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| 1 | Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction显示文摘Zika 病毒(ZIKV ) 的最近的爆发为治疗学加亮迫切需要。朊酶建筑群 NS2B-NS3 在 flaviviral polyprotein 处理期间起必要作用,并且因此代表一个吸引人的药目标。这里,我们开发了裂口酶识别直接指向 flavivirus NS2B-NS3 相互作用的 orthosteric 禁止者的基于互补的高产量的屏蔽试金。由屏蔽一个总数 2 816 同意了并且 investigational 药,我们识别了三个有势力候选人, temoporfin, niclosamide,和 nitazoxanide,,有 nanomolar 力量的 flavivirus NS2B-NS3 相互作用禁止者。显著地,在老鼠的在人的胎盘、神经的祖先房间的大多数有势力化合物, temoporfin,不是仅仅禁止的 ZIKV 复制,而且阻止的导致 ZIKV 的 viremia 和死亡当模特儿。结构的停靠建议 temoporfin 潜在地绑保持批评 NS2B 残余的 NS3 衣袋,因此禁止以一种非竞争的方式处理的 flaviviral polyprotein。当这些药已经在 USA 或另外的国家在另外的指示任何一个为临床的使用被同意了,他们由 ZIKV 和另外的 flaviviruses 为感染的管理代表有希望、容易开发的治疗。 | Zhong Li Matthew Brecher Yong-Qiang Deng Jing Zhang Srilatha Sakamuru Binbin Liu Ruili Huang Cheri A Koetzner Christina A Allen Susan A Jones Haiying Chen Na-Na Zhang Min Tian Fengshan Gao Qishan Lin Nilesh Banavali Jia Zhou Nathan Boles Menghang Xia Laura D Kramer Cheng-Feng Qin Hongmin Li | 2017 | Cell Research2017，27，8： | 11 |
| 2 | Assessment of the cardiovascular and gastrointestinal autonomic complications of diabetes显示文摘The global prevalence of diabetes mellitus is increasing; arguably as a consequence of changes in diet, lifestyle and the trend towards urbanization. Unsurprisingly, the incidence of both micro and macrovascular complications of diabetes mirrors this increasing prevalence. Amongst the complications with the highest symptom burden, yet frequently under-diagnosed and sub-optimally treated, is diabetic autonomic neuropathy, itself potentially resulting in cardiovascular autonomic neuropathy and gastrointestinal(GI) tract dysmotility. The aims of this review are fourfold. Firstly to provide an overview of the pathophysiological processes that cause diabetic autonomic neuropathy. Secondly, to discuss both the established and emerging cardiometric methods for evaluating autonomic nervous system function in vivo. Thirdly, to examine the tools for assessing pan-GI and segmental motility and finally, we will provide the reader with a summary of putative non-invasive biomarkers that provide a pathophysiological link between lowgrade neuro inflammation and diabetes, which may allow earlier diagnosis and intervention, which in future may improve patient outcomes. | Christina Brock Birgitte Brock Anne Grave Pedersen Asbjorn Mohr Drewes Niels Jessen Adam D Farmer | 2016 | World Journal of Diabetes2016，7，16： | 5 |
| 3 | Brain changes in diabetes mellitus patients withgastrointestinal symptoms显示文摘Diabetes mellitus is a common disease and its prevalence is increasing worldwide. In various studies up to 30%-70% of patients present dysfunction and complications related to the gut. To date several clinical studies have demonstrated that autonomic nervous system neuropathy and generalized neuropathy of the central nervous system(CNS) may play a major role. This systematic review provides an overview of the neurodegenerative changes that occur as a consequence of diabetes with a focus on the CNS changes and gastrointestinal(GI) dysfunction. Animal models where diabetes was induced experimentally support that the disease induces changes in CNS. Recent investigations with electroencephalography and functional brain imaging in patients with diabetes confirm these structural and functional brain changes. Encephalographic studies demonstrated that altered insular processing of sensory stimuli seems to be a key player in symptom generation. In fact one study indicated that the more GI symptoms the patients experienced, the deeper the insular electrical source was located. The electroencephalography was often used in combination with quantitative sensory testingmainly showing hyposensitivity to stimulation of GI organs. Imaging studies on patients with diabetes and GI symptoms mainly showed microstructural changes,especially in brain areas involved in visceral sensory processing. As the electrophysiological and imaging changes were associated with GI and autonomic symptoms they may represent a future therapeutic target for treating diabetics either pharmacologically or with neuromodulation. | Anne M Drewes Eirik Søfteland Georg Dimcevski Adam D Farmer Christina Brock Jens B Frøkjær Klaus Krogh Asbjørn M Drewes | 2016 | World Journal of Diabetes2016，7，2： | 4 |
| 4 | Cold dialysis and its impact on renal patients' health:An evidence-based mini review显示文摘Chronic renal disease is associated with advanced age,diabetes,hypertension,obesity,musculoskeletal problems and cardiovascular disease,the latter being the main cause of mortality in patients receiving haemodialysis(HD).Cooled dialysate(35 ℃-36 ℃) is recently employed to reduce the incidence of intradialytic hypotension in patients on chronic HD.The studies to date that have evaluated cooled dialysate are limited,however,data suggest that cooled dialysate improves hemodynamic tolerability of dialysis,minimizes hypotension and exerts a protective effect over major organs including the heart and brain.The current evidence-based review is dealing with the protective effect of cold dialysis and the benefits of it in aspects affecting patients' quality of care and life.There is evidence to suggest that cold dialysis can reduce cardiovascular mortality.However,large multicentre randomized clinical trials are urgently needed to provide further supporting evidence in order to incorporate cold dialysis in routine clinical practice. | Giorgos K Sakkas Argiro A Krase Christoforos D Giannaki Christina Karatzaferi | 2017 | World Journal of Nephrology2017，6，3： | 4 |
| 5 | Bacterial translocation in patients undergoing major gastrointestinal surgery and its role in postoperative sepsis显示文摘Bacteria of the human intestinal microflora have a dual role.They promote digestion and are part of a defense mechanism against pathogens.These bacteria could become potential pathogens under certain circumstances.The term“bacterial translocation”describes the passage of bacteria of the gastrointestinal tract through the intestinal mucosa barrier to mesenteric lymph nodes and other organs.In some cases,the passage of bacteria and endotoxins could result in blood stream infections and in multiple organ failure.Open elective abdominal surgery more frequently results in malfunction of the intestinal barrier and subsequent bacterial translocation and blood stream infections than laparoscopic surgery.Postoperative sepsis is a common finding in patients who have undergone non-elective abdominal surgeries,including trauma patients treated with laparotomy.Postoperative sepsis is an emerging issue,as it changes the treatment plan in surgical patients and prolongs hospital stay.The association between bacterial translocation and postoperative sepsis could provide novel treatment options. | Christos Doudakmanis Konstantinos Bouliaris Christina Kolla Matthaios Efthimiou Georgios D Koukoulis | 2021 | World Journal of Gastrointestinal Pathophysiology2021，12，6： | 2 |
| 6 | Histologic Pathologies of the Myocardium in Septic Shock: A Prospective Observational Study显示文摘 | Christian A. Schmittinger Martin W. Dünser Christian Torgersen Günter Luckner Ingo Lorenz Stefan Schmid Michael Joannidis Patrizia Moser Walter R. Hasibeder Milo Halabi Christina M. Steger | 2013 | Shock2013，，4： | 1 |
| 7 | Force modeling for needle insertion into soft tissue 显示文摘 | Okamura A M Christina Simone O' Lear) M D | 2004 | IEEE Trans on BioMed Eng2004，51，10： | 1 |
| 8 | Taxonomic characterization and plant colonizing abilities of some bacteria related to Bacillus amyloliquefaeiens and Bacillus subtilis显示文摘 | Oleg NR Christina D Johan M | | 0，，： | 1 |
| 9 | Using compost wood chip materials as biofilterials as biofiltration media显示文摘 | Jones Kim D Banuelos Christina | 2000 | Biocycle2000，41，10： | 1 |
| 10 | Taxonomic characteriza- tion and plant colonizing abilities of some bacteria related to Bacillus amyloliquefacieus and Bacillus subtilis 显示文摘 | Oleg NR Christina D Johan M | 2004 | FEMS Microbiology Ecology2004，48，： | 1 |
| 11 | Resistance to soybean aphid in early maturing soybean germplasm 显示文摘 | Mensah C Christina D F | 2005 | Crop Science2005，45，： | 1 |
| 12 | HIV-1 integrase crosslinked oligomers are active in vitro显示文摘 | Aur lie F Christina C Cecile D | 2005 | Nucleic Acids Research2005，33，3： | 1 |
| 13 | Taxonomic characterization and plant colonizing abilities of some bacteria related to Bacillus arnylolique f aciens and Bacillus subtilis 显示文摘 | Oleg N R Christina D Johan M | 2004 | FEMS Microbiology Ecology2004，48，： | 1 |
| 14 | Plasmodium vivax infection among Duffy antigen-negative individuals from the Brazilian Amazon region: an exception?显示文摘 | Carlos Eugênio Cavasini Luiz Carlos de Mattos álvaro Augusto D'Almeida Couto Cláudia Regina Bonini-Domingos Socrates Herrera Valencia Wanessa Christina de Souza Neiras Renata Tomé Alves Andréa Regina Baptista Rossit Lilian Castilho Ricardo Luiz Dantas Mac | 2007 | Transactions of the Royal Society of Tropical Medicine and Hygiene2007，，10： | 1 |
| 15 | Effect of an improved cloud climatology on the total ozone mapping spectrometer total ozone retrieval 显示文摘 | N Christina Hsu Richard D Mcpeters Colin J Seftor | 1997 | J Geophys Res1997，102，4： | 1 |
| 16 | Aberrant hypomethylation of the cancer–testis antigen PRAME correlates with PRAME expression in acute myeloid leukemia显示文摘 | Christina A. Ortmann Lewin Eisele Holger Nückel Ludger Klein-Hitpass Anja Führer Ulrich Dührsen Michael Zeschnigk | 2008 | Annals of Hematology2008，，10： | 1 |
| 17 | Hybrid PET/MRI of Intracranial Masses: Initial Experiences and Comparison to PET/CT显示文摘 | Boss Andreas Bisdas Sotirios Kolb Armin Hofmann Matthias Ernemann Ulrike Claussen Claus D Pfannenberg Christina Pichler Bernd J Reimold Matthias Stegger Lars | 2010 | The Journal of Nuclear Medicine2010，，8： | 1 |
| 18 | Flavopiridol sensitivity of cancer cells isolated from ascites and pleural fluids显示文摘 | Christina R Donald M Wilhelmina D | 2005 | Clinical Cancer Research2005，11，： | 1 |
| 19 | Hall efficiency of recombination reactions catalysed by the class 1 integron integrase IntI1显示文摘 | Christina M Collis Gavin D Recchia Mi-Jurng Kim | 2001 | J Bacteriol2001，183，8： | 1 |
| 20 | Intravitreal triamcinolone acetonide for refractory chronic pseudophakic cystoid macular edema显示文摘 | Mandi D Conway Christina Canakis Charalampos Livir-Rallatos Gholam A Peyman | 2003 | Journal of Cataract & Refractive Surgery2003，，1： | 1 |
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