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| 1 | S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3显示文摘建筑群由 S100 钙绑定蛋白质家庭,的二个成员形成了 S100A8/A9,在不同起源的各种各样的房间施加导致 apoptosis 活动。这里,我们内在的分子的机制包含的现在的证据两个都规划了房间死亡我(PCD 我, apoptosis ) 并且象死亡一样的 PCD II (autophagy ) 。有 S100A8/A9 的房间的处理引起了 Beclin-1 表示以及 Atg12-Atg5 形成的增加。S100A8/A9-induced 房间死亡被特定的 PI3-kinase 班 III 禁止者部分禁止, 3-methyladenine (3 麻省) ,并且由液泡 H+-ATPase 禁止者, bafilomycin-A1 (Baf-A1 ) 。S100A8/A9 挑起了 BNIP3 的 translocation, BH3 仅仅 pro-apoptotic Bcl2 家庭成员,到线粒体。与这发现一致,螖 T M-BNIP3 overexpression 部分禁止了 S100A8/A9-induced 细胞死亡,减少的反应的氧种(ROS ) 产生,并且部分在 S100A8/A9-treated 细胞在 mitochondrial transmembrane 潜力免于减少。另外,任何一个螖 T M-BNIP3 overexpression 或 N-acetyl-L-cysteine 合作处理减少了在与 S100A8/A9 对待的房间的 lysosomal 激活。我们的数据显示 S100A8/A9-promoted 房间死亡通过线粒体的串音发生,经由 ROS 和这个过程的 lysosomes 包含 BNIP3。 | Saeid Ghavami Mehdi Eshragi Sudharsana R Ande Walter J Chazin Thomas Klonisch Andrew J Halayko Karol D Mcneill Mohammad Hashemi Claus Kerkhoff Marek Los | 2010 | Cell Research2010，20，3： | 13 |
| 2 | Cerebral processing of auditory stimuli in patients with irritable bowel syndrome显示文摘瞄准:用大脑决定功能的磁性的回声成像(fMRI ) 非内脏的刺激的服的处理是否在急躁的肠症候群(IBS ) 被改变病人与健康题目相比。围绕针的内脏躯体集中机制,并且识别心理因素的可能的影响,我们使用了听觉的刺激刺激在他们的感情的质量不同。方法:在 8 个 IBS 病人和 8 控制, fMRI 大小用不同感情的质量(钟声,讨厌的偷看(2000 Hz ) ,中立的词,和感情的词的愉快的声音) 的 4 听觉的刺激的一个块图案被执行。坡度回响 T2 * 加权的顺序被用于功能的扫描。统计地图用一般线性模型被构造。结果:到感情的听觉的刺激,,相对控制的 IBS 病人在感情的处理区域的一个更大的变化与更强壮的释放反应了反应模式,在控制不同,没在令人烦恼或愉快的声音之间区分。到中立听觉的刺激,由对比,仅仅 IBS 病人与大重要激活反应了。结论:到在感情的处理刺激的区域的听觉的刺激的改变的服的反应模式建议在 IBS 的改变的感觉处理不能为内脏的感觉是特定的,但是可能在感情的敏感和感情方面的反应反映概括变化,可能与经常在 IBS 病人发现的心理 comorbidity 联系了。 | Viola Andresen Alexander Poellinger Chedwa Tsrouya Dominik Bach Albrecht Stroh Annette Foerschler Petra Georgiewa Marco Schmidtmann Ivo R van der Voort Peter Kobelt Claus Zimmer Bertram Wiedenmann Burghard F Klapp Hubert Monnikes | 2006 | World Journal of Gastroenterology2006，12，11： | 8 |
| 3 | Noninvasive detection and evaluation of atherosclerotic coronary plaques with multislice computed tomography 1 1 This study was performed without additional financial support.显示文摘 | Stephen Schroeder Andreas F Kopp Andreas Baumbach Christoph Meisner Axel Kuettner Christian Georg Bernd Ohnesorge Christian Herdeg Claus D Claussen Karl R Karsch | 2001 | Journal of the American College of Cardiology2001，，5： | 3 |
| 4 | Preoperative chemoradiotherapy and postoperative chemotherapy with fluorouracil and oxaliplatin versus fluorouracil alone in locally advanced rectal cancer: initial results of the German CAO/ARO/AIO-04 randomised phase 3 trial显示文摘 | Claus R?del Torsten Liersch Heinz Becker Rainer Fietkau Werner Hohenberger Torsten Hothorn Ullrich Graeven Dirk Arnold Marga Lang-Welzenbach Hans-Rudolf Raab Heiko Sülberg Christian Wittekind Sergej Potapov Ludger Staib Clemens Hess Karin Weigang-K?hler G | 2012 | Lancet Oncology2012，，7： | 2 |
| 5 | High expression of microRNA-625-3p is associated with poor response to first-line oxaliplatin based treatment of metastatic colorectal cancer显示文摘 | Mads H. Rasmussen Niels F. Jensen Line S. Tarpgaard Camilla Qvortrup Maria U. R?mer Jan Stenvang Tine P. Hansen Lise L. Christensen Jan Lindebjerg Flemming Hansen Benny V. Jensen Torben F. Hansen Per Pfeiffer Nils Brünner Torben F. ?rntoft Claus L. Anders | 2013 | Molecular Oncology2013，，3： | 2 |
| 6 | Pelvic inflammatory disease and risk of invasive ovarian cancer and ovarian borderline tumors显示文摘 | Christina B. Rasmussen Mette T. Faber Allan Jensen Estrid H?gdall Claus H?gdall Jan Blaak?r Susanne K. Kjaer | 2013 | Cancer Causes & Control2013，，7： | 2 |
| 7 | Influence of heart rate on vessel visibility in noninvasive coronary angiography using new multislice computed tomography显示文摘 | Stephen Schroeder Andreas F Kopp Axel Kuettner Christof Burgstahler Christian Herdeg Martin Heuschmid Andreas Baumbach Claus D Claussen Karl R Karsch Ludger Seipel | 2002 | Clinical Imaging2002，，2： | 2 |
| 8 | Multiple strain state measurements using conventional and absolute optical fiber-based extrinsic Fabry-Perot interferometric strain sensors显示文摘 | BHATI V MURPHY K CLAUS R | 1995 | Smart Materials and Structures1995，，4： | 2 |
| 9 | L 5-Hydroxytrypto- phan: Antioxidant and anti-apoptotic principle of the intertidal sponge Hyme~tiacido~* hetiophila显示文摘 | LYSEK N KINSCHERF R CLAUS R | 2003 | Zeitschrift Fur Naturfors- ehung C A Journal o[ Bioscienees2003，58，56： | 1 |
| 10 | Multiple strain state measurements using conventional and absolute optical fiber-based extrinsic Fabry-Perot interferometric strain sensors 显示文摘 | BHATI V MURPHY K CLAUS R | 1995 | Smart Materials and Structures1995，，4： | 1 |
| 11 | Preserving pre-rigor meat func- tionality for beef patty production显示文摘 | Claus J R Sorheim O | 2006 | Meat Science2006，73，3： | 1 |
| 12 | Layer-by laYer ionic self-assembly of Au colloids into multiplayer thin-films with bulk metal conductivity显示文摘 | LIU Y J WANG Y X CLAUS R | 1998 | Chemical Physics Letter1998，298，： | 1 |
| 13 | Effects of substituting added water for fat on the textural, sensory, and processing characteristics of bologna显示文摘 | CLAUS J R HUNT M C KASTNER C L | 1990 | Journal of Muscle Foods1990，1，1： | 1 |
| 14 | Estrogens and prostaglandin F2a in the semen and blood plasma of stallions显示文摘 | Claus R Dimmick MA Gimenez T Hudson LW | 1992 | Theriogenology1992，，38： | 1 |
| 15 | Layer-by layer ionic self- assembly of Au colloids into muhiplayer thin-films with bulk metal conductivity 显示文摘 | Liu Y J Wang Y X Claus R | 1998 | Chemical Physics Letter1998，298，： | 1 |
| 16 | Phase I-II Trial of Cetuximab, Capecitabine, Oxaliplatin, and Radiotherapy as Preoperative Treatment in Rectal Cancer显示文摘 | Claus R?del Dirk Arnold Matthias Hipp Torsten Liersch Kathrin Dellas Igors Iesalnieks Robert Michael Hermann Florian Lordick Axel Hinke Werner Hohenberger Rolf Sauer | 2008 | International Journal of Radiation Oncology Biology Physics2008，，4： | 1 |
| 17 | Structural Control: past, present, and future显示文摘 | Housner G Bergman L Gaughey T Chassiakos A Claus R Masri S Skellton R Soong T Spencer B Yao J | 1997 | Journal of Engineering Mechanics (ASCE)1997，123，： | 1 |
| 18 | Color stability of grand beef packed in low carbon monoxide atmosphere or vacuum 显示文摘 | JONG YOUN JEONG JAMES R CLAUS | 2011 | Meat Science2011，87，1： | 1 |
| 19 | Rapid and accurate high-performance liquid chromatographic method for the determina- tion of 3-methylindole (skatole) in faeces of various species 显示文摘 | Dehnhard M Bernal-Barragan H Claus R | 1991 | J Chromatogr1991，566，1： | 1 |
| 20 | Product innovation through coopetition in alliances: Singular or plural governance?显示文摘 | Bouncken R B Clau T Fredrich V | 2016 | Industrial Marketing Management2016，53，： | 1 |
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