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| 1 | 局部注射消痔灵促进胃癌细胞凋亡的初步研究显示文摘消痔灵是一种血管收敛剂,临床上主要用于治疗痔疮,我们采用消痔灵注射液对裸鼠人胃癌模型进行局部治疗的研究,观察抑瘤率和胃癌组织病理变化,检测消痔灵促胃癌细胞凋亡情况,从而掌握消痔灵的抗癌效果,并探讨其抗癌作用机理,为临床应用消痔灵治疗胃癌提供理论依据. | 秦庆亮 刘海燕 张本华 李安琪 常军 辛立 | 2002 | 中华消化内镜杂志2002，19，4： | 8 |
| 2 | Gene Expression of Fas,Soluble Fas and Fas-Ligand in Thyroid Tissues and Thyrocytes from Patients with Graves′ Disease显示文摘ObjectiveTo investigate Fas,soluble Fas(sFas)and Fas ligand(Fas L)gene expression in thyroid tissues and thyrocytes from patients with Graves disease(GD)and to find the interrelationship between apoptosis and pathogenesis of GD. MethodsThyroid tissues were obtained from 7 GD patients and 3 healthy subjects who died accidentally. Thyrocytes were cultured in Eagle′s medium. Total RNA was isolated from thyroid tissues and cultured thyrocytes. The cDNA was prepared by reverse transcription and amplified for Fas,sFas and Fas L by polymerase chain reaction(PCR). ResultsFas and sFas mRNA were detected in all samples from both GD and normal thyroid tissues and thyrocytes,but Fas L mRNA was only found in GD thyroid tissues and thyrocytes. Semi quantitative analysis showed that when compared with those of normal controls,the Fas and sFas mRNA levels were markedly increased in GD thyroid tissues(P<0.01),whereas in GD thyrocytes only the sFas mRNA levels was significantly elevated(P<0.01). ConclusionGene expression of Fas,sFas and Fas L showed abnormality in both thyroid tissues and thyrocytes from GD. The increased production of sFas might be involved in the hyperplasia of thyroid gland. | 武晓泓 刘超 覃又文 刘翠萍 段宇 蒋须勤 | 2002 | Journal of Nanjing Medical University2002，16，1： | 1 |
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