|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | HER3/ErbB3, an emerging cancer therapeutic target显示文摘HER3 是由四种密切相关的类型组成的 HER (EGFR/ErbB ) 受体家庭的一个成员 1 transmembrane 受体(EGFR, HER2, HER3,和 HER4 ) 。她的受体是与 Ras/Raf/MAPK, PI3K/AKT, JAK/STAT,和 PKC 发信号小径缠绕的一个复杂发信号网络的部分。HER 的异常激活受体和下游的发信号分子尖端细胞的事件上的平衡,导致癌症的各种各样的类型。Monoclonal 抗体(mAbs ) 和指向 EGFR 和 HER2 酷氨酸 kinase 活动的小分子禁止者在癌症,而是他们的临床的功效的几种类型的治疗展出临床的好处被药抵抗的出现限制。HER3 是 HER2 的比较喜欢的 dimerization 搭挡,它好证实 HER3 在药抵抗起一个重要作用到指向 EGFR 和指向 HER2 治疗。因为 HER3 限制了 kinase 活动, mAbs 正在被探索为癌症治疗指向 HER3。当前,近似一打 anti-HER3 mAbs 在临床的开发的不同阶段。然而,确定的 biomarkers 的缺乏使成层更挑战性癌症病人指向 HER3 治疗能是谁更有效的。在这评论,我们作为一个癌症药目标,在为 anti-HER3 治疗的 biomarker 发现的最近的发展,和在指向 HER3 mAbs 的临床的发展取得的进步集中于 HER3 的确认。 | Ningyan Zhang Yujun Chang Adan Rios Zhiqiang An | 2016 | Acta Biochimica et Biophysica Sinica2016，48，1： | 5 |
| 2 | Floristic diversity and regeneration status of woody plants in Zengena Forest, a remnant montane forest patch in northwestern Ethiopia显示文摘The study was conducted at Zengena forest, a fragmented remnant montane forest in northwestern Ethiopia, which surrounds Lake Zengena. The purpose was to assess the species composition, diversity and the regeneration status of woody plants. A total of 27 plots of 20 m × 20 m were sampled along the line transects laid down the altitudinal gradient from the edge of the forest encompassing the lake to the edge of the lake in eight aspects. In each plot, woody species were counted and the diameter at breast height and the height of trees and shrubs were measured. A total of 50 woody species belonging to 31 families were found, of which 17(34%) were trees, 7(14%) trees or shrubs, 23(46%) shrubs and 3(6%) lianas. The overall Shannon-Wiener diversity and evenness indices of woody species were 2.74 and 0.7, respectively. Clausena anisata had the highest relative density(23.5%), Rapanea rhododendroides the highest relative frequency(6.5%) and Prunus africana the highest relative dominance(45%) and importance value index(IVI, 51.6). The total basal area and density of woody plants were 22.3 m2?ha-1 and 2,202 individuals?ha-1, respectively. The population structure showed variations among woody plants and revealed varied regeneration patterns of different species. The importance value index and population structure revealed that some species are threatened and need prioritization for conservation measures. The results suggest that remnant forest patches in the highlands of northern Ethiopia host several woody plant species that are almost disappearing in other areas due to deforestation. | Desalegn Tadele Ermias Lulekal Destaw Damtie Adane Assefa | 2014 | Journal of Forestry Research2014，25，2： | 5 |
| 3 | Laboratory evaluation of traditional insect/mosquito repellent plants against Anopheles arabiensis, the predominant malaria vector in Ethiopia显示文摘 | Kaliyaperumal Karunamoorthi Adane Mulelam Fentahun Wassie | 2008 | Parasitology Research2008，，3： | 2 |
| 4 | Prognostic value of endothelial dysfunction in type 1 diabetes mellitus显示文摘Patients with diabetes mellitus are at high risk of developing atherosclerosis, associated with higher rates of micro and macro vascular involvement such as coronary artery disease and renal disease. The role of hyperglycemia to induce synthesis of reactive oxygen species by the oxidation of glucose, leading to an increased production of advanced glycosylation end products, as well as inflammation and oxidative stress has been proposed as a possible mechanism in the pathogenesis of endothelial dysfunction(ED). The interaction between C-peptide- the connecting segment of pro-insulin-and nitric oxide in vasodilation is also discussed. Therefore, endothelial dysfunction has been identified as an early marker of vascular disorder in type 1 and type 2 diabetes mellitus. In some other diseases, ED has been considered an independent predictor of vascular disease, regardless of the method used. Studies have demonstrated the importance of endothelial dysfunction as an useful tool for identifying the risk of vascular complications in patients with type 1 diabetes mellitus, particularly as regards to renal impairment. The aim of this review is to clarify the prognostic value of endothelial dysfunction as a marker of vascular disease in these subjects. | Ana Marice Ladeia Raphael Ribeiro Sampaio Maiara CostaHita Luis F Adan | 2014 | World Journal of Diabetes2014，5，5： | 2 |
| 5 | Effects of cropping systems and nitrogen levels on corn yields in the sonthem Piemount region 显示文摘 | Adans W E Morris H D Darson R N | 1970 | Agron J1970，，62： | 1 |
| 6 | Nailsalvage using the eponychia l flap显示文摘 | Adan R Leo G Tarallo L | 2006 | Tech Extrem Surg2006，10，4： | 1 |
| 7 | Non- invasive diagnosis of nonalcoholic fatty liver and nonalcoholic steatonhepa- titis显示文摘 | Adans LA Feldstein AE | 2011 | Dig Dis2011，12，1： | 1 |
| 8 | Superovulatory response of Murciana goats to treatments based on PMSG/Anti-PMSG or combined FSH/PMSG administration 显示文摘 | PINTADO B GUTIIARREZ -ADAN A PIAREZ L B | 1998 | Theriogenology1998，50，3： | 1 |
| 9 | A two state Markovian model of global radiation suitable for photovoltaic conversion 显示文摘 | Maafi A Adane A | 1989 | Solar and Wind Technology1989，12，3： | 1 |
| 10 | Horne&¨ostberg morningness-eveningness questionnaire:a reduced scale显示文摘 | Adan A Almirall H | 1991 | Pers Individ Dif1991，12，3： | 1 |
| 11 | Non-adherence to anti-tu- berculosis treatment and determinant factors among patients with tu- berculosis in northwest Ethiopia显示文摘 | Adane AA Alene KA Koye DN | 2013 | PLOS One2013，8，78： | 1 |
| 12 | Proper efficiency in vector optimization on real linear spaces 显示文摘 | Adan M Novo V | 2004 | Journal of Optimization Theory and Applications2004，121，3： | 1 |
| 13 | Corneal in vivo confocal scanning laser microscopy in patients with atopic keratoconjunctivitis 显示文摘 | Hu Y Matsumoto Y Adan ES | 2008 | Ophthalmology2008，115，： | 1 |
| 14 | Weak efficiency vector optimization using a closure of algebraic type under cone-convexlikeness 显示文摘 | Adan M Novo V | 2003 | European Journal of Operational Research2003，149，3： | 1 |
| 15 | Chemical and fatty acid composition of meat and liver of wild ducks显示文摘 | Angel Cobos Adan Veiga Olga Diaz | 2000 | Food Chemistry2000，68，： | 1 |
| 16 | A- nalysis of pesticides by gas chromatography/multiphoton ionization/mass spectrometry using a femtosecond laser 显示文摘 | Li Adan Imasaka Tomoko Uchimura Tomohiro | 2011 | Analytica Chimica Acta2011，701，： | 1 |
| 17 | Neuropeptides, food intake and body weight regulation: A hypothalamic focus显示文摘 | HILLEBRAND J J G DEWIED D ADAN R A H | 2002 | Peptides2002，23，： | 1 |
| 18 | Diagnosis and treatment of sicksinussyndrome显示文摘 | Adan V Crown LA | 2003 | Am Fam Physician2003，67，： | 1 |
| 19 | The interrelationship of sputum inflammatory markers in patients with chronic bronchitis显示文摘 | Adan T Hill Darren Bayley Robert A | 1999 | Am J Respir Crit Care Med1999，160，： | 1 |
| 20 | Optimality conditions for vector Optimization problems with generalized convexity in real linear spaces 显示文摘 | Adan M Novo V | 2002 | Optimization2002，81，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员