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| 1 | Beclin 1-Vps34 complex architecture: Understanding the nuts and bolts of therapeutic targets显示文摘Autophagy 是由毁坏并且再循环细胞内部的内容帮助细胞的动态平衡的维护的一条重要 lysosomal 降级小径。autophagy 的 Dysregulation 被连接到越来越多的人的疾病。Beclin 1-Vps34 蛋白质蛋白质相互作用网络为 autophagy 规定是批评的并且对细胞的正直因此必要。特别地经由 Beclin 1-Vps34 建筑群的行动的调整, autophagy 的操作被认为一条有希望的线路与 autophagy 相关的疾病作斗争。这里,我们在核心部件和 Beclin 1-Vps34 建筑群的结构的建筑学上总结最近的调查结果,并且怎么这些调查结果提供珍贵卓见进位于这些建筑群并且为设计治疗学的策略的多重函数下面的分子的机制。 | Deanna H. Morris Calvin K. Yip Yi Shi Brian T. Chait Qing Jun Wang | 2015 | Frontiers in Biology2015，10，5： | 17 |
| 2 | Circumcision reduces prostate cancer risk显示文摘 | Brian J Morris lake H Waskett | 2012 | Asian Journal of Andrology2012，14，5： | 3 |
| 3 | Diagnostic accuracy of tests for Helicobacter pylori in an Alaska Native population显示文摘AIM:To evaluate the accuracy of two non-invasivetests in a population of Alaska Native persons. Highrates of Helico bacter pylori(H. pylori) infection,H. pylori treatment failure,and gastric cancer in this population necessitate documentation of infection status atmultiple time points over a patient's life.METHODS:In 280 patients undergoing endoscopy,H. pylori was diagnosed by culture,histology,rapidurease test,13C urea breath test(UBT) ,and immuno-globulin G antibodies to H. pylori in serum. The performances of 13C-UBT and antibody test were compared to a gold standard defined by a positive H. pylori testby culture or,in case of a negative culture result,bypositive histology and a positive rapid urease test.RESULTS:The sensitivity and specificity of the 13C-UBT were 93% and 88%,respectively,relative to thegold standard. The antibody test had an equivalents ensitivity of 93% with a reduced specificity of 68%.The false positive results for the antibody test were as-sociated with previous treatment for an H. pylori infection [relative risk(RR) = 2.8]. High levels of antibodiesto H. pylori were associated with chronic gastritis and male gender,while high scores in the 13C-UBT testwere associated with older age and with the H. pyloribacteria load on histological examination(RR = 4.4) .CONCLUSION:The 13C-UBT out performed the anti-body test for H. pylori and could be used when a non-invasive test is clinically necessary to document treatment out come or when monitoring for reinfection. | Dana L Bruden Michael G Bruce Karen M Miernyk Julie Morris Debby Hurlburt Thomas W Hennessy Helen Peters Frank Sacco Alan J Parkinson Brian J McMahon | 2011 | World Journal of Gastroenterology2011，17，42： | 3 |
| 4 | Early infant male circumcision:Systematic review,risk-benefit analysis,and progress in policy显示文摘AIM To determine whether recent evidence-based United States polices on male circumcision(MC) apply to comparable Anglophone countries,Australia and New Zealand.METHODS Articles in 2005 through 2015 were retrieved from PubM ed using the keyword 'circumcision' together with 36 relevant subtopics.A further PubM ed search was performed for articles published in 2016.Searches of the EMBASE and Cochrane databases did not yield additional citable articles.Articles were assessed for quality and those rated 2+ and above according to the Scottish Intercollegiate Grading System were studied further.The most relevant andrepresentative of the topic were included.Bibliographies were examined to retrieve further key references.Randomized controlled trials,recent high quality systematic reviews or meta-analyses(level 1++ or 1+ evidence) were prioritized for inclusion.A risk-benefit analysis of articles rated for quality was performed.For efficiency and reliability,recent randomized controlled trials,metaanalyses,high quality systematic reviews and large welldesigned studies were used if available.Internet searches were conducted for other relevant information,including policies and Australian data on claims under Medicare for MC.RESULTS Evidence-based policy statements by the American Academy of Pediatrics(AAP) and the Centers for Disease Control and Prevention(CDC) support infant and later age male circumcision(MC) as a desirable public health measure.Our systematic review of relevant literature over the past decade yielded 140 journal articles that met our inclusion criteria.Together,these showed that early infant MC confers immediate and lifelong benefits by protecting against urinary tract infections having potential adverse long-term renal effects,phimosis that causes difficult and painful erections and 'ballooning' during urination,inflammatory skin conditions,inferior penile hygiene,candidiasis,various sexually transmissible infections in both sexes,genital ulcers,and penile,prostate and cervical cancer.Our risk-benefit analysis showed that benefits exceeded procedural risks,which are predominantly minor,by up to 200 to 1.We estimated that more than 1 in 2 uncircumcised males will experience an adverse foreskin-related medical condition over their lifetime.Wide-ranging evidence from surveys,physiological measurements,and the anatomical location of penile sensory receptors responsible for sexual sensation strongly and consistently suggested that MC has no detrimental effect on sexual function,sensitivity or pleasure.United States studies showed that early infant MC is cost saving.The evidence supporting early infant MC has further strengthened since the positive AAP and CDC reviews.CONCLUSION Affirmative MC policies are needed in Australia and New Zealand.Routine provision of accurate,unbiased education,and access in public hospitals,will maximize health and financial benefits. | Brian J Morris Sean E Kennedy Alex D Wodak Adrian Mindel David Golovsky Leslie Schrieber Eugenie R Lumbers David J Handelsman John B Ziegler | 2017 | World Journal of Clinical Pediatrics2017，6，1： | 2 |
| 5 | Phase II Pilot Study of Vemurafenib in Patients With Metastatic BRAF -Mutated Colorectal Cancer显示文摘 | Kopetz Scott Desai Jayesh Chan Emily Hecht Joel Randolph O’Dwyer Peter J. Maru Dipen Morris Van Janku Filip Dasari Arvind Chung Woonbook Issa Jean-Pierre J. Gibbs Peter James Brian Powis Garth Nolop Keith B. Bhattacharya Suman Saltz Leonard | 2015 | Journal of Clinical Oncology2015，，34： | 2 |
| 6 | Critical evaluation of unscientific arguments disparaging affirmative infant male circumcision policy显示文摘We evaluate recent claims opposing infant male circumcision,a procedure now supported by the evidencebased policy of the American Academy of Pediatrics.We find those criticisms depend on speculative claims about the foreskin and obfuscation of the strong scientific evidence supporting pediatric policy development.An argument that circumcision should be delayed to allow a boy to make up his own mind as an adult fails to appreciate the psychological,scheduling and financial burdens later circumcision entails,so reducing the likelihood that it will occur.In contrast,early infant circumcision is convenient,safer,quicker,lower risk,healing is faster,cosmetic outcome is routinely good and the lifetime benefits accrue immediately.Benefits include reduction in urinary tract infections,inflammatory skin conditions,foreskin problems,and,when older,substantial protection against sexually transmitted infections and genital cancers in the male and his female sexual partners.Some authorities regard the failure to offer parents early infant circumcision as unethical,just as it would be unethical to fail to encourage the vaccination of children.In conclusion,the criticisms of evidence-based infant male circumcision policy are seriously flawed and should be dismissed as unhelpful to evidence-based development and implementation of pediatric policy intended to improve public health and individual wellbeing. | Brian J Morris John N Krieger Jeffrey D Klausner | 2016 | World Journal of Clinical Pediatrics2016，5，3： | 2 |
| 7 | Reply to Letter by Dr. Christoph Kupferschmid: Commentary on "Countries with high circumcision prevalence have lower prostate cancer mortality"显示文摘 | Mitchell S Wachtel Shengping Yang Brian J Morris | 2016 | Asian Journal of Andrology2016，18，6： | 2 |
| 8 | The Effect of Progressive, Reinforcing Telephone Education and Counseling Versus Brief Educational Intervention on Knowledge, Self-Care Behaviors and Heart Failure Symptoms显示文摘 | David W. Baker Darren A. DeWalt Dean Schillinger Victoria Hawk Bernice Ruo Kirsten Bibbins-Domingo Morris Weinberger Aurelia Macabasco-O’Connell Kathy L. Grady George M. Holmes Brian Erman Kimberly A. Broucksou Michael Pignone | 2011 | Journal of Cardiac Failure2011，，10： | 1 |
| 9 | Physical Mapping of Puroindoline b-2 Genes in Wheat using ’Chinese Spring’ Chromosome Group 7 Deletion Lines显示文摘 | Geng Hongwei Beecher Brian S He Zhonghu Morris Craig F | 2012 | Crop Science2012，，6： | 1 |
| 10 | Prevalence of Puroindoline D1 and Puroindoline b-2 variants in U.S. Pacific Northwest wheat breeding germplasm pools, and their association with kernel texture显示文摘 | Hongwei Geng Brian Beecher Zhonghu He Alecia Kiszonas Craig Morris | 2012 | Theoretical and Applied Genetics2012，，7： | 1 |
| 11 | Innovative Hazard显示文摘 | Dixon Myles A Walsh R Scott Morris | 1990 | Waste Treat Technol Ser1990，2，： | 1 |
| 12 | Surface charge-dependent toxicity of silver nanoparticles显示文摘 | Amro M EI Badawy Rendahandi G Silva Brian Morris | 2011 | Environmental Science&Technology2011，45，1： | 1 |
| 13 | Physical mapping and a new variant of Puroindoline b-2 genes in wheat显示文摘 | Feng Chen Brian S. Beecher Craig F. Morris | 2010 | Theoretical and Applied Genetics2010，，4： | 1 |
| 14 | No association of Angiotensin-Converting enzyme 2 gene ( ACE2 ) polymorphisms with essential hypertension显示文摘 | Adam V. Benjafield William Y.S. Wang Brian J. Morris | 2004 | American Journal of Hypertension2004，，7： | 1 |
| 15 | Lung cancer-initiating cells: a novel target for cancer therapy显示文摘 | Brian J. Morrison John C. Morris Jason C. Steel | 2013 | Targeted Oncology2013，，3： | 1 |
| 16 | Association of Coronary Artery Disease With Glucocorticoid Receptor N363S Variant显示文摘 | Ruby C.Y. Lin Xing Li Wang Brian J. Morris | 2003 | Hypertension: Journal of the American Heart Association2003，，3： | 1 |
| 17 | Mitogen-activated protein kinase cascades in plants: a new nomenclature显示文摘 | MAPK Group (Kazuya Ichimura et al.) Kazuya Ichimura Kazuo Shinozaki Guillaume Tena Jen Sheen Yves Henry Anthony Champion Martin Kreis Shuqun Zhang Heribert Hirt Cathal Wilson Erwin Heberle-Bors Brian E Ellis Peter C Morris Roger W Innes Joseph R Ecker Die | 2002 | Trends in Plant Science2002，，7： | 1 |
| 18 | On the tensile failure of 3D woven composites显示文摘 | Brian N Cox Mahyar S Dadkhah W L Morris | 1996 | Composites Part A: Applied Science and Manufacturing1996，27，6： | 1 |
| 19 | Reducing ventilator-associated pneumonia in intensive care: Impact of implementing a care bundle显示文摘 | Andrew Conway Morris Alasdair W. Hay David G. Swann Kirsty Everingham Corrienne McCulloch Jane McNulty Odette Brooks Ian F. Laurenson Brian Cook Timothy S. Walsh | 2011 | Critical Care Medicine2011，，10： | 1 |
| 20 | Determinants of autobiographical memory in patients with unilateral temporal lobe epilepsy or excisions显示文摘 | Marie St-Laurent Morris Moscovitch Brian Levine Mary Pat McAndrews | 2009 | Neuropsychologia2009，，11： | 1 |
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