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| 1 | Targeting the PI3K/Akt signaling pathway in gastric carcinoma: A reality for personalized medicine?显示文摘Frequent activation of phosphatidylinositol-3 kinases(PI3K)/Akt/m TOR signaling pathway in gastric cancer(GC) is gaining immense popularity with identification of mutations and/or amplifications of PIK3 CA gene or loss of function of PTEN,a tumor suppressor protein,to name a few; both playing a crucial role in regulating this pathway. These aberrations result in dysregulation of this pathway eventually leading to gastric oncogenesis,hence,there is a need for targeted therapy for more effective anticancer treatment. Several inhibitors are currently in either preclinical or clinical stages for treatment of solid tumors like GC. With so many inhibitors under development,further studies on predictive biomarkers are needed to measure the specificity of any therapeutic intervention. Herein,we review the common dysregulation of PI3K/Akt/m TOR pathway in GC and the various types of single or dual pathway inhibitors under development that might have a superior role in GC treatment. We also summarize the recent developments in identification of predictive biomarkers and propose use of predictive biomarkers to facilitate more personalized cancer therapy with effective PI3K/Akt/m TOR pathway inhibition. | Shikha Satendra Singh Wei Ney Yap Frank Arfuso Shreya Kar Chao Wang Wanpei Cai Arunasalam M Dharmarajan Gautam Sethi Alan Prem Kumar | 2015 | World Journal of Gastroenterology2015，21，43： | 36 |
| 2 | Nucleocytoplasmic Trafficking of the Arabidopsis WD40 Repeat Protein XIW1 Regulates ABI5 Stability and Abscisic Acid Responses显示文摘WD40 repeat-containing proteins(WD40 proteins)serve as versatile scaffolds for protein-protein interac-tions,modulating a variety of cellular processes such as plant stress and hormone responses.Here we report the identification of a WD40 protein,XIW1(for XPO1-interacting WD40 protein 1),which positively regulates the abscisic acid(ABA)response in Arabidopsis.XIW1 is located in the cytoplasm and nucleus.We found that it interacts with the nuclear transport receptor XPO1 and is exported by XPO1 from the nucleus.Mutation of XIW1 reduces the induction of ABA-responsive genes and the accumulation of ABA Insensitive 5(ABI5),causing mutant plants with ABA-insensitive phenotypes during seed germination and seedling growth,and decreased drought stress resistance.ABA treatment upregulates the expression of XIW1,and both ABA and abiotic stresses promote XIW1 accumulation in the nucleus,where it interacts with ABI5.Loss of XIW1 function results in rapid proteasomal degradation of ABI5.Taken together,these findings suggest that XIW1 is a nucleocytoplasmic shuttling protein and plays a positive role in ABA responses by interacting with and maintaining the stability of ABI5 in the nucleus. | Xuezhong XU Wang Wan Guobin Jiang Yue Xi Haijian Huang Jiajia Cai Yanan Chang Cheng-Guo Duan Satendra KMangrauthia Xinxiang Peng Jian-Kang Zhu Guohui Zhu | 2019 | Molecular Plant2019，12，12： | 8 |
| 3 | A pair of transposon-derived proteins function in a histone acetyltransferase complex for active DNA demethylation显示文摘Transposons 被 epigenetic 机制通常包括 DNA methylation 使沉默。这里,我们识别了一双先驱导出 transposon 的蛋白质(HDP ) , HDP1 和 HDP2,在 Arabidopsis 的反沉默因素。hdp1 和 hdp2 异种显示了 transgenes 和某 transposons 的提高的 silencing。种系发生的分析表明 HDP1 和 HDP2 分别地从先驱编码 transposon 的 transposase 和 DNA 有约束力的蛋白质被共同驯养。HDP1 在原子核与 HDP2 交往,类似于他们的 transposon 对应物。而且, HDP1 和 HDP2 与组成在 DNA demethylation 工作的 histone acetyltransferase 建筑群的 IDM1, IDM2, IDM3 和 MBD7 被联系。HDP2 和 methyl-DNA-binding 蛋白质 MBD7 分享普通 genomic 绑定地点的一个大集合,显示他们联合决定 histone acetyltransferase 建筑群的目标特性。因此,我们的数据表明 HDP1 和 HDP2 组成被招募了到 histone acetyltransferase 建筑群阻止 DNA hypermethylation 和 epigenetic silencing 的一个功能的模块。 | Cheng-Guo Duan Xingang Wang Shaojun Xie Li Pan Daisuke Miki Kai Tang Chuan-Chih Hsu Mingguang Lei Yingli Zhong Yueh-Ju Hou ZhijuanWang Zhengjing Zhang Satendra K Mangrauthia Huawei Xu Heng Zhang Brian Dilkes W Andy Tao Jian-Kang Zhu | 2017 | Cell Research2017，27，2： | 6 |
| 4 | Synthesis of Schiff bases of naphtha[1,2-d]thiazol-2-amine and metal complexes of 2-(2'-hydroxy)benzylideneaminonaphthothiazole as potential antimicrobial agents显示文摘Objective: A series of 2-benzylideneaminonaphthothiazoles were designed and synthesized incorporating the lipo- philic naphthalene ring to render them more capable of penetrating various biomembranes. Methods: Schiff bases were synthe- sized by the reaction of naphtha[1,2-d]thiazol-2-amine with various substituted aromatic aldehydes. 2-(2'-Hydroxy)ben- zylideneaminonaphthothiazole was converted to its Co(II), Ni(II) and Cu(II) metal complexes upon treatment with metal salts in ethanol. All the compounds were evaluated for their antibacterial activities by paper disc diffusion method with Gram positive Staphylococcus aureus and Staphylococcus epidermidis and Gram negative Escherichia coli and Pseudomonas aeruginosa bac- teria. The minimum inhibitory concentrations of all the Schiff bases and metal complexes were determined by agar streak dilution method. Results: All the compounds moderately inhibited the growth of Gram positive and Gram negative bacteria. In the present study among all Schiff bases 2-(2'-hydroxy)benzylideneaminonaphthothiazole showed maximum inhibitory activity and among metal complexes Cu(II) metal complex was found to be most potent. Conclusion: The results obtained validate the hypothesis that Schiff bases having substitution with halogens, hydroxyl group and nitro group at phenyl ring are required for the antibacterial activity while methoxy group at different positions in the aromatic ring has minimal role in the inhibitory activity. The results also indicated that the metal complexes are better antibacterial agents as compared to the Schiff bases. | AZAM Faizul SINGH Satendra KHOKHRA Sukhbir Lal PRAKASH Om | 2007 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2007，8，6： | 4 |
| 5 | Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock显示文摘 | Anand Kumar Daniel Roberts Kenneth E. Wood Bruce Light Joseph E. Parrillo Satendra Sharma Robert Suppes Daniel Feinstein Sergio Zanotti Leo Taiberg David Gurka Aseem Kumar Mary Cheang | 2006 | Critical Care Medicine2006，，6： | 2 |
| 6 | Primary congenital anomalies of the coronary arteries:a coronary arteriographic study显示文摘 | Naveen G Satendra T Aditya K | 2000 | Int Cardiol2000，74，1： | 1 |
| 7 | Heart rate reductionwith ivabradine in patients with acute decompensated systolicheart failure 显示文摘 | Sargento L Satendra M Longo S | 2014 | Am J Cardiovasc Drugs2014，14，3： | 1 |
| 8 | Nutritional status of geriatric outpatients with systolic heart failure and its prognostic value regarding death or hospitalization, biomarkers and quality of life显示文摘 | Sargento L Satendra M Almeidal I | 2013 | J Nutr Health Aging2013，17，3： | 1 |
| 9 | Fretting corrosion behaviour of Ti6A14V alloy in artificial saliva containing varying concentrations of fluoride ions 显示文摘 | SIVAKUMAR B SATENDRA K SANKARA T S N | 2011 | Wear2011，270，： | 1 |
| 10 | Primary congenital anomalies of the coronary arteries: a coronary arteriographic study显示文摘 | Naveen Garg Satendra Tewari Aditya Kapoor Deepak Kumar Gupta Nakul Sinha | 2000 | International Journal of Cardiology2000，，1： | 1 |
| 11 | Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock显示文摘 | Anand Kumar Daniel Roberts Kenneth E. Wood Bruce Light Joseph E. Parrillo Satendra Sharma Robert Suppes Daniel Feinstein Sergio Zanotti Leo Taiberg David Gurka Aseem Kumar Mary Cheang | 2006 | Critical Care Medicine2006，，6： | 1 |
| 12 | Effect of Subsoiling and Preparatory Tillage on Sugar Yield, Juice Quality and Economics of Sugarcane (Saccharum species hybrid) in Sugarcane Plant-Ratoon Cropping System显示文摘 | Satendra Kumar Saini S K Amit Bhatnagar | 2012 | Society for Sugar Research & Promotion2012，14，4： | 1 |
| 13 | Nutritional status of geriatric outpatients with systolic heart failure and its prognostic value regarding death or hospitalization, biomarkers and quality of life显示文摘 | Sargento L Satendra M Ahneida I | 2013 | J Nutr Health Aging2013，17，4： | 1 |
| 14 | Multiple facets of poly(ADP-ribose) polymerase-1 in neurological diseases显示文摘The highly conserved abundant nuclear protein poly(ADP-ribose)polymerase-1(PARP-1)is activated by DNA damage.PARP-1 activation is associated in DNA repair,cell death and inflammation.Since oxidative stress induced robust DNA damage and wide spread inflammatory responses are common pathologies of various CNS diseases,the attention towards PARP-1 as a | Chandra Shaker Sriram Ashok Jangra Rajaram Mohanrao Madhana Satendra Singh Gurjar Pritam Mohan Babul Kumar Bezbaruah | 2015 | Neural Regeneration Research2015，10，1： | 1 |
| 15 | Improvement of performance of Electromagnetic welding process by use of driver materials显示文摘 | S.V. Desai Satendra Kumar P. Satyamurthy J.K. Chakravartty D.P. Chakravarthy | 2011 | International Journal of Applied Electromagnetics and Mechanics2011，，2： | 1 |
| 16 | Thermal oxidation of CP Ti — An electrochemical and structural characterization显示文摘 | Satendra Kumar T.S.N. Sankara Narayanan S. Ganesh Sundara Raman S.K. Seshadri | 2010 | Materials Characterization2010，，6： | 1 |
| 17 | Thermal oxidation of CP-Ti: Evaluation of characteristics and corrosion resistance as a function of treatment time显示文摘 | Satendra Kumar T.S.N. Sankara Narayanan S. Ganesh Sundara Raman S.K. Seshadri | 2009 | Materials Science & Engineering C2009，，6： | 1 |
| 18 | Propolis modulates cellular biochemistry, antioxidants, cytokine profile, histological and ultra-morphological status against antituberculosis drugs induced hepatic injury显示文摘To evaluate hepatic injury induced by antituberculosis drugs(ATDs) when administered orally for 2, 4, 6 and 8 weeks and the therapeutic potential of propolis(bee hive product) against ATDs induced hepatic injury. Methods: The ATDs were administered for 8 weeks as well as propolis extract at three different doses(100, 200, 400 mg/kg) conjointly for 8 weeks in rats. Silymarin(50 mg/kg) was given as positive control. Animals were euthanized after 8 weeks; blood and liver samples were collected to perform various biochemicals, serological and histopathological and ultramorphological studies. Results: Significant increase(P < 0.05) in aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, triglyceride and cholesterol along with reduction in glucose and albumin level were noted after ATDs induced hepatic injury. Significant increase(P < 0.05) in lipid peroxidation, triglyceride, cholesterol and CYP2E1 activity; decline in reduced glutathione, catalase, superoxide dismutase, glutathione reductase, glutathione peroxidase, glucose-6-phosphatase dehydrogenase activity were observed after ATDs intoxication. Due to presence of a wide range of flavonoids and polyphenols in propolis extract, its administration reduced hepatic injury and maintained biochemical indices towards control. Histopathological and electron microscopic observations indicated hepatoprotective potential of propolis at cellular level whereas, TNF-α, IL-6 and IGF-1 confirmed therapeutic potential of propolis at molecular level. Conclusions: It can be concluded that propolis possess hepatoprotective potential against ATDs induced hepatic injury that may prove itself as a clinically useful natural product in management of drug induced liver injury. | Nisha Sahu Gita Mishra Hemeshwer Kumar Chandra Satendra Kumar Nirala Monika Bhadauria | 2018 | Asian Pacific Journal of Tropical Medicine2018，11，11： | 1 |
| 19 | Primary Congenital Anomalies of the Coronary Arteries:a Coronary Arteriographic Study显示文摘 | Satendra T Aditya K Deepak KG | 2000 | Internat J Cardiol2000，74，1： | 1 |
| 20 | Reversal of acetaminophen induced subchronic hepatorenal injury by propolis extract in rats显示文摘 | Monika Bhadauria Satendra Kumar Nirala | 2008 | Environmental Toxicology and Pharmacology2008，，1： | 1 |
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