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| 1 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 2 | A theory for the ablation of glassy materials显示文摘 | BETHE H A ADAMS M C | 1959 | Journal of the Aero/Space Sciences1959，26，6： | 1 |
| 3 | Regulation of car- diac innervation and function via the p75 neurotrophin recep- tor显示文摘 | Beth A H Parizad B Camille L | 2008 | Auton Neurosci2008，140，12： | 1 |
| 4 | Serelaxin, recombinant human relaxin-2, for treatment of acute heart failure (RELAX-AHF): a randomised, placebo-controlled trial显示文摘 | John R Teerlink Gad Cotter Beth A Davison G Michael Felker Gerasimos Filippatos Barry H Greenberg Piotr Ponikowski Elaine Unemori Adriaan A Voors Kirkwood F Adams Maria I Dorobantu Liliana R Grinfeld Guillaume Jondeau Alon Marmor Josep Masip Peter S Pang | 2013 | The Lancet . 2013 (9860)2013，，9860： | 1 |
| 5 | Racial differences in motivators and barriersto blood donation among blood donors显示文摘 | Beth H Derrick GD | 2009 | rch Pathol Lab Med2009，133，9： | 1 |
| 6 | Pressure ulcer treatment strategies :A systematic comparative effec- tiveness review显示文摘 | ME Beth Smith Annette Totten David H | 2013 | Annals of Internal Medicine2013，159，1： | 1 |
| 7 | 查看详情显示文摘 | Bethe H A | | 0，，： | 1 |
| 8 | Enterprise Service Bus-making SOA Real显示文摘 | BETH H PETER L | 2008 | IBM Developer works2008，，2： | 1 |
| 9 | Theorie des Durchgangs schneller Korpuskularstrahlen durch Materie 显示文摘 | BETHE H MUNCHEN ZUR | 1930 | Annalen der Physik1930，397，3： | 1 |
| 10 | On the stopping of fast particles and on the creation of positive electrons 显示文摘 | BETHE H HEITLER W | 1934 | Proceedings of the Royal Society of London a1934，146，856： | 1 |
| 11 | Statins for secondary cardiovascular disease prevention for older primary care patients显示文摘 | BETH H | 2009 | Journal of the National Medical Association2009，101，7： | 1 |
| 12 | Theory of diffraction by small holes 显示文摘 | BETHE H A | 1944 | Physical Revlew1944，66，78： | 1 |
| 13 | Energy production in stars显示文摘 | | 1939 | Phys Rev1939，，55： | 1 |
| 14 | Equation of state in the gravitational collapse of stars显示文摘 | Bethe H A Brown G E Applegate J | 1979 | Nucl Phys A1979，324，： | 1 |
| 15 | Construct validation of the hospital anxiety and depression scale with clinical populations 显示文摘 | Marie J Beth P Peter H | 2000 | Journal of Psychosomatic Research2000，48，6： | 1 |
| 16 | Mitigation of Urban Heat Islands: Materials, Utility Programs, Updates显示文摘 | Rosenfeld Arthur H Hashem Akbari Sarah Bretz Beth L Fishman Dan M Kurn David J Sailor Haider Taha | 1995 | Energy and Buildings1995，22，： | 1 |
| 17 | Big effects from smallchanges: possible ways to explore nature's chemical diversity显示文摘 | Bode H B Bethe B H6fs R | 2002 | Chembiochem2002，3，7： | 1 |
| 18 | Progressive rise in red cell distribution width is associated with poor outcome after transcatheter aortic valve implantation显示文摘 | Nay Aung Rafal Dworakowski Jonathan Byrne Emma Alcock Ranjit Deshpande Kailasam Rajagopal Beth Brickham Mark J Monaghan Darlington O Okonko Olaf Wendler Philip A MacCarthy Guleed Adan Samer H Ghozlan | 2013 | Heart2013，，： | 1 |
| 19 | Intellectual Property Manage- ment in Publicly Funded R&D Centres-A Comparison of Univer- sity-based and Company-based Research Centres 显示文摘 | Beth Y Nola H D Stephen R | 2008 | Techno- vation2008，，28： | 1 |
| 20 | Statistical theory of superlattices显示文摘 | Bethe H A | | 0，，871： | 1 |
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