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| 1 | 对气候变暖响应下土壤CO_2释放的估计过高——老龄土壤有机质的分解具耐温性显示文摘本研究预测,相对于植被的净初级生产力(NPP)来说,随着全球变暖,有机质分解速度加快,土壤有机碳的贮藏速度将减少。因为土壤碳的含量是目前大气含量的两倍,而且从土壤中分解的碳要释放到大气中,因此,土壤碳贮量的减少会大量增加大气CO_2浓度。但是,土壤碳贮量减少的预测在很大程度上依赖于这样的隐含假设:所有土镶有机质的分解像新鲜凋落物的分解一样对温度较为敏感。我们测定了土壤碳的数量和年龄,以及沿温度梯度的凋落物的分解,并用一个简单的模型来描述土壤碳的动态,以显示老土壤有机质的分解阻抗温度的变化。因此,在对气候变暖的响应下,我们估算的分解速度的加快比从前预计的明显要低,并且预测北方森林土壤碳的贮量将增加。 | Jari Liski Annikki Mkel Carl Johan Westman 李叙勇 | 1999 | 人类环境杂志1999，28，2： | 16 |
| 2 | Results of percutaneous sclerotherapy and surgical treatment in patients with symptomatic simple liver cysts and polycystic liver disease显示文摘AIM: To evaluate the results of the treatment of simple liver cysts (solitary and multiple) and polycystic liver disease (PLD) using percutaneous sclerotherapy and/or surgical procedures in a single tertiary referral centre. METHODS: Retrospective analysis of 54 patients referred for evaluation and possible treatment of simple liver cysts (solitary and multiple) and PLD, from January 1997 to July 2006. RESULTS: Simple liver cysts were treated in 41 pts (76/) with a mean size of 12.6 cm. The most common reason for referral was abdominal pain or discomfort (85/). Percutaneous sclerotherapy was performed as initial treatment in 30 pts, showing cyst recurrence in 6 pts (20/). Surgical treatment was initially performed in 11 pts with cyst recurrence in 3 pts (27/). PLD was treated in 13 pts (24/) with a mean size of the dominant cyst of 13 cm. Percutaneous sclerotherapy for PLD was performed in 9 pts with recurrence in 7 pts (77.8/). Surgical treatment for PLD was undertaken in 4 pts (30.8/) with recurrence in all. Eventually, 2 pts with PLD in the presence of polycystic kidney disease underwent liver-and kidney transplantation because of deterioration of liver and kidney function. CONCLUSION: The majority of patients with simple liver cysts and PLD are referred for progressive abdominal pain. As initial treatment, percutaneous sclerotherapy is appropriate. Surgical deroofing is indicated in caseof cyst recurrence after percutaneous sclerotherapy. However, the results of percutaneous sclerotherapy and surgical treatment for PLD are disappointing. Partial liver resection is indicated when there is suspicion of a pre-malignant lesion. | Deha Erdogan Otto M van Delden Erik AJ Rauws Olivier RC Busch Johan S Lameris Dirk J Gouma Thomas M van Gulik | 2007 | World Journal of Gastroenterology2007，13，22： | 15 |
| 3 | Implication of the intestinal microbiome in complications of cirrhosis显示文摘The intestinal microbiome(IM) is altered in patients with cirrhosis,and emerging literature suggests that this impacts on the development of complications.The Pub Med database was searched from January 2000 to May 2015 for studies and review articles on the composition,pathophysiologic effects and therapeutic modulation of the IM in cirrhosis.The following combination of relevant text words and MeS H terms were used,namely intestinal microbiome,microbiota,or dysbiosis,and cirrhosis,encephalopathy,spontaneous bacterial peritonitis,hepatorenal syndrome,variceal bleeding,hepatopulmonary syndrome,portopulmonary hypertension and hepatocellular carcinoma.The search results were evaluated for pertinence to the subject of IM and cirrhosis,as well as for quality of study design.The IM in cirrhosis is characterized by a decreased proportion of Bacteroides and Lactobacilli,and an increased proportion of Enterobacteriaceae compared to healthy controls.Except for alcoholic cirrhosis,the composition of the IM in cirrhosis is not affected by the etiology of the liver disease.The percentage of Enterobacteriaceae increases with worsening liver disease severity and decompensation and is associated with bacteremia,spontaneous bacterial peritonitis and hepatic encephalopathy.Lactulose,rifaximin and Lactobacillus-containing probiotics have been shown to partial y reverse the cirrhosis associated enteric dysbiosis,in conjunction with improvement in encephalopathy.The IM is altered in cirrhosis,and this may contribute to the development of complications associated with end-stage liver disease.Therapies such as lactulose,rifaximin and probiotics may,at least partially,reverse the cirrhosisassociated changes in the IM.This,in turn,may prevent or alleviate the severity of complications. | Mamatha Bhat Bianca M Arendt Venkat Bhat Eberhard L Renner Atul Humar Johane P Allard | 2016 | World Journal of Hepatology2016，8，27： | 13 |
| 4 | Photochemical smog in China:scientific challenges and implications for air-quality policies显示文摘INTRODUCTION Severe air-pollution events in many parts of China pose a major threat to health and ecosystems[1].China’s air pollution is concentrated to economically developed areas,such as Beijing–Tianjin–Hebei(BTH)and Pearl–River–Delta(PRD)[2,3].The situation has received considerable attention in | Mattias Hallquist John Munthe Min Hu Tao Wang Chak K Chan Jian Gao Johan Boman Song Guo Asa M Hallquist Johan Mellqvist Jana Moldanova Ravi K Pathak Jan BC Pettersson Hakan Pleijel David Simpson Marie Thynell | 2016 | National Science Review2016，3，4： | 8 |
| 5 | Juvenile polyposis syndrome显示文摘Juvenile polyposis syndrome is a rare autosomal dominant syndrome characterized by multiple distinct juvenile polyps in the gastrointestinal tract and an increased risk of colorectal cancer.The cumulative life-time risk of colorectal cancer is 39% and the relative risk is 34.Juvenile polyps have a distinctive histology characterized by an abundance of edematous lamina propria with inflammatory cells and cystically dilated glands lined by cuboidal to columnar epithelium with reactive changes.Clinically,juvenile polyposis syndrome is defined by the presence of 5 or more juvenile polyps in the colorectum,juvenile polyps throughout the gastrointestinal tract or any number of juvenile polyps and a positive family history of juvenile polyposis.In about 50%-60% of patients diagnosed with juvenile polyposis syndrome a germline mutation in the SMAD4 or BMPR1A gene is found.Both genes play a role in the BMP/TGF-beta signalling pathway.It has been suggested that cancer in juvenile polyposis may develop through the socalled 'landscaper mechanism' where an abnormal stromal environment leads to neoplastic transformation of the adjacent epithelium and in the end invasive carcinoma.Recognition of this rare disorder is important for patients and their families with regard to treatment,follow-up and screening of at risk individuals.Each clinician confronted with the diagnosis of a juvenile polyp should therefore consider the possibility of juvenile polyposis syndrome.In addition,juvenile polyposis syndrome provides a unique model to study colorectal cancer pathogenesis in general and gives insight in the molecular genetic basis of cancer.This review discusses clinical manifestations,genetics,pathogenesis and management of juvenile polyposis syndrome. | Lodewijk AA Brosens Danielle Langeveld W Arnout van Hattem Francis M Giardiello G Johan A Offerhaus | 2011 | World Journal of Gastroenterology2011，17，44： | 7 |
| 6 | Gastroenterologist perceptions of faecal microbiota transplantation显示文摘AIM: To explore gastroenterologist perceptions towards and experience with faecal microbiota transplantation(FMT).METHODS: A questionnaire survey consisting of 17 questions was created to assess gastroenterologists' attitude towards and experience with FMT. This was anonymously distributed in hard copy format amongst attendees at gastroenterology meetings in Australia between October 2013 and April 2014. Basic descriptive statistical analyses were performed.RESULTS: Fifty-two clinicians participated. Twenty one percent had previously referred patients for FMT,8% more than once. Ninety percent would refer patients with Clostridium difficile infection(CDI) for FMT if easily available,37% for ulcerative colitis,13% for Crohn's disease and 6% for irritable bowel syndrome. Six percent would not refer any indication,including recurrent CDI. Eighty-six percent would enroll patients in FMT clinical trials. Thirty-seven percent considered the optimal mode of FMT administration transcolonoscopic,17% nasoduodenal,13% enema and 8% oral capsule. The greatest concerns regarding FMT were: 42% lack of evidence,12% infection risk,10% non infectious adverse effects/lack of safety data,10% aesthetic,10% lack of efficacy,4% disease exacerbation,and 2% inappropriate use; 6% had no concerns. Seventy seven percent believed there is a lack of accessibility while 52% had an interest in learning how to provide FMT. Only 6% offered FMT at their institution.CONCLUSION: Despite general enthusiasm,most gastroenterologists have limited experience with,or access to,FMT. The greatest concerns were lack of supportive evidence and safety issues. However a significant proportion would refer indications other than CDI for FMT despite insufficient evidence. These data provide guidance on where education and training are required. | Sudarshan Paramsothy Alissa J Walsh Thomas Borody Douglas Samuel Johan van den Bogaerde Rupert WL Leong Susan Connor Watson Ng Hazel M Mitchell Nadeem O Kaakoush Michael A Kamm | 2015 | World Journal of Gastroenterology2015，21，38： | 5 |
| 7 | Coxsackievirus mutants that can bypass host factor PI4KIIIβ and the need for high levels of PI4P lipids for replication显示文摘 | Hilde M van der Schaar Lonneke van der Linden Kjerstin H W Lanke Jeroen R P M Strating Gerhard Purstinger Erik de Vries Cornelis A M de Haan Johan Neyts Frank J M van Kuppeveld | 2012 | Cell Research2012，22，11： | 3 |
| 8 | 用于433MHz ISM频带的低功耗超再生接收器显示文摘设计师经常选择超再生接收器(super-regenerative recelvr)——尽管它的频率不稳定,选择性较差——用于那些以功耗为主要问题的电池供电短距离无线应用,例如远程无钥匙进入系统,汽车警报、生物医学监视器、传感器网络、计算机外设(参考文献1)。超再生检测器还能通过斜率检测来解调频率调制信号。 | Cedric Mélange Johan Bauwelinck Jan Vandewege | 2006 | 电子设计技术 EDN CHINA2006，13，5： | 2 |
| 9 | Appendectomy versus Antibiotic Treatment in Acute Appendicitis. A Prospective Multicenter Randomized Controlled Trial显示文摘 | Johan Styrud MD PhD Staffan Eriksson MD PhD Ingemar Nilsson MD PhD Gunnar Ahlberg MD PhD Staffan Haapaniemi MD PhD Gunnar Neovius MD Lars Rex MD Ibrahim Badume MD Lars Granstr?m MD PhD | 2006 | World Journal of Surgery2006，，6： | 2 |
| 10 | A National Strategic Change in Treatment Policy for Rectal Cancer—Implementation of Total Mesorectal Excision as Routine Treatment in Norway. A National Audit显示文摘 | Arne Wibe M.D. Bj?rn M?ller M.Sc. Jarle Norstein M.D. Erik Carlsen M.D. Ph.D. Johan N. Wiig M.D. Ph.D. Richard J. Heald F.R.C.S. Fr?ydis Langmark M.D. Helge E. Myrvold M.D. Ph.D. Odd S?reide F.R.C.S | 2002 | Diseases of the Colon & Rectum2002，，7： | 1 |
| 11 | An aggregate of public health indicator to response the impact of multiple environmental exposures 显示文摘 | Augustinus E M de Hollander Johan M Melse Erie Lebret | 1999 | Epidemiology1999，10，5： | 1 |
| 12 | Invasive aspergillosis in the Inten-sive Care Unit显示文摘 | Wouter M Katrien L Johan M | 2007 | Clinical Infectious Diseases 120072007，，： | 1 |
| 13 | Distant effect s of India Eurasia convergence and Mesozoic intracontinental deformation in Central Asia:Constraints from apatite fission-track thermo- chronology显示文摘 | Johan D G Michael M B Peter V H | 2006 | Journal of Asian Earth Sciences2006，，3： | 1 |
| 14 | Decreasing Time-Trends of Colorectal Cancer in a Large Cohort of Patients With Inflammatory Bowel Disease显示文摘 | Sverre S?derlund Lena Brandt Annika Lapidus Per Karlén Olle Brostr?m Robert L?fberg Anders Ekbom Johan Askling | 2009 | Gastroenterology2009，，5： | 1 |
| 15 | Taxonomic characterization and plant colonizing abilities of some bacteria related to Bacillus amyloliquefaeiens and Bacillus subtilis显示文摘 | Oleg NR Christina D Johan M | | 0，，： | 1 |
| 16 | Microbiol Review显示文摘 | Johan M T | 1984 | 48(1):42-591984，48，1： | 1 |
| 17 | Characteristics of a piezoelectric miniature motor 显示文摘 | Bexell M Johan Sson S | 1999 | Sensor Actuate A sensor- Phys1999，75，2： | 1 |
| 18 | Mismanagement of tacit knowledge: The importance of tacit knowledge, the danger of imformation technology, and what to do about it显示文摘 | Jon-Arild Johannessen Johan Olaisen Bjφm Olsen | 2001 | International Journal of Information Management2001，21，： | 1 |
| 19 | Effects of immunosup- pression by cyclosporine A on allogenic uterine transplant in the rat显示文摘 | Klaus G Shamima NA Johan M | 2012 | Eur J Obstet Gynecol Reprod Bio12012，163，1： | 1 |
| 20 | Short circuit current of wind turbines with doubly fed induction generator显示文摘 | Johan M Sjoerd W H | 2007 | IEEE Transactions on Energy Conversion2007，22，1： | 1 |
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