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| 1 | Circulating metastasis associated in colon cancer 1 transcripts in gastric cancer patient plasma as diagnostic and prognostic biomarker显示文摘AIM: To evaluate the diagnostic and prognostic value of circulating Metastasis Associated in Colon Cancer 1(MACC1) transcripts in plasma of gastric cancer patients.METHODS: We provide for the first time a blood-based assay for transcript quantification of the metastasis inducer MACC1 in a prospective study of gastric cancer patient plasma.MACC1 is a strong prognostic biomarker for tumor progression and metastasis in a variety of solid cancers.We conducted a study to define the diagnostic and prognostic power of MACC1 transcripts using 76 plasma samples from gastric cancer patients,either newly diagnosed with gastric cancer,newly diagnosed with metachronous metastasis of gastric cancer,as well as follow-up patients.Findings were controlled by using plasma samples from 54 tumor-free volunteers.Plasma was separated,RNA was isolated,and levels of MACC1 as well as S100A4 transcripts were determined by quantitative RT-PCR.RESULTS: Based on the levels of circulating MACC1 transcripts in plasma we significantly discriminated tumorfree volunteers and gastric cancer patients(P < 0.001).Levels of circulating MACC1 transcripts were increased in gastric cancer patients of each disease stage,compared to tumor-free volunteers: patients with tumors without metastasis(P = 0.005),with synchronous metastasis(P = 0.002),with metachronous metastasis(P = 0.005),and patients during follow-up(P = 0.021).Sensitivity was 0.68(95%CI: 0.45-0.85) and specificity was 0.89(95%CI: 0.77-0.95),respectively.Importantly,gastric cancer patients with high circulating MACC1 transcript levels in plasma demonstrated significantly shorter survival whencompared with patients demonstrating low MACC1 levels(P = 0.0015).Furthermore,gastric cancer patients with high circulating transcript levels of MACC1 as well as of S100A4 in plasma demonstrated significantly shorter survival when compared with patients demonstrating low levels of both biomarkers or with only one biomarker elevated(P = 0.001).CONCLUSION: Levels of circulating MACC1 transcripts in plasma of gastric cancer patients are of diagnostic value and are prognostic for patient survival in a prospective study. | Susen Burock Pia Herrmann Ina Wendler Markus Niederstrasser Klaus-Dieter Wernecke Ulrike Stein | 2015 | World Journal of Gastroenterology2015，21，1： | 7 |
| 2 | Determination of heavy metals in activated charcoals and carbon black for Lyocell fiber production using direct solid sampling high-resolution continuum source graphite furnace atomic absorption and inductively coupled plasma optical emission spectrometry显示文摘 | Fábio G. Lepri Daniel L.G. Borges Rennan G.O. Araujo Bernhard Welz Frank Wendler Marcus Krieg Helmut Becker-Ross | 2010 | Talanta2010，，3： | 3 |
| 3 | 理解和运用《教育与心理测试标准》——ETS的案例研究显示文摘《教育与心理测试标准》由美国心理协会(APA)、美国教育研究协会(AERA)和美国国家教育测量协会(NCME)联合制定,美国教育考试服务中心(ETS)仿效《教育与心理测试标准》,制定了《ETS质量和公平标准》。本文介绍这两套标准的制定过程以及历史发展,《ETS质量和公平标准》的理念以及在ETS考试产品中的应用。 | Cathy Wendler Barbara Kirsh 冯采 | 2017 | 中国考试2017，，10： | 2 |
| 4 | Capability of ICP-MS (Pneumatic Nebulization and ETV) for Pt-analysis in Different Matrices at Ecologically Relevant Concentrations显示文摘 | Schramel P Wendler I Lustig S | 1995 | Fresenius J Anal Chem1995，353，： | 1 |
| 5 | Salivary leptin as a can- didate diagnostic marker in salivary gland tumors 显示文摘 | Schapher M Wendler O Grfischl M | 2009 | Clinic Chem2009，55，5： | 1 |
| 6 | 新组织经济学显示文摘 | Janathan D. Day James C. Wendler | 2000 | 国际经济评论2000，，5： | 1 |
| 7 | Structural changes and Si redistribution in Si+ implanted silica glass显示文摘 | Wendler E Wesch W Herrmann U | 1996 | Nuclear Instruments and Methods in Physics Research Section B : Beam Interactions with Materials and Atoms1996，11，14： | 1 |
| 8 | Rinsing water recovery in the steel industry-a combined UF/NF treatment 显示文摘 | Wolters R Wendler B Schmidt B | 2008 | Desalination2008，224，123： | 1 |
| 9 | Translocation of amina acids in the xylem of apple (Malus demestica Borth)trees in spring as a consequence of both N remobilization and root uptake显示文摘 | Malaguti D Millard P Wendler R | 2001 | J Exp Bot2001，52，： | 1 |
| 10 | Minimal risk in pediatric re- search 显示文摘 | Wendler D Varma S | 2007 | The Journal of Pediatrics2007，149，6： | 1 |
| 11 | Turonian o ceanic red beds in the Eastern Alps: Concepts for palaeocean- ographic changes in the Mediterranean Tethys显示文摘 | Stephanie N M Wagreich M Wendler I | 2007 | Palaeo geography Palaeoclimatology Palaeoecology2007，251，2： | 1 |
| 12 | Extracorporeal plasma treatment in primary and recurrent focal segmental glomerular sclerosis:a review显示文摘 | Bosch T Wendler T | 2001 | Ther Apher2001，5，： | 1 |
| 13 | The urban heat island effect at Fairbanks, Alaska显示文摘 | Magee N Curtis J ld Wendler G | 1999 | Theoretical and Applied Climatology1999，64，： | 1 |
| 14 | Executing and observing CFD applications on the grid显示文摘 | WENDLER J SCHINTKE F | 2005 | Future Generation Computer Systems2005，21，1： | 1 |
| 15 | The oxidation of β-carotene显示文摘 | Wendler N L Rosenblum C Tishler M | 1950 | J Am Chem Soc1950，72，： | 1 |
| 16 | Stick insect locomotion on a walking wheel:inter-leg coordination of leg position显示文摘 | Dean J Wendler G | 1983 | Journal of Experimental Biology1983，103，： | 1 |
| 17 | Protoporphyrin IX binding and transport by recombinant mouse PBR显示文摘 | Wendler G M Lindemann P Lacapere J J | 2003 | Biochem Biophys Res Commun2003，311，4： | 1 |
| 18 | Is the fish embryotoxicity test(FET)with the zebrafish(Danio rerio)a potential alternative for thefish acute toxicity test?显示文摘 | Lammer E Carr G Wendler K | 2009 | Comp Biochem Physiol2009，149，2： | 1 |
| 19 | Children's and their parents' views on facing research risks for the benefit of others 显示文摘 | Wendler D Jenkins T | 2008 | Arch Pediatr Adolesc Med2008，162，1： | 1 |
| 20 | The hematopoietic system-specific minor histocompatibility antigen HA-1 shows aberrant expression in epithelial cancer cells显示文摘 | Wilke M Pool J Vermeulen C okland E Burghart E Krostina S Wendler N Passlick B Riethmueller G Goulmy E | 2002 | J Exp Med2002，196，3： | 1 |
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