)for GDF-15 to predict 1-year mortality was 0.707(95%confidence interval[CI]:0.648–0.762,P<0.001),and for NT-proBNP was 0.682(95%CI:0.622–0.738,P<0.001).No statistically significant difference was found between the two markers(P=0.650).Based on the optimal cut-offs(GDF-15:4526.0 ng/L;NT-proBNP:1978.0 ng/L),the combination of GDF-15 and NT-proBNP increased AUC for 1-year mortality prediction(AUC=0.743,95%CI:0.685–0.795,P<0.001).Conclusions:GDF-15,as a prognostic marker in patients with AHF,is not inferior to NT-proBNP.Combining the two markers could provide an early recognition of high-risk patients and improve the prediction values of AHF long-term prognosis.Clinical trial registration:ChiCTR-ONC-12001944,http://gffzz62a03ee25e6f4a77hxc5q9kw0wf0o6kc0.ffgz.tsg.suse.edu.cn. | Ji Hao Iokfai Cheang Li Zhang Kai Wang Hui-Min Wang Qian-Yun Wu Yan-Li Zhou Fang Zhou Dong-Jie Xu Hai-Feng Zhang Wen-Ming Yao Xin-Li Li | 2019 | Chinese Medical Journal2019，，19： | 8 |
| 2 | Using Imbalanced Triangle Synthetic Data for Machine Learning Anomaly Detection显示文摘The extreme imbalanced data problem is the core issue in anomaly detection.The amount of abnormal data is so small that we cannot get adequate information to analyze it.The mainstream methods focus on taking fully advantages of the normal data,of which the discrimination method is that the data not belonging to normal data distribution is the anomaly.From the view of data science,we concentrate on the abnormal data and generate artificial abnormal samples by machine learning method.In this kind of technologies,Synthetic Minority Over-sampling Technique and its improved algorithms are representative milestones,which generate synthetic examples randomly in selected line segments.In our work,we break the limitation of line segment and propose an Imbalanced Triangle Synthetic Data method.In theory,our method covers a wider range.In experiment with real world data,our method performs better than the SMOTE and its meliorations. | Menghua Luo Ke Wang Zhiping Cai Anfeng Liu Yangyang Li Chak Fong Cheang | 2019 | Computers, Materials & Continua2019，，1： | 4 |
| 3 | Method of delivery and pregnancy outcomes in Asia: the WHO global survey on maternal and perinatal health 2007–08显示文摘 | Pisake Lumbiganon Malinee Laopaiboon A Metin Gülmezoglu Jo?o Paulo Souza Surasak Taneepanichskul Pang Ruyan Deepika Eranjanie Attygalle Naveen Shrestha Rintaro Mori Nguyen Duc Hinh Hoang Thi Bang Tung Rathavy Kang Chuyun Kannitha Cheang Mario Festin Venus | 2010 | The Lancet2010，，9713： | 2 |
| 4 | Micro Manipulation Using Magnetic Microrobots显示文摘 | Hoyeon Kim Jamel Ali U Kei Cheang Jinwoo Jeong din Seok Kim Min dun Kim | 2016 | Journal of Bionic Engineering2016，13，4： | 2 |
| 5 | Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock显示文摘 | Anand Kumar Daniel Roberts Kenneth E. Wood Bruce Light Joseph E. Parrillo Satendra Sharma Robert Suppes Daniel Feinstein Sergio Zanotti Leo Taiberg David Gurka Aseem Kumar Mary Cheang | 2006 | Critical Care Medicine2006，，6： | 2 |
| 6 | Breast cancer subtypes and response to docctaxel in node-positive breast cancer: use of an immunohistochemical definition in the BCIRG 001 trial显示文摘 | Hugh J Hanson J Cheang MC | 2009 | J Clin Oucol2009，27，8： | 1 |
| 7 | Ki67 index, HER2 status, and prognosis of patients with luminal B breast cancer显示文摘 | Cheang MC Chia SK Voduc D | 2009 | J Natl Cancer Inst2009，101，10： | 1 |
| 8 | Prognostic significance of progesterone receptor-positive tumor cells within immunohis- tochemically defined luminal a breast cancer 显示文摘 | Prat A Cheang MC Martin M | 2013 | J Clin On- col2013，31，2： | 1 |
| 9 | Survival benefit of metas- tasectomy for Krukenberg tumors from gastric cancer显示文摘 | Cheang JH Hyung WJ Chen J | 2004 | Gynecol Oncol2004，94，2： | 1 |
| 10 | Ki-67 index,HER-2 status,and prognosis of patients with luminal B breast cancer显示文摘 | Cheang MCU Chia SK David V | 2009 | J Natl Cancer Inst2009，101，10： | 1 |
| 11 | Delayed onset muscle soreness: treatment strategies and performance factors 显示文摘 | Cheang K Hume P Maxwell L | 2003 | Sports Med2003，33，2： | 1 |
| 12 | Assessment ofTopoisomerase II alpha status in breast cancer by quantitativePCR,gene expression microarrays,immunohistochemistry,andfluorescence in situ hybridization显示文摘 | Romero A Martin M Cheang MC | 2011 | Am J Pathol2011，178，4： | 1 |
| 13 | Evaluation of immunohistochemical markers in non-small cell lung cancer by unsupervised hierarchical clustering analysis:a tissue microarray study of 284 cases and 18 markers显示文摘 | Au NH Cheang M Huntsman DG | | 0，，： | 1 |
| 14 | Titanium dioxide reinforced hydroxyapa- tite coatings deposited by high velocity oxy-fuel (HVOF) spray显示文摘 | Li H Khor KA Cheang P | 2002 | Biomaterials2002，23，1： | 1 |
| 15 | Mechanical properties of injection molded hydroxyapatite-polyetheretherketone biocomposites显示文摘 | M S Abu Bakar P Cheang K A Khor | 2003 | Composites Science and Technology2003，63，： | 1 |
| 16 | MDM2 protein expression is a negative prognostic marker in breast carcinoma 显示文摘 | Turbin DA Cheang MC Bajdik CD | 2006 | Mod- Patho2006，19，1： | 1 |
| 17 | Thermal Sprayed Hydroxyapatite Splats: Nanostructures, Pore Fformation Mechanism and TEM Charaeterization显示文摘 | Li H Khor K A Cheang P | 2004 | Biomaterials2004，25，： | 1 |
| 18 | Invasive fungal disease in adult undergoing remlssion-induction therapy for acute myeloid leukemia: the pathogenic role of the antileukemic regimen 显示文摘 | Bow EJ Loewen R Cheang MS | 1995 | Clin Infect Dis1995，21，2： | 1 |
| 19 | Glycoprotein Ⅱb/Ⅲa a receptor inhibitors in pereutan coronary intervention and acute coronary syndrome显示文摘 | Crouch MA Nappi JM Cheang KI | 2003 | Ann Pharmacother2003，37，6： | 1 |
| 20 | Defining the predictors of the placebo response in irritable bowel syndrome 显示文摘 | Pitz M Cheang M Bemstein CN | 2005 | Ciin Gastmenterol Hepato12005，3，2： | 1 |
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