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| 1 | Diagnosis and treatment recommendations for pediatric respiratory infection caused by the 2019 novel coronavirus显示文摘Since December 2019,an epidemic caused by novel coronavirus (2019-nCoV) infection has occurred unexpectedly in China.As of 8 pm,31 January 2020,more than 20 pediatric cases have been reported in China.Of these cases,ten patients were identified in Zhejiang Province,with an age of onset ranging from 112 days to 17 years.Following the latest National recommendations for diagnosis and treatment of pneumonia caused by 2019-nCo V (the 4th edition) and current status of clinical practice in Zhejiang Province,recommendations for the diagnosis and treatment of respiratory infection caused by 2019-nCoV for children were drafted by the National Clinical Research Center for Child Health,the National Children's Regional Medical Center,Children's Hospital,Zhejiang University School of Medicine to further standardize the protocol for diagnosis and treatment of respiratory infection in children caused by 2019-nCoV. | Zhi-Min Chen Jun-Fen Fu Qiang Shu Ying-Hu Chen Chun-Zhen Hua Fu-Bang Li Ru Lin Lan-Fang Tang Tian-Lin Wang Wei Wang Ying-Shuo Wang Wei-Ze Xu Zi-Hao Yang Sheng Ye Tian-Ming Yuan Chen-Mei Zhang Yuan-Yuan Zhang | 2020 | World Journal of Pediatrics2020，16，3： | 45 |
| 2 | The First Imported Case of Monkeypox in the Mainland of China—Chongqing Municipality,China,September 16,2022显示文摘Monkeypox is a zoonotic viral disease caused by the monkeypox virus(MPXV),and historically,all outbreaks have been linked to Africa;however,monkeypox has been posing an alarming challenge to the world in 2022(1)as approximately 60,000 cases have been reported in more than 100 nations and regions worldwide(2).Currently,many cases of monkeypox were identified in many nonendemic countries outside of Central and West Africa,and human-to-human transmission has occurred frequently,especially among men who have sex with men(MSM)presenting new clinical symptoms similar to syphilis and other sexually transmitted infections(3). | Hua Zhao Wenling Wang Li Zhao Sheng Ye Jingdong Song Roujian Lu Hua Zong Changcheng Wu Wei Huang Baoying Huang Yao Deng Ruhan A Wujuan Xie Li Qi Wenbo Xu Hua Ling Wenjie Tan | 2022 | China CDC weekly2022，4，38： | 35 |
| 3 | Risk factors for alcohol-related liver injury in the island population of China: A population-based case-control study显示文摘AIM:To investigate the association of alcohol dose, duration of drinking and obesity with abnormal alcohol-related liver injury indicators, the prevalence of alcohol-related liver injury in the island population of China.METHODS:Randomized multistage stratified cluster sampling from the island population of China was used in the population-based case-control study. Then interview, physical examination, laboratory assessments and ultrasonography were done. RESULTS:Daily alcohol intake ≥ 20 g, duration of drinking ≥ 5 years and obesity were closely related to alcohol-related liver injury (P < 0.05). The odds-ratio (OR) (95% CI) was 1.965 (1.122-3.442), 3.412 (1.789-6.507) and 1.887 (1.261-2.824), respectively. The prevalence rate of alcohol-related liver injury in ≥ 20 g daily alcohol intake group and < 20 g daily alcohol intake group was 37.14% and 12.06%, respectively. The prevalence rate of alcohol-related liver injury in ≥ 5 years drinking group and < 5 years drinking group was 34.44% and 8.53%, respectively. No significant dose-response relation was found between daily alcohol intake and abnormal alcohol-related liver injury indicators as well as between duration of drinking and abnormal alcohol-related liver injury indicators. There was no significant difference in the prevalence of alcohol-related liver injury between beer drinking group and yellow rice wine drinking group, hard liquor drinking group, multiple drinking group.CONCLUSION:The risk threshold of daily alcohol intake is 20 g and duration of drinking inducing alcohol-related liver injury 5 years in the island population of China. Liver injury induced by obesity should be concerned. | Zhe Shen You-Ming Li Chao-Hui Yu Yi Shen Lei Xu Cheng-Fu Xu Jin-Jin Chen Hua Ye Gen-Yun Xu | 2008 | World Journal of Gastroenterology2008，14，14： | 28 |
| 4 | DEL RBC transfusion should be avoided in particular blood recipient in East Asia due to allosensitization and ineffectiveness显示文摘Previously, both primary and secondary anti-D alloimmunizations induced by 'Asian type' DEL (RHD1227A allele) were observed in two incidents. We investigated how often these alloimmunization events occur. The transfusions of any D-negative patients were investigated in the First Affiliated Hospital of Xi'an Jiaotong University Medical College, China, during the entire 2009. The antigens of D, C, c, E, and e were routinely serotyped. The 'Asian type' DEL variant was genotyped and the RHD heterozygote was determined through two published methods. The changes in anti-D levels were monitored by the indirect antiglobulin test (IAT) and flow cytometry. Thirty D-negative transfused patients were included in the study. We focused on 11 recipients who were transfused with packed red blood cells (RBCs) from DEL donors at least one time. Of those 11 recipients, seven were anti-D negative before transfusion and four were anti-D positive (one patient with an autoantibody). One of the seven pre-transfusion anti-D negative patients produced a primary-response anti-D after being transfused with 400 ml of DEL blood twice. All four pre-transfusion antibody positive patients were not observed hemoglobin (Hb) levels increased, as expected after transfusions. Two patients had an increase in anti-D from 1:8 to 1:64 by IAT, which was also shown by flow cytometry. None of the patients experienced an acute hemolytic episode. Our data indicated that the primary anti-D induced by DEL transfusion or the secondary anti-D elevated by DEL in a truly D-negative patient might not be unusual. We suggest that a truly D-negative childbearing-aged woman should avoid DEL transfusion to protect her from primary anti-D allosensitization. In addition, anti-D positive recipients should also avoid DEL red cell transfusion due to the delayed hemolytic transfusion reaction (DHTR). | Chao-peng SHAO Bao-yan WANG Shi-hui YE Wen-li ZHANG Hua XU Nai-bao ZHUANG Xiao-ying WU Heng-gui XU | 2012 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2012，13，11： | 27 |
| 5 | Prevalence of Thyroid Nodules and Its Relationship with Iodine Status in Shanghai:a Population-based Study显示文摘Objective This study was designed to evaluate the prevalence of thyroid nodules(TNs) and its relationship with urine iodine concentrations(UICs) after the regional rapid economic growth and lifestyle changes. Methods A cross-sectional survey was conducted in the general population aged 15-69 years. A questionnaire regarding general and personal characteristics and relevant information was administered. Ultrasonography of the thyroid was performed, and serum triiodothyronine(T3), tetraiodothyronine(T4), serum thyroid stimulating hormone(TSH), free triiodothyronine(FT3), free tetraiodothyronine(FT4), thyroglobulin antibody(Tg Ab), thyroid peroxidase antibody(TPOAb), and TSH receptor antibody(TRAb) levels were measured for each individual subject. Results The prevalence rates of TNs in the whole population, females and males were 27.76%, 34.04%, and 21.60%, respectively. The prevalence of multiple nodules increased with age, whereas the prevalence peaks differed between males and females. The median UICs in the whole population and females with non-TNs were higher than those of subjects with TNs(P=0.0035, P=0.0068). The median UICs in subjects with a single TN were higher than those in subjects with multiple TNs(P=0.0164, P=0.0127). The result showed a U-shaped curve relationship between UIC and prevalence of TNs. The prevalence of TNs was the lowest when the UIC was 140-400 μg/L. Conclusion The prevalence of TNs was nearly 30% and increased with age. The relationship between UIC and prevalence of TNs is U-shaped, with an increase in risk when the UIC was <140 μg/L and >400 μg/L. Very low or high UIC levels need attention and correction. | SONG Jun ZOU Shu Rong GUO Chang Yi ZANG Jia Jie ZHU Zhen Ni MI Ming HUANG Cui Hua YU Hui Ting LU Xi RUAN Ye WU Fan | 2016 | Biomedical and Environmental Sciences2016，29，6： | 25 |
| 6 | Epidemiology of Diabetes in Adults Aged 35 and Older from Shanghai,China显示文摘Objective This study aimed to investigate the epidemiology of diabetes in adults from Shanghai, aged 35 and older, in 2013. Methods We estimated the diabetes prevalence in a representative sample of 18,736 adults who were selected through a multistage stratified cluster sampling process. A standard questionnaire containing questions about demographic characteristics and lifestyle factors was distributed. After an overnight fast of at least 10 hours, a venous blood sample was collected from each participant. For each patient without a history of diabetes, another blood sample was drawn 120 min after an oral glucose tolerance test to identify undiagnosed diabetes and prediabetic condition. Results Among Shanghai residents aged 35 and above, the overall weighted prevalence of diabetes was 17.6% [95% confidence interval(CI): 16.4%-18.8%]. The prevalences were 19.3% in men and 15.8% in women as well as 19.1%, 15.4%, and 16.1% in urban, suburban, and rural residents, respectively. In addition, the weighted prevalence of prediabetes was 16.5%(95% CI: 15.3%-17.8%), with the prevalences of 16.5% in men, 16.6% in women, 15.2% in urban residents, 18.0% in suburban residents, and 18.5% in rural residents. Among all patients with diabetes, 68.1%(95% CI: 64.3%-71.6%) were aware of their status, 63.5%(95% CI: 60.0%-66.9%) received diabetes treatment, but only 35.1%(95% CI: 32.4%-37.8%) had adequate glycemic control. Conclusion In Shanghai, diabetes and prediabetes are highly prevalent. However, 1/3rd of diabetes cases are undiagnosed, and the rate of glycemic control is low. | RUAN Ye YAN Qing Hua XU Ji Ying YANG Qun Di YAO Hai Hong LI Rui SHI Yan | 2016 | Biomedical and Environmental Sciences2016，29，6： | 22 |
| 7 | Pluripotent stem cells induced from mouse neural stem cells and small intestinal epithelial cells by small molecule compounds显示文摘最近,我们报导了一条化学途径从老鼠成纤维细胞产生 pluripotent 干细胞。然而,是否化学上导致了 pluripotent 干细胞(CiPSCs ) ,能从要示威的另外的房间类型遗体被导出。用系跟踪,这里,我们首先从成纤维细胞验证 CiPSCs 的产生。下次,我们证明从外胚层的神经干细胞(NSC ) 和从内胚叶的小肠的上皮的房间(IEC ) 能是化学上 reprogrammed 进 pluripotent 干细胞。CiPSCs 源于 NSC 和 IEC 类似于老鼠处于增长率,全球基因表示侧面, epigenetic 地位,自强和区别能力的胚胎的干细胞,和 germline 传播才能。有趣地, pluripotency 基因 Sall4 从不同房间类型,和一样的核心在化学 reprogramming 过程在起始的阶段被表示小分子为 reprogramming 被要求,在从这些多样的房间类型位于化学 reprogramming 下面的分子的机制建议保存。我们的分析也证明这些小分子的使用应该被调整从不同房间类型满足 reprogramming 的要求。一起,这些调查结果证明那条完整的化学 reprogramming 途径能在不同织物起源的房间被使用并且建议化学 reprogramming 是有要延长到更起始的类型的潜力的有希望的策略。 | Junqing Ye Jian Ge Xu Zhang Lin Cheng Zhengyuan Zhang Shan He Yuping Wang Hua Lin Weifeng Yang Junfang Liu Yang Zhao Hongkui Deng | 2016 | Cell Research2016，26，1： | 19 |
| 8 | Comparison of 5-hydroxytryptophan signaling pathway characteristics in diarrhea-predominant irritable bowel syndrome and ulcerative colitis显示文摘AIM: To study differences in the visceral sensitivity of the colonic mucosa between patients with diarrheapredominant irritable bowel syndrome(IBS-D) and those with ulcerative colitis(UC) in remission and to relate these differences with changes in the 5-hydroxytryptophan(5-HT) signaling pathway. METHODS: Gastrointestinal symptoms were used to determine the clinical symptom scores and rectal visceral sensitivity of patients with IBS-D and patients with UC in remission. Blood levels of 5-HT and5-hydroxyindoleacetic acid(5-HIAA) were measured using an HPLC-electrochemical detection system. The levels of 5-HT 3 receptor(3R), 4R, and 7R m RNAs in colonic biopsy samples were detected using reverse transcription-polymerase chain reaction. The protein expression of TPH1 was analyzed by Western blot and immunohistochemistry.RESULTS: Abdominal pain or discomfort, stool frequency, and the scores of these symptoms in combination with gastrointestinal symptoms were higher in the IBS-D and UC groups than in the control groups. However, no significant differences were observed between the IBS-D and UC remission groups. With respect to rectal visceral sensitivity, the UC remission and IBS-D groups showed a decrease in the initial perception threshold, defecating threshold and pain threshold. However, these groups exhibited significantly increased anorectal relaxation pressure. Tests examining the main indicators of the 5-HT signaling pathway showed that the plasma 5-HT levels, 5-HIAA concentrations, TPH1 expression in the colonic mucosa, and 5-HT3 R and 5-HT5 R expression were increased in both the IBS-D and the UC remission groups; no increases were observed with respect to 5-HT7 R expression.CONCLUSION: The IBS-D and UC groups showed similar clinical symptom scores, visceral sensitivity, and levels of serotonin signaling pathway indicators in the plasma and colonic mucosa. However, the pain threshold and 5-HT7 R expression in the colonic mucosa were significantly different between these groups. The results reveal that(1) IBS-D and UC are related to visceral sensitivity pathogenesis and the clinical manifestations of these conditions and(2) the observed differences in visceral hypersensitivity are possibly due to differences in levels of the 5-HT7 receptor, a component of the 5-HT signaling pathway. | Feng-Yan Yu Shao-Gang Huang Hai-Yan Zhang Hua Ye Hong-Gang Chi Ying Zou Ru-Xi Lv Xue-Bao Zheng | 2016 | World Journal of Gastroenterology2016，22，12： | 19 |
| 9 | Effects of baicalin in CD4 + CD29 + T cell subsets of ulcerative colitis patients显示文摘AIM:To evaluate the role of baicalin in ulcerative colitis(UC) with regard to the CD4+CD29+ T helper cell,its surface markers and serum inflammatory cytokines.METHODS:Flow cytometry was used to detect the percentage of CD4+CD29+ cells in patients with UC.Real time polymerase chain reaction was used to detect expression of GATA-3,forkhead box P3,T-box expressed in T cells(T-bet),and retinoic acid-related orphan nuclear hormone receptor C(RORC).Western blotting was used to analyze expression of nuclear factor-κB(NF-κB) p65,phosphorylation of NF-κB(p-NF-κB) p65,STAT4,p-STAT4,STAT6 and p-STAT6.The concentrations of interferon-γ(IFN-γ),interleukin(IL)-4,IL-5,IL-6,IL-10 and TGF-β in serum were determined by ELISA assay.RESULTS:The percentages of CD4+CD29+ T cells were lower in treatment with 40 and 20 μmol/L baicalin than in the treatment of no baicalin.Treatment with 40 or 20 μmol/L baicalin significantly upregulated expression of IL-4,TGF-β1 and IL-10,increased p-STAT6/STAT6 ratio,but downregulated expression of IFN-γ,IL-5,IL-6,RORC,Foxp3 and T-bet,and decreased ratios of T-bet/GATA-3,p-STAT4/STAT4 and p-NF-κB/NF-κB compared to the treatment of no baicalin.CONCLUSION:The results indicate that baicalin regulates immune balance and relieves the ulcerative colitis-induced inflammation reaction by promoting proliferation of CD4+CD29+ cells and modulating immunosuppressive pathways. | Feng-Yan Yu Shao-Gang Huang Hai-Yan Zhang Hua Ye Hong-Gang Chi Ying Zou Ru-Xi Lv Xue-Bao Zheng | 2014 | World Journal of Gastroenterology2014，20，41： | 18 |
| 10 | He-Ar isotope geochemistry of the Yaoling-Meiziwo tungsten deposit,North Guangdong Province:Constraints on Yanshanian crust-mantle interaction and metallogenesis in SE China显示文摘Isotopic abundances and ratios of He and Ar found in inclusion fluids in pyrites formed in the Yaoling-Meiziwo tungsten miner-alization epoch show that the concentration of 4He varies widely,from 1.54×10-7 cm3 STP/g to 2609×10-7 cm3 STP/g.3He is 0.759×10-12 cm3 STP/g-3.463×10-12 cm3 STP/g.3He/4He is 0.0043-4.362 Ra,varying from crustal to mantle values.The concen-tration of 40Ar ranges from 0.624×10-7 cm3 STP/g to 8.89×10-7 cm3 STP/g.The 40Ar/36Ar varies extensively,from 330 to 2952,between atmospheric and crustal or mantle radiogenic values.Mantle-derived He is present in ore-forming fluids and the calcu-lated average proportion of the mantle He is 22%;the maximum is 67%.Our research results show that mantle-derived fluids play a significant role in tungsten mineralization.The fractionation of He and Ar indicate that there was 4He-enriched air-saturated water(MSAW) in the ore-forming fluid.The ore-forming fluid was a mixture of mantle fluid,crustal magmatic fluid and MSAW.The occurrence of a mantle component in ore-forming fluid indicates the large-scale W and Sn mineralization,including Yaol-ing-Meiziwo,in southeastern China was the result of crust and mantle interaction.The underplating or intrusion of voluminous basaltic magma formed by partial melting of the upper mantle provided the necessary heat to cause partial melting of the crust and the generation of voluminous S-type granitic magmas.Crustal magmatic fluid and mantle fluid with high 3He/4He were released from magma crystallization and fractionation,mixed with the circulating modified air-saturated water,and filled the extensional tectonic fractures,leading to the formation of world-class W and Sn deposits in southeastern China. | ZHAI Wei SUN XiaoMing WU YunShan SUN YanYan HUA RenMin YE XianRen | 2012 | Chinese Science Bulletin2012，57，10： | 16 |
| 11 | Prognostic factors and survival in patients with gastric stump cancer显示文摘AIM:To elucidate the clinicopathological characteristics and prognostic factors of gastric stump cancer(GSC).METHODS:The clinical data for 92 patients with GSC were collected at Fudan University Shanghai Cancer Center.The prognostic factors were analyzed with Cox proportional hazard models.RESULTS:GSC tended to occur within 25 years following the primary surgery,when the initial disease is benign,whereas it primarily occurred within the first15 years post-operation for gastric cancer.Patients with regular follow-up after primary surgery had a better survival rate.The multivariate Cox regression analysis revealed that Borrmann type?Ⅰ/Ⅱ(HR=3.165,95%CI:1.055-9.500,P=0.040)and radical resection(HR=1.780,95%CI:1.061-2.987,P=0.029)were independent prognostic factors for GSC.The overall 1-,3-,and 5-year survival rates of the 92 patients were78.3%,45.6%and 27.6%,respectively.The 1-,3-,and 5-year survival rates of those undergoing radical resection were 79.3%,52.2%,and 37.8%,respectively.The 5-year survival rates for stages?Ⅰ,Ⅱ,Ⅲ,andⅣwere 85.7%,47.4%,16.0%,and 13.3%,respectively(P=0.005).CONCLUSION:The appearance of GSC occurs sooner in patients with primary malignant cancer than in patients with a primary benign disease.Therefore,close follow-up is necessary.The overall survival of patients with GSC is poor,and curative resection can improve their prognosis. | Hua Huang Wei Wang Zhong Chen Jie-Jie Jin Zi-Wen Long Hong Cai Xiao-Wen Liu Ye Zhou Ya-Nong Wang | 2015 | World Journal of Gastroenterology2015，21，6： | 16 |
| 12 | Epidermal growth factor receptor antibody plus recombinant human endostatin in treatment of hepatic metastases after remnant gastric cancer resection显示文摘We report a 55-year-old male who developed advanced hepatic metastasis and peritoneal carcinomatosis after resection of remnant gastric cancer resection 3 mo ago. The patient only received epidermal growth factor (EGF) receptor antibody (Cetuximab) plus recombinant human endostatin (Endostar). Anti-tumor activity was assessed by 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computer tomography (PET/CT) at baseline and then every 4 wk. The case illustrates that 18FDG-PET/CT could make an early prediction of the response to Cetuximab plus Endostar in such clinical situations. 18FDG-PET/CT is a useful molecular imaging modality to evaluate the biological response advanced hepatic metastasis and peritoneal carcinomatosis to Cetuximab plus Endostar in patients after remnant gastric cancer resection. | Long Sun Huang-Yang Ye Ying-Hong Zhang Yong-Song Guan Hua Wu | 2007 | World Journal of Gastroenterology2007，13，45： | 15 |
| 13 | AKT-modified autologous intracoronary mesenchymal stem cells prevent remodeling and repair in swine infarcted myocardium显示文摘成年骨头的背景移植导出髓的间充质的干细胞(MSC ) 为心脏的修理作为策略被建议了后面的心肌的损坏。然而,代替失去的心肌层的房间移植策略被无能限制交付抵抗 peritransplantation 接枝房间死亡的大量房间。因此,我们开始孤立并且膨胀成年的猪骨头,并且设计这些房间到 overexpress AKT1 (蛋白质 kinase B )导出髓的 MSC ,为了测试假设,那 AKT1 设计了 MSC 对 apoptosis 更抵抗并且能在移植以后提高心脏的修理进 ischemic 猪 heart.Methods CDS ( AKT1 的规定领域) AKT1-cDNA 碎片被放大,并且 MSC 是有 pCDH1-AKT1 shuttling plasmid 的 transfected 追随者合成。西方的弄污分析和即时反向的抄写聚合酶链反应(RT-PCR ) 被执行。心肌的梗塞(Ml ) 模型在 Meishan 猪被构造,并且心脏的功能被磁性的回声成像(MRI ) 评估大小和 4 个星期以后的 echocardiography。所有猪被分到四个组:控制(A) , DMEM (B) , MSC (C) ,和 AKT-transfected (D) 。MSC 是有 AKT1 基因,和自体同源的标记 BrdU 的干细胞的 transfected | YU Yun-sheng SHEN Zhen-ya YE Wen-xue HUANG Hao-yue HUA Fei CHEN Yi-huan CHEN Ke LAO Wei-jie TAO Li | 2010 | Chinese Medical Journal2010，，13： | 15 |
| 14 | A Scenario-Based Robust Transmission Network Expansion Planning Method for Consideration of Wind Power Uncertainties显示文摘This paper uses a novel scenario generation method for tackling the uncertainties of wind power in the transmission network expansion planning(TNEP)problem.A heuristic moment matching(HMM)method is first applied to generate the typical scenarios for capturing the stochastic features of wind power,including expectation,standard deviation,skewness,kurtosis,and correlation of multiple wind farms.Then,based on the typical scenarios,a robust TNEP problem is presented and formulated.The solution of the problem is robust against all the scenarios that represent the stochastic features of wind power.Three test systems are used to verify the HMM method and is compared against Taguchi’s Orthogonal Array(OA)method.The simulation results show that the HMM method has better performance than the OA method in terms of the trade-off between robustness and economy.Additionally,the main factors influencing the planning scheme are studied,including the number of scenarios,wind farm capacity,and penalty factors,which provide a reference for system operators choosing parameters. | Jinghua Li Liu Ye Yan Zeng Hua Wei | 2016 | CSEE Journal of Power and Energy Systems2016，2，1： | 15 |
| 15 | Circulating Dickkopf-1 and osteoprotegerin in patients with early and longstanding rheumatoid arthritis显示文摘背景风湿性关节炎(RA ) 被 synovial 膜的发炎描绘,导致进有象后果的关节的软骨和骨头的降级的邻近的软骨矩阵的 synovial 织物的侵略。Dickkopf-1 (DKK-1 ) 和 osteoprotegerin (OPG ) 被表明了是涉及改变的骨头侵蚀和骨头的关键分子。这研究的目的是在蛋白质 DKK-1 铺平的 RA.Methods 的不同舞台探索 DKK-1 和 OPG 的潜在的角色, OPG 被 ELISA 检测。浆液样品与 RA 和 60 健康控制从 300 个病人被收集。哪个, 150 个 RA 病人被定义为早 RA (疾病持续时间 1 年) ,和另外的 150 RA 病人们被定义为 longlasting RA (疾病持续时间 5 年) 。在浆液采样的时候,各种各样临床并且实验室参数被估计。 DKK-1 或 OPG 和 clinical/laboratory 参数的关联是 analyzed.Results 当没有重要差别在 OPG.In 对比的水平在二个组之间被观察时, DKK-1 的浆液水平与健康控制相比与长期的 RA 在病人被提高,在早 RA 病人,传播 OPG 被提高,当在 DKK-1 的表示的二个组之间没有重要差别时。浆液 DKK-1 在长期的 RA 病人与锋利的分数和 DAS28 被相关。在早 RA,年龄是是的唯一的参数显著地与在那里的浆液 OPG.Conclusions 有关是在 DKK-1 和 OPG 之间的串音,它在 RA 在骨头破坏包含了。在 RA 的不同舞台, DKK-1 和 OPG 可以在 RA 的致病起不同作用。 | LIU Yan-ying LONG Li WANG Shi-yao GUO Jian-ping YE Hua CUI Liu-fu YUAN Guo-hua LI Zhan-guo | 2010 | Chinese Medical Journal2010，，11： | 14 |
| 16 | Protective effects of Ligustrazine,Kakonein and Panax Notoginsenoside on the small intestine and immune organs of rats with severe acute pancreatitis显示文摘BACKGROUND:Severe acute pancreatitis (SAP) is characterized by fatal pathogenic conditions and a high mortality.It is important to study SAP complicated with multiple organ injury.In this study we compared the protective effects of three traditional Chinese medicines (Ligustrazine,Kakonein and Panax Notoginsenoside) on the small intestine and immune organs (thymus,spleen and lymph nodes) of rats with SAP and explored their mechanism of action.METHODS:One hundred forty-four rats with SAP were randomly divided into model control,Ligustrazine-treated,Kakonein-treated,and Panax Notoginsenoside-treated groups (n=36 per group).Another 36 normal rats comprised the sham-operated group.According to the different time points after operation,the experimental rats in each group were subdivided into 3-,6-and 12-hour subgroups (n=12).At various time points after operation,the mortality rate of rats and pathological changes in the small intestine and immune organs were recorded and the serum amylase levels were measured.RESULTS:Compared to the model control groups,the mortality rates in all treated groups declined and the pathological changes in the small intestine and immune tissues were relieved to different degrees.The serum amylase levels in the three treated groups were significantly lower than those in the model control group at 12 hours.The pathological severity scores for the small intestinal mucosa,thymus and spleen (at 3 and 12 hours) in the Ligustrazine-treated group,for the thymus (at 3 and 12 hours) and spleen (at 3 and 6 hours) in the Kakonein-treated group,and for the thymus (at 3 hours)and spleen (at 3 hours) in the Panax Notoginsenoside-treated group were significantly lower than those in the model control group.The pathological severity scores of the small intestinal mucosa (at 6 and 12 hours) and thymus (at 6 hours) in the Ligustrazine-treated group were significantly lower than those in the Kakonein-and Panax Notoginsenoside-treated groups.CONCLUSIONS:All the three traditional Chinese drugs significantly alleviated the pathological changes in the small intestine and immune organs of SAP rats.Ligustrazine was the most effective one among them. | Xi-Ping Zhang,Jun Jiang,Qi-Hui Cheng,Qian Ye,Wei-Juan Li,Hua Zhu and Jun-Ya Shen Department of General Surgery,Department of Gynecology and Obstetrics and Central Laboratory Department,Hangzhou First People’s Hospital,Hangzhou 310006,China Zhejiang Chinese Medical University,Hangzhou 310053,China | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，6： | 11 |
| 17 | Fixation of CO_2 by electrocatalytic reduction to synthesis of dimethyl carbonate in ionic liquid using effective silver-coated nanoporous copper composites显示文摘与高表面区域,开的孔和高效率,催化剂在 electrocatalytic 被准备并且第一采用了 CO2 的减小和 dimethyl 碳酸盐(直接数字控制) 的 electrosynthesis。为在离子的液体的 CO2 的 electrocatalytic 减小的电气化学的性质被周期的 voltammogram (CV ) 学习。象 electrocatalytic 性能上的温度,工作潜力和阴极材料一样的各种各样的反应变量的效果也被调查。直接数字控制的 80% 产量在最佳的反应条件下面被获得。 | Xuan Yun Wang Su Qin Liu Ke Long Huang Qiu Ju Feng De Lai Ye Bing Liu Jin Long Liu Guan Hua Jin | 2010 | Chinese Chemical Letters2010，21，8： | 10 |
| 18 | Role of JWA in acute promye-locytic leukemia cell differentiation and apoptosis triggered by retinoic acid,12-tetradecanoylphorbol-13- acetate and arsenic trioxide显示文摘JWA, a cytoskeleton associated gene, was primarily found to be regulated by all trans-retinoic acid (ATRA), 13 cis-retinoic acid (13 cis-RA) and 12-tetradecano-ylphorbol-13-acetate (TPA). Our previous data showed that JWA might be involved in both cellular differentiation and apoptosis induced by several chemicals. In this study, we addressed the possible mechanism of JWA in the regulation of cell differentiation and apoptosis in NB4, a human acute promyelocytic leukemia cell line. CD11b/CD33 expression and cell cycle were analyzed for detecting of cell differentiation and apoptosis. Both reverse-transcription polymerase chain reaction (RT-PCR) and Western blot assays were used for understanding the expressions of JWA. The results showed that under the indicated concentrations ATRA (10-6 mol/L) and As2O3 (10-6 mol/L) induced cell differentiation and apoptosis separately; while both 4HPR (10-6mol/L) and TPA (10-7 mol/L) showed dual-directional effects on NB4 cells, they not only trigger cells’ | CAO Haixia XIA Wei SHEN Qun LU Hua YE Jian LI Aiping ZOU Changping ZHOU Jianwei | 2002 | Chinese Science Bulletin2002，47，10： | 10 |
| 19 | Myeloid-specific targeting of Notch ameliorates murine renal fibrosis via reduced infiltration and activation of bone marrowderived macrophage显示文摘Macrophages play critical roles in renal fibrosis.However,macrophages exhibit ontogenic and functional heterogeneities,and which population of macrophages contributes to renal fibrosis and the underlying mechanisms remain unclear.In this study,we genetically targeted Notch signaling by disrupting the transcription factor recombination signal binding protein-JK(RBP-J),to reveal its role in regulation of macrophages during the unilateral ureteral obstruction(UUO)-induced murine renal fibrosis.Myeloid-specific disruption of RBP-J attenuated renal fibrosis with reduced extracellular matrix deposition and myofibroblast activation,as well as attenuated epithelial-mesenchymal transition,likely owing to the reduced expression of TGF-β.Mean while,RBP-J deletion significantly hampered macrophage infiltration and activation in fibrotic kidney,although their proliferation appeared unaltered.By using macrophage clearance experiment,we found that kidney resident macrophages made negligible contribution,but bone marrow(BM)-derived macrophages played a major role in renal fibrogenesis.Further mechanistic analyses showed that Notch blockade reduced monocyte emigration from BM by down-regulating CCR2 expression.Finally,we found that myeloid-specific Notch activation aggravated renal fibrosis,which was mediated by CCR2^+macrophages infiltration.In summary,our data have unveiled that myeloid-specific targeting of Notch could ameliorate renal fibrosis by regulating BM-derived macrophages recruitment and activation,providing a novel strategy for intervention of this disease. | Yali Jiang Yuanyuan Wang Pengfei Ma Dongjie An Junlong Zhao Shiqian Liang Yuchen Ye Yingying Lu Peng Zhang Xiaowei Liu Hua Han Hongyan Qin | 2019 | Protein & Cell2019，10，3： | 10 |
| 20 | Wind power prediction based on variational mode decomposition multi-frequency combinations显示文摘Because of the uncertainty and randomness of wind speed, wind power has characteristics such as nonlinearity and multiple frequencies. Accurate prediction of wind power is one effective means of improving wind power integration. Because the traditional single model cannot fully characterize the fluctuating characteristics of wind power, scholars have attempted to build other prediction models based on empirical mode decomposition(EMD) or ensemble empirical mode decomposition(EEMD) to tackle this problem. However, the prediction accuracy of these models is affected by modal aliasing and illusive components. Aimed at these defects, this paper proposes a multi-frequency combination prediction model based on variational mode decomposition(VMD). We use a back propagation neural network(BPNN),autoregressive moving average(ARMA)model, and least square support vector machine(LS-SVM) to predict high, intermediate,and low frequency components,respectively. Based on the predicted values of each component, the BPNN is applied to combine them into a final wind power prediction value.Finally,the prediction performance of the single prediction models(ARMA,BPNN and LS-SVM)and the decomposition prediction models(EMD and EEMD) are used to compare with the proposed VMD model according to the evaluation indices such as average absolute error, mean square error,and root mean square error to validate its feasibility and accuracy. The results show that the prediction accuracy of the proposed VMD model is higher. | Gang ZHANG Hongchi LIU Jiangbin ZHANG Ye YAN Lei ZHANG Chen WU Xia HUA Yongqing WANG | 2019 | Journal of Modern Power Systems and Clean Energy2019，7，2： | 10 |
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