|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Combined peripheral natural killer cell and circulating tumor cell enumeration enhance prognostic efficiency in patients with metastatic triple-negative breast cancer显示文摘Objective:Triple-negative breast cancer(TNBC)is a heterogeneous disease with poor prognosis.Circulating tumor cells(CTCs)are a promising predictor for breast cancer prognoses but their reliability regarding progression-free survival(PFS)is controversial.We aim to verify their predictive value in TNBC.Methods:In present prospective cohort study,we used the Pep@MNPs method to enumerate CTCs in baseline blood samples from 75 patients with TNBC(taken at inclusion in this study)and analyzed correlations between CTC numbers and outcomes and other clinical parameters.Results:Median PFS was 6.0(range:1.0–25.0)months for the entire cohort,in whom we found no correlations between baseline CTC status and initial tumor stage(P=0.167),tumor grade(P=0.783)or histological type(P=0.084).However,among those getting first-line treatment,baseline CTC status was positively correlated with ratio of peripheral natural killer(NK)cells(P=0.032),presence of lung metastasis(P=0.034)and number of visceral metastatic site(P=0.037).Baseline CTC status was predictive for PFS in first-line TNBC(P=0.033),but not for the cohort as a whole(P=0.118).This prognostic limitation of CTC could be ameliorated by combining CTC and NK cell enumeration(P=0.049).Conclusions:Baseline CTC status was predictive of lung metastasis,peripheral NK cell ratio and PFS in TNBC patients undergoing first-line treatment.We have developed a combined CTC-NK enumeration strategy that allows us to predict PFS in TNBC without any preconditions. | Xiaoran Liu Ran Ran Bin Shao Hope S.Rugo Yanlian Yang Zhiyuan Hu Zewen Wei Fengling Wan Weiyao Kong Guohong Song Hanfang Jiang Xu Liang Ruyan Zhang Ying Yan Guobing Xu Huiping Li | 2018 | Chinese Journal of Cancer Research2018，30，3： | 4 |
| 2 | Multi-agent reinforcement learning for edge information sharing in vehicular networks显示文摘To guarantee the heterogeneous delay requirements of the diverse vehicular services,it is necessary to design a full cooperative policy for both Vehicle to Infrastructure(V2I)and Vehicle to Vehicle(V2V)links.This paper investigates the reduction of the delay in edge information sharing for V2V links while satisfying the delay requirements of the V2I links.Specifically,a mean delay minimization problem and a maximum individual delay minimization problem are formulated to improve the global network performance and ensure the fairness of a single user,respectively.A multi-agent reinforcement learning framework is designed to solve these two problems,where a new reward function is proposed to evaluate the utilities of the two optimization objectives in a unified framework.Thereafter,a proximal policy optimization approach is proposed to enable each V2V user to learn its policy using the shared global network reward.The effectiveness of the proposed approach is finally validated by comparing the obtained results with those of the other baseline approaches through extensive simulation experiments. | Ruyan Wang Xue Jiang Yujie Zhou Zhidu Li Dapeng Wu Tong Tang Alexander Fedotov Vladimir Badenko | 2022 | Digital Communications and Networks2022，8，3： | 3 |
| 3 | Toll of Mental Disorders: TLR-Mediated Function of the Innate Immune System显示文摘Mental disorder is defined as a syndrome characterized by clinically significant disturbance in an individual’s cognition, emotion, or behavior that reflects a dysfunction in the psychological, biological, or developmental processes underlying mental functioning (DSM-V). | Jian-Feng Liu Ruyan Wu Jun-Xu Li | 2019 | Neuroscience Bulletin2019，35，4： | 3 |
| 4 | Study of tide prediction method influenced by nonperiodic factors based on support vector machines显示文摘Harmonic analysis, the traditional tidal forecasting method, cannot take into account the impact of noncyclical factors, and is also based on the BP neural network tidal prediction model which is easily limited by the amount of data. According to the movement of celestial bodies, and considering the insufficient tidal characteristics of historical data which are impacted by the nonperiodic weather, a tidal prediction method is designed based on support vector machine (SVM) to carry out the simulation experiment by using tidal data from Xiamen Tide Gauge, Luchaogang Tide Gauge and Weifang Tide Gauge individually. And the results show that the model satisfactorily carries out the tide prediction which is influenced by noncyclical factors. At the same time, it also proves that the proposed prediction method, which when compared with harmonic analysis method and the BP neural network method, has faster modeling speed, higher prediction precision and stronger generalization ability. | HE Shi-jun ZHOU Wenjun ZHOU Ruyan HUANG Dongmei | 2012 | Acta Oceanologica Sinica2012，31，5： | 3 |
| 5 | A competitive microcystin-LR immunosensor based on Au NPs@metal-organic framework(MIL-101)显示文摘An electrochemical immunosensor was developed for ultrasensitive detection of microcystin-LR in water. MIL-101, a porous metal-organic frameworks(MOFs) material based on trivalent chromium skeleton were synthesized by hydrothermal synthesis method, and loaded with Au nanoparticles(Au NPs) to prepare Au NPs@MIL-101 composite materials which were used as a marker to label anti microcystin-LR(Anti-MC-LR). The composite materials have strong catalytic properties to the oxidation of ascorbic acid. Anti-MC-LR was immobilized on glassy carbon electrode surface using electrodeposition graphene oxide(GO) as an immobilization matrix to construct a competitive microcystin-LR immunosensor. The electrochemical immunosensor display linear relationship in the range of 0.05 ng/mL-75 μg/mL with linear correlation coefficient of 0.9951 and detection limit of 0.02 ng/mL(S/N = 3). This sensor was used to detect microcystin-LR in the water sample. The recovery was 102.43%,which is satisfied. The good testing results indicate the sensor has a great prospect in practical application. | Kunlei Zhang Kun Dai Ruyan Bai Yuchan Ma Yan Deng Delei Li Xi Zhang Rong Hu Yunhui Yang | 2019 | Chinese Chemical Letters2019，30，3： | 2 |
| 6 | Method of delivery and pregnancy outcomes in Asia: the WHO global survey on maternal and perinatal health 2007–08显示文摘 | Pisake Lumbiganon Malinee Laopaiboon A Metin Gülmezoglu Jo?o Paulo Souza Surasak Taneepanichskul Pang Ruyan Deepika Eranjanie Attygalle Naveen Shrestha Rintaro Mori Nguyen Duc Hinh Hoang Thi Bang Tung Rathavy Kang Chuyun Kannitha Cheang Mario Festin Venus | 2010 | The Lancet2010，，9713： | 2 |
| 7 | Scalable privacy-preserving big data aggregation mechanism显示文摘 | Dapeng Wu Boran Yang Ruyan Wang | 2016 | Digital Communications and Networks2016，2，3： | 2 |
| 8 | Growth and dielectric properties of Ta2O5 single crystals grown by laser heated pedestal growth technique显示文摘Ta2O5 single crystals have been grown by the laser heated pedestal growth (LHPG) technique up to several centimeters length with diameter of 1.1 mm. The crystal, characterized by X-ray diffraction, dielectric measurement, and thermal expansion analysis, has Htri-Ta2O5 symmetry. Dielectric permittivity, loss tangent along [001] and [110] direction were investigated over the temperature range from -80 ℃ to 100 ℃. Large dielectric anisotropy in Ta2O5 single crystal was observed. At room temperature, the dielectric permittivities (1 MHz) along [001] and [110] are 33.2 and 231.9, respectively. The reason of dielectric enhancement in Ta2O5 crystal grown by LHPG was also discussed. | 蒋毅坚 Ruyan Guo A. S. Bhalla | 2008 | 中国激光2008，35，11： | 2 |
| 9 | Positive solutions for second order three-point boundary value problem 显示文摘 | Ma Ruyan | 2001 | Applied Mathematice Letters2001，14，： | 1 |
| 10 | Study on key techniques on ecological renovation design of existing buildings in China显示文摘With the rapid development of China economy and critical ecological situation in China,ecological renovation of existing buildings has become a special important topic. Key techniques on ecological renovation design of existing buildings in China are explored in this paper. Special attention is paid to specific treatments suitable for China. | Wu Jinxiu Zhang Hui Dong Wei Sun Ruyan | 2010 | Engineering Sciences2010，8，2： | 1 |
| 11 | 显示文摘 | Hathalkarn Choosuwan Ruyan Guo Amar Bhalla S Balachandran U | 2001 | Ferroelectrics2001，263，： | 1 |
| 12 | Zinc Oxide Single-crystal Microtubes显示文摘 | Jiping Cheng Ruyan Guo Qiming Wang | 2004 | Applied Physics Letters2004，85，22： | 1 |
| 13 | On-line scheduling with delivery time on a single batch machine显示文摘 | Tian Ji Fu Ruyan Yuan Jinjiang | 2007 | Theoretical Computer Science2007，374，123： | 1 |
| 14 | Existence positive padial solutions for elliptic systems显示文摘 | RUYAN M | 1996 | J Math Anal Appl1996，201，： | 1 |
| 15 | The perovskite structure---a review of its role in ceramics science and technology 显示文摘 | BHALLA A S GUO Ruyan ROY R | 2000 | Mat Res Innovat2000，4，： | 1 |
| 16 | ZnO Microtube Ultraviolet Detectors显示文摘 | Jiping Cheng Yunjin Zhang Ruyan Guo | 2008 | Journal of Crystal Growth2008，310，1： | 1 |
| 17 | Nb 2 O 5 -based oxide ceramics and single crystals-investigation of dielectric properties显示文摘 | H. Manuspiya Ruyan Guo A.S. Bhalla | 2004 | Ceramics International2004，，7： | 1 |
| 18 | A Successful Project of Progressive Exploration and Development for Natural Gas in Chenjiazhuang Arch显示文摘 | Sheng Ruyan Cao Zhongxiang and Xiang Xiyong | 2001 | SPE 681682001，，： | 1 |
| 19 | Coupling of Thermal-Hydraulic-Mechanical Processes for Geothermal Reservoir Modelling显示文摘This paper uses a fully coupled framework of thermal-hydraulic-mechanical processes to investigate how the injection and extraction of fluid within a geothermal reservoir impacts on the distributions of temperature,pore pressure,and deformation within the rock formations. Based on this formulation,a numerical model is developed in light of the thermodynamics of porous materials. The proposed procedure relies on the derivation of dissipative flow rules by postulating proper storage and dissipation functions. This approach opens new horizons for several resource engineering applications. Since it allows for full coupling,this formulation can play a key role in predicting risks when used for reservoir simulation. The results indicate that the injection-extraction process and temperature change have a definite impact on altering the in-situ properties of the reservoir. | Ali Karrechl Oussama Beltaief Ruyan Vincec Thomas Poulet Klaus Regenauer-Lieb | 2015 | Journal of Earth Science2015，26，1： | 1 |
| 20 | Multiple nonnegative solutions of second order systems of boundary value problems显示文摘 | RUYAN M | 2000 | Nonlinear Analysis2000，42，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员