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| 1 | NOTES ON FINITE ELEMENT METHOD AND ITS GENERALIZATION显示文摘NOTES ON FINITE ELEMENT METHOD AND ITS GENERALIZATIONNOTESONFINITEELEMENTMETHODANDITSGENERALIZATION￥L.Tao(InstituteofMechanic... | L. Tao (Institute of Mechanics, Chinese Academy of Sciences, Beijing 100080, P. R. China)G. Q. Chen (Center for Environmental Sciences, Peking University, Beijing 100871, P. R. China)K. R. Rajagopal (Department of Mechanical Engineering, University of Pit | 1996 | Journal of Hydrodynamics1996，8，3： | 9 |
| 2 | Role of innate immunity in the development of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is the most common form of liver cancer worldwide.It is caused by a variety of risk factors,most common ones being infection with hepatitis viruses,alcohol,and obesity.HCC often develops in the background of underlying cirrhosis,and even though a number of interventional treatment methods are currently in use,recurrence is fairly common among patients who have had a resection.Therefore,whole liver transplantation remains the most practical treatment option for HCC.Due to the growing incidence of HCC,intense research efforts are being made to understand cellular and molecular mechanisms of the disease so that novel therapeutic strategies can be developed to combat liver cancer.In recent years,it has become clear that innate immunity plays a critical role in the development of a number of liver diseases,including HCC.In particular,the activation of Toll-like receptor signaling results in the generation of immune responses that often results in the production of proinflammatory cytokines and chemokines,and could cause acute inflammation in the liver.In this review,the current knowledge on the role of innate immune responses in the development and progression of HCC is examined,and emerging therapeutic strategies based on molecular mechanisms of HCC are discussed. | Rajagopal N Aravalli | 2013 | World Journal of Gastroenterology2013，19，43： | 8 |
| 3 | Neuroendocrine carcinoma of the ampulla of Vater:a clinicopathologic evaluation显示文摘BACKGROUND:Only 105 cases of neuroendocrine tumor(NET)of the ampulla of Vater have been described, mostly as single case reports.The incidence of NET is rising.The changes in incidence may result from changes in detection.This study was to determine the relative incidence and clinicopathological characteristics of high- grade neuroendocrine carcinoma(small cell carcinoma and large cell carcinoma)of the ampulla of Vater at a single institution. METHODS:Sections from paraffin blocks of tumors of the ampulla of Vater taken from 45 patients who underwent Whipple's procedure and 6 patients who underwent palliative bypass between September 2003 and January 2007 were subjected to immunohistochemical analysis.The clinical and pathological data from 5 patients diagnosed with NET of the ampulla of Vater were analyzed. RESULTS:The patients were 3 men and 2 women,ranging in age from 39 to 47 years(mean 44 years).Operative procedures included Whipple's procedure in 4 patients and palliative bypass in 1 patient.Histopathological examination revealed large-cell neuroendocrine carcinoma in 2 patients,small cell carcinoma in 2,and carcinoid in 1.Three patients with high-grade neuroendocrine carcinoma who had undergone Whipple's procedure died at postoperatively 7,11,and 13 months.The patient who had undergone palliative triple bypass died 3 months after surgery.CONCLUSIONS:The relative incidence of high-grade neuroendocrine carcinomas of the ampulla of Vater is higher than that generally expected.The tumors behave aggressively and have a dismal prognosis despite aggressive treatment. | Eswaran Selvakumar Shanmugasundaram Rajendran Tirupporur Govindaswamy Balachandar Devy Gounder Kannan Satyanesan Jeswanth Palaniappan Ravichandran Rajagopal Surendran | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，4： | 7 |
| 4 | Long-term outcome of gastric access loop in hepaticojejunostomy显示文摘BACKGROUND:The incidence of hepaticojejunostomy stricture is 4%-10% in experienced centres. Many access loops have been designed and used to facilitate endoscopic intervention for this complication of hepaticojejunostomy. In this study, we investigated the effectiveness and safety of gastric access loop. METHODS:A retrospective analysis was conducted on 13 patients who had undergone hepaticojejunostomy with gastric access loop between June 1999 and September 2003. Eleven patients were followed up for a mean period of 51 months (range 20-81 months). Two patients were lost to follow up. RESULTS:On follow-up, 8 patients had patent jejuno- gastrostomy (end to side anastomosis between Roux loop of jejunum and stomach) and hepaticojejunostomy. Three patients developed stricture of jejunogastrostomy at 41 months, 63 months and 81 months of follow-up. Among these 3 patients, one also had hepaticojejunostomy stricture. In the patient with hepaticojejunostomy stricture, dilatation of jejunogastrostomy stricture was attempted but failed. None of the patients had any evidence of bile gastritis/cholangitis. There was no procedure related morbidity/mortality. CONCLUSIONS:Further studies involving large numbers of patients are required before wide application of gastric access loop in hepaticojejunostomy though it is a safer option than percutaneous transhepatic manipulations or revision surgery. | Eswaran Selvakumar Shanmugasundaram Rajendran Tirupporur G. Balachandar Devy Gounder Kannan Satyanesan Jeswanth Palaniappan Ravichandran Rajagopal Surendran | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，2： | 6 |
| 5 | 血管内皮生长因子受体3通过β抑制蛋白1调节内皮功能显示文摘受体信号转导对于维持血管内皮功能至关重要,其在动脉粥样硬化和肺动脉高压(pulmonary arterial hypertension,PAH)等血管疾病中出现失调。内皮功能相关受体信号包括血管内皮生长因子(vascular endothelial growth factor,VEGF)受体(VEGFR)和G蛋白耦联受体(G protein-coupled receptor,GPCR),激活特异的细胞内信号通路和反应。 | 刘青 叶鹏 Ma Z Yu YR Badea CT Kovacs JJ Xiong X Comhair S Piantadosi CA Rajagopal S | 2019 | 中华高血压杂志2019，27，1： | 5 |
| 6 | Reinforcement Learning Based Controller Synthesis for Flexible Aircraft Wings显示文摘Aeroelastic study of flight vehicles has been a subject of great interest and research in the last several years. Aileron reversal and flutter related problems are due in part to the elasticity of a typical airplane. Structural dynamics of an aircraft wing due to its aeroelastic nature are characterized by partial differential equations. Controller design for these systems is very complex as compared to lumped parameter systems defined by ordinary differential equations. In this paper, a stabilizing statefeedback controller design approach is presented for the heave dynamics of a wing-fuselage model. In this study, a continuous actuator in the spatial domain is assumed. A control methodology is developed by combining the technique of “proper orthogonal decomposition” and approximate dynamic programming. The proper orthogonal decomposition technique is used to obtain a low-order nonlinear lumped parameter model of the infinite dimensional system. Then a near optimal controller is designed using the single-network-adaptive-critic technique. Furthermore,to add robustness to the nominal single-network-adaptive-critic controller against matched uncertainties, an identifier based adaptive controller is proposed. Simulation results demonstrate the effectiveness of the single-network-adaptive-critic controller augmented with adaptive controller for infinite dimensional systems. | Manoj Kumar Karthikeyan Rajagopal Sivasubramanya Nadar Balakrishnan Nhan T.Nguyen | 2014 | IEEE/CAA Journal of Automatica Sinica2014，1，4： | 4 |
| 7 | Volumetric and Viscometric Studies of 4-Aminobutyric Acid in Aqueous Solutions of Salbutamol Sulphate at 308.15, 313.15 and 318.15K显示文摘密度(ρ) 并且粘性(η) 大小在 0.0041, 0.0125 和 0.0207 mol· 为 4-aminobutyric 酸被执行; L −1 在 308.15, 313.15 和 318.15 K 的水的 salbutamol 硫酸盐。密度和粘性的测量的值被用来估计象明显的臼齿的卷 V 那样的一些重要参数,限制明显的臼齿的体积,转移体积,水和数字 n 有温度的部分臼齿的体积的无限的冲淡导出的 H ,秒,粘性B系数,有温度 dB/dT 的 B 的变化,激活的免费精力每溶剂和溶质的鼹鼠,氨基酸的激活熵和激活热含量。这些参数在给定的答案以溶质溶质和溶质溶剂相互作用和溶质的结构做 / 打破能力被解释了。 | K. Rajagopal S.S. Jayabalakrishnan | 2009 | Chinese Journal of Chemical Engineering2009，17，5： | 4 |
| 8 | Gene expression profiling of MYC-driven tumor signatures in porcine liver stem cells by transcriptome sequencing显示文摘AIM:To identify the genes induced and regulated by the MYC protein in generating tumors from liver stem cells.METHODS:In this study,we have used an immortal porcine liver stem cell line,PICM-19,to study the role of c-MYC in hepatocarcinogenesis.PICM-19 cells were converted into cancer cells(PICM-19-CSCs)by overexpressing human MYC.To identify MYC-driven differential gene expression,transcriptome sequencing was carried out by RNA sequencing,and genes identified by this method were validated using real-time PCR.In vivo tumorigenicity studies were then conducted by injecting PICM-19-CSCs into the flanks of immunodeficient mice.RESULTS:Our results showed that MYC-overexpressing PICM-19 stem cells formed tumors in immunodeficient mice demonstrating that a single oncogene was sufficient to convert them into cancer cells(PICM-19-CSCs).By using comparative bioinformatics analyses,we have determined that>1000 genes were differentially expressed between PICM-19 and PICM-19-CSCs.Gene ontology analysis further showed that the MYCinduced,altered gene expression was primarily associated with various cellular processes,such as metabolism,cell adhesion,growth and proliferation,cell cycle,inflammation and tumorigenesis.Interestingly,six genes expressed by PICM-19 cells(CDO1,C22orf39,DKK2,ENPEP,GPX6,SRPX2)were completely silenced after MYC-induction in PICM-19-CSCs,suggesting that the absence of these genes may be critical for inducingtumorigenesis.CONCLUSION:MYC-driven genes may serve as promising candidates for the development of hepatocellular carcinoma therapeutics that would not have deleterious effects on other cell types in the liver. | Rajagopal N Aravalli Neil C Talbot Clifford J Steer | 2015 | World Journal of Gastroenterology2015，21，7： | 3 |
| 9 | Outcome of severe acute pancreatitis: Is there a role for conservative management of infected pancreatic necrosis?显示文摘BACKGROUND: Infected pancreatic necrosis is associated with high morbidity and mortality and is mandatory for surgical or radiological intervention. A selected group of patients with CT evidence of infected pancreatic necrosis and a comparatively lower APACHE score may be clinically stable throughout the course of their illness. METHODS: Case records of 52 patients with severe acute pancreatitis admitted from October 2000 to September 2005 were retrospectively analysed to assess the feasibility of conservative management of infected pancreatic necrosis. CT evidence of retroperitoneal air pockets, deteriorated clinical condition, sepsis and positive blood culture were used to diagnose infected pancreatic necrosis. RESULTS: In the 52 male patients reviewed, 24 patients had infected pancreatic necrosis. Eighteen patients who had progressively deteriorated clinical conditions required surgical intervention; five patients of whom (27.8%) died. Six patients with transient end organ dysfunction and stable clinical conditions were treated with prolonged administration of antibiotics and ICU support. All these patients recovered and discharged from the hospital, and no symptoms or readmission happened during follow-up of 6-44 months. CONCLUSIONS: Selected patients with infected pancreatic necrosis who are clinically stable with transient end organ dysfunction can be treated conservatively with a favourable outcome. Necrosectomy associated with high morbidityand mortality in these patients can be avoided. The need for intervention should be individualized and based on clinical conditions of the patients. | Amarapathy Sivasankar Devy Gounder Kannan Palaniappan Ravichandran Sathyanesan Jeswanth Tirupporur Govindasamy Balachandar Rajagopal Surendran | 2006 | Hepatobiliary & Pancreatic Diseases International2006，5，4： | 3 |
| 10 | A new nonlinear oscillator with infinite number of coexisting hidden and self-excited attractors显示文摘In this paper,we introduce a new two-dimensional nonlinear oscillator with an infinite number of coexisting limit cycles.These limit cycles form a layer-by-layer structure which is very unusual.Forty percent of these limit cycles are self-excited attractors while sixty percent of them are hidden attractors.Changing this new system to its forced version,we introduce a new chaotic system with an infinite number of coexisting strange attractors.We implement this system through field programmable gate arrays. | 唐妍霞 Abdul Jalil M Khalaf Karthikeyan Rajagopal Viet-Thanh Pham Sajad Jafari 田野 | 2018 | Chinese Physics B2018，27，4： | 2 |
| 11 | Dynamics of a neuron exposed to integer-and fractional-order discontinuous external magnetic flux显示文摘We propose a modified Fitzhugh-Nagumo neuron(MFNN) model. Based on this model, an integerorder MFNN system(case A) and a fractional-order MFNN system(case B) were investigated. In the presence of electromagnetic induction and radiation, memductance and induction can show a variety of distributions. Fractionalorder magnetic flux can then be considered. Indeed, a fractional-order setting can be acceptable for non-uniform diffusion. In the case of an MFNN system with integer-order discontinuous magnetic flux, the system has chaotic and non-chaotic attractors. Dynamical analysis of the system shows the birth and death of period doubling, which is a sign of antimonotonicity. Such a behavior has not been studied previously in the dynamics of neurons. In an MFNN system with fractional-order discontinuous magnetic flux, different attractors such as chaotic and periodic attractors can be observed. However, there is no sign of antimonotonicity. | Karthikeyan RAJAGOPAL Fahimeh NAZARIMEHR Anitha KARTHIKEYAN Ahmed ALSAEDI Tasawar HAYAT Viet-Thanh PHAM | 2019 | Frontiers of Information Technology & Electronic Engineering2019，20，4： | 2 |
| 12 | Human interleukin 24 (MDA-7/IL-24) protein kills breast cancer cells via the IL-20 receptor and is antagonized by IL-10显示文摘 | Mingzhong Zheng Dora Bocangel Blair Doneske Abner Mhashilkar Rajagopal Ramesh Kelly K. Hunt Suhendan Ekmekcioglu R. Bryan Sutton Nancy Poindexter Elizabeth A. Grimm Sunil Chada | 2007 | Cancer Immunology Immunotherapy2007，，2： | 2 |
| 13 | Synthesis and electrochemical performance of (100-x)Li7P3S11-xLi2OHBr composite solid electrolyte for all-solid-state lithium batteries显示文摘Li7P3S11solid electrolytes with high lithium-ion conductivity are promising candidates for use in all-solidstate lithium batteries.However,this electrolyte’s poor interfacial compatibility with lithium electrodes causes unstable cyclability.In this study,in order to address this problem,(100-x)Li7P3S11-xLi2OHBr(x=0,2,5,10,20,30,40,and 50)electrolytes are prepared by a high energy ball-milling technique and heat-treatment process.The resulting(100-x)Li7P3S11-xLi2OHBr(x=2,5,10,20,30,40,and 50)electrolytes provide improved electrochemical performance with good cycling stability and a wide electrochemical window of up to 10 V(vs.Li/Li+).Moreover,these electrolytes have high ionic conductivity of 10-4–10-5S/cm at room temperature.Particularly,the 90Li7P3S11-10Li2OHBr electrolyte displays the highest conductivity of 4.4×10-4S/cm at room temperature as well as improved cyclability.Moreover,90Li7P3S11-10Li2OHBr shows decreased interfacial resistance between the solid electrolyte and cathode electrode,which was revealed by Electrochemical Impedance Spectroscopy(EIS)analysis.The initial discharge capacity of 90Li7P3S11-10Li2OHBr was found to be 135 m Ah/g when used in a In|solid electrolyte|Li(Ni0.6Co0.2Mn0.2)O2 all-solid-state lithium battery(ASSLB).Thus,we can conclude the addition of Li2OHBr into the Li7P3S11results in enhanced electrochemical properties. | Su-Yeon Jung Rajesh Rajagopal Kwang-Sun Ryu | 2020 | Journal of Energy Chemistry2020，29，8： | 2 |
| 14 | Discrete large eddy simulation显示文摘Despite the intense effort expended towards obtaining a model for describing the turbulent flows of fluid, there is no model at hand that can do an adequate job. This leads us to look for a non-traditional approach to turbulence modeling. In this work we conjoin the notion of large eddy simulation with those of fuzzy sets and neural networks to describe a class of turbulent flows. In previous works we had discussed several issues concerning large eddy simulation such as filtering and averaging. Here, we discuss the use of fuzzy sets to improve the filtering procedure. | L. TAO, K. R. RAJAGOPAL and G. Q. CHEN(Department of Mechanical Engineering, Texas A&M University, College Station, Texas 77843-3123,USACentre for Environmental Sciences, Peking University, Beijing 100871, China | 2001 | Communications in Nonlinear Science and Numerical Simulation2001，6，1： | 2 |
| 15 | A critical review on inhibition of anaerobic digestion process by excess ammonia显示文摘 | Rajinikanth Rajagopal Daniel I. Massé Gursharan Singh | 2013 | Bioresource Technology2013，，： | 2 |
| 16 | Outbreaks of salmonellosis in three different poultry farms of Kerala,India显示文摘Avian salmonellosis is an important disease causing serious impediment to the development of poultry industry especially in developing countries of Asia and Africa.Since no'effective'immunoprophylactic measures are available for the disease till date,strict biosecurity is the only alternative to preclude the disease.For formulating the control measures,an understanding of the epidemiology of the disease,proper diagnosis and identification of the causative agent is quintessential.This report sheds light on three different outbreaks of salmonellosis in three different farms in Kerala(India)describing the disease diagnosis,antibiotic resistance and the suggested control measures.All the three isolates were revealed to be Salmonella gallinarum and were resistant to at least three of the antimicrobial agents tested. | Ramachandranpillai Rajagopal Mangattumuruppel Mini | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，6： | 2 |
| 17 | Functional Accumulation of Antenna Proteins in Chlorophyll b-Less Mutants of Chlamydomonas reinhardtii显示文摘绿水藻 Chlamydomonas reinhardtii 包含几轻收获的叶绿素 a/b 建筑群(LHC ) :四主要 LHCII,二次要的 LHCII,和九 LHCI。我们描绘了三叶绿素祝福异种在这些叶绿素 a/b 绑定蛋白质的函数,汇编,和稳定性上估计叶绿素 b 缺乏的效果。我们在使为叶绿素 a 负责的 CAO 基因失去活性到叶绿素 b 变换的二异种识别了点变化。所有 LHCII 在 CAO 异种积累了到野类型的层次,但是他们为 photosystem II 的轻收获的功能被损害。相反,大多数 LHCI 为我仍然是的 photosystem 在异种和他们的轻收获的能力积累了到野类型的层次未改变。出人意料地, LHCI 累积和 photosystem 我在异种增加与相比的功能的天线尺寸在野类型当在暗淡的光成长时。当 CAO 变化被放在一个 yellow-in-the-dark 背景(yid-BF3 ) 时,在哪个叶绿素合成在暗淡的光仍然保持有限,主要 LHCII 并且大多数 LHCI 的累积显著地被减少,显示叶绿素的那持续合成一是要求了保存天线蛋白质的解朊的抵抗。在为 thylakoid FtsH 朊酶活动与一个变异的有缺陷者一起穿过 yid-BF3 以后,确实, yid-BF3-ftsh1 恢复了 LHCI 的野类型的层次,它为 FtsH 朊酶把 LHCI 定义为新底层。 | Sandrine Bujaldon Natsumi Kodama Fabrice Rappaport Rajagopal Subramanyam Catherine de Vitry Yuichiro Takahashi FrancisAndre Wollman | 2017 | Molecular Plant2017，10，1： | 2 |
| 18 | Remarks on large eddy simulation显示文摘 | CHEN G Q TAO L RAJAGOPAL K R | 2000 | Commun in Nonlinear Sci and Nume Simul2000，5，3： | 1 |
| 19 | Ultrasound promoted Suzuki cross-coupling reactions in ionic liquid at ambient conditions显示文摘 | Rajagopal R Jarikote V Srinivasan K V | 2002 | Chem Commun2002，，6： | 1 |
| 20 | Stagnation point flow of a non-Newtonian fluid显示文摘 | Garg V K Rajagopal K R | 1990 | Mechanics Research Communication1990，17，： | 1 |
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