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| 1 | Association factors of target organ damage: analysis of 17 682 elderly hypertensive patients in China显示文摘背景高血压的目标机关损坏(狐)在在亚洲的高血压的狐上的老高血压的 patients.The 研究是为死亡或残疾的主要原因,特别在中国老高血压的病人,很这研究的 limited.The 目的是在这是的更旧的中国高血压的 inpatients.Methods 评估狐的流行和关联词因素回顾的调查和数据从 19 | CUI Hua WANG Fan FAN Li HU Yi-xin HU Guo-liang LIU Lin HONG Chang-ming | 2011 | Chinese Medical Journal2011，，22： | 60 |
| 2 | Programmable time-domain digital-coding metasurface for non-linear harmonic manipulation and new wireless communication systems显示文摘Optical non-linear phenomena are typically observed in natural materials interacting with light at high intensities, and they benefit a diverse range of applications from communication to sensing. However,controlling harmonic conversion with high efficiency and flexibility remains a major issue in modern optical and radio-frequency systems. Here, we introduce a dynamic time-domain digital-coding metasurface that enables efficient manipulation of spectral harmonic distribution. By dynamically modulating the local phase of the surface reflectivity, we achieve accurate control of different harmonics in a highly programmable and dynamic fashion, enabling unusual responses, such as velocity illusion. As a relevant application, we propose and realize a novel architecture for wireless communication systems based on the time-domain digital-coding metasurface, which largely simplifies the architecture of modern communication systems, at the same time yielding excellent performance for real-time signal transmission. The presented work, from new concept to new system, opens new pathways in the application of metamaterials to practical technology. | Jie Zhao Xi Yang Jun Yan Dai Qiang Cheng Xiang Li Ning Hua Qi Jun Chen Ke Guo Dong Bai Shuo Liu Shi Jin Andrea Alù Tie Jun Cui | 2019 | National Science Review2019，6，2： | 46 |
| 3 | Innate immunity in tuberculosis: host defense vs pathogen evasion显示文摘The major innate immune cell types involved in tuberculosis(TB)infection are macrophages,dendritic cells(DCs),neutrophils and natural killer(NK)cells.These immune cells recognize the TB-causing pathogen Mycobacterium tuberculosis(Mtb)through various pattern recognition receptors(PRRs),including but not limited to Toll-like receptors(TLRs),Nod-like receptors(NLRs)and C-type lectin receptors(CLRs).Upon infection by Mtb,the host orchestrates multiple signaling cascades via the PRRs to launch a variety of innate immune defense functions such as phagocytosis,autophagy,apoptosis and inflammasome activation.In contrast,Mtb utilizes numerous exquisite strategies to evade or circumvent host innate immunity.Here we discuss recent research on major host innate immune cells,PRR signaling,and the cellular functions involved in Mtb infection,with a specific focus on the host’s innate immune defense and Mtb immune evasion.A better understanding of the molecular mechanisms underlying host–pathogen interactions could provide a rational basis for the development of effective anti-TB therapeutics. | Cui Hua Liu Haiying Liu Baoxue Ge | 2017 | Cellular & Molecular Immunology2017，14，12： | 43 |
| 4 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 5 | Serum microRNA 125b as a diagnostic or prognostic biomarker for advanced NSCLC patients receiving cisplatin-based chemotherapy显示文摘 | En-hai CUI Hong-jiao LI Feng HUA Bin WANG Wei MAO Xue-ren FENG Jian-you LI Xiang WANG | 2013 | Acta Pharmacologica Sinica2013，34，2： | 28 |
| 6 | Prevalence of Thyroid Nodules and Its Relationship with Iodine Status in Shanghai:a Population-based Study显示文摘Objective This study was designed to evaluate the prevalence of thyroid nodules(TNs) and its relationship with urine iodine concentrations(UICs) after the regional rapid economic growth and lifestyle changes. Methods A cross-sectional survey was conducted in the general population aged 15-69 years. A questionnaire regarding general and personal characteristics and relevant information was administered. Ultrasonography of the thyroid was performed, and serum triiodothyronine(T3), tetraiodothyronine(T4), serum thyroid stimulating hormone(TSH), free triiodothyronine(FT3), free tetraiodothyronine(FT4), thyroglobulin antibody(Tg Ab), thyroid peroxidase antibody(TPOAb), and TSH receptor antibody(TRAb) levels were measured for each individual subject. Results The prevalence rates of TNs in the whole population, females and males were 27.76%, 34.04%, and 21.60%, respectively. The prevalence of multiple nodules increased with age, whereas the prevalence peaks differed between males and females. The median UICs in the whole population and females with non-TNs were higher than those of subjects with TNs(P=0.0035, P=0.0068). The median UICs in subjects with a single TN were higher than those in subjects with multiple TNs(P=0.0164, P=0.0127). The result showed a U-shaped curve relationship between UIC and prevalence of TNs. The prevalence of TNs was the lowest when the UIC was 140-400 μg/L. Conclusion The prevalence of TNs was nearly 30% and increased with age. The relationship between UIC and prevalence of TNs is U-shaped, with an increase in risk when the UIC was <140 μg/L and >400 μg/L. Very low or high UIC levels need attention and correction. | SONG Jun ZOU Shu Rong GUO Chang Yi ZANG Jia Jie ZHU Zhen Ni MI Ming HUANG Cui Hua YU Hui Ting LU Xi RUAN Ye WU Fan | 2016 | Biomedical and Environmental Sciences2016，29，6： | 25 |
| 7 | Expression of insulin-like growth factor Ⅱ and its receptor in hepatocellular carcinogenesis显示文摘INTRODUCTIONInsulin-like growth factor Ⅱ(IGF-Ⅱ) is a mitogenic peptide of 74 kD and is mostly synthesized in fetal liver tissue .IGF-Ⅱ is believed to play an important role in fetal growth and development and is involved in cellular proliferation and differentiation[1-5]. Recently ,several researchers have reported increased expression of the IGF-Ⅱgene in human hepatocellular carcinoma (HCC) and adjacent non-cancerous liver tissues [6-10]. | Zi Rong Fan Dong Hua Yang Jun Cui Han Rong Qin Chun Chi Huang Department of Gastroenterology, Zhujiang Hospital. The First Military Medical University, Guangzhou 510282.Guangdong Province. China | 2001 | World Journal of Gastroenterology2001，7，2： | 24 |
| 8 | A clinical neurophysiology study of Hirayama disease显示文摘 | WANG Xin-ning CUI Li-ying LIU Ming-sheng GUAN Yu-zhou LI Ben-hong DU Hua | 2012 | Chinese Medical Journal2012，，6： | 22 |
| 9 | nsights into battles between Mycobacterium tuberculosis and macrophages显示文摘 | Guanghua Xu Jing Wang George Fu Gao Cui Hua Liu | 2014 | Protein & Cell2014，5，10： | 22 |
| 10 | Celastrus orbiculatus extract induces mitochondrial-mediated apoptosis in human hepatocellular carcinoma cells显示文摘OBJECTIVE:To investigate the apoptotic effects and underlying molecular mechanisms of Celastrus orbiculatus(C.orbiculatus) extract in human hepatocellular carcinoma cells.METHODS:Human hepatocellular carcinoma cells(HCCLM6) were treated with C.orbiculatus extract(COE) at different nontoxic concentrations(10,20,40,80,and 160 μg/mL).The effect of COE on HC-CLM6 viability was examined using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide(MTT) assays.Cellular apoptosis following COE treatment was assessed by flow cytometry and western blot analysis.RESULTS:COE significantly inhibited cell viability and induced apoptosis of HCCLM6 cells in a dose-dependent manner.Apoptosis was accompanied by increased Bax expression and decreased Bcl-2 expression.In addition,COE treatment led to the release of cytochrome c,activation of caspase-3,and cleavage of poly(ADP-ribose) polymerase(PARP).Furthermore,activation of extracellular signal-regulated kinase(ERK),p38 kinase,and c-Jun N-terminal kinase(JNK) phosphorylation,and down-regulation of Akt phosphorylation was observed.CONCLUSION:COE induces mitochondrial-mediated,caspase-dependent apoptosis in HCCLM6 cells,which might be attributed to the activation of mitogen-activated protein kinase(MAPK) and inhibition of Akt signaling pathways.These data suggest that COE may be a potential treatment for human hepatocellular carcinoma. | Hua Zhang Yayun Qian Yanqing Liu Guoqing Li Pingfang Cui Yaodong Zhu Hui Ma Xue Ji Shiyu Guo Hisamits Tadashi | 2012 | Journal of Traditional Chinese Medicine2012，32，4： | 18 |
| 11 | Melatonin alleviates intervertebral disc degeneration by disrupting the IL-1β/NF-κB-NLRP3 inflammasome positive feedback loop显示文摘The inflammatory response is induced by the overexpression of inflammatory cytokines, mainly interleukin(IL)-1β, and is one of the main causes of intervertebral disc degeneration(IVDD). NLR pyrin domain containing 3(NLRP3) inflammasome activation is an important source of IL-1β. As an anti-inflammatory neuroendocrine hormone, melatonin plays various roles in different pathophysiological conditions. However, its roles in IVDD are still not well understood and require more examination. First, we demonstrated that melatonin delayed the progression of IVDD and relieved IVDD-related low back pain in a rat needle puncture IVDD model;moreover, NLRP3 inflammasome activation(NLRP3, p20, and IL-1β levels) was significantly upregulated in severely degenerated human discs and a rat IVDD model. Subsequently, an IL-1β/NF-κB-NLRP3 inflammasome activation positive feedback loop was found in nucleus pulposus(NP) cells that were treated with IL-1β. In these cells, expression of NLRP3 and p20 was significantly increased, NF-κB signaling was involved in this regulation, and mitochondrial reactive oxygen species(mt ROS)production increased. Furthermore, we found that melatonin disrupted the IL-1β/NF-κB-NLRP3 inflammasome activation positive feedback loop in vitro and in vivo. Melatonin treatment decreased NLRP3, p20, and IL-1β levels by inhibiting NF-κB signaling and downregulating mt ROS production. Finally, we showed that melatonin mediated the disruption of the positive feedback loop of IL-1β in vivo. In this study, we showed for the first time that IL-1β promotes its own expression by upregulating NLRP3 inflammasome activation. Furthermore, melatonin disrupts the IL-1β positive feedback loop and may be a potential therapeutic agent for IVDD. | Fan Chen Guowei Jiang Hui Liu Zemin Li Yuxin Pei Hua Wang Hehai Pan Haowen Cui Jun Long Jianru Wang Zhaomin Zheng | 2020 | Bone Research2020，8，2： | 18 |
| 12 | Methylation status of c-fms oncogene in HCC and its relationship with clinical pathology显示文摘INTRODUCTIONThe mechanism that DNA hypomethylation leads toactivation of oncogene and occurrence of malignantneoplasm is being increasingly recognized byresearchers. Normal DNA methylation playsimportant role in stabilizing the phenotype of cell.DNA methylation status reduction and/or patternalteration are related to activation and abnormallyhigh expression of some oncogenes and cellularmalignancy[1-6]. c-fms oncogene encodes for colonystimulating factor 1 receptor (CSF-1R)[7], c-fms/CSF-1R was highly expressed in hepatocellularcarcinoma (HCC) tissue, but the mechanismremained obscure[8,9]. | Jun Cui Dong Hua Yang Xiang Jun Bi Zi Rong Fan Department of Gastroenterology, Zhujiang Hospital, The First Military Medical University, Guangzhou 510282, Guangdong Province, China | 2001 | World Journal of Gastroenterology2001，7，1： | 16 |
| 13 | Impact of fish oil enriched total parenteral nutrition on elderly patients after colorectal cancer surgery显示文摘丰满的酸可以获利地影响愈合的背景多元不堡和 omega-3 处理,这研究的耐心的 outcomes.The 目的是学习鱼油的临床的功效在在 colorectal 癌症 surgery.Methods 以后的老病人的充实的全部的非肠道的营养有 colorectal 癌症的 57 个老病人在这被注册未来,使随机化,双窗帘,控制临床的 trial.All 病人收到了 isocaloric 和 isonitrogenous 总数由连续 i 的非肠道的营养这些结果到达了统计 significance.In 治疗组,有全身的煽动性的反应症候群(先生)的更少传染复杂并发症和发生,并且医院停留的更短的长度是医疗保健的 observed.The 总数费用为二 groups.No 是可比较的严肃的不利事件发生在任何一个 group.Conclusions 鱼每在 colorectal 外科是安全的并且可以弄短以后,管理到老病人的天给 0.2 g/kg 上油长度医院呆在并且改善 | Zhu Ming-wei Tang Da-nian Hou Jing Wei Jun-min Hua Bin Sun Jian-hua Cui Hong-yuan | 2012 | Chinese Medical Journal2012，，2： | 16 |
| 14 | Microstructure evolution and phase transformation of traditional cast and spray-formed hypereutectic aluminium-silicon alloys induced by heat treatment显示文摘Microstructural evolution and phase transformation induced by different heat treatments of the hypereutectic aluminium-silicon alloy,Al-25Si-5Fe-3Cu(wt%,signed as 3C),fabricated by traditional cast(TC) and spray forming(SF) processes,were investigated by differential scanning calorimetry(DSC) and scanning electron microscopy(SEM) combined with energy dispersive X-ray spectroscopy and X-ray diffraction techniques.The results show that Al7Cu2Fe phase can be formed and transformed in TC-and SF-3C alloys between 802-813 K and 800-815 K,respectively.The transformation from β-Al5FeSi to δ-Al4FeSi2 phase via peritectic reaction can occur at around 858-870 K and 876-890 K in TC-and SF-3C alloys,respectively.The starting precipitation temperature of δ-Al4FeSi2 phase as the dominant Fe-bearing phase in the TC-3C alloy is 997 K and the exothermic peak about the peritectic transformation of δ-Al4FeSi2→β-Al5FeSi is not detected in the present DSC experiments.Also,the mechanisms of the microstructural evolution and phase transformation are discussed. | Long-gang Hou Yuan-hua Cai Hua Cui Ji-shan Zhang | 2010 | International Journal of Minerals,Metallurgy and Materials2010，17，3： | 14 |
| 15 | Circulating Dickkopf-1 and osteoprotegerin in patients with early and longstanding rheumatoid arthritis显示文摘背景风湿性关节炎(RA ) 被 synovial 膜的发炎描绘,导致进有象后果的关节的软骨和骨头的降级的邻近的软骨矩阵的 synovial 织物的侵略。Dickkopf-1 (DKK-1 ) 和 osteoprotegerin (OPG ) 被表明了是涉及改变的骨头侵蚀和骨头的关键分子。这研究的目的是在蛋白质 DKK-1 铺平的 RA.Methods 的不同舞台探索 DKK-1 和 OPG 的潜在的角色, OPG 被 ELISA 检测。浆液样品与 RA 和 60 健康控制从 300 个病人被收集。哪个, 150 个 RA 病人被定义为早 RA (疾病持续时间 1 年) ,和另外的 150 RA 病人们被定义为 longlasting RA (疾病持续时间 5 年) 。在浆液采样的时候,各种各样临床并且实验室参数被估计。 DKK-1 或 OPG 和 clinical/laboratory 参数的关联是 analyzed.Results 当没有重要差别在 OPG.In 对比的水平在二个组之间被观察时, DKK-1 的浆液水平与健康控制相比与长期的 RA 在病人被提高,在早 RA 病人,传播 OPG 被提高,当在 DKK-1 的表示的二个组之间没有重要差别时。浆液 DKK-1 在长期的 RA 病人与锋利的分数和 DAS28 被相关。在早 RA,年龄是是的唯一的参数显著地与在那里的浆液 OPG.Conclusions 有关是在 DKK-1 和 OPG 之间的串音,它在 RA 在骨头破坏包含了。在 RA 的不同舞台, DKK-1 和 OPG 可以在 RA 的致病起不同作用。 | LIU Yan-ying LONG Li WANG Shi-yao GUO Jian-ping YE Hua CUI Liu-fu YUAN Guo-hua LI Zhan-guo | 2010 | Chinese Medical Journal2010，，11： | 14 |
| 16 | Risk factors for new onset diabetes mellitus after liver transplantation: A meta-analysis显示文摘AIM: To determine the risk factors for new-onset diabetes mellitus(NODM) after liver transplantation by conducting a systematic review and meta-analysis.METHODS: We electronically searched the databases of MEDLINE, EMBASE and the Cochrane Library from January 1980 to December 2013 to identify relevant studies reporting risk factors for NODM after liver transplantation. Two authors independently assessed the trials for inclusion and extracted the data. Discrepancies were resolved in consultation with a third reviewer. All statistical analyses were performed with the Rev Man5.0 software(The Cochrane Collaboration, Oxford, United Kingdom). Pooled odds ratios(OR) or weighted mean differences(WMD) with 95% confidence intervals(CIs) were calculated using either a fixed effects or a random effects model, based on the presence(I2 < 50%) or absence(I2 > 50%) of significant heterogeneity. RESULTS: Twenty studies with 4580 patients were included in the meta-analysis, all of which were retrospective. The meta-analysis identified the following significant risk factors: hepatitis C virus(HCV) infection(OR = 2.68; 95%CI: 1.92-3.72); a family history of diabetes(OR = 1.69, 95%CI: 1.09-2.63, P < 0.00001); male gender(OR = 1.53; 95%CI: 1.24-1.90; P < 0.0001); impaired fasting glucose(IFG; OR = 3.27; 95%CI: 1.84-5.81; P < 0.0001); a family history of diabetes(OR = 1.69; 95%CI: 1.09-2.63; P = 0.02); use of tacrolimus(OR = 1.34; 95%CI: 1.03-1.76; P = 0.03) and body mass index(BMI)(WMD = 1.19, 95%CI: 0.69-1.68, P < 0.00001). Other factors, such as hepatitis B virus infection and alcoholism, were not found to be associated with the incidence of NODM.CONCLUSION: The study showed that HCV infection, IFG, a family history of diabetes, male gender, tacrolimus and BMI are risk factors for NODM after liver transplantation. | Da-Wei Li Tian-Fei Lu Xiang-Wei Hua Hui-Juan Dai Xiao-Lan Cui Jian-Jian Zhang Qiang Xia | 2015 | World Journal of Gastroenterology2015，21，20： | 14 |
| 17 | A Prospective Randomized Multicenter Controlled Trial on Salvianolate for Treatment of Unstable Angina Pectoris in A Chinese Elderly Population显示文摘Objective: To evaluate the efficacy and safety of salvianolate in elderly patients with unstable angina pectoris(UAP). Methods: A prospective double-blind randomized placebo-controlled multicenter trial in elderly patients with UAP from 13 third-grade class-A hospitals in China was performed. A total of 318 patients were randomly allocated in a 1:1 ratio to an experimental group(160 patients) and a control group(158 patients). The experimental group was treated with salvianolate for 14 days on the basis of conventional medicine, and the control group was given a placebo for 14 days with the same criteria. Follow-up was lasted 28 days in both groups. The primary endpoint was biweekly frequency of angina pectoris attacks. The secondary endpoints included biweekly dosage of nitroglycerin, the Seattle Angina Questionnaire, angina pectoris severity and duration, myocardial injury markers, high-sensitivity C-reactive protein(hs-CRP) and N-terminal pro-B-type natriuretic peptide(NT-proBNP), as well as major adverse cardiovascular events(MACEs). Safety was assessed according to adverse events and serious adverse events. Results: Baseline characteristics were similar between treatment groups. Compared with those in the control group, the frequency of biweekly angi na attacks(2.92 vs. 4.08, P =0.025), th e biweekly dosage of nitroglycerin, as well as the severity and duration of angina attacks(P <0.01) were reduced by salvianolate. The Seattle Angina Questionnaire score was also significantly improved in the experimental group than in the control group(P <0.05). No significant differences were observed between the two groups with respect to the incidence of MACEs. Salvianolate was well tolerated. Conclusions: Salvianolate appear to have efficacy and well tolerated for elderly patients with UAP. | CUI Hua LI Xiao-ying GAO Xue-wen LU Xiang WU Xiu-ping WANG Xiao-fei ZHENG Xiang-qing HUANG Kui LIU Feng LUO Zhi YUAN Hui-shu SUN Gang KONG Jian DU Xiao-hong ZHENG Jin LIU Hong-ying ZHANG Wen-ju | 2019 | Chinese Journal of Integrative Medicine2019，25，10： | 13 |
| 18 | Prevalence of cardiovascular disease in subjects hospitalized due to chronic obstructive pulmonary disease in Beijing from 2000 to 2010显示文摘ObjectivesTo 在为长期的妨碍的肺的疾病( COPD )就医的题目调查心血管的疾病( CVD )的全面流行,并且在10年的 period.MethodsMedical 上与 COPD 在病人探索主要 CVD 复杂并发症和趋势的流行在 PLA 医院将军,的记录北京联合医学院医院,并且到 2010/03/03 的从 2000/01/01 的北京医院回顾地被考察。有 COPD 的 4960 个病人的一个总数在学习被考察(3570 男性,意味着年龄, 72.2 ±10.5 年;1390 女性,意味着年龄, 72.0 ±10.4 年) 在 COPD 病人的 CVD 的 .ResultsThe 流行是 51.7% 。三很流行的 CVD 是 ischemic 心疾病(28.9%) ,心失败(19.6%) ,和心律不齐(12.6%) 。在 10 年的学习时期期间,在 COPD 病人的各种各样的 CVD 的流行与增加年龄显示出一个渐渐的增加趋势。由于 ischemic 心疾病有更高的病态(P <0.01 ) 在男 COPD 病人比在女对应物。然而,心失败(P <0.01 ) 并且高血压(P <0.01 ) 比在女 COPD 病人不太经常发生在男 COPD 病人。而且, ischemic 心疾病的流行逐年减少了。除了心失败,在 COPD 病人的 CVD 复杂并发症的各种各样的类型趋于发生在更年轻的题目。在女人的 CVD 的所有主要类型的流行趋于在就医的病人由 CVD 的 year.ConclusionsThe 流行增加年因为在北京的 COPD 高。年龄,性别和 CVD 趋势,以及生活方式变化,当预防和控制策略被提出时,应该被考虑。 | Hua Cui Dong-Mei Miao Zhi-Min Wei Jian-Fang Cai Yi Li Ai-Min Liu Fan Li | 2012 | Journal of Geriatric Cardiology2012，9，1： | 11 |
| 19 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 20 | Gold immunochromatographic sensor for the rapid detection of twenty-six sulfonamides in foods显示文摘一个金 immunochromatographic 传感器(GICS ) 在蜂蜜样品为 26 硫安类药剂的快速的察觉被开发。传感器基于能认出所有 26 硫安类药剂的组特定的 monoclonal 抗体(mAb ) 。三 haptens (1 与 thiazole 包围的 hapten, 2 与苯包围的 hapten,和 3 与直碳锁住的 hapten ) 被用于抗原准备。与 hybridoma 技术,组特定的 mAb 与 50% 最大的禁止的集中被屏蔽(对 sulfathizole (STZ ) 和从 0.08 ~ 90.18 ng/mL 的另外的 25 类似物的 IC 50) 。单音分散金 nanoparticles 与 mAb 被结合开发侧面的 immunochromatographic 长带。0.1 g/mL 的标记的抗体集中和在测试线的 0.2 g/mL 的涂层抗原集中为长带准备被选择。在优化条件,为 STZ 的集中的察觉( vLOD )的视觉限制, sulfamethoxazole , sulfamethizole ,磺胺嘧啶, sulfamerazine , sulfadimethoxine , sulfamonomethoxine , sulfameter , sulfamethoxypyridazine ,和 sulfachloropyridazine 下面是 5 , 0.25 , 0.25 , 10 , 5 , 10 , 25 , 2.5 , 5 , 0.25 ,和 10 g/kg 分别地。在蜂蜜样品的扫描仪分析为 26 硫安类药剂的察觉揭示了好性能。商业蜂蜜样品与传感器被测试,积极结果与高效的液体层析被证实。建议脱衣传感器在爱人样品为硫安类药剂污染物质的快速、可靠的决心提供一个方便方法。 | Yanni Chen Liqiang Liu Liguang Xu Shanshan Song Hua Kuang Gang Cui Chuanlai Xu | 2017 | Nano Research2017，10，8： | 11 |
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