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| 1 | 肿瘤坏死因子α基因多态性与中国人自身免疫肝病相关性研究显示文摘目的 探讨肿瘤坏死因子α(TNFα)启动子基因多念性与中国人自身免疫性肝炎(AIH)、原发性胆汁性肝硬化(PBC)发病的相关性。 方法 采用序列特异性聚合酶链式反应方法分析49例AIH、58例PBC患者外周血单核细胞基因组DNA TNFα启动子-308、238 G/A基因多态性,并与160例正常对照组比较。 结果 正常对照组中国人与白种人TNFα*2携带率差异较大。虽然从百分率上可以看出中国人PBC患者TNF α*2携带率低于正常对照组(10.34%与16.88%),但统计学上两者差异无显著性,TNFα-238位基因多态性分布也与正常对照组差异无显著性;AIH患者TNF α自动子-308、-238 G/A基因多态性均与正常人差异无显著性。 结论 不同人种自身免疫肝病的免疫相关基因不同,中国人AIH、PBC与TNFα启动子基因的多态性间不存在基因连锁关系。 | 范列英 仲人前 屠小卿 Thomas Pfeiffer Ralph Feltens 朱烨 周琳 | 2004 | 中华肝脏病杂志2004，12，3： | 15 |
| 2 | 南极菲尔德斯半岛海鸟与种群分布显示文摘2000/2001-2002/2003南极夏季期间,对中国南极长城站所在地乔治王岛菲尔德斯半岛及邻近区海鸟群落组成与种群分布特征进行了观测研究.本文报道了对该地区三次考察期间记录的海鸟共11科25种.其中,有繁殖活动的海鸟12种,优势种有白眉企鹅(Pygoscelis papua)和黄蹼洋海燕(Oceanites oceanicus),常见种有纹颊企鹅(Pygoscelis antarctica)、巨鹱(Macronectes giganteus)、花斑鹱(Daption capenis)、南极燕鸥(Sterna vittata) 和灰贼鸥(Catharacta antarctica)等. | 王自磐 Hans Urlich Peter Simone Pfeiffer | 2004 | 极地研究2004，16，4： | 10 |
| 3 | 维生素D受体基因多态性与中国人自身免疫肝病相关性研究显示文摘目的 探讨维生素D受体 (VDR)基因多态性与中国人自身免疫性肝炎 (AIH)和原发性胆汁性肝硬化 (PBC)发病的相关性。方法 采用限制性长度多态性分析 (restrictionfragmentlengthpolymorphismanalysis ,RFLP)法分析 4 9例AIH、5 8例PBC患者外周血单核细胞基因组DNAVDR外显子2和外显子 7~外显子 9处限制性内切酶FokI、BsmI、ApaI和TaqI基因多态性 ,并与 16 0例正常对照组比较。结果 FokI基因多态性与AIH相关 ,AIH患者ff表型携带者明显高于正常对照组 (34 7%vs18 8% ,P =0 0 19) ;BsmI基因多态性与PBC相关 ,PBC患者携带Bb表型者较正常人明显降低(5 2 %vs 17 5 % ,P =0 0 2 1) ,而bb表型者明显升高 (94 8%vs 80 6 % ,P =0 0 1)。结论 研究结果表明VDR基因多态性与中国人AIH、PBC发病间存在基因连锁。虽然VDR基因表型分布不同 ,但不同人种 ,包括高加索人均存在相似的基因连锁。 | 范列英 仲人前 屠小卿 朱烨 弓长丽 周琳 赵智贤 Ralph Feltens Thomas Pfeiffer | 2003 | 中华医学杂志2003，83，21： | 8 |
| 4 | Combinatorial Complexity in a Transcriptionally Centered Signaling Hub in Arabidopsis显示文摘四 Phytochrome (phy ) 的一个亚科交往的 bHLH 抄写因素(程序信息文件) 一起在黑暗成年的幼苗支持 skotomorphogenic 开发。这项活动在暴露之上被颠倒到光,由导致程序信息文件的降级的用光使敏化的 phy 分子,从而触发驾驶转变到 photomorphogenesis 的 transcriptional 变化。程序信息文件冗余地并且部分工作在在这进程的 morphogenic 水平的差别。识别程序信息文件 transcriptional 规定的直接目标染色体宽,我们由 ChIP-seq 分析为所有四个程序信息文件分析了 DNA 有约束力的地点,并且定义每个程序信息文件 transcriptionally 调整的基因,用 pif 异种的 RNA-seq 分析。尽管有在在程序信息文件之间的 DNA-binding-motif 识别的可检测的差别的缺席,数据表演规章的模式的一个系列,从单个程序信息文件优势在所有四等于贡献。同样,倡导者体系结构的一个宽广数组被发现,从单个程序信息文件绑定地点,包含单个顺序主题,通过多重程序信息文件绑定地点,各包含至少一个主题,与一个优先地占据到多重程序信息文件的每个地点。每个程序信息文件导致的倡导者占有和表示水平的定量分析揭示了一个吸引人的模式。尽管越过目标基因人口广泛地没有柔韧的关联,是多重程序信息文件的分享的目标的单个基因的检查在关联显示出一个阶段从强烈积极通过 uncorrelated,到否定。这发现建议 transcriptional 规定的双分层的机制,两个都包括由每个程序信息文件和扮演每个程序信息文件上的差别的本地规定的附加的层的有约束力地点的占有的连续统,到在每个地点调制它的内在的 transcriptional 激活能力,在一个量的模式,那从基因在单个程序信息文件之间变化到基因。这些调查结果为探查有重叠直接目标的基因的抄写因素由集成的机制提供一个框架并且有选择地, transduce 发信号到他们的目标网络。 | Anne Pfeiffer | 2014 | Molecular Plant2014，7，11： | 8 |
| 5 | Synthesis of advanced ceramics by hydrothermal crystallization and modified related methods显示文摘The present article aims to give a brief overview about the advantages of the hydrothermal crystallization method for the synthesis of advanced ceramics.Emphasis is given,not only on the conventional hydrothermal crystallization,but also on some of its variants;such as ultrasound-assisted,electrochemical-assisted,microwave-assisted and surfactant-assisted hydrothermal methods which open up new opportunities for the synthesis of ceramic materials with novel properties demanded for advanced applications.In the current work the synthesis of barium titanate(BaTiO3),lithium metasilicate(Li2SiO3)and sodium-potassium niobate(Na,K)NbO3 powders are reported as cases of study. | JoséORTIZ-LANDEROS Carlos GÓMEZ-YÁÑEZ Rigoberto LÓPEZ-JUÁREZ Iván DÁVALOS-VELASCO Heriberto PFEIFFER | 2012 | Journal of Advanced Ceramics2012，1，3： | 6 |
| 6 | Simulation Modeling in Plant Breeding: Principles and Applications显示文摘Conventional plant breeding largely depends on phenotypic selection and breeder's experience, therefore the breeding efficiency is low and the predictions are inaccurate. Along with the fast development in molecular biology and biotechnology, a large amount of biological data is available for genetic studies of important breeding traits in plants, which in turn allows the conduction of genotypic selection in the breeding process. However, gene information has not been effectively used in crop improvement because of the lack of appropriate tools. The simulation approach can utilize the vast and diverse genetic information, predict the cross performance, and compare different selection methods. Thus, the best performing crosses and effective breeding strategies can be identified. QuLine is a computer tool capable of defining a range, from simple to complex genetic models, and simulating breeding processes for developing final advanced lines. On the basis of the results from simulation experiments, breeders can optimize their breeding methodology and greatly improve the breeding efficiency. In this article, the underlying principles of simulation modeling in crop enhancement is initially introduced, following which several applications of QuLine are summarized, by comparing the different selection strategies, the precision parental selection, using known gene information, and the design approach in breeding. Breeding simulation allows the definition of complicated genetic models consisting of multiple alleles, pleiotropy, epistasis, and genes, by environment interaction, and provides a useful tool for breeders, to efficiently use the wide spectrum of genetic data and information available. | WANG Jian-kang Wolfgang H Pfeiffer | 2007 | Agricultural Sciences in China2007，6，8： | 5 |
| 7 | 氮素形态对番茄根系液泡膜焦磷酸酶活性的影响(英文)显示文摘采用超速梯度离心提取液泡膜微囊 ,研究硝态氮和铵态氮供应情况下番茄 (LycopersiconesculentumL .)根系液泡膜焦磷酸酶活性的变化。结果表明 :供应铵态氮番茄根系专一性液泡膜焦磷酸酶活性比供应硝态氮的高37.7%;供应铵态氮根系液泡膜焦磷酸酶转运质子活力也明显高于供应硝态氮根系。Westernblot结果表明 。 | 朱祝军 钱亚榕 Wolfgang PFEIFFER | 2001 | Acta Botanica Sinica2001，43，11： | 4 |
| 8 | Particle-based hybrid and multiscale methods for nonequilibrium gas flows显示文摘Over the past half century,a variety of computational fluid dynamics(CFD)methods and the direct simulation Monte Carlo(DSMC)method have been widely and successfully applied to the simulation of gas flows for the continuum and rarefied regime,respectively.However,they both encounter difficulties when dealing with multiscale gas flows in modern engineering problems,where the whole system is on the macroscopic scale but the nonequilibrium effects play an important role.In this paper,we review two particle-based strategies developed for the simulation of multiscale nonequilibrium gas flows,i.e.,DSMC-CFD hybrid methods and multiscale particle methods.The principles,advantages,disadvantages,and applications for each method are described.The latest progress in the modelling of multiscale gas flows including the unified multiscale particle method proposed by the authors is presented. | Jun Zhang Benzi John Marcel Pfeiffer Fei Fei Dongsheng Wen | 2019 | Advances in Aerodynamics2019，1，1： | 4 |
| 9 | Could non-invasive brain-stimulation prevent neuronal degeneration upon ion channel re-distribution and ion accumulation after demyelination?显示文摘Fast and efficient transmission of electrical signals in the nervous system is mediated through myelinated nerve fibers.In neuronal diseases such as multiple sclerosis,the conduction properties of axons are disturbed by the removal of the myelin sheath,leaving nerve cells at a higher risk of degenerating.In some cases,the protective myelin sheath of axons can be rebuilt by remyelination through oligodendroglial cells.In any case,however,changes in the ion channel organization occur and may help to restore impulse conduction after demyelination.On the other hand,changes in ion channel distribution may increase the energy demand of axons,thereby increasing the probability of axonal degeneration.Many attempts have been made or discussed in recent years to increase remyelination of affected axons in demyelinating diseases such as multiple sclerosis.These approaches range from pharmacological treatments that reduce inflammatory processes or block ion channels to the modulation of neuronal activity through electrical cortical stimulation.However,these treatments either affect the entire organism(pharmacological)or exert a very local effect(electrodes).Current results show that neuronal activity is a strong regulator of oligodendroglial development.To bridge the gap between global and very local treatments,non-invasive transcranial magnetic stimulation could be considered.Transcranial magnetic stimulation is externally applied to brain areas and experiments with repetitive transcranial magnetic stimulation show that the neuronal activity can be modulated depending on the stimulation parameters in both humans and animals.In this review,we discuss the possibilities of influencing ion channel distribution and increasing neuronal activity by transcranial magnetic stimulation as well as the effect of this modulation on oligodendroglial cells and their capacity to remyelinate previously demyelinated axons.Although the physiological mechanisms underlying the effects of transcranial magnetic stimulation clearly need further investigations,repetitive transcranial magnetic stimulation may be a promising approach for non-invasive neuronal modulation aiming at enhancing remyelination and thus reducing neurodegeneration. | Friederike Pfeiffer Alia Benali | 2020 | Neural Regeneration Research2020，15，11： | 3 |
| 10 | 青光眼患者血清抗视网膜抗原的抗体轮廓质谱分析显示文摘目的比较原发性开角型青光眼(POAG)患者与正常对照(CTRL)者间的抗体轮廓差异。方法病例对照研究。将44例POAG患者与48例CTRL者的血清分别加入到含有预洗Dyna珠-G蛋白的反应管中,以捕获人免疫球蛋白G(IgG)抗体,形成的IgG—G蛋白复合体用来捕获目标抗原(匀质化牛视网膜组织)。经洗提后获得的抗原蛋白通过“表面增强激光解吸附-电离-飞行时间-质谱”仪进行检测。采用Proteomic software project统计学软件,对两组质谱数据连同受检者年龄和性别等参数,自动进行t检验和初步多变量判别分析;随后采用Statistica version8.0统计学软件,进行包括抗原蛋白质谱数据、蛋白质芯片类型和激光解吸附-电离能量等的多变量判别分析。结果CTRL组的平均质谱强度为4244.427±4721.115,POAG组为4049.864±4083.819,两组间差异有统计学意义(F=1.340,P〈0.01);在POAG患者中,出现了部分高调节免疫反应,但主要表现为低调节免疫反应。结论在POAG患者与CTRL者之间存在明显的抗体轮廓差异,在POAG组中出现的低调节免疫反应表明部分患者可能与“异常免疫”有关。 | 严良 Joachim S. C Pfeiffer N Grus F.H Erb C | 2009 | 中华眼科杂志2009，45，7： | 3 |
| 11 | 超声辅助下切割针吸活检诊断头颈部淋巴瘤:是否可以取代淋巴结摘取活检?显示文摘Sonography-assisted cutting needle biopsy in the head and neck for the diagnosis of lymphoma: can it replace lymph node extirpation? Pfeiffer J, Kayser G, Ridder GJ. Laryngoscope, 2009, 119(4):689-695. | Pfeiffer J Kayser G Ridder GJ | 2009 | 中国口腔颌面外科杂志2009，7，4： | 3 |
| 12 | Assessment of cardiac preload and extravascular lung water by single transpulmonary thermodilution显示文摘 | S. G. Sakka C. C. Rühl U. J. Pfeiffer R. Beale A. McLuckie K. Reinhart A. Meier-Hellmann | 2000 | Intensive Care Medicine2000，，2： | 2 |
| 13 | Screening for autoantibodies in chronic hepatitis C patients has no effect on treatment initiation or outcome显示文摘 | S. Mauss F. Berger A. Schober G. Moog R. Heyne C. John S. Pape D. Hueppe H. Pfeiffer‐Vornkahl U. Alshuth | 2012 | J Viral Hepat2012，，4： | 2 |
| 14 | A descriptive analysis on the implementation of Balanced Scorecards in German-speaking countries显示文摘 | Gerhard Speckbacher Juergen Bischof Thomas Pfeiffer | 2003 | Management Accounting Research2003，，4： | 2 |
| 15 | Multifingered dextrous robotics hand design and control: a review显示文摘 | Pons J L Ceres R Pfeiffer F | 1999 | Robotica1999，17，： | 2 |
| 16 | 在电休克治疗中重复间歇使用依托咪酯不会造成持久的肾上腺皮质功能抑制显示文摘依托咪酯作为一种麻醉诱导用药,在20世纪80年代开始用于危重症患者机械通气的镇静。然而Ledingham等1983年在柳叶刀的报道指出:接受依托咪酯治疗的患者死亡率远高于未接受此治疗的同类患者。此后一系列相关研究阐明了其机制并导致此项应用的终止。多项研究表明依托咪酯会抑制肾上腺皮质功能,即使单次剂量也可造成此抑制,虽然单次剂量的抑制是短暂的。 | Philip Lebowitz Susan Cohen Shiry Weisberg Bernard Wyszynski Charles Ramesar Peter Pfeiffer | 2013 | 临床麻醉学杂志2013，29，6： | 2 |
| 17 | High expression of microRNA-625-3p is associated with poor response to first-line oxaliplatin based treatment of metastatic colorectal cancer显示文摘 | Mads H. Rasmussen Niels F. Jensen Line S. Tarpgaard Camilla Qvortrup Maria U. R?mer Jan Stenvang Tine P. Hansen Lise L. Christensen Jan Lindebjerg Flemming Hansen Benny V. Jensen Torben F. Hansen Per Pfeiffer Nils Brünner Torben F. ?rntoft Claus L. Anders | 2013 | Molecular Oncology2013，，3： | 2 |
| 18 | No Impact of Repeated Endoscopic Screens on Gastric Cancer Mortality in a Prospectively Followed Chinese Population at High Risk显示文摘 | B. Riecken R. Pfeiffer J.L. Ma M.L. Jin J.Y. Li W.D. Liu L. Zhang Y.S. Chang M.H. Gail W.C. You | 2002 | Preventive Medicine2002，，1： | 2 |
| 19 | Degradability of black carbon and its impact on trace gas fluxes and carbon turnover in paddy soils显示文摘 | Christian Knoblauch Arina-Ann Maarifat Eva-Maria Pfeiffer Stephan M. Haefele | 2010 | Soil Biology and Biochemistry2010，，9： | 2 |
| 20 | Possible role of power-to-heat and power-to-gas as flexibleloads in German medium voltage networks显示文摘Germany's energy transition triggered a rapidand unilateral growth of renewable energy sources (RES)in the electricity sector. With increasing shares ofintermittent RES, overcapacities during periods of strongwind and photovoltaic electricity generation occur. In theface of insufficient transmission capacities, due to aninhibited network extension, the electricity generation hasto be curtailed. This curtailment of RES leads to economiclosses and could be avoided through flexible loads. As anoption to cope with those problems, the technologies ofpower-to-gas (PtG) and power-to-heat (PtH) are presentedin this paper. First, the alkaline electrolyzer (AEL),polymer electrolyte membrane electrolyzer (PEMEL),and solid oxide electrolyzer cell (SOEC) are investigatedregarding their operational parameters. Second, the electricboiler, electrode heating boiler, and heat pumps areconsidered. Ultimately, the network-supporting abilitiesand the potential to provide ancillary services, such ascontrol power, load sequence operation, cold start and partload capability, are compared among one another. | Mark KUPRAT Martin BENDIG Klaus PFEIFFER | 2017 | Frontiers in Energy2017，11，2： | 2 |
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