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| 1 | Relationships between serum lipid,lipoprotein,triglyceride-rich lipoprotein,and high-density lipoprotein particle concentrations in post-renal transplant patients显示文摘Objective:Disturbances in lipid and lipoprotein profiles in patients after kidney transplantation (Tx) are still not understood. Methods:Serum levels of lipids,lipoprotein,triglyceride-rich lipoproteins (TRLs),and high-density lipoprotein (HDL) particles were determined,lipid and lipoprotein ratios were calculated,and their relationships in Tx patients with hypertriglyceridemia (HTG) and lower apolipoprotein AI (apoAI) concentration were examined. Serum lipid and lipoprotein levels were measured in 109 Tx patients and 89 healthy subjects. HDL particle levels were de-termined by enzyme-linked immunosorbent assay (ELISA). Results:Tx patients had disturbed concentration,com-position,and metabolism of TRLs and HDL particles. Multivariance analysis showed significant and positive correlation between HDL cholesterol/apoAI (HDL-C/apoAI) and HDL-C/HDL ratios,which indicates that both ratios could sensi-tively reflect changes in the HDL subclasses and their distribution into smaller size particles. In Tx patients,the de-creased HDL-C/apoAI ratio indicates that,along with the decreased apoAI concentration,the HDL-C level is de-creased. However,a low HDL-C/HDL ratio indicates that HDL particles in Tx patients transport lesser content of HDL-C but more triglyceride (TG) (high TG/HDL ratio),and thus are hypercatabolized and removed; therefore,con-centration of HDL particles in serum was decreased. Conclusion:The decrease of HDL-C/apoAI ratio seems to be a good marker of HDL subclass distribution into smaller size particles. | ElZbieta KIMAK Magdalena HALABI Iwona BARANOWICZ-GASZCZYK | 2010 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2010，11，4： | 5 |
| 2 | Association between moderately oxidized low-density lipoprotein and high-density lipoprotein particle subclass distribution in hemodialyzed and post-renal transplant patients显示文摘Disturbances in the metabolism of lipoprotein profiles and oxidative stress in hemodialyzed(HD) and post-renal transplant(Tx) patients are proatherogenic,but elevated concentrations of plasma high-density lipoprotein(HDL) reduce the risk of cardiovascular disease.We investigated the concentrations of lipid,lipoprotein,HDL particle,oxidized low-density lipoprotein(ox-LDL) and anti-ox-LDL,and paraoxonase-1(PON-1) activity in HD(n=33) and Tx(n=71) patients who were non-smokers without active inflammatory disease,liver disease,diabetes,or malignancy.HD patients had moderate hypertriglyceridemia,normocholesterolemia,low HDL-C,apolipoprotein A-I(apoA-I) and HDL particle concentrations as well as PON-1 activity,and increased ox-LDL and anti-ox-LDL levels.Tx patients had hypertriglyceridemia,hypercholesterolemia,moderately decreased HDL-C and HDL particle concentrations and PON-1 activity,and moderately increased ox-LDL and anti-ox-LDL levels as compared to the reference,but ox-LDL and anti-ox-LDL levels and PON-1 activity were more disturbed in HD patients.However,in both patient groups,lipid and lipoprotein ratios(total cholesterol(TC)/HDL-C,LDL-C/HDL-C,triglyceride(TG)/HDL-C,HDL-C/non-HDL-C,apoA-I/apoB,HDL-C/apoA-I,TG/HDL) were atherogenic.The Spearman's rank coefficient test showed that the con-centration of ox-LDL correlated positively with HDL particle level(R=0.363,P=0.004),and negatively with TC(R=?0.306,P=0.012),LDL-C(R=?0.283,P=0.020),and non-HDL-C(R=?0.263,P=0.030) levels in Tx patients.Mul-tiple stepwise forward regression analysis in Tx patients demonstrated that ox-LDL concentration,as an independent variable,was associated significantly positively with HDL particle level.The results indicated that ox-LDL and de-creased PON-1 activity in Tx patients may give rise to more mildly-oxidized HDLs,which are less stable,easily un-dergo metabolic remodeling,generate a greater number of smaller pre-β-HDL particles,and thus accelerate reverse cholesterol transport,which may be beneficial for Tx patients.Further studies are necessary to confirm this. | Elzbieta KIMAK Magdalena HALABI Iwona BARANOWICZ-GASZCZYK Janusz SOLSKI Andrzej KSIAZEK | 2011 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2011，12，5： | 5 |
| 3 | Influence of lysosomal sequestration on multidrug resistance in cancer cells显示文摘Chemotherapy remains a primary treatment modality for various malignancies.However,resistance to chemotherapeutic drugs is a major obstacle to curative cancer therapy.Lysosomes are acidic organelles that participate in cellular digestion.However,there is rising interest in lysosomes because of their involvement with cancer.For example,extracellular secretion of lysosomal enzymes promote tumorigenesis;cytosolic leakage of lysosomal hydrolases promote apoptosis;and weak chemotherapeutic bases diffuse across the lysosomal membrane and become entrapped in lysosomes in their cationic state.Lysosomal drug sequestration lowers the cytotoxic potential of chemotherapeutics,reduces drug availability to sites of action,and contributes to cancer resistance.This review examines various mechanisms of lysosomal drug sequestration and their consequences on cancer multidrug resistance.Strategies for overcoming drug resistance by exploiting lysosomes as subcellular targets to reverse drug sequestration and drug resistance are also discussed. | Reginald Halaby | 2019 | Cancer Drug Resistance2019，2，1： | 2 |
| 4 | Mental health in the post-COVID-19 era:challenges and the way forward显示文摘The COVID-19 pandemic has posed a serious threat to global mental health.Multiple lines of evidence suggest that there is a varying yet considerable increase in mental health issues among the general population and vulnerable groups.12 The aftermath is obscure and speculative from a social,economic,individual and public mental health perspective.Recently published studies support the existence of an emotional epidemic curve,describing a high probability of an increase in the burden of mental health issues in the post-pandemic era.34 Furthermore,previous major public health emergencies showed that more than half of the population devel-oped mental health problems and required mental health intervention.45 There is,therefore,an urgent need to reorganise existing mental health services to address the current unmet needs for mental health and to prepare for future challenges in the postpandemic era in terms of prevention and management. | Ramyadarshni Vadivel Sheikh Shoib Sarah El Halabi Samer El Hayek LamiaàEssam Drita Gashi Bytyçi Ruta Karaliuniene Andre Luiz Schuh Teixeira Sachin Nagendrappa Rodrigo Ramalho Ramdas Ransing Victor Pereira-Sanchez Chonnakarn Jatchavala Frances Nkechi Adiukwu Ganesh Kudva Kundadak | 2021 | General Psychiatry2021，34，1： | 2 |
| 5 | Histologic Pathologies of the Myocardium in Septic Shock: A Prospective Observational Study显示文摘 | Christian A. Schmittinger Martin W. Dünser Christian Torgersen Günter Luckner Ingo Lorenz Stefan Schmid Michael Joannidis Patrizia Moser Walter R. Hasibeder Milo Halabi Christina M. Steger | 2013 | Shock2013，，4： | 1 |
| 6 | Contemporary evidence on the physiological role of reactive oxygen species in human sperm function显示文摘 | Du Plessis SS Agarwal A Halabi J | 2015 | J Assist Reprod Genet2015，32，： | 1 |
| 7 | Hydrocortisone with or without mitoxantrone in men with hormone-refractory prostate cancer:Results of the cancer and leukemia group B 9182 study显示文摘 | Kantoff PW Halabi S Conaway M | 1999 | J Clin Oncol1999，17，8： | 1 |
| 8 | The relationship between extravascular lung water and oxygenation in three pati- ents with influenza A (H1N1) -induced respiratory failure 显示文摘 | Hasibeder WR Diinser MW Halabi M | 2010 | Wien Klm Wochenschr2010，122，2122： | 1 |
| 9 | Pharmacokinetics of moxifloxacin, a novel 8- methoxy- quinolone, in patients with renal dysfunction显示文摘 | STASS H KUBITZA D HALABI A et ol | 2002 | Br J Clin Pharmacol2002，53，3： | 1 |
| 10 | Risk Factors for Anastomot- ic Leakage After Anterior Resection for Rectal Cancer显示文摘 | Kang CY Halabi WJ Chaudhry OO | 2013 | JAMA Sur- gery2013，148，1： | 1 |
| 11 | Androgen receptor muta- tions in androgen-independent prostate cancer: Cancer and Leukemia Group B Study 9663 显示文摘 | Taplin ME Rajeshkumar B Halabi S | 2003 | Clin Oncol2003，21，： | 1 |
| 12 | Hydrocortisone with or without mitoxantrone in men with hormone-refractory prostate cancer:results of the cancer and leukemia group B 9182 study显示文摘 | Kantoff PW Halabi S Conaway M | 1999 | J Clin Oncol1999，17，： | 1 |
| 13 | Quality of care and survival of haemodialysed patients in western Switzerl显示文摘 | Saudan P Kossovsky M Halabi G | 2008 | Nephrol Dial Transplant2008，23，6： | 1 |
| 14 | Vascular endothelial growth factor and basic fibroblast growth factor urine levels as predictors of outcome in hormone-refractory prostate cancer patients:a cancer and leukemia group B study显示文摘 | Bok RA Halabi S Fei DT | 2001 | Cancer Res2001，61，6： | 1 |
| 15 | Phase Ⅱ study of high-dose fish oil capsules for patients with cancer-related cachexia显示文摘 | Burns CP Halabi S Clamon G | 2004 | Can-cer2004，101，2： | 1 |
| 16 | The development of a preceptor training program on clinical nursing education in Jordan in collaboration with Sweden 显示文摘 | Halabi JO Abdalrabim MS Persson GL | 2012 | J Contin Educ Nurs2012，43，3： | 1 |
| 17 | Platelet inhibitor therapy for patients with cardiovascular disease: looking toward the future 显示文摘 | Aljaroudi WA Halabi AR Harrington RA | 2005 | Curr Hematol Rep2005，4，5： | 1 |
| 18 | Necrotizing enterecolitis in neonates receiving octreotide for the management of congenital hyperinsulinism显示文摘 | Laje P Halaby L Adzick NS | 2010 | Pediatr Diabetes2010，11，2： | 1 |
| 19 | Validation of a breast cancer risk assessment model in women with a positive family history显示文摘 | Lustbsder ER halabi S | 1994 | J Natl Cancer nst1994，86，8： | 1 |
| 20 | Analgesic drug use and risk of ovarian cancer 显示文摘 | Schildkraut JM Moorman PG Halabi S | 2006 | E pidemiology2006，17，1： | 1 |
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