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| 1 | Identifying high-risk individuals for gastric cancer surveillance from western and eastern perspectives: Lessons to learn and possibility to develop an integrated approach for daily practice显示文摘Current evidence shows that individuals with gastric dysplasia, severe and extensive gastric atrophy, extensive gastric intestinal metaplasia and the incomplete subtype of intestinal metaplasia are at high risk for gastric cancer(GC) development. There are several approaches to identifying these subjects,including noninvasive methods, esophagogastroduodenoscopy and histology.The main approach in Western countries is histology-based while that in Eastern countries with a high prevalence of GC is endoscopy-based. Regarding asymptomatic individuals, the key issues in selecting applicable approaches are the ability to reduce GC mortality and the cost-effectiveness of the approach. At present, population-based screening programs have only been applied in a few Asian countries with a high risk of GC. Pre-endoscopic risk assessment based on demographic and clinical features, such as ethnicity, age, gender, smoking and Helicobacter pylori status, is helpful for identifying subjects with high pre-test probability for a possibly cost-effective approach, especially in intermediate-and low-risk countries. Regarding symptomatic patients with indications for esophagogastroduodenoscopy, the importance of opportunistic screening should be emphasized. The combination of endoscopic and histological approaches should always be considered as endoscopy provides a real-time assessment of the patient’s risk level. In addition, imaging enhanced endoscopy(IEE) has been shown to facilitate targeted biopsies resulting in better correlation between endoscopic and histological findings. Currently, the use of IEE is recommended for endoscopic examinations, and the Operative Link for Gastric Intestinal Metaplasia or Operative Link on Gastritis Assessment grading systems are recommended for histological examinations whenever available. However,resource limitations are an important barrier in many regions worldwide. Thus,for an approach to be applicable in real-life practice, it should be not only evidence-based but also resource-sensitive. In this review, we discuss the current understanding and approaches to identifying high-risk individuals from western and eastern perspectives, as well as the possibility of an integrated, resourcesensitive approach. | Duc Trong Quach Toru Hiyama Takuji Gotoda | 2019 | World Journal of Gastroenterology2019，25，27： | 18 |
| 2 | Gene and mutation independent therapy via CRISPR-Cas9 mediated cellular reprogramming in rod photoreceptors显示文摘 | Zhu, Jie Ming, Chang Fu, Xin Duan, Yaou Duc Anh Hoang Rutgard, Jeffrey Zhang, Runze Wang, Wenqiu Hou, Rui Zhang, Daniel Zhang, Edward Zhang, Charlotte Hao, Xiaoke Xiong, Wenjun Zhang, Kang | 2017 | Cell Research2017，27，6： | 11 |
| 3 | 不同含水状态下基床级配碎石填料变形特性研究显示文摘基床级配碎石在外界雨水侵入时含水状态发生改变对其变形特性不利,从而影响行车安全,但目前研究含水率对基床级配碎石变形特性的成果甚少,为进一步揭示不同含水状态下基床级配碎石的变形特性,对不同含水率的级配碎石试样开展了多组大型静动三轴试验。首先,通过静三轴试验探讨了含水率对级配碎石应力-应变关系和强度特性的影响;然后,基于动三轴试验,重点研究了含水率、动应力水平对累积应变随荷载作用次数发展规律的影响;在此基础上,建立了综合考虑含水率、荷载作用次数、动应力水平相互耦合作用的累积应变预测模型。基于含水率为5.0%和7.3%的累积应变试验结果,确定了模型中的待定参数,通过含水率为8.6%的试验结果验证了其正确性和合理性,此模型不仅克服了不同动应力水平下累积应变计算模型的分散性,而且能够直观地体现出含水率对累积应变的影响。 | 刘宝 PHAM Duc Phong 苏谦 桂波 | 2016 | 岩土力学2016，37，5： | 10 |
| 4 | 不同含水状态级配碎石临界动应力及变形规律研究显示文摘为评估含水率变化对高速铁路无砟轨道基床表层级配碎石动力性能的影响,本文针对最优含水率和饱和含水率两种状态下级配碎石循环动力性能开展室内大型动三轴试验研究,分析级配碎石的临界动应力和累积变形特性。研究表明:累积变形与荷载作用次数、含水率关系密切,荷载作用次数超过10 000次后,含水率的影响逐渐显现,荷载作用次数达到20 000次时,饱和含水率的累积变形相对最优含水率增大70%;不同含水率级配碎石的衰减型和破坏型累积变形曲线可分别用Stewart模型和Monismith模型预测;级配碎石临界动应力随含水率增大而减小,随围压的增大线性增大,饱和含水状态对应的临界动应力较最优含水状态平均小13%。 | 刘宝 苏谦 PHAM Duc Phong 白皓 LAM Thi Huyen Hanh | 2016 | 铁道学报2016，38，6： | 10 |
| 5 | Global Robust and Adaptive Output Feedback Dynamic Positioning of Surface Ships显示文摘A constructive method was presented to design a global robust and adaptive output feedback controller for dynamic positioning of surface ships under environmental disturbances induced by waves, wind, and ocean currents. The ship's parameters were not required to be known. An adaptive observer was first designed to estimate the ship's velocities and parameters. The ship position measurements were also passed through the adaptive observer to reduce high frequency measurement noise from entering the control system. Using these estimate signals, the control was then designed based on Lyapunov's direct method to force the ship's position and orientation to globally asymptotically converge to desired values. Simulation results illustrate the effectiveness of the proposed control system. In conclusion, the paper presented a new method to design an effective control system for dynamic positioning of surface ships. | Khac Duc Do | 2011 | Journal of Marine Science and Application2011，10，3： | 10 |
| 6 | 方解石原位U-Pb测年结合磷灰石裂变径迹方法约束鄂尔多斯盆地西南部构造演化显示文摘鄂尔多斯盆地下古生界油气资源丰富,盆地西南部下古生界海相碳酸盐岩地层沉积厚度大、有机质丰度较高,烃源岩热演化达到过成熟生干气阶段,但是构造演化缺乏深入研究,早期构造事件具体时限是一个亟待解决的关键科学问题。在详细的野外调查、显微结构特征、原位微量元素分析和区域沉积-埋藏演化历史的约束下,结合下古生界碳酸盐岩地层及其断裂破碎带内次生方解石原位U-Pb测年与磷灰石裂变径迹时间-温度曲线模拟结果,揭示了鄂尔多斯盆地西南部晚奥陶世、晚三叠世、晚侏罗世和早白垩世末期—新生代以来的4期构造事件。结果表明研究区晚奥陶世(452±13)Ma存在一期热液改造事件,可能与加里东期原特提斯洋俯冲闭合密切相关;印支期(214±22)Ma的断裂活动是引起区域构造-热事件的重要原因,印支期构造事件规模有限;燕山期和喜马拉雅期构造活动强烈,造成鄂尔多斯盆地西南部大幅度隆升和强烈剥蚀。盆地西南部多阶段复杂的构造演化历史导致油气保存条件破坏严重,对寻找古生界天然气藏不利,应重视盆地天然气保存条件的研究。研究结果对鄂尔多斯盆地古生界油气勘探工作有重要指导意义。将低温热年代学与断裂带方解石原位U-Pb定年相结合分析构造演化的新思路,为解析复杂叠合盆地盆缘带构造演化及其后期改造过程的研究提供了新途径。 | 杨鹏 任战利 Jianxin Zhao Ai Duc Nguyen Yuexing Feng 祁凯 王琨 | 2021 | 石油与天然气地质2021，42，5： | 7 |
| 7 | Stem cell-based therapy for human diseases显示文摘Recent advancements in stem cell technology open a new door for patients suffering from diseases and disorders that have yet to be treated.Stem cell-based therapy,including human pluripotent stem cells(hPsCs)and multipotent mesenchymal stem cells(MSCs),has recently emerged as a key player in regenerative medicine.hPSCs are defined as self-renewable cell types conferring the ability to differentiate into various cellular phenotypes of the human body,including three germ layers.MsCs are multipotent progenitor cells possessing self-renewal ability(limited in vitro)and differentiation potential into mesenchymal lineages,according to the International Society for Cell and Gene Therapy(ISCT).This review provides an update on recent clinical applications using either hPSCs or MSCs derived from bone marrow(BM),adipose tissue(AT),or the umbilical cord(UC)for the treatment of human diseases,including neurological disorders,pulmonary dysfunctions,metabolic/endocrine-related diseases,reproductive disorders,skin burns,and cardiovascular conditions.Moreover,we discuss our own clinical trial experiences on targeted therapies using MsCs in a clinical setting,and we propose and discuss the MSC tissue origin concept and how MSC origin may contribute to the role of MSCs in downstream applications,with the ultimate objective of facilitating translational research in regenerative medicine into clinical applications.The mechanisms discussed here support the proposed hypothesis that BM-MSCs are potentially good candidates for brain and spinal cord injury treatment,AT-MSCs are potentially good candidates for reproductive disorder treatment and skin regeneration,and UC-MsCs are potentially good candidates for pulmonary disease and acute respiratory distress svndrometreatment. | Duc M.Hoang Phuong T.Pham Trung Q.Bach Anh T.L.Ngo Quyen T.Nguyen Trang T.K.Phan Giang H.Nguyen Phuong T.T.Le Van T.Hoang Nicholas R.Forsyth Michael Heke Liem Thanh Nguyen | 2022 | Signal Transduction and Targeted Therapy2022，7，9： | 7 |
| 8 | Xanthine oxidase inhibitors from Archidendron clypearia(Jack.) I.C. Nielsen: Results from systematic screening of Vietnamese medicinal plants显示文摘Objective: To screen Vietnamese medicinal plants for xanthine oxidase(XO) inhibitory activity and to isolate XO inhibitor(s) from the most active plant. Methods: The plants materials were extracted by methanol. The active plant materials were fractionated using different organic solvents, including n-hexane, ethyl acetate, and n-butanol. Bioassay-guided fractionation and column chromatography were used to isolate compounds. The compounds structures were elucidated by analysis of spectroscopic data, including IR, MS, and NMR. Results: Three hundreds and eleven methanol extracts(CME) belonging to 301 Vietnamese herbs were screened for XO inhibitory activity. Among these plants, 57 extracts displayed XO inhibitory activity at 100 μg/m L with inhibition rates of over 50%. The extracts of Archidendron clypearia, Smilax poilanei, Linociera ramiflora and Passiflora foetida exhibited the greatest potency with IC_(50) values below 30 μg/m L. Chemical study performed on the extract of Archidendron clypearia resulted in the isolation of six compounds, including 1-octacosanol, docosenoic acid, daucosterol, methyl gallate, quercitrin and(-)-7-O-galloyltricetiflavan. The compound(-)-7-O-galloyltricetiflavan showed the most potent XO inhibitory activity with an IC_(50) value of 25.5 μmol/L. Conclusions: From this investigation, four Vietnamese medicinal plants were identified to have XO inhibitory effects with IC_(50) values of the methanol extracts below 30 μg/m L. Compound(-)-7-O-galloyltricetiflavan was identified as an XO inhibitor from Archidendron clypearia with IC_(50) value of 25.5 μmol/L. | Nguyen Thuy Duong Pham Duc Vinh Phuong Thien Thuong Nguyen Thi Hoai Le Nguyen Thanh Tran The Bach Nguyen Hai Nam Nguyen Hoang Anh | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，6： | 5 |
| 9 | 木鳖果热泵低温干燥工艺研究显示文摘木鳖果是越南的一种常见高营养水果,近年来越南木鳖果产业发展迅速,但对其干燥研究较少,本文采用热泵低温干燥的方法,对木鳖果进行了干燥研究,确定木鳖果干燥的最佳工艺参数,并分析比较干燥对营养成分的影响。结果表明:风速不变,风温越高干燥物料所需时间越短,感官评定就越差,胡萝卜素损失越大;风温不变,风速越高干燥物料所需时间越短,感官评定越差,胡萝卜素损失越大;木鳖果热泵干燥最佳工艺参数为:风温:50℃;风速:10 m/s。 | NGUYEN DINH DUC 李保国 薛雅萌 | 2014 | 制冷学报2014，35，6： | 5 |
| 10 | Value of a new stick-type rapid urine test for the diagnosis of Helicobacter pylori infection in the Vietnamese population显示文摘AIM:To assess the value of a new test for the diagnosis of Helicobacter pylori(H.pylori) infection,Rapirun H.pylori Antibody Stick(Rapirun Stick),in a Vietnamese population.METHODS:Eligible patients without previous history of H.pylori eradication were recruited.Rapid urease test(RUT) and histologic examination were used to diagnose the H.pylori infection.Patients were considered H.pylori positive when the RUT results were positive and/or the bacteria were detected histologically.Rapirun Stick tests were performed using urine samples,and the results were compared with the other 2 methods.RESULTS:We enrolled 200 patients with a mean age of 36(range,18-76) years.There were 116 females and 84 males.Of the 200 patients,111(55.5%) were diagnosed as being H.pylori positive.The sensitivity,specificity,and accuracy of the Stick test were 84.7%,89.9%,and 87.0%,respectively.There were 17(8.5%) falsenegative patients and 9(4.5%) false-positive patients.CONCLUSION:The Rapirun Stick test has high sensitivity,specificity,and accuracy for the diagnosis of H.pylori infection in the Vietnamese population.The test can be clinically applied in Vietnamese populations. | Duc T Quach Toru Hiyama Fumio Shimamoto Quang D Le Linh X Ho Nhu HT Vu Masaharu Yoshihara Naomi Uemura | 2014 | World Journal of Gastroenterology2014，20，17： | 4 |
| 11 | Double-loop Control Structure Using Proportional Resonant and Sequence-decoupled Resonant Controllers in Static Coordinates for Dynamic Voltage Restorer显示文摘Among incidents on grids,the sag/swell voltage is considered as the most frequent incident.To solve this problem,custom power devices are used.In particular,the dynamic voltage restorer(DVR)is a modern and efficient customer device.DVRs are used to mitigate voltage sag/swells and harmonics on the load bus,thus protecting the sensitive loads.The DVR is a serial compensator that applies a voltage to the point of common coupling to maintain the voltage of sensitive load at the nominal value.To improve the performance of DVRs,in this study,the control strategy of the two-stage loop circuit is implemented.The external voltage control loop uses a sequence-decoupled resonant(SDR)controller,and the inner current-control loop uses the proportional resonant(PR)controller implemented in the stationary frameαβ. | Vu Thai Hung Hongchun Shu Le Ngoc Giang Nguyen Duc The | 2019 | Chinese Journal of Electrical Engineering2019，5，3： | 4 |
| 12 | P波在饱和粗颗粒夹层界面上的反射和透射显示文摘为研究应力波在埋入式桩板路基饱和粗颗粒夹层结构界面的反射和透射效应,以平面P波为例,结合埋入式桩板路基的结构特点,基于Biot饱和多孔介质波动理论和弹性波动理论,建立了考虑饱和粗颗粒夹层反射波叠加影响的弹性介质-饱和粗颗粒夹层-弹性介质界面效应模型;采用引入势函数的方法推导了应力波在饱和粗颗粒夹层交界面上的反射和透射系数;通过数值算例研究了不同因素对反射和透射系数的影响规律.研究结果表明:夹层厚度、孔隙率、剪切模量改变了能量在交界面上的分配关系,且表现出周期性谐振特性,孔隙率由0.2变化到0.4时,反射系数增大了约25%;剪切波的传播引起反射系数在剪切波谐振频率处震荡且受阻尼作用,渗透率及透水条件对粗颗粒夹层的反射系数影响明显. | 刘宝 苏谦 赵文辉 刘亭 PHAM Duc Phong 周珩 | 2017 | 西南交通大学学报2017，52，2： | 4 |
| 13 | Genetic diversity in two threatened species in Vietnam:Taxus chinensis and Taxus wallichiana显示文摘Taxus chinensis and T. wallichiana in have been threatened in their distribution areas in recent decades because of their over-exploitation and reduction and destruction of native habitats. Determining the genetic diversity in populations of the two species will provide guidelines for their protection and preservation. Two hundred and fifteen trees from six populations of T. chinensis and150 sampled trees of T. wallichiana were sampled. Six microsatellite primer pairs selected from 16 primer pairs were used to investigate genetic variation at the population and species levels. Five yielded polymorphic alleles, and among the 13 putative alleles amplified, 11 were polymorphic(accounting for 76.33 %).Shannon's information index(I) and percentage of polymorphic bands(PPB)(I = 0.202 and PPB = 67.22 % for T. chinensis; I = 0.217 and PPB = 65.03 % for T. wallichiana). Both species had low levels of genetic diversity(mean H_o= 0.107, H_e= 0.121 for T. chinensis; H_o= 0.095, H_e= 0.109 for T. wallichiana). Genetic differentiation among populations was higher(FST= 0.189) for T. chinensis and lower(0.156) for T.wallichiana, indicating limited gene flow(Nm) among populations for T. chinensis(0.68) and T. wallichiana(0.65).Variation among individuals of T. chinensis was 63.59 and73.12 % for T. wallichiana. Thus, the threatened status of the two conifers is related to a lack of genetic diversity. All populations are isolated in small forest remnants. An ex situ conservation site should be established with a new population for these species that comprises all the genetic groups for the best chance to improve their fitness under environmental stresses. | Dinh Duy Vu Thi Tuyet Xuan Bui Minh Tam Nguyen Dinh Giap Vu Minh Duc Nguyen Van Thang Bui Xiaohua Huang Yi Zhang | 2017 | Journal of Forestry Research2017，28，2： | 4 |
| 14 | 感染人类的禽流感病毒A(H5N1)研究进展显示文摘 | Abdel-Nasser Abdel-Ghafar Tawee Chotpitayasunondh Zhancheng Gao Frederick G. Hayden Nguyen Duc Hien Menno D. de Jong Azim Naghdaliyev J.S. Malik Peiris Nahoko Shindo Santoso Soeroso Timothy M. Uyeki 钟晓琴(译) 王关嵩(校) | 2009 | 中华肺部疾病杂志(电子版)2009，2，1： | 4 |
| 15 | 兰坪金顶蜂子山铅锌矿床的构造控矿:来自三维空间数据分析的证据显示文摘滇西金顶超大型铅锌矿床的热液成矿和构造控矿特点突出,对其主要容矿岩石和断层耦合控矿机制仍不清楚。利用三维空间数据分析方法,对代表性的蜂子山铅锌矿床开展了矿化结构及其空间展布特征的综合研究。结果表明:Pb和Zn矿化中心呈现出东西向分带及差异性分段富集的特点,空间上并与黄铁矿、天青石(—重晶石)和石膏矿体共置;成矿流体的运聚受近SN向逆冲断层和近EW向走滑断层的共同控制,为其提供通道和沉淀空间;而金顶群(N_(1)j)的湖相氧化性含矿卤水在两组方向断层的联合驱动下,在三合洞组上段(T_(3)s^(3))地层中与其赋存的还原性流体幕式混合成矿,是该矿床发育的重要机制。尤其是,近SN向逆冲断层和近EW向走滑断层联合控矿特征的发现,为深入理解金顶超大型铅锌矿床成矿作用及指导找矿勘查提供了新的依据。 | 刘靖坤 薛传东 薛力鹏 杨天云露 曾招阳 姚远涛 LENH Phan Duc GHAZI Rehana | 2021 | 地球科学进展2021，36，10： | 4 |
| 16 | 木鳖果的真空冷冻干燥工艺研究显示文摘木鳖果是越南的一种常见高营养水果,近年来越南木鳖果产业发展很快,但是其干燥研究较少。采用真空冷冻干燥的方法确定木鳖果的最佳工艺参数,并分析比较干燥处理对木鳖果营养成分的影响。结果表明:木鳖果的共晶点为-16.71℃,共融点为-5.11℃。在冻结温度-45℃、时间2 h、真空度维持在2 000 Pa;一次干燥温度-13℃、时间1 h、真空度维持在500 Pa;二次干燥温度30℃、时间2 h、真空度维持在400 Pa左右的条件下工艺最佳。 | Nguyen Dinh Duc 张意锋 李保国 | 2013 | 广东农业科学2013，40，22： | 4 |
| 17 | Ethanol extracts of Scutellaria baicalensis protect against lipopolysaccharide-induced acute liver injury in mice显示文摘Objective: To investigated the protective potential of ethanol extracts of Scutellaria baicalensis(S. baicalensis) against lipopolysaccharide(LPS)-induced liver injury. Methods: Dried roots of S. baicalensis were extracted with ethanol and concentrated to yield a dry residue. Mice were administered 200 mg/kg of the ethanol extracts orally once daily for one week. Animals were subsequently administered a single dose of LPS(5 mg/kg of body weight, intraperitoneal injection). Both protein and m RNA levels of cytokines, such as tumor necrosis factor alpha, interleukin-1β, and interleukin-6 in liver tissues were evaluated by ELISA assay and quantitative PCR. C yclooxygenase-2, inducible nitric oxide synthase, and nuclear factor-κB protein levels in liver tissues were analyzed by western blotting. Results: Liver injury induced by LPS signifi cantly increased necrosis factor alpha, interleukin-1β, interleukin-6, cyclooxygenase-2, inducible nitric oxide synthase, and nuclear factor-κB in liver tissues. Treatment with ethanol extracts of S. baicalensis prevented all of these observed changes associated with LPS-induced injury in liver mice.Conclusions: Our study showed that S. baicalensis is potentially protective against LPS-induced liver injury in mice. | Hai Nguyen Thanh Hue Pham Thi Minh Tuan Anh Le Huong Duong Thi Ly Tung Nguyen Huu Loi Vu Duc Thu Dang Kim Tung Bui Thanh | 2015 | Asian Pacific Journal of Tropical Biomedicine2015，5，9： | 3 |
| 18 | A comparative study of three different learning algorithms applied to ANFIS for predicting daily suspended sediment concentration显示文摘The modeling and prediction of suspended sediment in a river are key elements in global water recourses and environment policy and management. In the present study, an Adaptive Neuro-Fuzzy Inference System model trained with the Levenberg-Marquardt learning algorithm is considered for time series modeling of suspended sediment concentration in a river. The model is trained and validated using daily river discharge and suspended sediment concentration data from the Schuylkill River in the United States. The results of the proposed method are evaluated and compared with similar networks trained with the common Hybrid and Back-Propagation algorithms, which are widely used in the literature for prediction of suspended sediment concentration. Obtained results demonstrate that models trained with the Hybrid and Levenberg-Marquardt algorithms are comparable in terms of prediction accuracy.However, the networks trained with the Levenberg-Marquardt algorithm perform better than those trained with the Hybrid approach. | Keivan Kaveh Minh Duc Bui Peter Rutschmann | 2017 | International Journal of Sediment Research2017，32，3： | 3 |
| 19 | 亲和性促生菌DW12-L的定殖及其对大豆生长的影响显示文摘为了研究大豆亲和性根际促生菌(PGPR)菌株在大豆根际的定殖及其对大豆生长发育的影响,采用电转化法将luxAB基因转入对大豆凝集素(SBA)具有亲和性的PGPR菌株DW12中。将标记菌株DW12?L接种于大豆品种中黄606根际,以SBA非亲和的PGPR菌株P34?L作对照,考察DW12?L在大豆根际定殖的时空特征,检测菌株的定殖对大豆生长以及根系发育的影响。结果表明,DW12?L可长期定居于大豆根际,并随根系的生长在新的根段根际吸附定殖,而P34?L在大豆根际不能稳定存活;DW12?L显著促进大豆地上部和地下部生物量的积累以及根系的发育,P34?L在大豆生长30 d时由于不能定殖于根际而无显著促生效果。与大豆凝集素具有亲和性的PGPR菌株DW12?L可定殖于大豆根际并促进大豆生长,定殖能力的强弱是决定菌株能否发挥促生功能的关键。 | 曹媛媛 陈春 郭婷婷 钱叶 张程飞 何相怡 李婷 Lay Khien Duc 唐欣昀 邵文韬 王晓波 邱丽娟 | 2019 | 江苏农业学报2019，35，4： | 3 |
| 20 | Functional constipation in children:What physicians should know显示文摘Functional constipation(FC)is considered the most common functional gastrointestinal disorder in children with a pooled global prevalence of 14.4%(95%confidence interval:11.2-17.6)when diagnosed based on the Rome IV criteria.Its pathophysiological mechanisms are thought be multifactorial and complicated,resulting in difficult management.Currently,the most effective medication,when used in parallel with toilet training,is osmotic laxatives.Children’s adherence to medication and parental concern regarding long-term laxative use are the main contributors to treatment failure.Recently,novel therapies with a high safety profile have been developed,such as probiotics,synbiotics,serotonin 5-hydroxytryptamine 4 receptor agonists,chloride channel activators,and herbal and transitional medicines;nonetheless,well-designed research to support the use of these therapies is needed.This review aims to focus on multiple aspects of FC in children,including global prevalence,pathogenesis,diagnostic criteria,tools,as well as conventional and novel treatment options,such as non-pharmacological management,including adequate fiber and fluid intake,physiotherapy,or neuromodulators.We also report that in very difficult cases,surgical intervention may be required. | Duc Long Tran Palittiya Sintusek | 2023 | World Journal of Gastroenterology2023，29，8： | 3 |
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