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| 1 | Intelligent Manufacturing in the Context of Industry 4.0: A Review显示文摘 | Ray Y. Zhong Xun Xu Eberhard Klotz Stephen T. Newman | 2017 | Engineering2017，3，5： | 130 |
| 2 | Hepatitis B virus-induced oncogenesis显示文摘Hepatocellular carcinoma (HCC) is one of the most com- mon cancers in the world with an annual incidence of more than 500 000 in the year 2000. Its incidence is rising in many countries. Recently, it has been estimated that about 53% of HCC cases in the world are related to hepatitis B virus (HBV). The epidemiological association of HBV with HCC is well established. In recent studies, it was revealed that HBsAg carriers have a 25-37 times increased risk of developing HCC as compared to non-infected people. At present, HBV-associated carcinogenesis can be seen as a multi-factorial process that includes both direct and indirect mechanisms that might act synergistically. The integration of HBV DNA into the host genome occurs at early steps of clonal tumor expansion. The integration has been shown in a number of cases to affect a variety of cancer- related genes and to exert insertional mutagenesis. The permanent liver inflammation, induced by the immune response, resulting in a degeneration and regeneration process confers to the accumulation of critical mutations in the host genome. In addition to this, the regulatory proteins HBx and the PreS2 activators that can be encoded by the integrate exert a tumor promoter-like function resulting in positive selection of cells producing a functional regulatory protein. Gene expression profiling and proteomic techniques may help to characterize the molecular mechanisms driving HBV-associated carcino- genesis, and thus potentially identify new strategies in diagnosis and therapy. | Joachim Lupberger Eberhard Hildt | 2007 | World Journal of Gastroenterology2007，13，1： | 56 |
| 3 | 盐胁迫条件下杨树组织及细胞中钾、钙、镁的变化显示文摘该文研究了NaCl对群众杨 (Populus‘popularis 35 44’ ,P .popularis)、I 2 1 4杨 (P .×euramericanacv .I 2 1 4 ,P .cv.I 2 1 4 )和胡杨 (P .euphratica) 3种杨树组织和细胞营养状况的影响 .为期 30d的盐处理降低了群众杨和I 2 1 4杨根和茎组织中K+、Ca2 +、Mg2 +的水平 ,而对于叶片营养元素的水平基本没有影响 .与群众杨和I 2 1 4杨比较 ,胡杨组织的营养水平受NaCl的影响最小 .根皮层细胞X 射线微区分析的结果显示 ,NaCl降低了群众杨和I 2 1 4杨细胞壁和液泡中K+、Mg2 +的水平 ,但对于胡杨细胞营养元素水平的影响较小 .实验结果表明 ,胡杨在盐胁迫条件下能保持对营养元素的吸收 ,维持较好的营养状况 ,这是其抗盐性强的原因之一 ;I 2 1 4杨和群众杨的抗盐性弱 。 | 陈少良 李金克 尹伟伦 王沙生 Eberhard Fritz Andrea Polle Aloys Httermann | 2002 | 北京林业大学学报2002，24，5： | 41 |
| 4 | 纳米定位测量机操作测量结果(英文)显示文摘伊尔梅瑙工业大学过程测量和传感技术研究所研制了三维纳米定位和测量机 (NPMM ) .阿贝无偏设计使得该机器异常精确 .在整个 2 5mm× 2 5mm× 5mm的定位和测量域内 ,干涉测长系统分辨力可达 0 .1nm ,不确定度达 5~ 10nm .提供了纳米定位测量机的基本信息 ,介绍其操作模式 。 | JAGER Gerd GRUNWALD Rainer MANSKE Eberhard HAUSOTTE Tino FUβL Roland | 2004 | 纳米技术与精密工程2004，2，2： | 14 |
| 5 | 盐胁迫下胡杨和毛白杨叶细胞中的离子区隔化显示文摘该文以抗盐的胡杨和盐敏感的毛白杨组培再生苗为实验材料,利用X--射线微区分析技术研究盐胁迫下(为期20d的盐处理)叶片各种类型细胞内主要元素Na+、Cl-、K+的分布情况,测定的细胞类型包括:①叶脉细胞(叶脉维管束导管、叶脉维管束内部和外部的薄壁细胞);②叶肉细胞(栅栏组织、海绵组织);③表皮细胞(上、下表皮细胞).结果表明,胡杨和毛白杨叶细胞对盐离子的区隔化有明显差异:与毛白杨相比,盐处理后的胡杨叶细胞不但具有较高的拒Na+能力,即将Na+贮存在质外体中,而且液泡区隔Na+的能力也强于毛白杨.在Cl-的区隔化方面,对照处理胡杨各种类型的细胞(包括叶脉、叶肉和表皮细胞)Cl-浓度都高于毛白杨,但在盐胁迫下,胡杨叶片的细胞壁、液泡甚至叶绿体中Cl-的含量都低于毛白杨,这是胡杨根细胞限制Cl-离子根冠运输的结果.盐处理使胡杨叶片各种类型细胞中的K+浓度降低;与胡杨不同,毛白杨叶片细胞中质外体的K+浓度下降,而液泡中的K+水平却相应提高,这是毛白杨细胞内K+重新分配的结果:由于盐处理后毛白杨液泡内积累了过多的Cl-,K+从细胞壁进入液泡,用以平衡液泡内Cl-积累所带来的负电荷. | 戴松香 陈少良 Eberhard Fritz Andrea Olbrich Christine Kettner Andrea Polle Aloys Hüttermann | 2006 | 北京林业大学学报2006，28，S2： | 14 |
| 6 | 多边形和多面体顶点法矢的数值估计显示文摘证明了两个定理 :定理 1揭示了三点多边形的外接圆在中点处的法矢与两个边界法矢的关系 ;定理 2揭示了四面体外接球面在中点处的法矢与三个相邻三角平面的法矢量的关系 .给出了一个判别二维多边形和三维多面体顶点法矢计算方法优劣的准则 .在此基础上 ,提出一种用于估计三维多面体顶部的法矢量的计算方法 . | 姜寿山 Peter Eberhard | 2002 | 计算机辅助设计与图形学学报2002，14，8： | 14 |
| 7 | Implication of the intestinal microbiome in complications of cirrhosis显示文摘The intestinal microbiome(IM) is altered in patients with cirrhosis,and emerging literature suggests that this impacts on the development of complications.The Pub Med database was searched from January 2000 to May 2015 for studies and review articles on the composition,pathophysiologic effects and therapeutic modulation of the IM in cirrhosis.The following combination of relevant text words and MeS H terms were used,namely intestinal microbiome,microbiota,or dysbiosis,and cirrhosis,encephalopathy,spontaneous bacterial peritonitis,hepatorenal syndrome,variceal bleeding,hepatopulmonary syndrome,portopulmonary hypertension and hepatocellular carcinoma.The search results were evaluated for pertinence to the subject of IM and cirrhosis,as well as for quality of study design.The IM in cirrhosis is characterized by a decreased proportion of Bacteroides and Lactobacilli,and an increased proportion of Enterobacteriaceae compared to healthy controls.Except for alcoholic cirrhosis,the composition of the IM in cirrhosis is not affected by the etiology of the liver disease.The percentage of Enterobacteriaceae increases with worsening liver disease severity and decompensation and is associated with bacteremia,spontaneous bacterial peritonitis and hepatic encephalopathy.Lactulose,rifaximin and Lactobacillus-containing probiotics have been shown to partial y reverse the cirrhosis associated enteric dysbiosis,in conjunction with improvement in encephalopathy.The IM is altered in cirrhosis,and this may contribute to the development of complications associated with end-stage liver disease.Therapies such as lactulose,rifaximin and probiotics may,at least partially,reverse the cirrhosisassociated changes in the IM.This,in turn,may prevent or alleviate the severity of complications. | Mamatha Bhat Bianca M Arendt Venkat Bhat Eberhard L Renner Atul Humar Johane P Allard | 2016 | World Journal of Hepatology2016，8，27： | 13 |
| 8 | Liver transplantation and non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD) is an important health problem worldwide. NAFLD encompasses a histological spectrum ranging from bland liver steatosis to severe steatohepatitis(nonalcoholic steatohepatitis, NASH) with the potential of progressing to cirrhosis and its associated morbidity and mortality. NAFLD is thought to be the hepatic manifestation of insulin resistance(or the metabolic syndrome); its prevalence is increasing worldwide in parallel with the obesity epidemic. In many developed countries, NAFLD is the most common cause of liver disease and NASH related cirrhosis is currently the third most common indication for liver transplantation. NASH related cirrhosis is anticipated to become the leading indication for liver transplantation within the next one or two decades. In this review, we discuss how liver transplantation is affected by NAFLD, specifically the following:(1) the increasing need for liver transplantation due to NASH;(2) the impact of the increasing prevalence of NAFLD in the general population on the quality of deceased and live donor livers available for transplantation;(3) the long term graft and patient outcomes after liver transplantation forNASH,and finally;and(4)the de novo occurrence of NAFLD/NASH after liver transplantation and its impact on graft and patient outcomes. | Petros Zezos Eberhard L Renner | 2014 | World Journal of Gastroenterology2014，20，42： | 12 |
| 9 | Identification and characterization of a novel bipartite nuclear localization signal in the hepatitis B virus polymerase显示文摘AIM:To characterize the nuclear import of hepatitis B virus(HBV)polymerase(P)and its relevance for the viral life cycle.METHODS:Sequence analysis was performed to predict functional motives within P.Phosphorylation of P was analyzed by in vitro phosphorylation.Phosphorylation site and nuclear localization signal(NLS)were destroyed by site directed mutagenesis.Functionality of the identified NLS was analyzed by confocal fluorescence microscopy and characterizing the karyopherin binding.Relevance of the structural motives for viral life cycle was studied by infection of primary Tupaia hepatocytes with HBV.RESULTS:We identified by sequence alignment and functional experiments a conserved bipartite NLS containing a casein kinaseⅡ(CKⅡ)phosphorylation site located within the terminal protein domain(TP)of the HBV polymerase.Inhibition of CKⅡimpairs the functionality of this NLS and thereby prevents the nuclear import of the polymerase.Binding of the import factor karyopherin-α2 to the polymerase depends on its CKⅡ-mediated phosphorylation of the bipartite NLS.In HBV-infected primary Tupaia hepatocytes CKⅡinhibition in the early phase(post entry phase)of the infection process prevents the establishment of the infection.CONCLUSION:Based on these data it is suggested that during HBV infection the final import of the genome complex into the nucleus is mediated by a novel bipartite NLS localized in the TP domain of HBV polymerase. | Joachim Lupberger Stephanie Schaedler Alexander Peiran Eberhard Hildt | 2013 | World Journal of Gastroenterology2013，19，44： | 8 |
| 10 | Adaptive nonlinear model predictive control design of a flexible-link manipulator with uncertain parameters显示文摘This paper presents a novel adaptive nonlinear model predictive control design for trajectory tracking of flexible-link manipulators consisting of feedback linearization, linear model predictive control, and unscented Kalman filtering. Reducing the nonlinear system to a linear system by feedback linearization simplifies the optimization problem of the model predictive controller significantly, which,however, is no longer linear in the presence of parameter uncertainties and can potentially lead to an undesired dynamical behaviour. An unscented Kalman filter is used to approximate the dynamics of the prediction model by an online parameter estimation, which leads to an adaptation of the optimization problem in each time step and thus to a better prediction and an improved input action. Finally,a detailed fuzzy-arithmetic analysis is performed in order to quantify the effect of the uncertainties on the control structure and to derive robustness assessments. The control structure is applied to a serial manipulator with two flexible links containing uncertain model parameters and acting in threedimensional space. | Fabian Schnelle Peter Eberhard | 2017 | Acta Mechanica Sinica2017，33，3： | 5 |
| 11 | Red Light-Induced Phytochrome Relocation into the Nucleus in Adiantum capillus-veneris显示文摘在种子植物的 Phytochromes 被知道搬到一种红轻依赖者的方式进原子核与或没有交往的因素。这里,我们由部分孢子照耀实验在 phytochrome 依赖的石长生属植物 capillus-veneris 孢子萌芽显示出 phytochrome 重定位到原子区域。原子或吸入的孢子的无核区域与红或 far-red 光和涉及孢子萌芽的 phytochrome 的本地化的微光束被照耀从萌芽率被估计。为孢子萌芽的 phytochrome 在吸收以后在黑暗下面在整个整个孢子存在,但是逐渐地移居了到原子区域追随者红光照耀。粒子轰炸在发芽孢子表示的 PHYGUS 熔化蛋白质的细胞内部的分发显示出 Acphy2,然而并非 Acphy1 的迁居,进以一种红轻依赖者的方式的原子核,建议 Acphy2 是为蕨纲植物孢子萌芽的光敏电阻器。 | Hidenori Tsuboi Sachihiko Nakamura Eberhard Schaifer Masamitsu Wadaa | 2012 | Molecular Plant2012，5，3： | 4 |
| 12 | The Dual Spaces of Sets of Difference Sequences of Order m and Matrix Transformations显示文摘让 p =(p κ)_( κ = 0 )~ ∞是积极 reals, m ∈ N 和非零术语的 ube s 顺序的一个围住的序列。如果 x =( x κ)_(κ= 0 )~∞ 是我们为 x 和Δ_u^((m))的 m-th 顺序差别的顺序给Δ^((m)) x 写的复杂数字的任何顺序 X ={ x =(x)_(κ= 0 )~∞ : u Δ^((m)) x ∈ X }为序列的任何集合 X 。我们决定α - ,β双和集合Δ _u^((m)) 的γ - duals 为 X = c_0 (p) 的 X, c (p) , l_ ∞(p ) 并且描绘在这些空格Δ ^((m)) 之间的一些矩阵转变 X。 | Eberhard MALKOWSKY M.MURSALEEN Suthep SUANTAI | 2007 | Acta Mathematica Sinica,English Series2007，23，3： | 4 |
| 13 | Thermal Reversion of Plant Phytochromes显示文摘Phytochromes are red/far-red reversible photoreceptors essential for plant growth and development.Phytochrome signaling is mediated by the physiologically active far-red-absorbing Pfr form that can be inactivated to the red-absorbing Pr ground state by light-dependent photoconversion or by light-independent thermal reversion,also termed dark reversion.Although the term“dark reversion”is justified by historical reasons and frequently used in the literature,“thermal reversion”more appropriately describes the process of light-independent but temperature-regulated Pfr relaxation that not only occurs in darkness but also in light and is used throughout the review.Thermal reversion is a critical parameter for the light sensitivity of phytochrome-mediated responses and has been studied for decades,often resulting in contradictory findings.Thermal reversion is an intrinsic property of the phytochrome molecules but can be modulated by intra-and intermolecular interactions,as well as biochemical modifications,such as phosphorylation.In this review,we outline the research history of phytochrome thermal reversion,highlighting important predictions that have been made before knowing the molecular basis.We further summarize and discuss recent findings about the molecular mechanisms regulating phytochrome thermal reversion and its functional roles in light and temperature sensing in plants. | Cornelia Klose Ferenc Nagy Eberhard Schafer | 2020 | Molecular Plant2020，13，3： | 4 |
| 14 | 【特刊综述】睾酮缺乏症的历史渊源显示文摘睾丸和睾酮的生物学作用在远古时代就被知晓。亚里士多德对于阉割效果的认识,和他关于受精的假说是生殖生物学上的第一次科学偶遇。几个世纪以前阉割已经成为了一种惩罚手段,同时用于产生顺从的奴隶,和保留青春期前的男童高音。古代中国皇家(以及东方其他国家)招募太监作为后宫的监察员,他们往往能获得较高的政治地位。1786年在伦敦,John Hunter将睾丸移植到了阉鸡上,从此开启了睾丸移植和器官疗法的新时代。Hunter的实验目的在于证明“救命原则”是现代移植医学的基础,但他并没有考虑到内分泌方面的因素。1849年在哥根廷,Arnold Adolph Berthold通过他的睾丸移植实验提出了内在分泌功能假说,因此他被称为内分泌之父。通过他的研究,睾丸制剂,尽管充其量只有安慰剂效果,开始应用于治疗。1889年charles-Edouard Brown-S6quard在伦敦进行了自体实验后,睾内制剂流行起来。20世纪20年代SergioVoronoff将动物的睾丸移植到男人身上,但其有效性被否定了。时至今日,睾丸移植正被干细胞研究和生殖细胞移植逐步精细化。现代雄激素治疗始于1935年Enrest Lacquer在阿姆斯特丹从公牛睾丸中分离出了睾酮。同年,哥廷根的AdolfButenandt和巴塞尔的LeopoldRuzicka分别独立通过化学方法合成了睾酮。因为睾酮口服无效,所以曾经被压缩成皮下颗粒或制成能口服的17ct。甲基睾酮,但由于其有肝毒性现己过时了。睾酮治疗的早期阶段与Klinefelter,和Kalhnann,DelCasfillo及Pasqualini第一次描述的性腺功能减退症的最突出症状相一致。20世纪50年代,长效注射型庚酸睾酮成为首选治疗方法。20世纪50、60年代,研究集中在雄激素的化学修饰上,以加强其合成代谢作用。虽然促蛋白合成类固醇已经基本上不作为临床药物使用,但他们仍作为兴奋剂在体育竞技中被非法使用。20世纪70年代,高效的口服十一酸睾酮被添加到了这个睾酮制剂家族中。最近,透皮凝胶和长效注射制剂为生理性睾酮替代治疗提供了新的选择。 | Eberhard Nieschlag Susan Nieschlag | 2014 | Asian Journal of Andrology2014，16，2： | 3 |
| 15 | Stability analysis of a thin-walled cylinder in turning operation using the semi-discretization method显示文摘In this work, the stability of a flexible thin cylindrical workpiece in turning is analyzed. A process model is derived based on a finite element representation of the workpiece flexibility and a nonlinear cutting force law. Repeated cutting of the same surface due to overlapping cuts is modeled with the help of a time delay. The stability of the so obtained system of periodic delay differential equations is then determined using an approximation as a time-discrete system and Floquet theory. The time-discrete system is obtained using the semi-discretization method. The method is implemented to analyze the stability of two different workpiece models of different thicknesses for different tool positions with respect to the jaw end. It is shown that the stability chart depends on the tool position as well as on the thickness. | Arnab Chanda Achim Fischer Peter Eberhard Santosha Kumar Dwivedy | 2014 | Acta Mechanica Sinica2014，30，2： | 3 |
| 16 | Wound Complications in 1145 Consecutive Transumbilical Single-Incision Laparoscopic Procedures显示文摘 | Helmut G. Weiss Walter Brunner Matthias O. Biebl Jan Schirnhofer Katharina Pimpl Christof Mittermair Christian Obrist Eberhard Brunner Tobias Hell | 2014 | Annals of Surgery2014，，1： | 3 |
| 17 | 2013年ISMRM年会前列腺MRI研究进展显示文摘第21届国际医学磁共振学会(ISMRM2013)在美国犹他州盐湖城举行,此次会议共收录与前列腺相关的论文91篇,这些论文主要关注磁共振功能成像技术,如扩散加权成像(DWI)、磁共振波谱成像(MRS)、标记靶分子成像和动态增强图像(DCE)等在前列腺癌诊断、鉴别诊断中的应用。本文对以上的研究现状进行综述,旨在提高我国对前列腺磁共振成像研究的新认识。 | 冯朝燕 李亮 胡道予 夏黎明 陈敏 Jinxing Yu Steven Eberhard 王良 | 2013 | 放射学实践2013，28，7： | 3 |
| 18 | Recurrence of autoimmune liver diseases after liver transplantation显示文摘Liver transplantation(LT) is the most effective treatment modality for end stage liver disease caused by many etiologies including autoimmune processes. That said, the need for transplantation for autoimmune hepatitis(AIH) and primary biliary cirrhosis(PBC), but not for primary sclerosing cholangitis(PSC), has decreased over the years due to the availability of effective medical treatment. Autoimmune liver diseases have superior transplant outcomes than those of other etiologies. While AIH and PBC can recur after LT, recurrence is of limited clinical significance in most, but not all cases. Recurrent PSC, however, often progresses over years to a stage requiring re-transplantation. The exact incidence and the predisposing factors of disease recurrence remain debated. Better understanding of the pathogenesis and the risk factors of recurrent autoimmune liver diseases is required to develop preventive measures. In this review, we discuss the current knowledge of incidence, diagnosis, risk factors, clinical course, and treatment of recurrent autoimmune liver disease(AIH, PBC, PSC) following LT. | Nabiha Faisal Eberhard L Renner | 2015 | World Journal of Hepatology2015，7，29： | 3 |
| 19 | Single port laparoscopy in gastroenterology and hepatology: A fine step forward显示文摘Single incision laparoscopy(SIL) has become an emerging technology aiming at a further reduction of abdominal wall trauma in minimally invasive surgery. Available data is encouraging for the safe application of standardized SIL in a wide range of procedures in gastroenterology and hepatology. Compared to technically simple SIL procedures, the merit of SIL in advanced surgeries, such as liver or colorectal interventions, compared to conventional laparsocopy is self-evident without any doubt. SIL has already passed the learning curve and is routinely utilized in expert centers. This minimized approach has allowed to enter a new era of surgical management that can not be acceded without a fruitful combination of prudent training, consistent day-to-day work and enthusiastic motivation for technical innovations. Both, basic and novel technical specifics as well as particular procedures are described herein. The focus is on the most important surgical interventions in gastroenterology and aims at reviewingthe current literature and shares our experience in a high volume center. | Christof Mittermair Jan Schirnhofer Eberhard Brunner Katharina Pimpl Christian Obrist Michael Weiss Helmut G Weiss | 2014 | World Journal of Gastroenterology2014，20，42： | 3 |
| 20 | Effect of NaCl on growth and ion relations in two salt-tolerant strains of Paxillus involutus显示文摘The effect of NaCl on growth,biomass and ion relations of two salt-tolerant isolates of Paxillus involutus,MAJ and NAU were investigated.The two Paxillus strains were exposed to the following concentrations of NaCl:0,100,200 and 500 mmol·L-1.Growth of MAJ and NAU was enhanced by 100 mmol·L-1 NaCl but severely inhibited at the concentration of 500 mmol·L-1.NAU exhibited a greater capacity to exclude Na+ and Clunder all salinity levels,whereas the salt-includer MAJ had a higher capacity in nutrient uptake under salt stress.The ratios Na+/K+,Na+/Ca2+ and Na+/Mg2+ in NaCl-treated MAJ and NAU did not increase at levels of 100 and 200 mmol·L-1 NaCl but markedly increased at 500 mmol·L-1.This suggests that the two strains,especially MAJ,enhanced nutrient uptake corresponding to the increased Na+ influx at moderate salinity.We conclude that both MAJ and NAU are able to tolerate 500 mmol·L-1 NaCl but there are species-specific differences in retaining ionic homeostasis in the two Paxillus strains.NAU is a salt-excluder,MAJ is a salt-includer but retains a high capacity in nutrient selectivity under saline conditions.Their definite mechanisms to enhance salt tolerance of mycorrhizal hosts need further study. | ZHANG Hua LI Jing CHEN Shao-liang LU Cun-fu WANG Rui-gang DAI Song-xiang ZHU Hui-juan ZHANG Yun-xia SHI Yong WANG Mei-juan LU Yan-jun LI Li-si Rosemarie LANGENFELD-HEYSER Fritz EBERHARD Andrea POLLE | 2008 | Forestry Studies in China2008，10，2： | 3 |
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